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All Journal Saintika Medika: Jurnal Ilmu Kesehatan dan Kedokteran Keluarga. CoMPHI Journal : Community Medicine and Public Health of Indonesia Journal
Hawin Nurdiana
Universitas Muhammadiyah Malang
Health Professions Medicine & Pharmacology Nursing Public Health

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METABOLISME ASAM LEMAK OTOT JANTUNG Nurdiana, Hawin
Saintika Medika: Jurnal Ilmu Kesehatan dan Kedokteran Keluarga Vol 7, No 2 (2011): Desember 2011
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (289.467 KB) | DOI: 10.22219/sm.v7i2.4077

Abstract

Otot jantung memiliki ATP content yang relatif rendah (5 ?mol/g wet wt) dan hidrolisis ATP yang cepat ( 0.5 ?mol · g wetwt?1 · s?1 at rest), jadi pada kondisi normal cadangan ATP mengalami pergantian secara lengkap tiap 10 detik (Stanley et al., 2005). Sekitar 60?70% hidrolisis ATP digunakan untuk kontraksi, sedangkan 30?40% sisanya digunakan untuk sarcoplasmic reticulum Ca2+- ATPase dan pompa ion lainnya (Suga H, 1990). Pada jantung normal kecepatan fosforilasi oksidatif berhubungan dengan kecepatan hidrolisis sehingga ATP content tetap konstan meskipun pada saat kekuatan jantung meningkat hebat (Balaban RS,1990), seperti saatexercise atau stress katekolamin akut. Fosforilasi oksidatif dalam mitokondria dicukupi oleh energi dari elektron yang ditransfer dari hasil reaksi dehidrogenasi yang menghasilkan NADH dan FADH2 pada jalur oksidasi b asam lemak, siklus asam sitrat, dan dalam jumlah kecil oleh reaksi dehidrogenasi piruvat dan glikolisis. Acetyl-CoA yang dibutuhkan dalam siklus asam sitrat dihasilkan dari dekarboksilasi piruvat dan oksidasi asam lemak. Pada jantung yang normal, 60?90% acetyl-CoA berasal dari oksidasi asam lemak dan 10?40% berasal dari oksidasi piruvat yang diperoleh dalam jumlah yang hampir sama dengan yang berasal dari glikolisis dan oksidasi laktat (Stanley et al., 2005). Oksidasi asam lemak mencukupi 60-70% kebutuhan energi otot jantung (Kudo N et al., 1995). Meskipun demikian, mekanisme uptake asam lemak rantai panjang melalui oksidasi b belum sepenuhnya diketahui (Luiken JJ et al., 2001). Kata Kunci: asam lemak, otot jantung
Metabolisme Asam Lemak Otot Jantung Hawin Nurdiana
Saintika Medika Vol. 7 No. 2 (2011): Desember 2011
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/sm.v7i2.4077

Abstract

Otot jantung memiliki ATP content yang relatif rendah (5 μmol/g wet wt) dan hidrolisis ATP yang cepat ( 0.5 μmol · g wetwt–1 · s–1 at rest), jadi pada kondisi normal cadangan ATP mengalami pergantian secara lengkap tiap 10 detik (Stanley et al., 2005). Sekitar 60–70% hidrolisis ATP digunakan untuk kontraksi, sedangkan 30–40% sisanya digunakan untuk sarcoplasmic reticulum Ca2+- ATPase dan pompa ion lainnya (Suga H, 1990). Pada jantung normal kecepatan fosforilasi oksidatif berhubungan dengan kecepatan hidrolisis sehingga ATP content tetap konstan meskipun pada saat kekuatan jantung meningkat hebat (Balaban RS,1990), seperti saatexercise atau stress katekolamin akut. Fosforilasi oksidatif dalam mitokondria dicukupi oleh energi dari elektron yang ditransfer dari hasil reaksi dehidrogenasi yang menghasilkan NADH dan FADH2 pada jalur oksidasi b asam lemak, siklus asam sitrat, dan dalam jumlah kecil oleh reaksi dehidrogenasi piruvat dan glikolisis. Acetyl-CoA yang dibutuhkan dalam siklus asam sitrat dihasilkan dari dekarboksilasi piruvat dan oksidasi asam lemak. Pada jantung yang normal, 60–90% acetyl-CoA berasal dari oksidasi asam lemak dan 10–40% berasal dari oksidasi piruvat yang diperoleh dalam jumlah yang hampir sama dengan yang berasal dari glikolisis dan oksidasi laktat (Stanley et al., 2005). Oksidasi asam lemak mencukupi 60-70% kebutuhan energi otot jantung (Kudo N et al., 1995). Meskipun demikian, mekanisme uptake asam lemak rantai panjang melalui oksidasi b belum sepenuhnya diketahui (Luiken JJ et al., 2001). Kata Kunci: asam lemak, otot jantung
The Effect Of Papaya Leaf Extract (Carica Papaya L) On Methemoglobin Percentage And The Number Of Erythrocyte Cells In Wistar Strain White Male Rats Induced With Sodium Nitrite Diah Hermayanti; Hawin Nurdiana; Jessica Alda
Saintika Medika Vol. 17 No. 2 (2021): December 2021
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/sm.Vol17.SMUMM2.18803

Abstract

Sodium nitrite is widely used nowadays, especially in the meat processing industry. In the case of an overdose, it can cause poisoning, which causes the oxidation of the iron component in the hemoglobin of erythrocytes to methemoglobin, thereby damaging cell membranes and hemolytic. Papaya leaves contain antioxidants that can inhibit the oxidation of iron components in hemoglobin. To determine the effect of papaya leaf extract on methemoglobin levels and the number of erythrocytes in white male Wistar rats strain induced with sodium nitrite. True experimental research design using post test only control group design. The object of this study was male white rats (Rattus novergicuswistar strain) induced intraperitoneally with sodium nitrite. The study was divided into a negative control group, a positive control group, a treatment group with a dose of papaya leaf extract PI (0.7 ml/200 g BW), PII (1.4 ml/200 g BW), PIII (2.8 ml/200 g BW). BB). Kruskal-Wallis test, methemoglobin levels sig. 0.001 (p<0.05). One wayannova test, erythrocyte cell count sig. 0.021 (p<0.05). Post Hoc test there was a significant difference between the negative control group and the positive control group on all variables, not different from the PII group for methemoglobin levels, not significantly different from the three treatment groups for the number of erythrocytes. Papaya leaf extract contains antioxidants that can inhibit the formation of methemoglobin, and maintain the number of erythrocytes. Papaya leaf extract can inhibit the formation of methemoglobin, maintain the number of erythrocytes in male Wistar strain rats induced with sodium nitrite.
The Influence Of Sleep Patterns Based On The Sleep Disturbance Scale For Children (Sdsc) On The Height Of Children Aged 8-11 Years Rosari Listiana; Annisa Nurul Arofah; Laksmitha Saktiono Safiitri; Hawin Nurdiana
Saintika Medika Vol. 18 No. 1 (2022): June 2022
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/sm.Vol18.SMUMM1.22153

Abstract

Sleep main an essential role in human development because growth hormone works best during the slow wave phase. About 20-30% of children have sleep problems. Children's bedtime has fallen more than usual over the last century, with school-age children having the most significant rate of change. This study aims to determine the effect of sleep patterns on height in children of SD Muhammadiyah 4 Malang aged 8-11 years. The cross-section method was used in this study. The sample in this study were all boys aged 8-11 years up to 98 children who met the inclusion criteria in SD Muhammadiyah 4 Malang. Data on height and weight were obtained from schools, and sleep patterns were obtained from questionnaires filled out by parents. Statistical analysis used Fisher's exact test with significance at p = 0.5. The results of this study did not show a significant effect between the child is sleeping position and height (p = 0.649). Most 8-year-old participants had poorer sleep patterns than their parents' height in the relevant categories. SD Muhammadiyah 4 Malang There is no significant effect between sleep patterns and height in children aged 8-11.
Analisis Tingkat Kepuasan Pasien Rawat Inap BPJS Terhadap Mutu Pelayanan Kesehatan Pada Rumah Sakit Tipe C Viva Maiga Mahliafa Noor; Feny Tunjungsari; Hawin Nurdiana; Muchammad Arif Fanani
CoMPHI Journal: Community Medicine and Public Health of Indonesia Journal Vol. 3 No. 2 (2022): Oktober
Publisher : Perhimpunan Dokter Kedokteran Komunitas dan Kesehatan Masyarakat Indonesia (PDK3MI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37148/comphijournal.v3i2.100

Abstract

The quality of health services is the degree of perfection of health services in accordance with professional standards and service standards. The quality of health services can be measured by five quality dimensions, namely reliability, assurance, tangible, empathy, responsiveness. The ultimate goal of the quality of health services is the creation of patient satisfaction. This study aims to determine the relationship between the quality of health services and the satisfaction of inpatients class III JKN participants at Prof. Dr. Soekandar Hospital at Mojosari. The research design is analytical observational with a cross sectional approach. The sample is 201 inpatients. Hypothesis testing using Kendall's tau test. Based on the results of the analysis, it was found that p = 0.000 which stated that there was a relationship between the quality of health services and the satisfaction of class III inpatients of JKN participants. This shows that the quality of health services greatly affects the satisfaction of inpatients. If the quality of health services provided is good, the patient will feel satisfied. The study concluded that there was a relationship between the quality of health services and the level of satisfaction of inpatients. Good service quality will result in a high level of satisfaction.
The Effect Of Moringa Leaf (Moringa Oleifera Lam) And Vitamin C Combination Extract In Improving Anemia Indicators Deficiency Of White Rice Iron Male Diet Low Rice Iron Diah Hermayanti; Hawin Nurdiana; Wahyu Setiawan; Refa Maulana Azhar
Saintika Medika Vol. 16 No. 2 (2020): December 2020
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/sm.Vol16.SMUMM2.15029

Abstract

Iron deficiency anemia is still a major health problem in developing countries. Therapy with iron preparations often causes undesirable side effects. Moringa leaf extract which is rich in iron can be used as an alternative therapy in iron deficiency, and combination with vitamin C can increase the effectiveness of iron absorption in the gastrointestinal tract. determine the effect of the combination of Moringa oleifera lam. Extract and vitamin C on the indicator of iron deficiency anemia in white rats (Rattus Novergicus Strain Wistar) who were given a diet low in iron aking rice. True experimental research design using post test only control group design. The object of this study was male white rats (Rattus novergicus Strain wistar) induced by a low-iron rice diet. The study was divided into negative control group, positive control group, the treatment group with Moringa leaf extract dose of 400 mg / kg body weight, 800 mg / kg body weight, 1,600 mg / kg body weight. The treatment group was given vitamin C in a dose of 40 mg. Results and Discussion One wayAnova test, hemoglobin sig. 0,000 (p <0.05), MCV sig 0.27 (p> 0.05), MCH sig 0.16 (p> 0.05), serum iron sig. 0,000 (p <0.05), transferrin saturation sig. 0.006 (p <0.05), and TIBC sig 0.68 (p> 0.05). Pearson correlation for hemoglobin 0.746 (sig.0,000), and linear regression with R2 0.557 (sig.0,000); for serum iron 0.742 (sig.0,000) with R2 0.551 (sig.0,000). There was an increase in hemoglobin and serum iron levels in the treatment group.
Assessment of Sleep Patterns and Their Correlation with Height in Children Aged 8–11 Years: Insights from the Sleep Disturbance Scale for Children (SDSC) Ahmad mahfur; Safitri, Laksmitha Saktiono; Nurdiana, Hawin; Arofah, Annisa Nurul
Saintika Medika Vol. 20 No. 1 (2024): June 2024
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/sm.Vol20.SMUMM1.38539

Abstract

Sleep plays a crucial role in human growth, particularly during slow-wave sleep when the growth hormone functions optimally. Sleep disturbances are prevalent in 20–30% of children. Over the past century, there has been a notable decline in children’s sleep duration, with the most significant reductions observed in school-aged children. This study investigates the relationship between sleep patterns and the height of boys aged 8–11 years at Muhammadiyah 4 Elementary School in Malang. A cross-sectional design was employed, involving 98 boys who met the inclusion criteria. Data on height and weight were collected from school records, while sleep pattern information was obtained through parent-completed questionnaires. Statistical analysis was conducted using Fisher's exact test with a significance level of p ≤ 0.05. The results revealed no significant association between sleep patterns and children's height (p = 0.649). Most participants were 8 years old, with poor sleep patterns observed. However, based on maternal and paternal height, the majority were categorized as having an appropriate height. This study concludes that there is no significant relationship between sleep patterns and the height of boys aged 8–11 years at Muhammadiyah 4 Elementary School in Malang
Co-Authors Ahmad mahfur Annisa Nurul Arofah Diah Hermayanti Feny Tunjungsari Jessica Alda Laksmitha Saktiono Safiitri Muchammad Arif Fanani Refa Maulana Azhar Rosari Listiana Safitri, Laksmitha Saktiono Viva Maiga Mahliafa Noor Wahyu Setiawan