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All Journal Medika Alkhairaat : Jurnal Penelitian Kedokteran dan Kesehatan Indian Journal of Forensic Medicine & Toxicology Archives of The Medicine and Case Reports Jurnal EduHealth The International Journal of Medical Science and Health Research
Dian Amelia Abdi
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Effect of Photoprotective Cream of Mangosteen Pericarp Extract (Garcinia Mongostana L) Against 8-OHdG After UVB Exposure On Albino Mice Dian Amelia Abdi; Nasrum Massi; Khairuddin Djawad; Sri Vitayani; Nesyana Nurmadilla
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14705

Abstract

Objective: This study aims to determine the effect of the application of mangosteen pericarp extract cream(Garcinia Mangostana L) on levels of 8-OHdG on the skin of mice after exposure to UVB.Method: The study use a pure animal experimental research design with control group. The criteria forinclution were species Swiss albino mice, aged 6 – 9 weeks, weight 20-30 g, female gender and healthy.. Thesamples that met the criteria were divided into 5 groups : UVB, Base Cream plus UVB, 3 groups mangosteenpericarp extract cream with different concentration UVB radiation in mice using a 311 nm narrowband UVB(Dermalight 1000) with the power 450 mJ/cm three times a week for 4 week. Elisa examination was carriedout before and after the experiment.Result: This study used 25 mice albino selected randomly and were divided into 5 treatment groupconsisting of 5 group : UVB alone, UVB with base cream, UVB with mangosten pericarp extract cream withconcentration of 1 %, 3 % and 5 %. The Comperative test levels of 8-OhdG between each group with PostHoc test and found It was concluded that the decrease in OhdG was greatest in group 2 followed by groups5, 4, 3, and 1 (control group), respectively.Conclution: The ELISA levels of 8-OHdG was found that there are significant difference as between thevarious treatment groups (p>0,05). However, the increasing concentration of mangosten pericarp extractcream showed decreased level of 8-OHdG.
HIV Complications On Ears, Nose, Throat And Skin: Literature Review Dinda Humayrah; Dian Amelia Abdi; Iin Fatimah Hanis
Jurnal EduHealth Vol. 15 No. 03 (2024): Jurnal EduHealt (September), Year 2024
Publisher : Sean Institute

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Abstract

Human immunodeficiency virus (HIV) is an agent that can cause infection. HIV/AIDS can cause various complications that affect various parts of the body, including the skin, ears, nose and throat.This research is a Literature Review with a Narrative Review design. The type of data is data published from internationally accredited scientific journals.In total there are 8 studies published in the last 10 years (2012-2022) consisting of 1 prospective study, 5 cross sectional studies, and 2 case report studies. Human Immunodeficiency Virustargets CD4+ T lymphocyte helper cells, causing an extreme form of immune resistance with persistent depletion of CD4+ T lymphocyte helper cells. HIV infection that is left unchecked eventually develops into Acquired Immunodeficiency Syndrome (AIDS). At this stage, the immune system cannot prevent infection, resulting in the death of the individual due to opportunistic infections. Common ear, nose, throat and skin manifestations in HIV positive patients include oral candidiasis, enlarged lymph nodes, rhinosinusitis, allergic rhinitis, enlarged lymph nodes. clear neck, enlarged adenoids, chronic suppurative otitis media, suppurative hidradenitis, lesions on the head and neck, with the most common being rhinosinusitis. Patients with chronic HIV infection without AIDS can experience oropharyngeal candidiasis, recurrent vulvovaginal candidiasis, disseminated cutaneous herpes simplex. Skin manifestations such as seborrhoeic dermatitis, bacillary angiomatosis, varicella-zoster virus reactivation, and molluscum contagiosum infections are common and tend to be severe in HIV patients. The incidence of HIV infection continues to increase, and Indonesia is one of the Southeast Asian countries experiencing a high number of cases. In Indonesia, around 540,000 people live with HIV. The number of new HIV infections increased from approximately 21,511 in 2012 to 41,250 in 2016.
Unison Infestation: A Rare Case of Norwegian Scabies in a Mother-Baby Dyad Laili, Fahmiatul; Dian Amelia Abdi; Setia Budi Salekede
Archives of The Medicine and Case Reports Vol. 5 No. 4 (2024): Archives of The Medicine and Case Reports
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/amcr.v5i4.647

Abstract

Norwegian scabies, also known as crusted scabies, is an uncommon but highly contagious skin disease caused by an infestation of the Sarcoptes scabiei mite. It is characterized by extensive crusting and scaling of the skin, often accompanied by intense itching. Norwegian scabies is typically seen in individuals with weakened immune systems or those who are unable to care for themselves properly. We reported a case of Norwegian scabies in a 33-year-old mother and her 9-month-old baby. The mother's symptoms began during her third trimester of pregnancy, and the baby became infected a few months after birth. Both patients presented with generalized pruritus and characteristic skin lesions. The baby was also found to be severely malnourished. In conclusion, this case highlights the importance of early diagnosis and treatment of Norwegian scabies, especially in vulnerable populations. Prompt and effective management can prevent complications and improve the quality of life for affected individuals.
Literature Review: Ramsay Hunt Syndrome As A Complication Of Herpes Zoster Disease Fitriani, Fitriani; Dian Amelia Abdi; Fransina R. Sarungallo; Lisa Yuniati; Fanny Iskandar
Jurnal EduHealth Vol. 16 No. 01 (2025): Jurnal EduHealt, Edition January - March, 2025
Publisher : Sean Institute

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Abstract

Ramsay Hunt syndrome as a complication of herpes zoster, mostly occurs in immunocompromised patients. Disruption of the immune system plays a role in the reactivation of Varicella Zoster Virus (VZV). After primary varicella infection, VZV remains and is latent in the dorsal sensory ganglion roots. Then, several decades later, this neurotropic virus can reactivate and cause shingles. Ramsay Hunt syndrome is characterized by a triad of facial paralysis, ipsilateral ear pain/otalgia accompanied by facial paralysis, and the appearance of vesicle lesions in the ear according to the dermatome of the facial nerve. The purpose of this study was to determine Ramsay Hunt Syndrome as a complication of Herpes Zoster based on immunity, VZV latency period, age, gender, clinical manifestations, and management. This study used a literature review method with a Narrative Review design. The results obtained 15 journals that included inclusion criteria, namely references in the last 5 years, according to keywords, from scientific journal references, and case report research designs. The results showed that the influence of the immune system plays a major role in the reactivation of VZV, especially in elderly patients because old age causes functional changes in T cells and monocytes that function as a defense against viruses causing VZV reactivation, so Ramsay Hunt syndrome is rarely found in children <6 years. The presence of other risk factors such as a history of malignant lymphoma, HIV infection, history of immunosuppressive therapy, history of chronic disease, history of use of immunosuppressive drugs, or history of habits (consuming alcohol) can be the cause of reactivation of Varicella Zoster Virus (VZV).
Case Report: Latent Syphilis in the Second Trimester of Pregnancy Vanda Tri Andini; Dian Amelia Abdi; Abdul Azis
The International Journal of Medical Science and Health Research Vol. 13 No. 6 (2025): The International Journal of Medical Science and Health Research
Publisher : International Medical Journal Corp. Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70070/acv9h929

Abstract

Syphilis is a sexually transmitted infection caused by exposure to the bacterium Treponema pallidum. Syphilis is predominantly transmitted through sexual intercourse, from mother to fetus, and through blood transfusion processes. In pregnant women with syphilis, the Treponema pallidum bacterium is transmitted from the mother to the fetus through the placental capillary blood vessels. This case report discusses a 27-year-old married female patient who presented at the Cendrawasih Public Health Center (PKM) for Antenatal Care. During the examination, the patient did not report any complaints of headache, nausea, vomiting, or back pain. A history of red spots on the palms, soles, and mouth was denied. The patient also denied having any odorous vaginal discharge, or itching or burning sensations on her body. A history of sores or lumps around the genital area was denied. There were no indications of complaints related to significant weight loss, diarrhea, persistent cough, or fever. A history of joint pain or enlarged glands was also denied. Syphilis is caused by the Treponema pallidum bacterium, which has chronic and systemic characteristics. Syphilis can be generally classified into two groups: congenital and acquired. Congenital syphilis typically presents with symptoms such as hepatosplenomegaly, neurosyphilis, fever, skin lesions, comprehensive lymphadenopathy, and pneumonitis. In contrast, acquired syphilis is usually characterized by a single ulcer (chancre), a body rash, fever, and malaise. A definitive diagnosis is made using a darkfield microscope, PCR, or a direct fluorescent antibody test.
Risk Factors Associated With Disabilities In Morbus Hansen Patient Annisa Tri Srilistiany; Dian Amelia Abdi; Solecha Setiawati
Jurnal EduHealth Vol. 14 No. 04 (2023): Jurnal eduHealt, 2023, December
Publisher : Sean Institute

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Abstract

Morbus Hansen, or better known as leprosy, is an infectious disease that can cause various serious complications, including disability. This study aims to identify risk factors associated with the incidence of disability in Morbus Hansen patients. The research was carried out by collecting data from various sources, research journals conducted previously. The research results show that the risk factors that play a role in the incidence of disability in Morbus Hansen patients include the severity of the disease, delays in diagnosis and treatment, as well as socio-economic factors that influence patient access to medical care. These results have important implications for efforts to prevent and manage Hansen's Morbus, emphasizing the importance of early diagnosis, accessibility of treatment, and special attention to patients with more severe disease.
KORELASI USIA DENGAN SKOR KEPARAHAN DERMATITIS ATOPIK PADA PASIEN DI RUMAH SAKIT IBNU SINA MAKASSAR TAHUN 2022-2024 Dian Febriyanti Nur; Berry Erida Hasbi; Sri Vitayani; Dian Amelia Abdi; Dahliah
Medika Alkhairaat: Jurnal Penelitian Kedokteran dan Kesehatan Vol 7 No 03 (2025): Desember
Publisher : Fakultas Kedokteran Universitas Alkhairaat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31970/ma.v7i03.377

Abstract

ABSTRAK Dermatitis atopik merupakan penyakit kulit inflamasi kronis yang prevalensinya terus meningkat dan berdampak signifikan terhadap kualitas hidup pasien. Penelitian ini bertujuan untuk mengetahui korelasi usia dengan skor keparahan dermatitis atopik pada pasien di Rumah Sakit Ibnu Sina Makassar periode 2022–2024. Penelitian dilakukan dengan desain observasional analitik menggunakan pendekatan cross-sectional. Sampel penelitian adalah seluruh pasien dengan diagnosis dermatitis atopik yang tercatat dalam rekam medis, dengan penilaian tingkat keparahan menggunakan skor SCORAD. Data dianalisis secara univariat untuk distribusi frekuensi dan bivariat menggunakan uji Fisher’s Exact Test karena ukuran sampel kecil. Hasil penelitian menunjukkan prevalensi dermatitis atopik sebesar 4,05% dari total kunjungan, dengan mayoritas penderita berada pada kelompok usia dewasa 17 sampel (81%) dan berjenis kelamin perempuan 13 sampel (61,9%). Tingkat keparahan sebagian besar berada pada kategori sedang 13 sampel (61,9%). Uji statistik menghasilkan p-value 0,253 sehingga tidak ditemukan hubungan signifikan antara usia dengan skor keparahan dermatitis atopik. Simpulan penelitian ini adalah bahwa usia bukan merupakan faktor yang berhubungan langsung dengan tingkat keparahan dermatitis atopik pada populasi penelitian, meskipun distribusi kasus lebih banyak ditemukan pada kelompok usia dewasa. ABSTRACT Atopic dermatitis is a chronic inflammatory skin disease with increasing prevalence that significantly impacts patients’ quality of life. This study aimed to determine the correlation between age and the severity score of atopic dermatitis among patients at Ibnu Sina Hospital Makassar during 2022–2024. The research employed an analytical observational design with a cross-sectional approach. The study population consisted of all patients diagnosed with atopic dermatitis recorded in medical records, while disease severity was assessed using the SCORAD index. Data were analyzed univariately for frequency distribution and bivariately using Fisher’s Exact Test due to the small sample size. The results showed that the prevalence of atopic dermatitis was 4.05% of total outpatient visits, with the majority of patients being adults (81%) and females (61.9%). Most patients had moderate severity (61.9%). Statistical analysis revealed a p-value of 0.253, indicating no significant correlation between age and the severity score of atopic dermatitis. In conclusion, age was not directly associated with disease severity in this study population, although the majority of cases were found in adults.
Co-Authors Abdul Azis Annisa Tri Srilistiany Berry Erida Hasbi Dahliah Dian Febriyanti Nur Dinda Humayrah Fanny Iskandar Fitriani Fitriani Fransina R. Sarungallo Iin Fatimah Hanis Khairuddin Djawad Laili, Fahmiatul Lisa Yuniati Muh. Nasrum Massi Nurmadilla, Nesyana Setia Budi Salekede Solecha setiawati Sri Vitayani Vanda Tri Andini