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All Journal Jurnal Ilmiah Farmasi EKSAKTA: Journal of Sciences and Data Analysis AJIE (Asian Journal of Innovation and Entrepreneurship) INDONESIAN JOURNAL OF PHARMACY JSFK (Jurnal Sains Farmasi & Klinis) PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat JFIOnline Media Farmasi Indonesia JGEN : Jurnal Pengabdian Kepada Masyarakat Jurnal Kefarmasian Indonesia
Dimas Adhi Pradana
Prodi Farmasi Fakultas Matematika Dan Ilmu Pengetahuan Alam, Universitas Islam Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Earth & Planetary Sciences Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences Other

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Journal : EKSAKTA: Journal of Sciences and Data Analysis

 1 
Effect Of Curcumin And Honey To Pharmacokinetics Of Paracetamol In Male Wistar Rats Dimas Adhi Pradana; Farida Hayati; Agung Giri Samudra; Amalinda Setya Kartika
EKSAKTA: Journal of Sciences and Data Analysis VOLUME 12, ISSUE 1, February 2011
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam

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Abstract

Honey and curcumin is widely consumed by children as food supplements. Honey is useful as an antioxidant and antibacterial, while curcumin  is useful as an antioxidant, antiinflammatory,  antibacterial,  antiviral. Both  health  supplements  are  not  infrequently used in conjunction with drugs, especially paracetamol. This study aims to determine the effect of curcumin and honey on the pharmacokinetic parameters of paracetamol in male rats.  In  this  study,  test  animals  were  divided  into  3  groups:  control,  treatment  I  and treatment  II.  In  the  control  group  mice  were  given  paracetamol  150mg  /  KgBW, treatment  group  I  rats  were  given  curcumin  18  mg  /  KgBW,  1  hour  and  then  given paracetamol 150mg  / KgBW whereas  the  treatment group  II  rats given a dose of honey 7.65 mL / KgBW along with giving paracetamol 150mg KgBB . The results showed that administration of curcumin on the pharmacokinetics of paracetamol in mice can decrease the  primary  parameters  of  the  elimination  phase  of  CLT  for  68.25%,  increasing  the secondary parameter t 1 / 2 at 193.72%, thus increasing the derivative parameters AUC0-inf for 88.36%, and MRT of 155.17% (p
Co-Authors . PRAPTIWI Agung Giri Samudra Amalinda Setya Kartika Amar, Muhammad Apriani, Lalily Arifa Caryn Dea Utami Hasyono Ayuningrum, Fahmay Dwi Baharun, Suraya Bambang Hernawan Nugroho Bambang Suwerda, Bambang Bili, Losarida Amelia Cynthia Astiti Putri Deasy Wulan Dwiratna Dian Sukma Dzihni Meytasari Erlina Marfianti Erlina Marfianti, Erlina Farah Deastasa Nabilah Faras Sophia Rahmah Handayani, Erny Tri Hayati, Farida Irna Destya Anggriani Iwan Dwiprahasto Lalily Apriani Lutfi Chabib, Lutfi Maulana Ardhi Nita Trimulyaningsih P, Leonardus Rayvaldo K. Qrio Susanto Rochmy Istikharah Satibi Satibi Sitarina Widyarini Sri Haryanti Sunarto - Tri Ratna Setyaningrum Tri Ratna Setyaningrum Winano, Agus