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All Journal Folia Medica Indonesiana Health Notions Journal Orthopaedi and Traumatology Surabaya (JOINTS) SURABAYA PHYSICAL MEDICINE AND REHABILITATION JOURNAL Indian Journal of Forensic Medicine & Toxicology Indonesia Journal of Physical Medicine and Rehabilitation Indonesia Journal Physical Medicine and Rehabilitation Jurnal Penyakit Dalam Indonesia Journal Medical Informatics Technology
Rwahita Satyawati Dharmanta
Departement Of Physical Medicine And Rehabilitation, Faculty Of Medicine, Universitas Airlangga
Chemical Engineering, Chemistry & Bioengineering Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Engineering Health Professions Medicine & Pharmacology Neuroscience Nursing Physics Public Health Other

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Journal : Indonesia Journal of Physical Medicine and Rehabilitation

 1 
Moderate Intensity Physical Exercise Decreases Gastrocnemius Caspase-3 Expression on Mus musculus with Statin Treatment Junita Jeanne Paliman; Ratna Darjanti Haryadi; Rwahita Satyawati Darmanta; Willy Sandhika; Martha Kurnia Kusumawardani
Indonesian Journal of Physical Medicine & Rehabilitation Vol 10 No 01 (2021): Indonesian Journal Of Physical Medicine and Rehabilitation
Publisher : Indonesian Journal of Physical Medicine & Rehabilitation

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1685.19 KB) | DOI: 10.36803/ijpmr.v10i1.281

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ABSTRACTIntroduction: Dyslipidemia is a lipid metabolism abnormality marked by increase or decrease of lipid fraction in the plasma. Statin or 3-Hydroxy-3-Methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor is an important dyslipidemia medication that may induce apoptosis of the skeletal muscle.Decrease of Bcl-2 and Bax ratio causing caspase-9 activation followed by caspase-3 activation occur in apoptosis. Moderate intensity physical exercise (MIPE) decreases DNA fragmentation, increases Bcl-2 protein level and decreases Bax transcript level.Methods: Thirty healthy BALB/C strain Mus musculus divided into 3 groups: first intervention group with statin only treatment (S), second intervention group with statin treatment plus MIPE using motorized treadmill (ST), and control (C) group with no statin and nor exercise. The duration of treatmentwas 28 days. Statin treatment dose was 2.06mg/kg bodyweight. Measurement caspase-3 was done by immunohistochemistry evaluation and the expression of capase-3 was calculated by cells count which expressing caspase-3.Results: There were more muscle cells expressing caspase-3 in the S group (47.00±12.92cells) than the C group (2.70±1.94 cells); p=0.000, the ST group (21.44±10.13 cells) than the C group (p=0.001), as well as S group and the ST group (p=0.000).Conclusion: Moderate intensity physical exercise can decrease caspase-3 expression in statin treated subject.Keywords: apoptosis, caspase-3, dyslipidemia, moderate intensity physical exercise, statin.
The Role of Pelvic Floor Muscles Exercises with Biofeedback as Adjuvant Treatment in Men with Erectile Dysfunction Guido O Vianney; Ratna D Haryadi; Rwahita Satyawati; Onny P Sono
Indonesian Journal of Physical Medicine & Rehabilitation Vol 3 No 01 (2014): Indonesian Journal Of Physical Medicine and Rehabilitation
Publisher : Indonesian Journal of Physical Medicine & Rehabilitation

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (114.481 KB) | DOI: 10.36803/ijpmr.v3i01.238

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Objective: To evaluate the efficacy of pelvic floor muscle exercise programs for men with erectile dysfunction problems.Methods: A randomized controlled group designed study. Sixteen men with erectile dysfunction who had undergone pharmacological treatment from the Andrology Clinic and were referred to thePhysical Medicine and Rehabilitation Department Dr. Soetomo Hospital were divided into 2 groups. The first group was treated with pelvic floor muscle exercises for 12 weeks, while the second groupacted as control. The parameters of this study were evaluated in weeks 4, 8 and 12. This consisted of an evaluation of pelvic floor muscle strength, which was performed by digital anal assessment, and pressurebiofeedback Myomed 932. The evaluation of erectile function was based on the IIEF-5 (International Index of Erectile Function – 5) questionnaire and the EHS (Erectile Hardness Score).Results: An increase in the maximum contraction of pelvic floor muscles was seen in the intervention group after 8 weeks of treatment (p=0.011). Six subjects in the intervention group (75%) gained anormal anal strength based on digital anal assessment at the end of study. The IIEF-5 score of the intervention group improved after 8 weeks of treatment (p=0.012). Threesubjects (37.5%) in the intervention group got a maximum hardness score and 4 subjects (50%) gained an improvement of the hardness score.Conclusion: Comparing of the results of the protocol reported here shows that pelvic floor muscle exercises improve erectile function in men with erectile dysfunction problems.Keywords: pelvic floor muscle exercises, biofeedback, erectile dysfunction
Co-Authors Andriana, RA Meisy Diah Indriani Fikri Rasikh Pritanto Guido O Vianney Hewiz, Alya Shafira Imam Subadi, Imam Jihan Nabila Pranjasdhina Juatmadja, Bastianus Alfian Junita Jeanne Paliman Kristiana, Titin Lukman Hakim Martha Kurnia Kusumawardani Martino, Nieko Caesar Agung Mei Wulan, Sri Mardjiati Mifta Nurmalasari Mouli Edward Novira Widajanti, Novira Nurmalasari, Mifta Nuruzzaman, Andi Onny P Sono Ratna D Haryadi Ratna Darjanti Haryadi Wardhani, Indrayuni Lukitra Willy Sandhika