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All Journal Indian Journal of Forensic Medicine & Toxicology Celebes Journal of Community Services
Khairuddin Djawad
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Humanities Economics, Econometrics & Finance Education Public Health Social Sciences

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Effectiveness of Giving Secang Wood Extract (Caesalpinia Sappan L) Against IL-6 And IL-10 Levels in Balb / C Mice With Vulvovaginalis Candidiasis Sri Wahyu; Firdaus Hamid; Mochammad Hatta; Khairuddin Djawad; Agussalim Bukhari; Rosdiana Natzir; Alfina Baharuddin
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14567

Abstract

The aim of this study was to test the effectiveness of secang wood extract (Caesalpinia sappan L) onIL-6 and IL-10 expression in Balb / c mice with vulvovaginalis candidiasis. This type of research is anexperimental laboratory, with a control group design using experimental animals as research objects. Theresearch subjects were BALB / c mice weighing 35-40 grams, aged 10-12 weeks, the number of experimentalanimals needed in this study was 18 for 3 random groups, each group being 6. Analysis and data processingusing the excel program SPSS Repeated ANOVA Test was used to measure differences in cytokine levels.IL-6 levels in group 1 (control) where the value of IL-6 expression after infection (H1) was 4309.40 pg /mL(IQR value 3803.8-4963.5) after treatment (H7) in the control group increased by 5578.12 pq / mL (IQR5330.3 - 6162.9). In group 2 that were given fluconazole and secang wood extract, IL-6 levels tended todecrease by 3516.4 pq / mL (IQR: 3070.4-4061.6) Secang wood after infection decreased from 3417.34 pq/ mL to 2782.97 pq / mL after treatment. In Group 2 that was given fluconazole and secang wood extract,IL-10 levels increased by 1414.8 pq / ml (IQR: 1061.7- 3158) after infection, to 3268.35 pq / ml (IQRvalue: 1789.9-3709.6) after treatment. given secang wood after infection increased from 2032.67 pq / ml to3091.83 pq / mL after treatment. The p value is 0.008. Obtained the effect of secang wood extract in reducinglevels of Interleukin 6 and can increase the value of IL-10 levels after administration of secang wood extracton candidiasis vulvovaginalis
Effect of Photoprotective Cream of Mangosteen Pericarp Extract (Garcinia Mongostana L) Against 8-OHdG After UVB Exposure On Albino Mice Dian Amelia Abdi; Nasrum Massi; Khairuddin Djawad; Sri Vitayani; Nesyana Nurmadilla
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14705

Abstract

Objective: This study aims to determine the effect of the application of mangosteen pericarp extract cream(Garcinia Mangostana L) on levels of 8-OHdG on the skin of mice after exposure to UVB.Method: The study use a pure animal experimental research design with control group. The criteria forinclution were species Swiss albino mice, aged 6 – 9 weeks, weight 20-30 g, female gender and healthy.. Thesamples that met the criteria were divided into 5 groups : UVB, Base Cream plus UVB, 3 groups mangosteenpericarp extract cream with different concentration UVB radiation in mice using a 311 nm narrowband UVB(Dermalight 1000) with the power 450 mJ/cm three times a week for 4 week. Elisa examination was carriedout before and after the experiment.Result: This study used 25 mice albino selected randomly and were divided into 5 treatment groupconsisting of 5 group : UVB alone, UVB with base cream, UVB with mangosten pericarp extract cream withconcentration of 1 %, 3 % and 5 %. The Comperative test levels of 8-OhdG between each group with PostHoc test and found It was concluded that the decrease in OhdG was greatest in group 2 followed by groups5, 4, 3, and 1 (control group), respectively.Conclution: The ELISA levels of 8-OHdG was found that there are significant difference as between thevarious treatment groups (p>0,05). However, the increasing concentration of mangosten pericarp extractcream showed decreased level of 8-OHdG.
Meningkatkan Kesehatan Anak, Remaja, dan Petani Pesisir melalui Bakti Sosial Terpadu Bidang Dermatologi, Venereologi, dan Estetika di Kabupaten Bantaeng Widya Widita; Khairuddin Djawad; Anis Irawan Anwar; Siswanto Wahab; Muhlis; Airin R Nurdin; Andi Hardianty; Nurul Rezki Fitriani Azis
Celebes Journal of Community Services Vol. 4 No. 2 (2025): Juni - November
Publisher : STIE Amkop Makassar, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37531/celeb.v4i2.3153

Abstract

Masyarakat pesisir di Kabupaten Bantaeng, khususnya anak-anak, remaja, dan petani rumput laut, menghadapi tantangan kesehatan yang nyata. Anak-anak masih terkendala keterbatasan akses layanan dasar, remaja memiliki literasi rendah terkait penyakit menular seksual dan perawatan kulit, sementara petani rumput laut rentan terhadap penyakit kulit akibat pekerjaan. Kegiatan pengabdian masyarakat ini dilaksanakan untuk memberikan solusi yang terintegrasi guna meningkatkan kesehatan kelompok rentan tersebut sekaligus memperkuat peran institusi pendidikan tinggi dalam pelayanan masyarakat. Departemen Dermatologi, Venereologi, dan Estetika FK Universitas Hasanuddin melaksanakan empat intervensi utama: (1) sirkumsisi massal untuk 52 anak SD, (2) chemical peeling wajah untuk 38 remaja dengan jerawat/hiperpigmentasi, (3) penyuluhan kesehatan bagi 126 peserta tentang PMS, skabies, tumor kulit, dan kesehatan reproduksi, serta (4) pemeriksaan dan pengobatan 64 petani rumput laut dengan keluhan dermatitis, infeksi jamur, dan eksim. Program melibatkan 280 penerima manfaat langsung. Evaluasi pre–post test menunjukkan peningkatan pengetahuan sebesar 45,2%. Peserta sirkumsisi puas dengan pelayanan tanpa komplikasi serius, sementara remaja memperoleh perbaikan klinis awal pasca peeling. Petani rumput laut melaporkan berkurangnya gejala pruritus dan inflamasi dalam dua minggu. Intervensi multidisiplin ini berdampak promotif, preventif, kuratif, dan rehabilitatif, sekaligus memperkuat peran perguruan tinggi sebagai motor penggerak pengabdian berbasis kebutuhan lokal.
Co-Authors Airin R Nurdin Alfina Baharuddin Andi Hardianty Anis Irawan Anwar Bukhari, Agussalim Dian Amelia Abdi Firdaus Hamid Mochammad Hatta Muh. Nasrum Massi Muhlis Nurmadilla, Nesyana Nurul Rezki Fitriani Azis Rosdiana Natzir Siswanto Wahab Sri Vitayani Sri Wahyu Widya Widita