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All Journal Jurnal Insan Farmasi Indonesia Jurnal Farmasi Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan
Lusia Murtisiwi
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Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Physics Public Health

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PERBANDINGAN EKSTRAKSI JAMUR TIRAM (Pleurotus ostreatus) DAN JAMUR KANCING (Agaricus bisporus) Christa Marthaningsih Prisida; Christe Mareta Ardika Sari; Tarasia Gandes Belani; Lusia Murtisiwi
Jurnal Insan Farmasi Indonesia Vol 2 No 2 (2019)
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jifi.v2i2.326

Abstract

Mushrooms contain polysaccharides with the main components namely β-glucan and α-mannan. Polysaccharides can be useful as immune enhancers because beta-glucans can increase phagocytic activity and cytokine production. β- (1,3) -glukan has the ability to activate the cellular and humoral immunity system which is a component of the body's immune system. β- (1,3) -glukan increases the antimicrobial activity of mononuclear and neutrophil cells and increases the functional activity of macrophages. Polysaccharides from oyster mushrooms and button mushrooms can be extracted using the Yap & Ng method. The purpose of this study was to compare the yield of extracts produced from oyster mushrooms and button mushrooms. The method used in this research is water extraction method based on Yap & Ng. Data analysis of this study was carried out by calculating the percentage of extracts of oyster mushrooms and button mushrooms, then compared. The results of this study indicate that the yield of oyster mushroom extract is0,013% while the yield of button mushroom extract is 0,0055%. This shows the yield of oyster mushroom extract is greater than the yield of button mushroom extract if extracted by the Yap & Ng method.
UJI AKTIVITAS ANTIBAKTERI EKSTRAK DAN FRAKSI n-HEKSAN, ETIL ASETAT DAN AIR DARI SABUT KELAPA MUDA (Cocos nucifera Linn) TERHADAP Escherichia coli ESBL (Extended Spectrum Beta Lactamase) Novia Dewi Purwaningrum; Lusia Murtisiwi; Diah Pratimasari
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 7 No 1 (2022): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (133.066 KB) | DOI: 10.36387/jiis.v7i1.773

Abstract

Young coconut coir contains flavonoid compounds, phenols, tannins and saponins. The ethanol extract of young coconut coir was studied to have good antibacterial activity. This study aimed to see the inhibitory activity of ethanol extract compared fractions of young coconut coir ethanol extract in inhibiting Escherichia coli ESBL (Extended Spectrum Beta Lactamase) bacteria. Young coconut coir of extracted using 95% ethanol solvent of maceration method and patition using n-hexane and ethyl acetate solvent. Antibacterial activities using the diffusion method with concentrations of 25%, 50% and 75%. The negative control used DMSO 10%, while positve control used was chloramphenikol. Ethanol extract and fractions of ethanol extract of young coconut coir inhibited Escherichia coli ESBL bacteria. The largest radical inhibition zone was found in the ethyl acetate fraction with a concentration of 75% at 10.9 mm.
Sintesis 2,5-bis(4-hidroksibensilidin) siklopentanon dari p-hidroksibenzaldehid dan Siklopentanon dengan Katalis Asam Sulfat Murtisiwi, Lusia; Lusia Murtisiwi
Jurnal Farmasi (Journal of Pharmacy) Vol. 1 No. 1 (2012): Jurnal Farmasi (Journal of Pharmacy), October 2012
Publisher : Jurnal Farmasi (Journal of Pharmacy)

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Abstract

2,5-bis(4-hydroxybenzilidene)cyclopentanone is one of curcumin analog compound. The aim of this research is to synthesize 2,5-bis(4-hydroxybenzilidene)cyclopentanone               from              p- hydroxybenzaldehyde and cyclopentanone using sulfuric acid as a catalyst. Persumably, sulfuric acid, a diprotic acid can be used as a catalyst in synthesizing 2,5-bis(4-hydroxybenzilidene)cyclopentanone. The The research could be clasified as the descriptive explorative non-analytic research with the succedd of synthesizing of 2,5-bis(4- hydroxybenzilidene)-cyclopentanone as the parameter. The research was done by reacting 0,06 mol p-hydroxybenzaldehyde and 0,03 mol cyclopentanone in methanol solution with sulfuric acid as a catalyst. The analysis was occupied with two ways, they were qualitative and quantitative. The qualitative analysis was done in a series of test. They were organoleptic test, solubility test, thin layer chromatography (TLC) test, melting point estimation, elucidation of synthesized compound with infra red (IR) spectroscopy, proton nuclear magnetic resonance (1H-NMR) and carbon-13 nuclear magnetic resonance (13C-NMR) spectroscopy. The quantitative analysis was done by estimating the yield of synthesized compound. The research result showed that synthesized compound was a yellowish powder, specified odor, tasteless but it has specified effect on tongue. The melting point of synthesized compound was more than 300˚C. The TLC test showed that synthesized compound has an Rf as much as 0,73 which was different with p-hydroxybenzaldehyde that was 0,84. The IR, 1H-NMR and 13C-NMR spectra showed that the synthesized compound was 2,5-bis(4-hydroxybenzilidene)- cyclopentanone with yield for about 10,64%.  
Co-Authors Christa Marthaningsih Prisida Christe Mareta Ardika Sari Diah Pratimasari Murtisiwi, Lusia Novia Dewi Purwaningrum Tarasia Gandes Belani