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Exsa Hadibrata
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Pengaruh Jus Tomat (Solanum lycopersicum) terhadap Tebal Epitel Seminiferus Tikus Putih Galur Sprague dawley yang Diinduksi Gentamisin Fahmi Ikhtiar; Exsa Hadibrata
Medula Vol 12 No 2 (2022): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v12i2.382

Abstract

Aminoglycosides including gentamicin have been used successfully for decades in the treatment of gram-negative bacterial infections. However, gentamicin produces testicular toxicity, resulting in limited therapeutic doses. Lycopene, one of the antioxidants in tomatoes, has singlet-oxygen and free radical scavenging capacity. Moreover, lycopene serves as a promising intervention for testicular toxicity associated with oxidative stress. Researchers wanted to see the effect of tomato juice on the seminiferous tubules of white rats. This type of research is experimental research with post test only control group design. The rats used were 29 male white rats (Rattus novergicus) which were divided into 5 groups, namely the negative control group as normal control. The positive control group was given gentamicin 20 mg/kgBW. Treatment groups 1, 2, and 3 were the treatment groups with gentamicin 20 mg/kgBW and tomato juice 25%, 50%, and 100%. Gentamicin was given for 10 days and tomato juice was given for 24 days. Data analysis was carried out using the One Way Annova method and continued with Post Hoc. After statistical testing, there was a significant effect of giving tomato juice on seminiferous epithelial thickness induced by gentamicin in white rats of the Sprague Dawley strain (p<0.05).
Efikasi dan Komplikasi Supine Percutaneous Nephrolithotomy (PCNL) dengan Panduan Kombinasi Ultrasonografi (USG) dan Fluoroskopi Exsa Hadibrata; Mars Dwi Tjahyo; Suharmanto Suharmanto
Jurnal Penelitian Perawat Profesional Vol 5 No 1 (2023): Februari 2023, Jurnal Penelitian Perawat Profesional
Publisher : Global Health Science Group

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/jppp.v5i1.1287

Abstract

Operasi minimal invasif untuk tatalaksana batu ginjal diantaranya, Electro Shock Wave Lithotripsy (ESWL), ureteroskopi, bedah laparoskopik dan Percutaneous Nephrolithotripsy (PCNL) yang telah mengubah manajemen batu ginjal. Penelitian ini dilakukan untuk mengetahui delta Hb, kebutuhan tranfusi, durasi operasi, durasi fluoroskopi, stone free rate, lama perawatan dan komplikasi tindakan supine PCNL dengan teknik kombinasi USG dan flouroskopi pada pasien batu ginjal di Rumah Sakit Umum Daerah Abdul Moeloek tahun 2020. Penelitian ini merupakan studi retrospektif menggunakan rekam medik dan digunakan teknik total sampling pada 31 orang. Data dikumpulkan dari rekam medik dan dianalisis menggunakan analisis univariat berupa distribusi frekuensi. Hasil penelitian mendapatkan stone burden 20-50 mm sebanyak 23 sampel, dan 50 mm sebanyak 8 sampel. Pasca tindakan supine PCNL stone free rate sebesar 84%, dengan rerata durasi operasi 104 menit dan rerata durasi flouroskopi 12,4 menit. Sebanyak 8 sampel membutuhkan tranfusi darah. Komplikasi terbanyak yang timbul pasca tindakan berdasarkan modified clavien grading skor adalah grade 1 dan grade 2. Tindakan supine PCNL merupakan tindakan yang dapat dijadikan pilihan sebagai tataklasana batu ginjal > 20 mm dengan stone free rate cukup baik dan komplikasi yang minimal.
Ewing Sarkoma: Ulasan Singkat Keganasan: Indonesia Rafi Gutra Aslam; Helmi Ismunandar; Risal Wintoko; Exsa Hadibrata; Anisa Nuraisa Jausal
Medula Vol 13 No 5 (2023): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v13i5.336

Abstract

A malignancy that identified first by James Ewing in 1921. Ewing sarcoma is a malignancy of the bones caused by abnormal activity of progenitor cell mesenchymal occurs by a genetic factor where the patient had a combination of translocation chromosome non-random in t(11; 22) (q24;q12) or t(21; 22) (q22; q12). The patient will have pathognomonic findings of periosteal reaction similar to "Onion skin", lesions like “Moth-eaten”, and “Codman’s Triangle” in radiology findings. Second highest malignancy bone prevalent worldwide after osteosarcoma. This malignancy occurs commonly in the male gender, incidence peaked in the approximately first decade in life with a prognosis range of about 5 years more or less. The malignancy occurs in the metaphysis-diaphysis part of the bone that has a variety of prognoses based on stage, metastasis, and therapy. Literature Review method is used in this article writing by article, journal, and book that review shortly about Ewing sarcoma from multi-aspect of etiology, epidemiology, pathogenesis and pathophysiology, clinical manifestations, treatment, staging, prognosis, complication, and education as the last topic. Prognosis of Ewing Sarcoma patient will be better if given multimodal therapy including chemotherapy, radiotherapy, and operation that adjusted with the condition in every patient. Nevertheless, further research is needed about best treatment in goals to extend patient survivability and enhance prognoses approximately in 3 years.
Potensi Ekstrak Streptomyces sp. strain i18 sebagai Antibiotik terhadap Bakteri Escherichia coli Farhan Dzaki Alfahri; Endah Setyaningrum; Exsa Hadibrata
Jurnal Penelitian Perawat Profesional Vol 6 No 5 (2024): Oktober 2024, Jurnal Penelitian Perawat Profesional
Publisher : Global Health Science Group

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/jppp.v6i5.4492

Abstract

Mikroba resisten antibiotik (MRA) merupakan mikroba yang mampu melawan efek antibiotik, sehingga mikroba tersebut tetap tumbuh. Escherichia coli sudah menjadi patogen yang banyak terdapat pada makanan dan minuman yang dapat menyebabkan diare, kolitis perdarahan dan hemolytic uremic syndrome pada manusia. Salah satu sumber metabolit sekunder yang bersifat antibiotik dapat berasal dari genus Streptomyces. Penelitian ini bertujuan untuk mengetahui potensi ekstrak Streptomyces sp strain i18 sebagai antibiotik terhadap bakteri Escherichia coli. Penelitian ini terdiri dari ui fitokimia, uji diameter zona hambat metode sumuran, uji Kadar Hambat Minimum (KHM), Kadar Bunuh Minimum (KBM) dengan bahan uji ekstrak Streptomyces sp strain i18 dengan konsentrasi 5%, 10%, 20%, 40%, 80%, aquadest sebagai kontrol negatif dan siprofloksasin sebagai kontrol positif terhadap pertumbuhan bakteri Escherichia coli. Penelitian ini menunjukkan tidak terdapat diameter zona hambat, KHM dan KBM pada bakteri Escherichia coli oleh ekstrak Streptomyces sp strain i18, hasil uji fitokimia menunjukkan ekstrak Streptomyces sp strain i18 memiliki kandungan metabolit sekunder berupa saponin, triterpenoid dan anthrakuinon glikosida. Hasil penelitian dianalisis menggunakan uji Shapiro-Wilk.
Co-Authors Anisa Nuraisa Jausal Endah Setyaningrum Fahmi Ikhtiar Farhan Dzaki Alfahri Helmi Ismunandar Mars Dwi Tjahyo Rafi Gutra Aslam Risal Wintoko Suharmanto Suharmanto