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Hippocampal Volume and Entorhinal Cortex Thickness in Alzheimer’s Disease Leon Agung Manurung; Widiana Ferriastuti; Bambang Soeprijanto; Hartono Yudi Sarastika
Indian Journal of Forensic Medicine & Toxicology Vol. 16 No. 1 (2022): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v16i1.17577

Magnetic Resonance Imaging (MRI) is the standard imaging evaluations in Alzheimer’s Disease (AD).Information regarding hippocampus and entorhinal cortex sizes plays an important role in Alzheimer’sdisease. This study aims to determine hippocampal volume and entorhinal cortex thickness inAlzheimer’s disease obtained from a group of patients who underwent head MRI.This study was an observational study with retrospective approach in patients who were diagnosedwith AD and had available head MRI examination results. A total of 14 patients were diagnosed by aneurologist with AD using MMSE, Hachinsky, and NIA-AA criteria.From head MRI measurement in AD patients, we found that the mean volume of right, left, andtotal hippocampal was 1700±0.395 cm3; 1.670±0.349 cm3; and 3.370±0.725 cm3, respectively. Themean thickness of right, left, and total entorhinal cortex was 1.821±0.459 mm; 1.463±0.369 mm; and3.285±0.791 mm, respectively. There is a possible difference between the early and late stages of AD inthe same patient. Further studies with larger cohorts are needed to examine these correlations.

UNet-VGG16 with transfer learning for MRI-based brain tumor segmentation Anindya Apriliyanti Pravitasari; Nur Iriawan; Mawanda Almuhayar; Taufik Azmi; Irhamah Irhamah; Kartika Fithriasari; Santi Wulan Purnami; Widiana Ferriastuti
TELKOMNIKA (Telecommunication Computing Electronics and Control) Vol 18, No 3: June 2020
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/telkomnika.v18i3.14753

A brain tumor is one of a deadly disease that needs high accuracy in its medical surgery. Brain tumor detection can be done through magnetic resonance imaging (MRI). Image segmentation for the MRI brain tumor aims to separate the tumor area (as the region of interest or ROI) with a healthy brain and provide a clear boundary of the tumor. This study classifies the ROI and non-ROI using fully convolutional network with new architecture, namely UNet-VGG16. This model or architecture is a hybrid of U-Net and VGG16 with transfer Learning to simplify the U-Net architecture. This method has a high accuracy of about 96.1% in the learning dataset. The validation is done by calculating the correct classification ratio (CCR) to comparing the segmentation result with the ground truth. The CCR value shows that this UNet-VGG16 could recognize the brain tumor area with a mean of CCR value is about 95.69%.

A Case Report of Placenta Percreta Widiana Ferriastuti; Dwi P. R. Tampubolon; Qonita Qonita
Health Notions Vol 5, No 4 (2021): April
Publisher : Humanistic Network for Science and Technology (HNST)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33846/hn50406

There has been an increased incidence of placenta accreta in recent decades, which is associated with an increase in cesarean delivery. A woman aged 39 years GIVP1111 at 8 months of gestation was a breech location with antepartum bleeding et. causa placenta previa totalis suspected percreta bladder infiltration and hematuria. The last abdominal ultrasound showed no visible clot retention and mild right-sided hydronephrosis (possibly a physiological condition). Due to doubts regarding the suspicion of placental invasion of the bladder, an MRI examination of the abdomen was performed. A network was irregular in shape and can not be oriented either right or left, some of which have been split. Attached to the placenta. It was not clear that the cervix and bladder were visible, the total weight was 500 grams, the size was 15x13x5 cm. Based on both macroscopic and microscopic histopathological examinations, it could be concluded that the uterus, adnexa, surgery: placenta percreta, adenomyosis uteri. Keywords: placenta percreta; uterus; antepartum bleeding

Penghitungan Volumetrik Perdarahan dengan Metode Volume Automatik (Software Volume Evaluation) dan Metode Manual (Broderick) pada MSCT Kepala (Study Eksperimen pada Pasien Perdarahan Intraserebral di RS. Haji Surabaya) Agus Setyo Kiswoyo; Gatot Murti Wibowo; Widiana Ferriastuti
Jurnal Imejing Diagnostik (JImeD) Vol 3, No 2: July 2017
Publisher : Poltekkes Kemenkes Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jimed.v3i2.3190

Background : Intracerebral hemorrhage (ICH) is the brain parenchyma bleeding. The volume of intracerebral hemorrhage can affect mild to severe clinical symptoms due to increased intracranial pressure and it has a high risk of death. In addition, CT scan CTScan is a gold standard on PIS examination. Methods : This was a quantitative research with experimental approach. There are two methods of volumetric hemorrhage calculation, namely automatic and manual method. Automatic Volume Method (SVE) is a volume calculation by computer software available on CT Scan tool with voxel calculation in HU value range. The manual method (Broderick) used is AXBXC/2 which is the multiplication of length (A), width (B) and height/thickness of bleeding slice (C) divided by 2. From the result, the volume differencewas tabulated and measured, then the normality and different test were done.Results : The sample consisted of 10 new bleeding patient data which then classified into small hemorrhage group, calculated volumes automatic(SVE) and manual(Broderick). volume calculations obtained different values of volume ranging from 0.37 cm³ to 10.01 cm³, the percentage ranged from 3% to 41%. The result showed a very significant difference value due to the different test Paired Samples T Test with significance value of 0.001 (p-Value 0.05). From the data, 8 patients with different percentage above 20%,with average 25% were PIS with irregular shape. And 2 patients with volume difference below 10% with average 6 % were Intracerebral Hemorrhage regular shape. Conclussions : There is a difference in the calculation of volumetric Intracerebral hemorrhage between the automatic volume method (SVE) and the manual method (Broderick). With a percentage average difference of average volume of 6% for regular shapes and 25% for irregular hemorrhage.

DIFFERENCE OF THE IMAGE INFORMATION AXIAL PELVIC MRI USING DIFFUSION WEIGHTED IMAGE SEQUENCE WITH THE VARIATION OF B VALUE IN CERVICAL CANCER Rini Indrati; Distyarini Primadita; Widiana Ferriastuti; Marichatul Jannah; Sri Mulyati; Siti Daryati
Jurnal Riset Kesehatan Vol 8, No 2 (2019): NOVEMBER 2019
Publisher : Poltekkes Kemenkes Semarang

Cervical cancer is the second most common type of cancer worldwide, it is reaching 15% of all kind of cancer in women. There are several ways to diagnose cervical cancer, one of them is an MRI. One of the MRI sequences which can perform the pathology of cervical cancer is Diffusion-Weighted Image. The aim of this research is to find out the anatomical differences between axial slice image of Pelvic MRI which is using DWI sequence with the variation of b value in the case of cervical cancer, and also to reveal the optimal b value to obtain the image of Pelvic MRI which is using DWI sequence in the case of cervical cancer. The method of this research is experimental with the comparison of static groups. Data is 30 images of axial DWI Pelvic MRI from 10 patients in the case of cervical cancer with 3 different variations of b value, which are 600 s/mm2, 800 s/mm2, and 1000 s/mm2. Assessment of information image data done by the radiologist. Data analysis by Friedman and Wilcoxon Test. The result showed that there are differences of image information between axial Pelvic MRI which is using the DWI sequence with the variation of b value in the case of cervical cancer with a significant p-value less than 0.001. Differences in image information occur in the tumor, expansion of tumor, parametrium until the pelvic wall and lymph. The optimal use of b value for axial Pelvic MRI with DWI sequence in the case of cervical cancer is 600 s/mm2.

Head Computed Tomography Images of HIV/AIDS Patients with Suspected Cerebral Toxoplasmosis in Dr. Soetomo General Hospital Surabaya Ria Wibawani; Bambang Soeprijanto; Widiana Ferriastuti; Erwin A Triyono
Biomolecular and Health Science Journal Vol. 2 No. 1 (2019): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Introduction: Toxoplasma gondii is an intracellular pathogenic parasite with the majority of co-infections occurring in HIV/AIDS patients. This study assesses the head computed tomography (CT) images of cerebral toxoplasmosis in patients with HIV/AIDS.Methods: This study was a cross-sectional design using head CT images of 35 HIV/AIDS patients with suspected cerebral toxoplasmosis. Variables include lesion type, location, size, CD4 count, and therapeutic result with anti-cerebral toxoplasmosis. All data analysed descriptively.Results: From total 110, 35 patients met the inclusion criteria. 24 patients (68.6%) were male and 11 (31.4%) female, average age, was 36.1. 8 patients (22.3%) had lesions in cortical, 31 patients (88.6%) had < 1 cm lesion. Single lesions mainly calcified and found in the right centrum semiovale while multiple lesions were subcortical. A hypodense lesion with rim or nodular contrast enhancement is found in 75% of patients with CD4 > 200 in contrast to slight rim contrast enhancement and perifocal edema in patients with CD4 < 200. 20 patients (57.4%) had improved condition after anti-toxoplasmosis therapy.Conclusion: Cerebral toxoplasmosis lesions in HIV/AIDS patients have various types of imaging findings, mostly multiple, with most frequent location being cortical and diameter < 1 cm. Total recovery is achieved in the majority of patients with therapy.

The Correlation between Apparent Diffusion Coefficient Value on MRI and the Pathology Consistency of Meningioma Wyka Faulani Hafizah Nur; Widiana Ferriastuti; Bambang Soeprijanto
Biomolecular and Health Science Journal Vol. 3 No. 2 (2020): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bhsj.v3i2.22171

Introduction: Preoperative evaluation of meningioma consistency is important because it will affect surgical procedures, surgical optimization, risk assessment, and patient management. The consistency of meningioma can be predicted by Apparent Diffusion Coefficient (ADC) value on MRI. ADC values are useful in quantitative tumor assessment based on diffusivity in the tumor. The objective of the study is to find out the correlation between ADC value and the pathology consistency of meningioma.Methods: A retrospective study was carried out using medical records at Dr. Soetomo General Hospital, Surabaya by January 2017 - December 2018. The ADC value was obtained by placing three ROI in the tumor and the consistency was obtained from the results of the pathology examination, followed by the Spearman correlation test.Results: There The tumor range value of ADC was 0.58 x 10-3mm2 s to 1.63 x 10-3mm2/s. The mean ADC value in soft, intermediate, and hard consistency was 1.247+ 0.200 x 10-3mm2/s, 0.950 + 0.453 x 10-3mm2/s, and 0.793 + 0.161 x 10-3mm2/s, the cut-off value of ADC was + 0.822 x 10-3mm2/s with specificity 68% and sensitivity 85%, the AUC is 0.740 with a significance value of 0.0043 (p<α, α = 0.05). It was obtained an ADC correlation with the consistency of meningioma, the significance value is p=0.000 (p<α, α = 0.05).Conclusion: There is a correlation between the ADC value and the consistency of meningioma. The ADC value can be considered for an optimal preoperative evaluation in assessing the consistency of meningioma.

Narrowband Ultraviolet B (NB-UVB) Phototherapy in Psoriasis: A Retrospective Study Prameswari, Faida Ufaira; Cita Rosita Sigit Prakoeswa; Ferriastuti, Widiana
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 34 No. 2 (2022): AUGUST
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V34.2.2022.99-108

Background: Psoriasis with higher Psoriasis Area and Severity Index (PASI) scores correlate with impaired quality of life. Assessing narrowband ultraviolet B (NB-UVB) phototherapy as a new therapy option in Indonesia is necessary to find the most effective treatment for psoriasis patients. Purpose: To determine the usage of NB-UVB phototherapy and the therapy response in psoriasis patients. Methods: This retrospective descriptive observational study was conducted at Dr. Soetomo General Academic Hospital Surabaya in March 2019-November 2020. The variables were collected through medical records. Result: A total of 28 patients were obtained at this study. Psoriasis type plaque/vulgaris were found in 92.9% of the patients. The patients mostly started with PASI score >10 with the initial dose of NB-UVB phototherapy is 260 mJ/cm2. The most common initial phototherapy frequency is 3 times per week (53.6%). The latest dose and frequency distribution was varied in each subject. The mean total number of sessions was 31.54 ± 20.549. Patients were also administered various combination therapy. The majority of patients had missed NB-UVB phototherapy sessions and the phototherapy dose needed to be reduced (57.1%). The achievement of PASI-75 (treatment success) was mostly achieved by subjects that went through 40-60 sessions of phototherapy and subjects with psoriasis type plaque/vulgaris. Conclusion: The achievement of PASI-75 was found to be low (17.5%), influenced by multiple factors such as the total number of NB-UVB phototherapy sessions, combination therapy, dose of NB-UVB phototherapy, frequency of NB-UVB phototherapy, and the level of patient compliance to therapy.

Panoramic Radiography Measurements Not Correlated with BMD Results in End-stage Chronic Kidney Disease Patients Ni'ami, Muhamad Aufa; Ferriastuti, Widiana; Rahardjo, Paulus
Global Medical & Health Communication (GMHC) Vol 13, No 1 (2025)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v13i1.14182

Chronic kidney disease (CKD) is a disorder of the kidney defined by a glomerular filtration rate of less than 60 ml/min/1.73 m2 for a minimum of three months, progressive and irreversible. One complication is chronic kidney disease-metabolic bone disorders (CKD-MBD), which can cause osteoporosis. This is diagnosed using bone mineral densitometry-dual energy absorptiometry (BMD-DXA) and panoramic radiographs, which can also detect thinning of the mandibular cortex in patients with CKD. This study aims to determine the correlation between osteoporosis images on panoramic photos with the results of lumbar and hip areal T-scores in chronic kidney disease (CKD). This research is an observational study with a prospective approach and cross-sectional design. The subjects of this study were 52 patients with chronic kidney disease (CKD). Undergoing hemodyalize procedure (HD) at Dr. Soetomo General Hospital for February–March 2024. Data was collected by taking the results of the panoramic photo examination and BMD-DXA to see the results of the T-score in each patient—data analysis using the Spearman test on SPSS software. Which resulted in the p-values for the panoramic mandibular index (PMI), mandibular cortical width (MCW), and mandibular cortical index (MCI) with a lumbar T-score range of 0.093 to 0.676 and the PMI, MCW, and MCI with left-right hip T-score, the p-values ranged from 0.318 to 0.970 (all p-values >0.05). It can be concluded that there is no correlation between the results of the T-score for the lumbar and hip regions and the measurements of PMI, MCW, and MCI. Therefore, employing these three measurements as a standard for osteoporosis screening using panoramic x-rays is not feasible.

Panoramic Radiography Measurements Not Correlated with BMD Results in End-stage Chronic Kidney Disease Patients Ni'ami, Muhamad Aufa; Ferriastuti, Widiana; Rahardjo, Paulus
Global Medical & Health Communication (GMHC) Vol 13, No 1 (2025)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/gmhc.v13i1.14140

Chronic kidney disease (CKD) is a disorder of the kidney defined by a glomerular filtration rate of less than 60 ml/min/1.73 m2 for a minimum of three months, progressive and irreversible. One complication is chronic kidney disease-metabolic bone disorders (CKD-MBD), which can cause osteoporosis. This is diagnosed using bone mineral densitometry-dual energy absorptiometry (BMD-DXA) and panoramic radiographs, which can also detect thinning of the mandibular cortex in patients with CKD. This study aims to determine the correlation between osteoporosis images on panoramic photos with the results of lumbar and hip areal T-scores in chronic kidney disease (CKD). This research is an observational study with a prospective approach and cross-sectional design. The subjects of this study were 52 patients with chronic kidney disease (CKD). Undergoing hemodyalize procedure (HD) at Dr. Soetomo General Hospital for February–March 2024. Data was collected by taking the results of the panoramic photo examination and BMD-DXA to see the results of the T-score in each patient—data analysis using the Spearman test on SPSS software. Which resulted in the p-values for the panoramic mandibular index (PMI), mandibular cortical width (MCW), and mandibular cortical index (MCI) with a lumbar T-score range of 0.093 to 0.676 and the PMI, MCW, and MCI with left-right hip T-score, the p-values ranged from 0.318 to 0.970 (all p-values >0.05). It can be concluded that there is no correlation between the results of the T-score for the lumbar and hip regions and the measurements of PMI, MCW, and MCI. Therefore, employing these three measurements as a standard for osteoporosis screening using panoramic x-rays is not feasible.

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