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Fahmi Ikhtiar
Fakultas Kedokteran Universitas Lampung
Education Medicine & Pharmacology Neuroscience Public Health

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Journal : Medula

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Gagal Ginjal Akut Akibat Rabdomiolisis yang Diinduksi Status Epileptikus Fahmi Ikhtiar; riskita fiannisa; evi kurniawati; ari wahyuni
Medula Vol 11 No 4 (2021): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v11i4.292

Abstract

Status epilepticus is any type of epileptic seizure that fails to stop and lasts for more than 30 minutes. This condition is an emergency in the field of neurology. In adults, almost 50% of status epilepticus is caused by acute cerebrovascular disease, hypoxia, metabolic disorders, and inadequate epilepsy treatment. While in children caused by infection of the central nervous system, metabolic disorders, trauma, and anoxia. If the seizures do not stop and last for a long time, they can lead to complications such as rhabdomyolysis. Rhabdomyolysis is a syndrome that can be life-threatening due to the breakdown of skeletal muscle cells. Skeletal muscle cells release toxic substances such as myoglobin which will clog the tubules in the kidneys, interfere with urinary excretion, and cause acute renal failure. Diagnosis is based on clinical signs and symptoms, and laboratory tests. Early signs are non-specific. Symptoms may include muscle weakness, increased body temperature and local or generalized muscle pain. Laboratory tests are carried out to confirm the diagnosis, namely looking at the amount of creatine kinase. The incidence of acute renal failure due to rhabdomyolysis is around 10% - 40%. In addition, antiepileptic drugs such as phenytoin have been reported to have an association with acute kidney failure.
Pengaruh Jus Tomat (Solanum lycopersicum) terhadap Tebal Epitel Seminiferus Tikus Putih Galur Sprague dawley yang Diinduksi Gentamisin Fahmi Ikhtiar; Exsa Hadibrata
Medula Vol 12 No 2 (2022): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v12i2.382

Abstract

Aminoglycosides including gentamicin have been used successfully for decades in the treatment of gram-negative bacterial infections. However, gentamicin produces testicular toxicity, resulting in limited therapeutic doses. Lycopene, one of the antioxidants in tomatoes, has singlet-oxygen and free radical scavenging capacity. Moreover, lycopene serves as a promising intervention for testicular toxicity associated with oxidative stress. Researchers wanted to see the effect of tomato juice on the seminiferous tubules of white rats. This type of research is experimental research with post test only control group design. The rats used were 29 male white rats (Rattus novergicus) which were divided into 5 groups, namely the negative control group as normal control. The positive control group was given gentamicin 20 mg/kgBW. Treatment groups 1, 2, and 3 were the treatment groups with gentamicin 20 mg/kgBW and tomato juice 25%, 50%, and 100%. Gentamicin was given for 10 days and tomato juice was given for 24 days. Data analysis was carried out using the One Way Annova method and continued with Post Hoc. After statistical testing, there was a significant effect of giving tomato juice on seminiferous epithelial thickness induced by gentamicin in white rats of the Sprague Dawley strain (p<0.05).
Phosphodiesterase Inhibitors : Alternatif Pengobatan Lower Urinary Tract Symptomps yang disebabkan Benign Prostate Hyperplasia Fahmi Ikhtiar; Exsa Hadibrata
Medula Vol 13 No 5 (2023): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v13i5.576

Abstract

Lower urinary tract symptoms (LUTS) secondary to benign prostatic hyperplasia (BPH) are often bothersome and hinder the quality of life for eldery. The incidence of BPH in Indonesia, namely at Cipto Mangunkusumo Hospital from 1994-2013, found 3,804 cases with an average age of patients 66.61 years. Adrenoceptor antagonists (α‑blockers, ABs) and 5-Alpha reductase Inhibitors (5-ARIs) are recommended first-line treatment for LUTS due to BPH. Although effective, these medications may have adverse effects, including dizziness, hypotension, and sexual dysfunction. Phosphodiesterase 5 Inhibitors (PDE5-Is) have been used globally as first-line drugs for erectile dysfunction. The first study in 2002 reported that PDE5‑Is could improve urinary tract symptom scores in patients w
Co-Authors ari wahyuni evi kurniawati Exsa Hadibrata Exsa Hadibrata riskita fiannisa