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All Journal Indian Journal of Forensic Medicine & Toxicology
Fayhaa M. Khaleel
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Public Health

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The Role of Biochemical Parameters in Prediction of Retinal Diseases and their Relationship to Cataract, Diabetes, and Hypertension, in Ibn Al Haytham Hospital, Baghdad, Iraq Huda H. Hassan; Fayhaa M. Khaleel; Khudair Abbas Jassim
Indian Journal of Forensic Medicine & Toxicology Vol. 16 No. 1 (2022): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v16i1.17680

Abstract

This work summarize multiple protective roles serum Zeaxanthin, and Malondialdehyde, in association with metabolic profiles and as a risk of retinal disorder disease with cataract, diabetes, and hypertension, totally thirty healthy control group, and seventy-five patients group for both genders were studied. Retinal disorder disease subdivided after clinical diagnosis, into three major -subgroups, the first cohort was twenty-five patients suffers of cataract, the second twenty-five of diabetic patients, while the third group is twenty-five hypertensive patients. Lipid-profile, Fasting-insulin-levels, serum zeaxanthin and malondialdehyde, have been done to all groups. Important findings presented in the roles of serum zeaxanthin, and malondialdehyde, by similarities and differences, in retinal diseases with cataract, diabetes, and hypertension. The activity levels of serum zeaxanthin in hypertensive retinopathy patients (32.80±30.56 ng/mL), was non-significantly (P>0.01) reduced compared to healthy control (88.85±139.31 ng/mL), in compression with the same patients for serum malondialdehyde MDA which expressed the highest level of MDA (2.456±2.149 μg/mL) among the rest groups, which was significantly higher (P<0.05) than that in control (0.783±0.937 μg/mL), but the differences were non-significant (P>0.05) compared to diabetic retinopathy group (1.839±1.515 μg/mL).The activity levels are negatively associated with malondialdehyde levels in retinal disease patients with cataract, diabetes, and hypertension. Retinal disease patients with cataract, diabetes, and hypertension pathogenesis aren’t legitimately ensured. But multiple protective roles may be adopted in clinical diagnosis of retina, also in response to higher levels of oxidative stress, including serum malondialdehyde, and zeaxanthin, by fasting at least eight hours pre sophisticated lens surgery.
Study Some Kinetic Parameters for Purified Arginase from Two Different Sources: Red Blood Cells and Serum of( Healthy and TypeII Diabetic Patient) Fayhaa M. Khaleel; Essam F.A.Al-Jumaili
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14551

Abstract

Kinetics parameters for arginase that purified from RBCs, and serum (control, and diabetic patients)revealed that the Km values are (200, 416, and 333mM), Vmax values are (47, 5.5, and 9 U/min),andThe values of catalytic constant Kcat are (174, 45.8, and 81.8 min-1). The effect of atrovastatin was alsostudied on serum arginase, the arginase activity is decreasing by increasing statin concentration, whereinat the lower concentration (0.112 mg/ml) the allosteric regulation percentage is 26% and it is ongoing untilreaching its maximum (85%) at the highest concentration (0.9mg/ml). In conclusion affinity of arginase tothe L-arginine, and its velocity is more in RBCs, and serum patients compared with serum controls, andstatin appears to be an allosteric regulator for arginase.
Purification and Characterization of Arginase from Serum of Healthy and Type II Diabetic Iraqi Patients Noor N.O. Al-Saad; Fayhaa M. Khaleel; Essam F. A. Al-Jumaili
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 3 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i3.15475

Abstract

Arginase was purified from human serum of healthy and patient with type II Diabetes mellitus subjects.The purification steps included, DEAE-cellulose chromatography and gel filtration on Sepharoe6B.Themolecular weight of native arginase was find to be (94 Kd), by gel filtration. The purified human serumarginase is characterized by optimum pH of (9.5), optimum pH of stability is between (9-10), optimumtemperature (350C), temperature of stability is between (30-500C) in both healthy and patient subjects.
Co-Authors Essam F. A. Al-Jumaili Essam F.A.Al-Jumaili Huda H. Hassan Khudair Abbas Jassim Noor N.O. Al-Saad