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All Journal Jurnal Kedokteran Brawijaya MNJ (Malang Neurology Journal) eJournal Kedokteran Indonesia
Rosy Aldina
Laboratorium Ilmu Kesehatan Mata Rumah Sakit Umum Dr . Saiful Anwar Malang
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Perbandingan Konsentrasi IL-4 Air Mata Penderita Alergi Okuli pada Pemberian Pemirolast potassium0,1% dan Cromolyn sodium4% Elyana, Nurul; Aldina, Rosy
Jurnal Kedokteran Brawijaya Vol 26, No 3 (2011)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (492.993 KB) | DOI: 10.21776/ub.jkb.2011.026.03.9

Abstract

Interleukin  4  merupakan  sitokin  yang  berperan  dalam  patofisiologi  alergi  okuli.  Penelitian  ini  dilakukan  untuk  mengetahui penurunan konsentrasi IL-4 dan perbedaan penurunan konsentrasi IL-4 air mata penderita alergi okuli sesudah diterapi dengan pemirolast potassium 0,1% dan cromolyn sodium   4%. Desain uji klinis acak tersamar ganda dilakukan pada 32 sampel  penderita  alergi  okuli  yang  dibagi  menjadi  dua  kelompok,  yaitu  16  subjek  yang  mendapatkan  tetes  mata pemirolast  potassium  0,1%    dan  16  sampel  yang  mendapatkan  tetes  mata  cromolyn  sodium  4%.  Air  mata  penderita diambil  dua  kali  untuk  dilakukan  pemeriksaan  konsentrasi  IL-4,  yaitu  saat  datang  dan  satu  minggu  setelah  terapi. Konsentrasi IL-4 diperiksa menggunakan ELISA. Analisa data dengan uji t berpasangan dan uji t tidak berpasangan. Pada kelompok pemirolast potassiumterdapat penurunan signifikan (p<0,001) rata-rata konsentrasi IL-4 sebelum pemberian (24,65±SD 2,04 pg/ml) dan sesudah pemberian (20,17±SD 2,34 pg/ml). Penurunan IL-4  yang signifikan (p<0,001)    juga didapat  pada  kelompok  cromolyn  sodium  dengan  rata-rata  konsentrasi  IL-4  awal  23,50±SD  0,95  pg/ml  menjadi 22,51  ±  SD 1,07  pg/ml.  Penurunan  konsentrasi  IL-4  pada  kelompok  pemirolast  potassium  (4,47±SD  1,74  pg/ml)  secara  signifikan (p<0,001)  lebih  besar  dibanding  kelompok  cromolyn  sodium  (0,99±SD  0,50  pg/ml).  Dapat  disimpulkan  pemberian pemirolast potassium 0,1% atau cromolyn sodium 4 % dapat menurunkan konsentrasi IL-4 air mata dengan penurunan lebih  besar  pada  pemberian  pemirolast  potassium  0,1%.
THE RELATIONSHIP BETWEEN RISKS OF OBSTRUCTIVE SLEEP APNEA AND DRY EYE DISEASE Aldina, Rosy; Yanuar, Ferdian; Afif, Zamroni; Holipah; Prayitnaningsih, Seskoati
MNJ (Malang Neurology Journal) Vol. 10 No. 2 (2024): July
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2024.010.02.21

Abstract

Introduction: Dry Eye Disease (DED) may lead to decreased visual function, chronic tissue changes, eyelid, conjunctival, and corneal abnormality. The prevalence of DED in Asia ranges from 21.6%–37.6%. Several studies pointed out the relationship between DED and Obstructive Sleep Apnea (OSA). In patients with OSA, oxidative stress, hypoxia, and ocular surface inflammation increase, leading to a decrease in the functions of meibomian glands, goblet cells, corneal sensitivity, and tear production as a response to the stimulations from the lacrimal glands. The loss of conjunctival goblet cells and meibomian glands are implications of damage to the tear film quality, which results in DED. Method: This is a population-based cross-sectional study. Data were obtained from the database of Biomarker Smarthealth Research in Mendalanwangi, Sidorahayu, and Cepokomulyo Villages, which are located in Malang Regency, having risks of OSA (based on the STOP-BANG questionnaire), above ≥40 years old, and DED Examination with Tear Break-Up Time (TBUT), MGD (Meibominan Gland Dysfunction), Tear Meniscus (TM) involving a total of 518 respondents. The available data were then processed according to the variables and went through DED examinations. This study employed the purposive sampling method. Result: In this study, moderate risk of OSA suggests a significant influence on the occurrence of DED with an odds ratio (OR) 1.66 (p<0.05). In addition, moderate risk of OSA predisposes ADDE (Aqueous Deficiency Dry Eye)-type and Mix-type DED with OR 2.85 and 1.23 (p<0.05). High risk of OSA correlates with the occurrence of ADDE-type DED with OR 2.37 (p<0.05). The age group >60 years old shows a correlation with Mix-type DED with OR 2.09 (p<0.05). Women have a higher predisposition to ADDE-type with OR 2.58 (p<0.05). Conclusion: Moderate risk of OSA influences the occurrence of DED, both ADDE-type and Mix type; whereas high risk of OSA only correlates with ADDE-type. Older age plays a role in the occurrence of Mix-type DED and women have a higher tendency to present with ADDE- type.
THE CORRELATION OF SLEEP QUALITY WITH DRY EYE DISEASE (DED) IN RURAL AREAS Redjeki, Daniela Pauline; Dewi, Debby Shintiya; Aldina, Rosy
MNJ (Malang Neurology Journal) Vol. 12 No. 1 (2026): January
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2026.012.01.06

Abstract

Background: Dry Eye Disease (DED) is a multifactorial ocular condition characterized by tear film instability and ocular surface inflammation. The severity of DED is closely related with poorer quality of life. Studies showed that poor sleep quality occurs in more than 40% of patients with DED. This is due to decreased tear secretion and increased tear osmolarity due to poor sleep. Sleep deprivation is associated with higher risk of diseases that have been shown to be associated with an increased risk of dry eye. Objective: This study was conducted to find the relationship between sleep quality and dry eye disease in Indonesia. Methods: This study was an analytic observational study using a cross sectional study design on 240 respondents in Mendalanwangi Village, Wagir District, Malang Regency. The study was conducted by examining Fluorescein TBUT and filling out the DEQ-5 questionnaire to assess DED and the PSQI questionnaire to assess sleep quality among the study subjects. Results: Among participants who experienced DED, 63.9% reported poor sleep quality, whereas only 36.1% reported good sleep quality. Conversely, in the non-DED group, 56.7% had good sleep quality while 43.3% had poor sleep quality. The results of statistical analysis using the chi-square test with a significance value of p = 0.003 (p < 0.05) and OR 2.31 which indicates there is an association between sleep quality and DED. Conclusion: Poor sleep quality increases the risk of DED 2.3 times compared to good sleep quality and affecting person's quality of life, hence increasing morbidity and mortality.
Association of Dyslipidemia with Severity of Meibomian Gland Dysfunction and Type of Dry Eye Disease Rofiq, Rofiqi; Aldina, Rosy; Mandrasari, Yurike; Holipah, Holipah; Prayitnaningsih, Seskoati
eJournal Kedokteran Indonesia Vol. 13 No. 3 (2025): Vol. 13 No. 3 - Desember 2025
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23886/ejki.13.1116.1

Abstract

The meibomian gland is physiologically involved in lipid secretion; thus, abnormalities in systemic lipid levels may be related to meibomian gland lipid secretion. Meibomian gland dysfunction (MGD) has been strongly associated with dry eye disease (DED), especially the evaporative type. The MGD has been known to increase cholesterol levels, mainly cholesterol ester, in meibomian gland secretions, which is associated with the pathology of MGD. The aim of the study is to assess the association of dyslipidemia with MGD and DED. This was a cross-sectional population-based study using consecutive sampling. Data was taken from the database of the Smart Health Study conducted in Mendalanwangi, Sidorahayu, and Cepokomulyo Village, Malang, from July to November 2019. There were 867 subjects aged ≥40years old with risk of MGD. Assessment of DED ocular surface disease index (OSDI) score, tear breakup time (TBUT), Tear Meniscus (TM), MGD, and dyslipidemia (level of Triglycerides (TG) and High-Density Lipoprotein (HDL)) was performed. The majority of subjects were female with no DED or dyslipidemia. Most respondents had MGD grade 1. Patients with dyslipidemia had a 1.4-fold risk for evaporative dry eye (EDE) compared to patients with normal lipid levels [OR 1.417 (95% CI: 1.0-2.070)]. Patients with MGD had a lower risk of aqueous deficiency dry eye (ADDE) [OR 0.160 (95% CI: 0.699 – 0.366)]. There was no significant association between dyslipidemia and MGD and DED. Patients with dyslipidemia had a 1.4-fold risk of EDE compared to patients with normal lipid levels.
Co-Authors Debby Shintiya Dewi Holipah Holipah, Holipah Mandrasari, Yurike Nurul Elyana Redjeki, Daniela Pauline Rofiq, Rofiqi Seskoati Prayitnaningsih Yanuar, Ferdian Zamroni Afif