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All Journal JURNAL ILKES (Jurnal Ilmu Kesehatan) JURPIKAT (Jurnal Pengabdian Kepada Masyarakat)
Fedelita Aistania Putri
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Dentistry Education Health Professions Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences

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Efek Alprazolam Terhadap Jumlah Sel Leydig Mus Musculus Model Stres Kronik Fedelita Aistania Putri; Renny I’tishom; Arifah Mustika
JURNAL ILKES : Jurnal Ilmu Kesehatan Vol 10 No 2 (2019): Jurnal Ilkes (Jurnal Ilmu Kesehatan)
Publisher : STIKES Karya Husada Kediri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35966/ilkes.v10i2.140

Abstract

Infertility is one of the stress stimulated for couple has been marriage. Misuse hypnotic drugs types of benzodiazepine in alprazolam as their primary drug problem. Benzodiazepine dependence can also affect the central nervous system that interfere with neurotransmitters dopamine and serotonin. Oxidative stress caused by exposure to benzodiazepines can cause interference pro-apoptotic protein balance and anti-apoptotic, with a marked increase in pro-apoptotic protein and a decrease in anti-apoptotic proteins such as in the Leydig cells. Oxidative stress stimulation activates the intrinsic apoptotic pathway. Objective: to see a decrease in the number of Leydig cells of male mice after exposure to the stress with cums method, and the mice would be given anti-anxiety medication therapy was alprazolam with maximum dossage. Materials and methods: The research subject using male mice (Mus musculus) strain Balb-c had aclimitazion proecess and randomize sampling. There were divided into three groups consisting of negative control group (K0), without stress and drugs when spermatogenesis time is positive control group (K1) and treatment group (K2). The mice get a daily alprazolam drugs (alganax) by gavage sonde with maximum dossage (4mg/kg/weight). The measurement’s do after obtained from the testis that has been cut crosswise and do the Hematoxylin-eosin (HE). Calculations carried out under a light microscope (Olympus BX 41). Results: Statistical test in Leydig cell showed that there was significant difference with kruskal walis p=0,000 (p<0,05). Conclusion: administration of alprazolam might decrease the number of Leydig cells of mice Mus musculus model of chronic stress
Upaya Peningkatan Status Kesehatan Bagi Siswa di Sekolah Indonesia Jeddah Melalui Pemeriksaan Kesehatan Gratis dan Penyuluhan Reproduksi Remaja Endang Sri Wahjuni; Anjani, Nur Ilahi Anjani; Abdul Fauzi; Satria Eureka Nurseskasatmata; Nidya Comdeca Nurvitriana; Fedelita Aistania Putri; Sherly Aurellia Ardyananda; Agatha Rachel Kristilla
JURPIKAT (Jurnal Pengabdian Kepada Masyarakat) Vol. 6 No. 1 (2025)
Publisher : Politeknik Piksi Ganesha Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37339/jurpikat.v6i1.2221

Abstract

Kesehatan reproduksi remaja menjadi perhatian global, dengan 33% beban penyakit perempuan terkait kesehatan reproduksi (WHO, 2010). Di Indonesia, prevalensi keputihan pada remaja perempuan mencapai 18% (SDKI, 2012), diperparah oleh akses terbatas terhadap informasi yang benar. Kondisi ini juga dialami siswa Sekolah Indonesia Jeddah (SIJ) yang membutuhkan edukasi kesehatan reproduksi dan pemeriksaan kesehatan reguler. Program pengabdian ini mencakup pemeriksaan kesehatan siswa TK-SD dan penyuluhan reproduksi remaja bagi siswa SMP-SMA. Penyuluhan dilakukan secara daring dengan pendekatan interaktif, menghasilkan peningkatan pengetahuan sebesar 20,5 poin (pre-test 65,7 menjadi post-test 86,2). Pemeriksaan kesehatan siswa TK-SD menemukan sebagian besar dalam status gizi normal, namun terdapat kasus obesitas dan gizi kurang. Program ini berhasil meningkatkan pemahaman siswa tentang kesehatan reproduksi dan mendukung lingkungan belajar sehat. Keberlanjutan program diharapkan melalui kolaborasi SIJ dan Universitas Negeri Surabaya secara berkala.
Co-Authors Abdul Fauzi Agatha Rachel Kristilla Anjani, Nur Ilahi Anjani Arifa Mustika Endang Sri Wahjuni Nidya Comdeca Nurvitriana Renny I’tishom Satria Eureka Nurseskasatmata Sherly Aurellia Ardyananda