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All Journal Pharmascience JSFK (Jurnal Sains Farmasi & Klinis) Manuju : Malahayati Nursing Journal Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Indonesian Journal of Biomedicine and Clinical Sciences Jurnal Elementaria Edukasia
Rika Yulia
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Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Other

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Evaluasi Penggunaan Antibiotik pada Pasien Bedah Bersih Terkontaminasi di Rumah Sakit Bhayangkara Surabaya Nurul Akhirin Nisak; Rika Yulia; Ruddy Hartono; Fauna Herawati
Jurnal Pharmascience Vol 9, No 1 (2022): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v9i1.10107

Abstract

Bedah bersih terkontaminasi merupakan prosedur bedah yang dilakukan pada traktus bilier, traktus urinarius, respiratorius dan digestif, reproduksi kecuali ovarium atapun operasi tanpa disertai kontaminasi yang nyata. Bedah bersih terkontaminasi memiliki potensi terjadinya infeksi sebesar 3-11% untuk mencegah dan mengatasi terjadinya infeksi diperlukan pemberian antibiotik. Penelitian ini bertujuan untuk mengevaluasi penggunaan antibiotik dalam satuan Defined Daily Dose (DDD)/100 patient-days pada pasien bedah bersih terkontaminasi di RS Bhayangkara Surabaya. Metode penelitian dilakukan secara retrospektif observasional pada pasien rawat inap bedah dalam periode 1 Januari-31 Desember 2020. Hasil penelitian didapatkan 40 data medis kesehatan pasien yang memenuhi kriteria inklusi dan eksklusi. Total nilai DDD/100 patient-days antibiotik profilaksis tertinggi adalah ceftriaxone 25 DDD/100 patient-days, sedangkan antibiotik terapi yang paling tinggi adalah amoxicillin 38,35 DDD/100 patient-days. Antibiotik yang termasuk dalam segmen DU 90% pada penggunaan antibiotik profilaksis adalah ceftriaxone, cefazolin, dan amoxicillin; sedangkan untuk antibiotik terapi adalah amoxicillin, ceftriaxone, metronidazole, dan cefadroxil. Kesimpulan dari penelitian ini adalah penggunaan antibiotik pada bedah bersih terkontaminasi tinggi dan jenis antibiotik yang paling banyak digunakan adalah antibiotik golongan sefalosporin generasi 3 (ceftriaxone) yang spektrum antibakterinya lebih luas daripada antibiotik golongan sefalosporin generasi 2 (cefazolin).Kata Kunci: DDD/100 patient-days, Bedah Bersih Terkontaminasi, AntibiotikClean-contaminated surgery is a surgical procedure performed on the biliary tract, urinary tract, respiratory and digestive tracts, reproduction except for the ovaries or surgery with no contamination encountered. This procedure has a potential infection in the range of 3-11%, therefore it is necessary to give antibiotics to prevent and treat the possibility of infections. This study was to evaluate the use of antibiotics using the Defined Daily Dose (DDD)/100 patient-days in clean-contaminated surgical patients at Bhayangkara Hospital Surabaya. Data was collected retrospectively observational in surgical inpatients from 1st January-31st December 2020. Total samples 40 met the inclusion and exclusion criteria. The highest total DDD prophylactic antibiotic value was ceftriaxone 25 DDD/100 patient-days. On the other hand, the highest therapeutic antibiotic was amoxicillin 38.35 DDD/100 patient-days. The antibiotics included in the 90% DU segment in the use of prophylactic antibiotics were ceftriaxone, cefazolin, and amoxicillin. Meanwhile, for therapeutic antibiotics, namely amoxicillin, ceftriaxone, metronidazole, and cefadroxil. The use of antibiotics in clean surgery is high and the type of antibiotic that is most widely used is the third generation cephalosporin antibiotic (ceftriaxone) whose antibacterial spectrum is wider than the second generation cephalosporin antibiotic (cefazolin).
An Assay of Antioxidant Power of Methanolic Extract Various Type of Soybean Rika Yulia; Azminah Azminah; Michella Michella; Andre Tanzil
Jurnal Sains Farmasi & Klinis Vol 1, No 2 (2015): J Sains Farm Klin 1(2), Mei 2015
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (960.87 KB) | DOI: 10.29208/jsfk.2015.1.2.28

Abstract

This study aimed to examine the antioxidant activity of methanolic extract of various type of soybean (Glycine max L.Merill) i.e Argomulyo, Burangrang, Ijen, and Kaba by using DPPH (1,1-Diphenyl-2-picryhydrazyl) method. The soybean was crushed, defatted using n-hexan, and extracted using methanol 90%. The processes of defatting and extracting were conducted by kinesthetic maceration. Identification of flavonoid content using KLT and an assay of the antioxidant power of soybean were carried out qualitatively and quantitavely. Qualitative analysis, the color of DPPH solution was fading from violet into yellowish. Quantitative analysis showed that the maximum wave-length of DPPH in methanol was 516,00 nm within 15-minute reaction time. The effective concentration 50% (EC50) of each extract was alsa determined. Results of this study revealed that the methanolic extract of soybean taken from varieties of Argomulyo, Burangrang, Ijen, and Kaba contained flavonoid, with EC50 value of each variety subsequently ranging from 3620.22 bpj; 5290.71 bpj; 4145.99 bpj; and 4253.50 bpj. Argomulyo variety showed the highest antioxidant power.
Profil Penggunaan Obat pada Pasien Covid -19 di Ruang Isolasi Rumah Sakit X Kabupaten Malang Retno Juwita Sari; Rika Yulia; Fauna Herawati
Malahayati Nursing Journal Vol 4, No 11 (2022): Volume 4 Nomor 11 2022
Publisher : Universitas Malahayati Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/mnj.v4i11.7169

Abstract

ABSTRACT Respiratory tract infections in early 2020 increased drastically due to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Up to this point, therapy for this infection is referring to SARS-CoV-1 and MERS-CoV infections. Implementing secure and effective treatment for COVID-19 is indispensable. Drug repurposing/ drug reuse is a process to identify new indications of existing drugs. WHO recommends to optimize supportive care to support the main therapy in treating COVID-19.Objective of the study is to describe drug usage during COVID-19 pandemic. This study is observational, on adult subjects with confirmed COVID-19, with moderate to severe level of disease, data of whom was collected retrospectively during the period of April – March 2021. The findings reported 212 patients were treated as sample of the study, most of whom were male (50.9%). The highest age group was 56 – 65 years old by 27.4%. Frequent clinical symptoms were cough and shortness of breath; the highest profile of drug usage was supplement; and outcome for discharge improvement by 85.3%. Keywords: COVID-19, Drug Profile, Hospitalization, Outcome  ABSTRAK Kasus infeksi saluran pernafasan awal tahun 2020 meningkat secara drastis disebabkan oleh virus  Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Hinggga saat ini terapi yang digunakan mengacu dari pengobatan infeksi SARS-CoV-1 dan MERS-CoV. Kebutuhan pengobatan COVID-19 yang aman serta efektif sangatlah penting. Drug repurposing/ penggunaan obat kembali merupakan proses untuk mengidentifikasi indikaasi baru dari obat yang telah ada. WHO merekomendasikan perawatan suportif tetap dioptimalkan untuk menunjang terapi utama dalam pengobatan COVID-19. Penelitian ini bertujuan untuk mendiskripsikan penggunaan obat dimasa pandemik COVID-19. Penelitian ini merupakan penelitian observasional dengan pendekatan secara cross sectional,pada subyek dewasa yang terkonfirmasi COVID-19 derajat penyakit sedang hingga berat dengan pengambilan data penelitian secara retrospektif selama periode April 2020 – Maret 2021. Hasil menunjukkan terdapat sampel penelitian sebanyak 212 pasien yang terbanyak laki-laki (50,9%).. Penelitian ini bertujuan mendiskripsikan profil penggunaan obat dimasa pandemik COVID-19. Penelitian ini merupakan penelitian observasional pada subyek dewasa yang terkonfirmasi COVID-19 derajat penyakit sedang hingga berat dengan pengambilan data penelitian secara retrospektif selama periode April 2020 – Maret 2021. Hasil menunjukkan terdapat sampel penelitian sebanyak 212 pasien yang terbanyak laki-laki (50,9%). Rentang usia tertinggi pada usia 56 – 65 tahun sebesar 27,4%. Gejala klinis yang sering timbul adalah batuk dan sesak, profil penggunaan obat terbanyak yaitu suplemen serta outcome pulang perbaikan sebesar 85,3%. Kata Kunci: COVID-19, Profil Obat, Rawat Inap, Outcome
STUDI EFEKTIVITAS DAN EFEK SAMPING FAVIPIRAVIR PADA PASIEN COVID-19 PNEUMONIA DI RUMAH SAKIT BHAYANGKARA SURABAYA Rika Yulia; Fauna Herawati; Klara Rosjuita Hima; Ruddy Hartono; Puri Safitri Hanum
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 8 No 2 (2023): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v8i2.1486

Abstract

Favipiravir's indication extended for COVID-19 disease. This background consideration is related to its mechanism of action or effectivity in some COVID-19 patients, with or without pneumonia. This research is a retrospective observational study and analysis descriptively. The research material is medical records of patients with COVID-19 pneumonia using favipiravir from December 2020-May 2021. A total of 33 samples obtained met the inclusion and exclusion criteria. Effectiveness was analyzed by calculating the percentage of COVID-19 pneumonia patients who only used favipiravir while they were being treated until the patient was discharged. The side effects were the number of COVID-19 patients who drug injury liver disease (AST and ALT increase more than three times upper limit) and neutrophenia. This study reported that favipiravir was effective in COVID-19 patients with pneumonia, seen from 78.79% of patients who only used favipiravir during treatment. There were no patients who had an increase in AST ALT >3×upper limit of normal, and only seven patients with neutropenia.
Pegembangan KATARIAN Sebagai Media Edutainment Untuk Meningkatkan Kemampuan Berhitung Perkalian Siswa Kelas 3 Sekolah Dasar Rika Yulia; Isrok'atun; Ani Nur Aeni
Jurnal Elementaria Edukasia Vol. 7 No. 1 (2024): Maret
Publisher : Elementary Teacher Education Program, Majalengka University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31949/jee.v7i1.8263

Abstract

The purpose of this research is to develop KATARIAN as an Android-based Edutainment media to improve the multiplication calculation skills of class III students at SDN Lebak Gede and find out the feasibility of the media being developed. Apart from that, through this research, it will be known how students' abilities increase before and after using KATARIAN media. This research uses a type of development research with the ADDIE development model. The research instruments used were material expert validation sheets, media experts validation sheets, pretest-posttest question sheets, teacher and student response questionnaires. Data analysis techniques for validation by experts and teachers are measured using a Likert scale, then the pretest and posttest sheets use the N-Gain formula analysis. Meanwhile, media feasibility is measured by teacher and student response questionnaires. From the research results, it is known that this Edutainment-based KATARIAN media is very valid in terms of validation results from material experts and media experts with an average percentage of 96% in the very valid category. Judging from the pretest-posttest results before and after media use, the N-Gain result was 0.6073 with a "medium" increase category. The suitability of the media can be determined through the results of the teacher questionnaire, namely getting 98% results and student response questionnaires getting 99% results. Based on these results, KATARIAN media can be categorized as very suitable for use in learning.
Analysis of antibiotic use in diabetic ulcer patients at a private hospital in Surabaya Fauna Herawati; Nadila Suleman; Rika Yulia; Heru Wijono
Indonesian Journal of Biomedicine and Clinical Sciences Vol 56 No 4 (2024)
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/inajbcs.v56i4.18422

Abstract

Diabetic ulcer is one of the complications of diabetes mellitus in the form of chronic wounds due to neuropathy and peripheral arterial disease. Bacteria enter in a wound and cause a skin infection. Appropriate antibiotic therapy is needed to prevent antibiotic resistance. The purpose of this study was to evaluate the quantity profile of antibiotic use using the prescribed daily dose (PDD) and days of therapy (DOT) methods compared with the therapeutic guidelines (PPAB) in diabetic ulcer patients for the period January 2020 - June 2022 at a private hospital in Surabaya, Indonesia. This observational study with the retrospective data collection using medical records was analysed descriptively. The results showed that the total PDD value was 20.44 g/day. The highest antibiotic prescriptions were ceftriaxone (2.39 g/day) and metronidazole (1.46 g/day), respectively. The total days of therapy was 12.13 DOT; the DOT more than 4.00 were metronidazole (4.15 DOT) and ceftriaxone (4.09 DOT). This study reported a high PDD and DOT that will cause antibiotic resistance in the future.
Co-Authors Andre Tanzil Ani Nur Aeni Azminah Azminah Fauna Herawati Fauna Herawati Heru Wijono Isrok'atun Klara Rosjuita Hima Michella Michella Muhammad Hasan Wattiheluw Nadila Suleman Nurul Akhirin Nisak Puri Safitri Hanum Retno Juwita Sari Ruddy Hartono Ruddy Hartono Setiasih Setiasih