Debby Shintiya Dewi
Laboratorium Ilmu Penyakit Mata Fakultas Kedokteran Unibraw / RSU dr. Saiful Anwar Malang

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HUBUNGAN ANTARA KADAR ENZIM GLUTATION REDUKTASE DENGAN DERAJAT KEKERUHAN INTI LENSA Sulistya, T Budi; Dewi, Debby Shintiya; Suyuti, Hidayat; Sumarno, Sumarno
Jurnal Kedokteran Brawijaya Vol 22, No 1 (2006)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (305.234 KB) | DOI: 10.21776/ub.jkb.2006.022.01.7

Abstract

The aim of this study was to determine the correlation between the level of glutathione reductase [GR] in relation with the severity of nuclear cataract and the increase of age. An analytic cross sectional observasional study  of nuclear cataract patient seen at Saiful Anwar Hospital and Mass Cataract Surgery performed by Perdami Malang was carried out. Patients were classified into 3 groups based on ageand 4 groups based on severity of nuclear cataract. The samples were taken by consecutive sampling and were operated on visual indication. The extracted lens were examined for [GR]. The laboratory findings of [GR] were compared with the severity of senile cataract. The data were analyzed with one way ANOVA. Confidence limit was set at 95%. A total of  55 patients were included with the sample size in 40-50 age group less than estimation. The [GR] were found to be significanfly lower in the older age (p=0,01) and the more severe cataract groups (p=0,00). The [GR] were also found to be significantly decreased with the increase of cataract severity in 40-50 age group (p=0,00), 50-60 age group (p=0,01) and >60 age group (p=0,00). In the grade 2 cataract, there were no significant difference of [GR] between age group (p=0.22). This also occured in grade 3 (p=0.23) while  in the grade 4, there were significant difference between age group (p=0.01). This also occured in grade 5 (p=0.06).
THE CORRELATION OF SLEEP QUALITY WITH DRY EYE DISEASE (DED) IN RURAL AREAS Redjeki, Daniela Pauline; Dewi, Debby Shintiya; Aldina, Rosy
MNJ (Malang Neurology Journal) Vol. 12 No. 1 (2026): January
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2026.012.01.06

Abstract

Background: Dry Eye Disease (DED) is a multifactorial ocular condition characterized by tear film instability and ocular surface inflammation. The severity of DED is closely related with poorer quality of life. Studies showed that poor sleep quality occurs in more than 40% of patients with DED. This is due to decreased tear secretion and increased tear osmolarity due to poor sleep. Sleep deprivation is associated with higher risk of diseases that have been shown to be associated with an increased risk of dry eye. Objective: This study was conducted to find the relationship between sleep quality and dry eye disease in Indonesia. Methods: This study was an analytic observational study using a cross sectional study design on 240 respondents in Mendalanwangi Village, Wagir District, Malang Regency. The study was conducted by examining Fluorescein TBUT and filling out the DEQ-5 questionnaire to assess DED and the PSQI questionnaire to assess sleep quality among the study subjects. Results: Among participants who experienced DED, 63.9% reported poor sleep quality, whereas only 36.1% reported good sleep quality. Conversely, in the non-DED group, 56.7% had good sleep quality while 43.3% had poor sleep quality. The results of statistical analysis using the chi-square test with a significance value of p = 0.003 (p < 0.05) and OR 2.31 which indicates there is an association between sleep quality and DED. Conclusion: Poor sleep quality increases the risk of DED 2.3 times compared to good sleep quality and affecting person's quality of life, hence increasing morbidity and mortality.