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Metilasi DNA dan Mukosa Mulut Nuraeny, Nanan; Hakim, Dzulfikal DL; Susilaningsih, Fransisca S; Herawati, Dewi MD
Sriwijaya Journal of Medicine Vol. 2 No. 2 (2019): Sriwijaya Journal of Medicine
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (655.045 KB)

Pengaruh lingkungan eksternal pada gen manusia akan berpengaruh pada patogenesis penyakit, dan hal ini dapat diturunkan. Studi tentang perubahan gen fenotip yang diwariskan yang tidak disebabkan oleh perubahan urutan DNA disebut epigenetik. Salah satu mekanisme epigenetik adalah metilasi DNA yang penting dalam mengatur ekspresi gen. Ulasan ini akan menjelaskan studi tentang metilasi DNA pada mukosa mulut. Metode pencarian sistematis Google Scholar dan Pubmed dilakukan untuk semua studi dalam sepuluh tahun terakhir. Hasil pencarian mendapatkan sebanyak tujuh artikel dengan ukuran sampel yang bervariasi, 16 hingga 177 sampel, sebagian besar studi kasus-kontrol padaoral premalignan lesions (OPL), oral lichenoid disease (OLD), mucositis oral pada acute lymphoblactic leukemia (ALL), dan oral squamous cell carcinoma (OSCC). Metilasi DNA pada kanker mulut menunjukkan bahwa terdapat hipermetilasi beberapa gen, walaupun status metilasi DNA dalam beberapa kasus belum menunjukkan perbedaan yang signifikan antara gen yang diperiksa. Hasil penelitian lain menunjukkan bahwa tidak ada korelasi antara metilasi DNA dan perkembangan mukositis oral pada ALL yang menerima terapi metotreksat (MTX). Mekanisme metilasi DNA pada sel malignanadalah dengan menambahkan gugus metil ke sitosin dinukleotida di CpG (cytosine phosphate guanine) pada daerah promoter oleh enzim DNA methyltransferase sehingga dapat menghambat ekspresi beberapa gen terkait pertumbuhan sel, perbaikan DNA, dan penghambat metastasis. Metilasi DNA adalah biomarker penting dalam perkembangan penyakit mukosa mulut.

Tingkat pengetahuan dan sumber informasi mengenai lesi ulserasi mulut pada siswa sekolah dasarLevel of knowledge and sources of information regarding oral ulcerations in elementary school students Harmonisa Sheilla Witadiana; Indah Suasani Wahyuni; Nanan Nuráeny
Padjadjaran Journal of Dental Researchers and Students Vol 4, No 1 (2020): April 2020
Publisher : Fakultas Kedokteran Gigi Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjdrs.v4i1.25655

Pendahuluan: Lesi ulserasi mulut, atau sariawan, adalah lesi berbentuk cekung berbatas jelas dan berwarna putih kekuningan di mukosa mulut yang terasa sakit. Kondisi ini sering ditemukan pada anak-anak, sehingga pengetahuan tentang lesi ulserasi mulut perlu dimiliki. Tingkat pengetahuan seseorang mengenai lesi ulserasi mulut salah satunya dipengaruhi oleh informasi yang diterima. Penelitian ini bertujuan untuk mengetahui tingkat pengetahuan anak-anak siswa Sekolah Dasar dan sumber informasi mengenai lesi ulserasi mulut. Metode: Jenis penelitian deskriptif cross sectional. Alat ukur penelitian berupa kuesioner yang sudah valid dan reliabel, terdiri atas 12 pertanyaan mengenai pengetahuan dan enam pertanyaan sumber informasi tentang lesi ulserasi mulut. Sampel yang digunakan berjumlah 323 siswa kelas V SD, dengan teknik purposive sampling. Hasil: Sejumlah 51.08% siswa memiliki pengetahuan yang baik, 46.75% siswa pada tingkat pengetahuan sedang, serta 2.17% memiliki pengetahuan yang buruk mengenai lesi ulserasi mulut. Sumber informasi tentang lesi ulserasi mulut diperoleh sebagian besar dari televisi (55.72%) atau sekolah (54.48%). Siswa yang memiliki pengalaman pribadi pernah mengalami sariawan sejumlah 92.56%, sedangkan sumber cerita mengenai pengalaman sariawan paling banyak dari keluarga, sebesar 68.73%. Simpulan: Tingkat pengetahuan sebagian besar siswa adalah baik dan sedang dan sumber informasi mengenai lesi ulserasi mulut pada siswa sekolah dasar sebagian besar adalah dari televisi dan sekolah informasi mengenai pengalaman sariawan paling banyak dari keluarga.Kata kunci: Lesi ulserasi rongga mulut, sumber informasi, tingkat pengetahuan. ABSTRACTIntroduction: Oral ulcerations are painful, concave-shaped with clear border and yellowish-white lesions in the oral mucosa. This condition is often found in children; therefore, knowledge regarding this matter is needed. Children's level of knowledge about oral ulcerations is influenced by the source of information obtained. This study described the oral ulcerations knowledge in elementary school students in Jatinangor Subdistrict, Sumedang, Indonesia, and related-sources of information. Methods: This research was descriptive with a cross-sectional approach. The instrument of the study was a valid and reliable questionnaire that was consisted of twelve knowledge questions and six questions about sources of information concerning oral ulcerations. The sample used was 323 fifth grade elementary school students, with a purposive sampling technique. Results: As much as 51.08% of students had good knowledge, 46.75% of students at a moderate level of knowledge, and 2.17% had poor knowledge about oral ulcerations. Sources of information about oral ulcerations were obtained mostly from television (55.72%) or schools (54.48%). Students with personal experience of oral ulcerations were 92.56%, while 68.73% answered that the source of information about the oral ulcerations experience mostly came from the family. Conclusion: The level of knowledge of most students is good and moderate, and the source of information regarding oral ulceration lesions in primary school students is mostly from television and information schools about the most thrush experiences from families.Keywords: Knowledge level, information source, oral ulceration lesions.

PENGALAMAN KARIES, KADAR HAEMOGLOBIN, BERAT BADAN DAN TINGGI BADAN PADA ANAK DENGAN LESI MUKOSA ORAL Indah Suasani Wahyuni; Fajar Fatriadi; Diani Prisinda; Fidya Meditia Putri; Nanan Nuraeny; Wahyu Hidayat
ODONTO : Dental Journal Vol 4, No 2 (2017): December 2017
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.4.2.79-84

Background: Oral mucosal lesions in children caused by nutritional problems, dental infection, poor oral hygiene and trauma. Oral health in children as the next generation of the nation should always be maintained. However there is still lack of data on the emergence of oral mucosal lesions in Indonesian children. Purpose. To describe an overview of the caries experience, Haemoglobin/Hematokrit (Hb Ht), weight (BB) and height (TB) in children aged 6-7 years in several elementary schools at Tanjungsari, Sumedang.Result: 44 of 137 students who had oral mucosal lesions, had completesupporting data. Total of 43 students had an average caries experience of 8.4 teeth/child (1-17 teeth/child), while 1 student was caries-free. The average of weight = 19.3 kg, height = 115.5 cm, and Hb/Ht = 12.5/36.5%. Oral lesions found were plaques on the tongue, ulcers, macules, nodules, pustules and desquamatives.Discussion: The condition of untreated dental caries can cause pain anddiscomfort, so the child will have difculty eating and interfere with the growth process. This can be seen through the child’s caries experience with data on weight and height. Tooth decay aﬀects the nutrient intake and was estimated to lead to a decrease in Hb/Ht. Oral mucosal lesions due to trauma and poor oral hygiene were not expected to aﬀect systemic conditions.Conclusion: The results of this study indicate that the caries experience was very high, the average value of weight and height were normal below the ideal, Hb/Ht levels within normal limits, while Coated tongue was the common diagnosis found from subjects

Metilasi DNA dan Mukosa Mulut Nanan Nuraeny; Dzulfikar DL. Hakim; Fransisca S. Susilaningsih; Dewi MD. Herawati; Dida A. Gurnida
Sriwijaya Journal of Medicine Vol. 2 No. 2 (2019): Vol 2, No 2, 2019
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v2i2.42

Pengaruh lingkungan eksternal pada gen manusia akan berpengaruh pada patogenesis penyakit, dan hal ini dapat diturunkan. Studi tentang perubahan gen fenotip yang diwariskan yang tidak disebabkan oleh perubahan urutan DNA disebut epigenetik. Salah satu mekanisme epigenetik adalah metilasi DNA yang penting dalam mengatur ekspresi gen. Ulasan ini akan menjelaskan studi tentang metilasi DNA pada mukosa mulut. Metode pencarian sistematis Google Scholar dan Pubmed dilakukan untuk semua studi dalam sepuluh tahun terakhir. Hasil pencarian mendapatkan sebanyak tujuh artikel dengan ukuran sampel yang bervariasi, 16 hingga 177 sampel, sebagian besar studi kasuskontrol padaoral premalignan lesions (OPL), oral lichenoid disease (OLD), mucositis oral pada acute lymphoblactic leukemia (ALL), dan oral squamous cell carcinoma (OSCC). Metilasi DNA pada kanker mulut menunjukkan bahwa terdapat hipermetilasi beberapa gen, walaupun status metilasi DNA dalam beberapa kasus belum menunjukkan perbedaan yang signifikan antara gen yang diperiksa. Hasil penelitian lain menunjukkan bahwa tidak ada korelasi antara metilasi DNA dan perkembangan mukositis oral pada ALL yang menerima terapi metotreksat (MTX). Mekanisme metilasi DNA pada sel malignanadalah dengan menambahkan gugus metil ke sitosin dinukleotida di CpG (cytosine phosphate guanine) pada daerah promoter oleh enzim DNA methyltransferase sehingga dapat menghambat ekspresi beberapa gen terkait pertumbuhan sel, perbaikan DNA, dan penghambat metastasis. Metilasi DNA adalah biomarker penting dalam perkembangan penyakit mukosa mulut.

PENGALAMAN KARIES, KADAR HAEMOGLOBIN, BERAT BADAN DAN TINGGI BADAN PADA ANAK DENGAN LESI MUKOSA ORAL Indah Suasani Wahyuni; Fajar Fatriadi; Diani Prisinda; Fidya Meditia Putri; Nanan Nuraeny; Wahyu Hidayat
Odonto : Dental Journal Vol 4, No 2 (2017): December 2017
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Background: Oral mucosal lesions in children caused by nutritional problems, dental infection, poor oral hygiene and trauma. Oral health in children as the next generation of the nation should always be maintained. However there is still lack of data on the emergence of oral mucosal lesions in Indonesian children. Purpose. To describe an overview of the caries experience, Haemoglobin/Hematokrit (Hb Ht), weight (BB) and height (TB) in children aged 6-7 years in several elementary schools at Tanjungsari, Sumedang.Result: 44 of 137 students who had oral mucosal lesions, had completesupporting data. Total of 43 students had an average caries experience of 8.4 teeth/child (1-17 teeth/child), while 1 student was caries-free. The average of weight = 19.3 kg, height = 115.5 cm, and Hb/Ht = 12.5/36.5%. Oral lesions found were plaques on the tongue, ulcers, macules, nodules, pustules and desquamatives.Discussion: The condition of untreated dental caries can cause pain anddiscomfort, so the child will have difculty eating and interfere with the growth process. This can be seen through the child’s caries experience with data on weight and height. Tooth decay aﬀects the nutrient intake and was estimated to lead to a decrease in Hb/Ht. Oral mucosal lesions due to trauma and poor oral hygiene were not expected to aﬀect systemic conditions.Conclusion: The results of this study indicate that the caries experience was very high, the average value of weight and height were normal below the ideal, Hb/Ht levels within normal limits, while Coated tongue was the common diagnosis found from subjects

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