Wahyu Hidayat
Bagian Ilmu Penyakit Mulut Fakultas Kedokteran Gigi Universitas Padjadjaran

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Manifestasi oral pada ibu hamil berdasarkan perbedaan trimester kehamilanOral manifestations in pregnant women based on trimester differences Larasati Dyah Utami; Wahyu Hidayat; Irna Sufiawati
Padjadjaran Journal of Dental Researchers and Students Vol 4, No 2 (2020): Oktober 2020
Publisher : Fakultas Kedokteran Gigi Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjdrs.v4i2.25261

Abstract

Pendahuluan: Kehamilan merupakan suatu kondisi yang membawa berbagai macam perubahan pada wanita bahkan pada wanita hamil dengan kondisi fisik yang sehat. Hal tersebut dapat terjadi karena perubahan metabolisme, perubahan respon imun, serta perubahan hormon. Keterkaitan antara faktor-faktor pemicu tersebut, secara tidak langsung dapat menimbulkan berbagai macam manifestasi oral pada ibu hamil, seperti epulis gravidarum, coated tongue, cheilitis exfoliative, geographic tongue, fissured tongue, RAS, atrophic glossitis, dan cheilitis angularis. Tujuan penelitian adalah untuk mengetahui manifestasi oral pada ibu hamil berdasarkan perbedaan trimester kehamilan. Metode: Penelitian ini mengunakan metode deskriptif observatif dengan pendekatan cross-sectional. Populasi dalam penelitian ini ialah seluruh pasien ibu hamil yang datang untuk berobat ke Puskesmas Garuda Bandung. Sampel dalam penelitian ini diambil berdasarkan teknik purposive sampling dan accidental sampling yaitu jumlah sampel yang diambil berdasarkan pasien ibu hamil yang datang untuk berobat ke Puskesmas Garuda Bandung, bersedia untuk dilakukan penelitian, serta memenuhi kriteria inklusi dan ekslusi dengan batas waktu yang telah ditetapkan. Data diperoleh dengan melakukan tanya jawab mengenai kondisi umum, serta pemeriksaan rongga mulut pasien ibu hamil. Hasil: Manifestasi oral yang paling banyak timbul pada ibu hamil adalah coated tongue yaitu terjadi pada 54 orang (78,26%). Coated tongue paling banyak ditemukan pada trimester III kehamilan yaitu sebanyak 31 orang (42,03%) dan exfoliative cheilitis sebanyak 21 orang. Hasil penelitian tidak menemukan adanya cheilitis angularis. Simpulan: Coated tongue menjadi manifestasi orang yang paling banyak ditemukan pada rongga mulut ibu hamil yang merata pada semua trimester.Kata kunci: Kehamilan, manifestasi oral. ABSTRACT Introduction: Pregnancy is a condition that induces various changes in women, even in healthy pregnant women. This condition may occur due to changes in metabolism, immune response, and hormonal system. The relation between these triggers may indirectly lead to various oral manifestations in pregnant women, such as epulis gravidarum, coated tongue, exfoliative cheilitis, geographic tongue, fissured tongue, recurrent aphthous stomatitis (RAS), atrophic glossitis, and angular cheilitis. The purpose of this study was to determine the oral manifestations in pregnant women based on trimester differences. Methods: This research was a descriptive observational with a cross-sectional approach. The population in this study were all pregnant women who came for treatment to the Garuda Community Health Centre, Bandung. The sample in this study was taken based on purposive sampling and accidental sampling techniques, which were pregnant women who came for treatment to the Garuda Community Health Centre, Bandung, willing to participate in the research, and meet the inclusion and exclusion criteria within a predetermined time limit. Data was obtained through questions and answers regarding general conditions, as well as examining the oral cavity of pregnant women. Results: The results of data analysis showed that the most frequent oral manifestations in pregnant women was coated tongue, which was found in 54 respondents (78.26%). The most common oral manifestations found on the first to the third trimester of gestational period was coated tongue, coated tongue most commonly found in the third trimester, which was found in 31 respondents (42.03%) and exfoliative cheilitis in 21 respondents. Angular cheilitis was not found in all respondents. Conclusion: The coated tongue is the most common oral manifestation in pregnant women which is evenly distributed in all trimesters. Keywords: Pregnancy, oral manifestations.
Profil oral candidiasis di bagian ilmu penyakit mulut RSHS Bandung periode 2010-2014 Nanan Nur'aeny; Wahyu Hidayat; Tenny Setiana Dewi; Erna Herawati; Indah Suasani Wahyuni
Majalah Kedokteran Gigi Indonesia Vol 3, No 1 (2017): April
Publisher : Faculty of Dentistry, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (310.332 KB) | DOI: 10.22146/majkedgiind.11320

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Oral candidiasis prole in oral medicine department of RSHS Bandung in the period of 2010 – 2014 C. albicans is the primary causative agent in oral candidiasis. Candida species are commensal microorganisms as normal ora in the mouth, without causing any symptoms. Oral candidiasis may be caused by systemic condition, autoimmune disease and poor oral hygiene.Candida spp can become pathogenic in the decline of the condition of the immune system, especially in autoimmune disease conditions given with steroids drug as the steroids in nature could deteriorate the immune systems or long term of systemic drugs therapy. Study related to oral candidiasis in Indonesia is still lacking. The aim of the study is to know the description of oral candidiasis of RSHS Bandung, Indonesia at 2010 – 2014, descriptively in the oral medicine clinic. The results showed during the period of 2010  to 2014, 49 patients oral candidiasis were found. The most prevalent was 34 males (69.3%) and 15 women (30.7%) in which the most predisposing factor is systemic factor about 40.2%. The whitish pseudomembran plaque is commonly found in the dorsal area of the tongue. The prole of oral candidiasis in patients visiting the oral medicine clinic at RSHS generally is caused by systemic conditions, autoimmune diseases and poor oral hygiene, the use of nystatin is still effective to be used to treat candidiasis.ABSTRAKCandida. albicans (C.albicans) merupakan agen penyebab primer pada oral candidiasis. Candida spp merupakan mikroorganisme komensal atau ora normal dalam mulut dengan tanpa menimbulkan gejala. Candida spp dapat menjadi patogen saat kondisi daya tahan tubuh menurun terutama dalam kondisi penyakit autoimun yang diberikan terapi steroid karena steroid bersifat menurunkan sistem imun atau terapi obat-obatan secara sistemik dalam jangka waktu lama. Penelitian oral candidiasis di Indonesia masih belum banyak dilakukan. Penelitian ini bertujuan untuk mengetahui prol oral candidiasis pada pasien-pasien yang ditangani di Bagian Penyakit Mulut di Rumah Sakit dr. Hasan Sadikin (RSHS), Bandung, Indonesia periode tahun 2010 – 2014. Hasil penelitian menunjukkan selama periode 2010 hingga 2014 sebanyak 49 orang pasien yang datang ke klinik ilmu penyakit mulut ditemukan oral candidiasis. Prevalensi terbanyak adalah pria sebesar 34 orang (69,3%) dan wanita 15 orang (30,7%), dengan faktor predisposisi terbanyak adalah keterlibatan penyakit sistemik sebesar 40,2%. Lokasi paling sering ditemukan lesi plak pseudomembran putih dan terdapat di daerah dorsal lidah. Prol kandidiasis pada pasien yang berkunjung ke klinik ilmu penyakit mulut RSHS secara garis besar umumnya disebabkan oleh kondisi sistemik, penyakit autoimun dan kebersihan rongga mulut yang buruk sedangkan untuk terapi kandidiasis, penggunaan nystatin masih efektif untuk digunakan mengobati kandidiasis.
PENGALAMAN KARIES, KADAR HAEMOGLOBIN, BERAT BADAN DAN TINGGI BADAN PADA ANAK DENGAN LESI MUKOSA ORAL Indah Suasani Wahyuni; Fajar Fatriadi; Diani Prisinda; Fidya Meditia Putri; Nanan Nuraeny; Wahyu Hidayat
ODONTO : Dental Journal Vol 4, No 2 (2017): December 2017
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.4.2.79-84

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Background: Oral mucosal lesions in children caused by nutritional problems, dental infection, poor oral hygiene and trauma. Oral health in children as the next generation of the nation should always be maintained. However there is still lack of data on the emergence of oral mucosal lesions in Indonesian children. Purpose. To describe an overview of the caries experience, Haemoglobin/Hematokrit (Hb Ht), weight (BB) and height (TB) in children aged 6-7 years in several elementary schools at Tanjungsari, Sumedang.Result: 44 of 137 students who had oral mucosal lesions, had completesupporting data. Total of 43 students had an average caries experience of 8.4 teeth/child (1-17 teeth/child), while 1 student was caries-free. The average of weight = 19.3 kg, height = 115.5 cm, and Hb/Ht = 12.5/36.5%. Oral lesions found were plaques on the tongue, ulcers, macules, nodules, pustules and desquamatives.Discussion: The condition of untreated dental caries can cause pain anddiscomfort, so the child will have difculty eating and interfere with the growth process. This can be seen through the child’s caries experience with data on weight and height. Tooth decay affects the nutrient intake and was estimated to lead to a decrease in Hb/Ht. Oral mucosal lesions due to trauma and poor oral hygiene were not expected to affect systemic conditions.Conclusion: The results of this study indicate that the caries experience was very high, the average value of weight and height were normal below the ideal, Hb/Ht levels within normal limits, while Coated tongue was the common diagnosis found from subjects
Correlation between reactive oxygen species and oral conditions in elderly individuals with hypertension: a preliminary study Nanan Nur'aeny; Wahyu Hidayat; Indah Suasani Wahyuni
Dental Journal (Majalah Kedokteran Gigi) Vol. 50 No. 3 (2017): September 2017
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (583.8 KB) | DOI: 10.20473/j.djmkg.v50.i3.p111-115

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Background: The increased number of elderly people in Indonesia can be a positive phenomenon if their health is well-preserved. The elderly are influenced by physiological changes, environmental factors, and personal habits making them susceptible to chronic diseases. The oral cavity is also subject to change, one of the causes being reduced salivary flow that is manifested in dental caries and other oral health concerns. This disease is stimulated by oxidative stress in the body due to an imbalance between reactive oxygen species (ROS) and the antioxidant defense system. Purpose: This preliminary study aimed to investigate ROS-related hypertension and the state of oral health of elderly patients. Methods: The study constitutes a combination of cross-sectional observation and consecutive sampling. Twelve subjects, selected on the basis of inclusive and exclusive criteria, consisted of two males and ten females. Physical examinations and blood sampling were performed on all subjects. R version 3.4.1 for Windows operating system was used to perform statistical tests. Results: The 12 patients shared a history of hypertension, the lowest ROS level was 0.87 IU/ml, while the highest was one of 7.20 IU/ml. The correlation between ROS and oral conditions showed only ROS and tooth loss as having a significant positive correlation. An independent t test showed there to be a mean difference between ROS with Miyazaki index 1 and 2 but it was statistically insignificant. Conclusion: There was no correlation between the ROS level in the bloodstream and general oral health, except in the relationship between the ROS level in the bloodstream and tooth loss which had a positive correlation.
Pengalaman karies dan kesehatan periodontal serta kebutuhan perawatan ibu hamilCaries experience, periodontal health, and oral treatment needs of pregnant women Anne Agustina Suwargiani; Indra Mustika Setia Pribadi; Wahyu Hidayat; Riana Wardani; Tadeus Arufan Jasrin; Cucu Zubaedah
Jurnal Kedokteran Gigi Universitas Padjadjaran Vol 30, No 1 (2018): April
Publisher : Fakultas Kedokteran Gigi Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (281.191 KB) | DOI: 10.24198/jkg.v30i1.16282

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Pendahuluan: Kesehatan gigi Ibu hamil  sangat perlu dijaga, untuk menghindarkan terjadinya infeksi pada gigi dan gusi. Upaya ini akan menghindarkan dari infeksi yang berisiko yang menyebabkan prematur dan kelahiran berat bayi lahir rendah. Tujuan penelitian untuk mengetahui pengalaman karies dan kesehatan periodontal dan kebutuhan perawatan ibu hamil. Metode: Metode penelitian yang digunakan deskriptif. Populasi penelitian adalah ibu hamil yang datang ke Klinik Cantik Banjaran Bandung. Sampel penelitian yaitu ibu hamil yang bersedia menjadi subjek penelitian dan tidak mempunyai kelainan sistemik. Teknik pengambilan sampel adalah convinience sampling. Variabel penelitian pengalaman karies diukur dengan indeks DMFT, Kebutuhan perawatan karies adalah perhitungan kebutuhan perawatan berdasarkan penilaian persen kebutuhan perawatan dan kebutuhan perawatan periodontal diukur dengan indeks Community Periodontal Index and Treatment Needs (CPITN). Analisis data yang digunakan adalah distribusi frekuensi relatif. Hasil: Indeks DMFT ibu hamil 4,4 termasuk kriteria sangat rendah. Hasil CPITN yaitu periodontal sehat 0%; bleeding on probing (BOP), 43%; kalkulus, 53%; poket 4-5 mm, 3,3%; poket 6 mm, 0%. Kebutuhan perawatan gigi berlubang pada ibu hamil 30,9%. Kebutuhan perawatan jaringan periodontal diperlukan pada semua ibu hamil, berupa perbaikan oral hygiene 43%, perbaikan oral hygiene dan skeling 56%, Simpulan: Pengalaman karies ibu hamil pada kriteria sangat rendah, sedangkan kondisi jaringan periodontal ibu hamil semuanya memerlukan perawatan jaringan periodontal tetapi bukan perawatan periodontal kompleks.Kata kunci: Ibu hamil, indeks DMFT, indeks CPITN. ABSTRACTIntroduction: The oral health of pregnant women needs to be maintained to avoid infection of the teeth and gums. This effort will avoid dangerous infections that can cause premature and low birth weight babies. The purpose of this study was to determine the caries experience, periodontal health, and the oral treatment needs of pregnant women. Methods: The research method was descriptive. The study population was pregnant women who came to the Cantik Clinic of Banjaran, Bandung, whom willing to be the subject of research with no systemic abnormalities. The sampling technique was convenience sampling. The caries experience was measured by DMFT index. Caries treatment needs were the calculation of treatment needs based on the assessment of general and periodontal treatment needs to be measured by the Community Periodontal Index and Treatment Needs (CPITN) index. Data analysis used was the relative frequency distribution. Results: DMFT index of pregnant women was 4.4, included in the very low criteria. CPITN index measurement results were 0% healthy periodontal; 43% bleeding on probing (BOP); 53% calculus; 3.3% pocket of 4-5 mm; and 0% 6 mm pocket. General treatment needs of pregnant women mostly were tooth decay treatment (30.9%). Periodontal treatment needs were needed for all pregnant women, in the form of oral hygiene improvement only (43%), oral hygiene improvement and scaling (56%). Conclusion: The caries experience of pregnant women was very low, while the periodontal conditions require a non-complex periodontal treatment.Keywords: Pregnant women, DMFT Index, CPITN index.
Tatalaksana infeksi herpes simpleks virus tipe-1 dan necrotizing ulcerative stomatitis pada anak dengan anemia aplastikManagement of type-1 herpes simplex virus infection and necrotising ulcerative stomatitis in children with aplastic anaemia Yannie Febby Martina Lefaan; Wahyu Hidayat; Nanan Nur'aeny
Jurnal Kedokteran Gigi Universitas Padjadjaran Vol 33, No 3 (2022): Maret 2022 (Suplemen 3)
Publisher : Fakultas Kedokteran Gigi Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/jkg.v33i3.30642

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ABSTRAKPendahuluan: Necrotizing ulcerative stomatitis (NUS) merupakan penyakit inflamasi pada rongga mulut, ditandai oleh ulser nekrosis akut, berkembang cepat serta menyebabkan kerusakan masif pada jaringan. NUS dapat berkembang dari kondisi necrotizing ulcerative gingivitis (NUG) dan necrotizing ulcerative periodontitis (NUP). NUS dapat disertai infeksi lain, salah satunya infeksi herpes simplex tipe 1 (HSV-1). Infeksi HSV-1 dan NUS pada anak dengan anemia aplastik jarang ditemukan. Anemia aplastik merupakan kelainan hematologi, ditandai dengan hipoplastik/aplasia sumsum tulang dan pansitopenia, sehingga menurunkan resistensi host terhadap infeksi. Gingivostomatitis herpetik primer memudahkan perkembangan bakteri komensal seperti bakteri Fusiform, Spirochetes dan Pseudomonas aeruginosa  menjadi patogen pada kondisi imunosupresif sehingga meningkatkan progresivitas penyakit periodontal menjadi NUS. Tujuan laporan kasus ini adalah menjelaskan tatalaksana infeksi HSV-1 dan NUS pada anak dengan anemia aplastik. Laporan kasus: Seorang anak perempuan usia 3 tahun dengan diagnosis anemia aplastik dan febrile neutropenia, dirujuk oleh divisi Hematologi-onkologi anak Rumah Sakit Dr. Hasan sadikin (RSHS) Bandung dengan keluhan pembengkakan pada bibir dan stomatitis. Hasil pemeriksaan darah menunjukan adanya pansitopenia dan pemeriksaan anti HSV-1 IgG reaktif. Diagnosis terkait kondisi bibir dan mulut pasien adalah Infeksi HSV-1 dan NUS. Tatalaksana yang dilakukan adalah debridement dengan Hidrogen peroksida 1,5% (H2O2 1,5%), kontrol plak dengan chlorhexidine digluconate 0,12% dan multivitamin. Pembengkakan mulai membaik setelah 3 hari debridement serta memberikan hasil yang signifikan setelah 1 bulan perawatan. Simpulan: Tatalaksana berupa peningkatan oral hygiene dan terapi antiseptik dapat memperbaiki kondisi infeksi HSV-1 dan NUS, khususnya pada pasien dengan kondisi imunosupresif seperti anemia aplastik.Kata kunci: febrile neutropenia; stomatitis; herpes simpleks; anemia; spirochetes ABSTRACTIntroduction: Necrotising ulcerative stomatitis (NUS) is an inflammatory disease of the oral cavity, characterised by acute necrotising ulcers, proliferating, and causing massive tissue damage. NUS can be developed from necrotising ulcerative gingivitis (NUG) and necrotising ulcerative periodontitis (NUP). NUS can be accompanied by other infections, such as herpes simplex type 1 (HSV-1) infection. However, HSV-1 and NUS infections in children with aplastic anaemia are rare. Aplastic anemia is a haematological disorder characterised by hypoplastic/bone marrow aplasia and pancytopenia, reducing the host's resistance to infection. Primary herpetic gingivostomatitis facilitates the development of commensal bacteria such as Fusiform bacteria, Spirochetes and Pseudomonas aeruginosa to become pathogens under immunosuppressive conditions, thereby increasing the progression of periodontal disease to NUS. This case report aims to describe the management of HSV-1 and NUS infections in children with aplastic anemia. Case report: A 3-year-old female child diagnosed with aplastic anaemia and febrile neutropenia was referred by the paediatric haematology-oncology division of Dr Hasan Sadikin Hospital (RSHS) Bandung with complaints of swelling of the lips and stomatitis. Blood test results showed pancytopenia and reactive anti-HSV-1 IgG examination. The diagnosis related to the patient's lips and mouth condition was HSV-1 and NUS infection. The treatment is debridement with 1.5% hydrogen peroxide (H2O2 1.5%), plaque control with 0.12% chlorhexidine digluconate and multivitamins. After three days of debridement, the swelling started to improve and gave significant results after one month of treatment. Conclusion: Management of improving oral hygiene and antiseptic therapy can improve the condition of HSV-1 and NUS infections, especially in patients with immunosuppressive conditions such as aplastic anemia.Keywords: febrile neutropenia; stomatitis; herpes simplex; anaemia; spirochetes
Inhibition growth of pomegranate seeds extract against streptococcus sanguis: the cause of recurrent aphthous stomatitis Riani Setiadhi; Irna Sufiawati; Dewi Zakiawati; Nanan Nur’aeny; Wahyu Hidayat; Dani R. Firman
Journal of Dentomaxillofacial Science Vol. 2 No. 1 (2017): (Available online: 1 April 2017)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15562/jdmfs.v2i1.452

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Objective : Pomegranate (Punica granatum L.) seeds contain high of phytonutrients and phytochemicals, rich in polyphenol antioxidants namely tannins and flavonoids which also have antibacterial activity. Streptococcus sanguis is a bacterium known as one of the factors causing Recurrent Aphthous Stomatitis (RAS). To examine the potential antibacterial of Pomegranate seeds against Streptococcus sanguis.Material anda Methods : In vitro study of Pomegranate seed were extracted with maceration method using 70% ethanol as the solvent to obtain stable extract, continued with phytochemical screening against phenolic, flavonoids, alkaloids, steroids, triterpenoid, saponins and tannins.  The extract was evaluated for Minimum Inhibitory Concentration and Minimum Bactericide Concentration against Streptococcus sanguis ATCC 10556, using microdiluted method through 96 wells microplate. Results : Chlorhexidine was used as positive control while 70% ethanol was used as solvent as well as negative control. Phytochemical screening gave positive results for phenolics, flavonoids, steroids, saponins and tannins. Microdilution test showed the concentration of 500 ppm as MIC and MBC value at 2,000 ppm.Conclusion : Pomegranate seeds extract have a growth inhibitory against Streptococcus sanguis with MIC value of 500 ppm and 2,000 ppm as MBC.
Evaluation of antibacterial activity and acute toxicity of pomegranate (punica granatum l.) seed ethanolic extracts in swiss webster mice Riani Setiadhi; Irna Sufiawati; Dewi Zakiawati; Nanan Nur’aeny; Wahyu Hidayat; Dani R. Firman
Journal of Dentomaxillofacial Science Vol. 2 No. 2 (2017): (Available online: 1 August 2017)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15562/jdmfs.v2i2.536

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Objective: To evaluate the safety of a pomegranate seeds ethanolic extract in Swiss Webster mice.Material and Methods: Pomegranate seed’s ethanolic extracts were evaluated for minimum inhibitory concentration against streptococcus sanguis ATCC 10556, using microdilution method through 96-wells microplate. In acute toxicity test, 12 females and 12 males Swiss Webster mice weighing 20–30 grams were divided into four groups, each consisting of 3 females and 3 males. Three groups were orally given of sample with concentrations 0.2% equivalent to 40 mg/kg, 0.4% equivalent to 80 mg/kg, and 0.8% equivalent to 160 mg/kg, while the control group was given distilled water. Observations were made at 30, 60, and 90 minutes, for 24 hours and 7 days.Results: The MIC against Streptococcus sanguis was on 2000 ppm concentration and until 24 hours observation no lethal effect occurred on the mice, but at the 7 days observation in the group of 0.8% per kilogram body weight, the lethal effect occurred at one mice.Conclusion: The ethanolic extract of pomegranate seeds has antibacterial effect and no acute systemic toxicity, which can be considered safe on the use as oral topical solution since the toxic dose is greater than 160 mg/kg of body weight.
Identification of active component in red pomegranate (punica granatum L.) seeds ethanolic extract Riani Setiadhi; Irna Sufiawati; Wahyu Hidayat
Journal of Dentomaxillofacial Science Vol. 4 No. 2 (2019): (Available online: 1 August 2019)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15562/jdmfs.v4i2.934

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Objective: Pomegranate (punica granatum L.) have many benefits for health and used as traditional medicine. The pomegranate seeds are rich in antioxidants, namely flavonoids and tannins as well as alkaloid which is an antibacterial.  The aim of this study was to identify the pure isolate/active component of red pomegranate seeds ethanolic extract. Material and Methods: Two-ways TLC of the purified crystals which were obtained from the hexan fraction of ethanolic extract red pomegranate seeds, were used to make sure there was only 1 active compound of red pomegranate seeds. The isolate was identified using dragendorff, Mg and HCl, NaOH, Bunchard, Liebermen, FeCL3 and HCl concentrated reagents.Results: Isolate identification test using dragendorf reagents showed positive result (an orange-coloured).Conclusion: The pure isolate/active component of red pomegranate seeds is alkaloid.
PENENTUAN LAJU ALIR SALIVA PADA PASIEN GERIATRI SEBAGAI PERTIMBANGAN MANAJEMEN KOMPREHENSIF PADA STOMATITIS HERPETIKA Mega Rafika; Indah Suasani Wahyuni; Wahyu Hidayat
B-Dent: Jurnal Kedokteran Gigi Universitas Baiturrahmah Volume 5, Nomor 2, Desember 2018
Publisher : Universitas Baiturrahmah

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (115.542 KB) | DOI: 10.33854/jbd.v5i2.163

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Latar belakang Laju saliva adalah sekresi saliva yang dinyatakan dalam ml/menit. Pada pasien geriatri dengan riwayat hipertensi dapat menurunkan kuantitas, kualitas dan laju saliva. Kondisi ini dapat meningkatkan terjadinya infeksi rongga mulut seperti stomatitis herpetika.Tujuan Mengukur laju saliva pada pasien geriatri dengan riwayat hipertensi yang didiagnosa stomatitis herpetika, keilitis eksfoliatif dan hiposalivasi sebagai pertimbangan perawatan yang komprehensif. Laporan kasus Seorang wanita usia 63 tahun datang ke klinik karena sariawan selama beberapa tahun dan mengganggu sejak 2 bulan yang lalu. Pemeriksaan ekstraoral berupa bibir kering. Pemeriksaan intraoral menunjukkan oral hygiene buruk, kondisi mukosa oral yang kering dan terdapat ulser multipel. Pemeriksaan laboratorium menunjukkan eosinofil dan monosit di bawah normal, dan IgG anti HSV-1 reaktif. Laju saliva 0,2 ml/menit, dilakukan dengan metode spitting untuk menegakkan diagnosa hiposalivasi. Penatalaksanaan kasus Pasien diberikan vitamin B12, asam folat untuk meningkatkan daya tahan tubuh, Vaseline album untuk melembabkan bibir, chlorhexidine gluconate 0,2%, oral hygiene instruction dan scalling dilakukan untuk memperbaiki oral hygiene serta disarankan nutrisi seimbang dan hidrasi yang memadai sebagai terapi nonfarmakologi. Diskusi Pasien ini memiliki kondisi yang kompleks: geriatri, oral hygiene yang buruk, menggunakan obat antihipertensi, dan juga mengalami stres emosional. Hal ini dapat menyebabkan penurunan kuantitas dan kualitas saliva sebagai pertahanan mukosa mulut. sehingga pasien akan lebih rentan terhadap infeksi HSV-1 dan reaktivasi. Simpulan Laju saliva dapat menjadi pertimbangan dalam tatalaksana stomatitis herpetika pada pasien geriatri dengan hipertensi dan pengobatan anti hipertensinya.