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All Journal JOURNAL OF COMMUNITY MEDICINE AND PUBLIC HEALTH RESEARCH Indian Journal of Forensic Medicine & Toxicology
Muhammad Riza Kurniawan
Unknown Affiliation
Health Professions Medicine & Pharmacology Public Health

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Fibroblast Growth Factor 23 in Children with Chronic Kidney Disease Muhammad Riza Kurniawan; Risky Vitria Prasetyo; Ninik Asmaningsih Soemyarso; Mohammad Sjaifullah Noer
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14821

Abstract

Background: Decreased of glomerular filtration rate in chronic kidney disease (CKD) changes the calciumand phosphate balance. High phosphate levels in children with CKD stimulate secretion of FibroblastGrowth Factor 23 (FGF23). High FGF23 levels have harmful that potentially increase the morbidity andmortality of children with CKD.Objective: To analyze the level of FGF23 in children with CKD.Methods: A cross sectional study was performed in Pediatric Nephrology Ward and Outpatient Clinic ofDr. Soetomo General Hospital Surabaya, during December 2019-March 2020 for children with CKD stage1-5, aged 3 months to 18 years old. Children on phosphate-binder, vitamin D therapy, or severely ill wereexcluded. Blood level of FGF23 was measured using ELISA with statistic analysis with SPSS 20.Results: A total of 52 CKD stage 1-5 children were involved, mean age was 11.44 years old, and 50% wereboys. There were 51% children have FGF23 level more than 30 pg/ml. The lowest mean of FGF23 levelswas found in the CKD grade 1 (8.94 ± 8.77 pg/mL) and the highest mean at CKD grade 5 (113.30 ± 78.73pg/mL).Conclusion: The FGF23 level increasing accordance with increasing in the grade of CKD
The Impact of Community Service on Early Detection of Conenital Anomalies of the Kidney and Urinary Tract and Congenital Heart Disease in Children at Primary Health Care Sobo, Banyuwangi, Indonesia Risky Vitria Prasetyo; Arief Rakhman Hakim; Fandaruzzahra Putri; Susianto, Steven Christian; Agus Budiarto; Muhammad Riza Kurniawan; Ninik Asmaningsih Soemyarso; Mohammad Sjaifullah Noer
Journal of Community Medicine and Public Health Research Vol. 6 No. 2 (2025): Journal Community Medicine and Public Health Research
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jcmphr.v6i2.75284

Abstract

Congenital anomalies of the kidney and urinary tract (CAKUT) and congenital heart disease (CHD) represent significant global public health challenges, contributing substantially to childhood morbidity and mortality. This study aimed to determine the impact of the community service on CAKUT and CHD early detection conducted by Universitas Airlangga, Surabaya, Indonesia, at Puskesmas Sobo, Banyuwangi Regency. This pre-test post-test design study was conducted among health cadres, parents of students, and the elderly in Puskesmas Sobo District. The subjects' knowledge was assessed by comparing pre- and post-test scores, which included 10 questionnaire questions. We conducted an early detection program for children in grades 4-6 of elementary school, which included weight, height, blood pressure, saturation, heart sound screening, and a complete urine dipstick examination. 62 subjects participated in the community service, with Pre-Test Scores of 62.9±16.5 and Post-Test Scores of 71.7±20.2. There were 25 children examined in our community service, with 100% regular heart examination and 76% with trace proteinuria; systolic blood pressure 90 ± 11.7 mmHg and diastolic blood pressure 59.4 ± 11.6 mmHg. This community service initiative demonstrated its dual impact on enhancing health knowledge and facilitating the early detection of potential congenital abnormalities in children. The findings underscore the critical need for more systematic, comprehensive screening programs for kidney and heart health in children across the region.
Co-Authors Agus Budiarto Arief Rakhman Hakim Fandaruzzahra Putri Mohammad Sjaifullah Noer Ninik Asmaningsih Soemyarso Risky Vitria Prasetyo Susianto, Steven Christian