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Murtisiwi, Lusia
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Standarisasi Ekstrak Sarang Semut untuk Pemenuhan Mutu Ekstrak Menuju Obat Herbal Terstandar Antikanker Lindawati, Novena Yeti; Murtisiwi, Lusia
Jurnal Farmasi Indonesia Vol 8, No 2 (2016)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (459.701 KB) | DOI: 10.35617/jfi.v8i2.522

Abstract

Dry extract of sarang semut (Myrmecodia pendens Merr & Perry) water/n-butanol fraction is native plant from Papua is proven to be active against cancer cells. This research aims to improve the quality of extracts of sarang semut become the raw material that meets the standards of medicinal plant extracts in the fulfillment of the quality of the extracts into anticancer Standardized Herbal Medicine / Obat Herbal Terstandar (OHT). Extraction with ultrasonic methods (1:10 with methanol) and fractionation with water:butanol (1:1) as much as 1:20. Standardization and data analysis based on parameters of the Medicinal Plant Extracts (Kepmenkes RI No: 55/Menkes/SK/I/2000) and BPOM RI Regulation No. 12, Year 2014 about quality requirements of traditional medicine. Dry extract of sarang semut (water/n-butanol fraction) met the standards of raw material preparation for OHT with organoleptics shaped dried extracts, dark brown color, aromatic smell, and has a sour-bitter taste. Moisture content was 9,259 ± 0.001 (� 10%). Total Plate Count was 5 x 103 colonies/g (< 104 colonies/g). Yeast and Mold Count was 0,5 x 101 colonies/g (< 103 colonies/g). Pathogenic bacteria test shows that MPN Coliform value was 0 colonies/g and negatively to the presence of Escherichia coli, Salmonella sp, Staphylococcus aureus, Pseudomonas aeruginosa, and Shiggella sp. The extract was not detected the presence of aflatoxin total (aflatoxin B1, B2, G1 and G2). The content of heavy metal Cd was 0,0052 ± 0.0005 ppm (� 0.3 ppm) and heavy metals Pb was 0,9429 ± 0,0087 ppm (� 10 ppm).
UJI AKTIVITAS ANTIOKSIDAN EKSTRAK ETANOL 70% BUNGA TELANG (CLITORIA TERNATEA L) DARI DAERAH SLEMAN DENGAN METODE DPPH Andriani, Disa; Murtisiwi, Lusia
Pharmacon: Jurnal Farmasi Indonesia Vol 17, No 1 (2020)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v17i1.9321

Abstract

Telang flower (Clitoria ternatea L.) contains phenolic compounds which can act as antioxidants by donating hydrogen so as to stabilize the lack of electrons in free radicals. This study aims to determine the antioxidant potential of telang flower ethanol extract by looking at the IC50 value. Telang flowers were extracted by maceration method using 70% ethanol solvent. The potential for antioxidants was determined by the DPPH (1,1-diphenyl-2-picrylhydrazyl) method with a comparison of vitamin C which had been shown to have the potential of free radicals which were very potent. The results showed the IC50 value of telang flower ethanol extract was 41.36 ± 1.191 ?g / mL, based on that value the telang flower extract from the Sleman area was in the very potent category so that it could be developed as a source of antioxidants from natural ingredients.
Hubungan Karakteristik Pasien dengan Tingkat Kepatuhan Penggunaan Obat Antihipertensi pada Pasien Hipertensi di Puskesmas Gajahan Surakarta Annisya, Difa Suci; Ovikariani, O; Murtisiwi, Lusia
Indonesian Journal on Medical Science Vol 11 No 2 (2024): IJMS 2024
Publisher : Unit Penelitian dan Pengabdian Masyarakat Politeknik Kesehatan Bhakti Mulial

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70050/ijms.v11i2.495

Abstract

Hypertension is a chronic disease with an increase in arterial blood pressure that cannot be cured so it requires long-term medical therapy, so that long-term medical therapy will affect the fulfillment of many medications. Previous research results showed that less than 50% of patients were non-compliant in taking medication. The results of previous research show that there are factors characteristic of respondents such as age, gender, education level, employment status, comorbidities, and medical therapy. The aim of the research was to determine the characteristics of respondents, the level of respondent compliance and analyze the relationship between characteristics and the level of respondent compliance at the Gajahan Surakarta Community Health Center. This research is a Cross Sectional Study and uses the MARS-5 questionnaire. The number of respondents was 176 selected using purposive sampling. The validity test obtained valid and reliable results, namely the coefficient value for each statement was >0.463 and the Cronbach's Alpha value was 0.704>0.70. The characteristics of respondents were based on age, the highest was 40-60 years, gender was female, educational level, the highest was low education, unemployed employment status, comorbidities with comorbidities and a lot of medical therapy, namely ? 2 drug therapy. The results of the satisfaction level of respondents obtained a high level of satisfaction (51.1%) and low satisfaction (48.9%). The research results show that there is a relationship between the age of the respondent and the level of compliance with a p-value of 0.022 <0.05.
Hubungan Tingkat Pengetahuan dengan Kepatuhan Penggunaan Obat Anti Tuberkulosis Pada Pasien Penderita Tuberkulosis Di Rumah Sakit Umum Pusat Surakarta Tyas, Jatining; Murtisiwi, Lusia; Adiningsih, Retnowati
JURNAL KESEHATAN KARTIKA Vol. 17 No. 2 (2022): Jurnal Kesehatan Kartika
Publisher : Faculty of Health Science and Technology, University of Jenderal Achmad Yani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/jkkes.v17i2.240

Abstract

Tingkat kepatuhan pasien tuberkulosis paru dalam meminum obat anti tuberkulosis masih rendah. Berdasarkan penelitian di BKPM Pati tingkat kepatuhan pasien TB paru sebesar 26% (Dhewi, 2011) di Puskesmas Umbulsari sebesar 44,2% (Fauziyah, 2016). Salah satu faktor yang menjadi penyebab ketidakpatuhan adalah keterbatasan pengetahuan mengenai penyakit TB. Penelitian ini bertujuan untuk mengetahui hubungan tingkat pengetahuan dengan kepatuhan penggunaan OAT pada pasien penderita TB. Penelitian ini menggunakan rancangan studi cross sectional. Penentuan sampel menggunakan teknik purposive sampling. Besar sampel yang digunakan minimal 105 responden. Instrumen penelitian ini menggunakan kuesioner pengetahuan yang telah diuji validitas dan reliabilitas oleh Febriyanti (2020) dan kuesioner Medication Adherence Report Scale (MARS) yang telah diuji validitas dan reliabilitas oleh Zuhra (2019). Hasil penelitian menunjukkan pasien dengan pengetahuan baik sebesar 50,9% pengetahuan cukup sebesar 42,5% dan pengetahuan kurang sebesar 6,6%. Pasien dengan kepatuhan tinggi sebesar 87,7% dan kepatuhan rendah sebesar 12,3%. Uji analisis hubungan pengetahuan dengan kepatuhan penggunaan obat yang dilakukan dengan chi square menunjukkan adanya hubungan antara pengetahuan dengan kepatuhan didapatkan nilai P value = 0,004 (P<0,05). Hasil ini menunjukkan bahwa terdapat hubungan yang bermakna antara pengetahuan dengan kepatuhan penggunaan obat anti tuberkulosis.
Evaluasi Kepatuhan Penggunaan Obat Antidiabetik Oral Pada Pasien Rawat Jalan Diabetes Melitus Tipe 2 Di Rumah Sakit Universitas Sebelas Maret: EVALUATION OF ADHERENCE TO THE USE OF ORAL ANTIDIABETIC DRUGS IN OUTPATIENTS WITH TYPE 2 DIABETES MELLITUS AT THE UNS HOSPITAL Latipah, Ayu; Murtisiwi, Lusia; Adiningsih, Retnowati
JURNAL KESEHATAN KARTIKA Vol. 17 No. 2 (2022): Jurnal Kesehatan Kartika
Publisher : Faculty of Health Science and Technology, University of Jenderal Achmad Yani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/jkkes.v17i2.242

Abstract

Diabetes mellitus is a chronic disease that can cause complications, both microangiopathy and macroangiopathy if not treated properly. The success of diabetes mellitus therapy is influenced by patient compliance in drug use. The purpose of this study was to determine adherence to the use of oral antidiabetic drugs in outpatients with type 2 diabetes mellitus at Sebelas Maret University Hospital. This research is a non-experimental descriptive research. Sampling was done by purposive sampling in accordance with the inclusion criteria and exclusion criteria that have been determined. Compliance data retrieval using the Medication Adherence Report Scale questionnaire in Indonesian which has been tested for validity and reliability by Alfian (2017) which is distributed to patients. Data collection techniques were direct interviews with patients and filling out a questionnaire for patient data and the MARS-5 medication adherence questionnaire. Data analysis was carried out descriptively by describing the patient's characteristics. Analysis of the level of compliance in this study using a total scoring questionnaire MARS-5. This research has obtained a research permit with an ethical feasibility letter No: 788/VI/HREC/2022. Data collection was carried out in June-July 2022. The results showed that from 205 respondents, the level of adherence to the use of oral antidiabetic drugs included a low adherence rate of 50.2% and a high adherence rate of 49.8%.
EDUKASI MENGATASI PERMASALAHAN STUNTING DAN PENGOLAHAN BAHAN PANGAN LOKAL MENJADI MAKANAN YANG TINGGI PROTEIN DAN ZAT BESI BAGI MASYARAKAT DI KELURAHAN CEMANI SUKOHARJO Ovikariani; Murtisiwi, Lusia; Putra, Greggy Giovananda Afandty; Agustin, Riska Sulistyani; Nani, Sisilia Laurentin Evelin; Sailirrahma, Nabila Sepgialuni
Awal Bros Journal of Community Development Vol 6 No 1 (2025): Awal Bros Journal of Community Development
Publisher : LPPM Universitas Awal Bros

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54973/abjcd.v6i1.636

Abstract

Stunting is a health problem that has an impact on inhibiting physical, mental, and health growth of children. Data obtained from the Central Statistics Agency of Sukoharjo District in 2023, the prevalence of stunting in the Sukoharjo area reached 24.3%. The Cemani area is included in one of the sub-districts in the Sukoharjo area. When viewed from the description of the problem, it is necessary to handle it through a community service program that aims to improve community understanding and skills in processing local fish into healthy food as an effort to prevent stunting. Community service activities were carried out at the Nusa Idah Posyandu Center, Cemani, which consisted of several stages such as planning, implementation, pre-test, socialization, product demonstration, Q&A and post-test. The results of the community service activities were that the activities ran smoothly with 37 participants attending. The question and answer session showed that participants were interested in the demonstration of the use of local food ingredients as a solution to prevent stunting. In addition, the community service carried out was able to increase community understanding as evidenced by the average pre-test score of 71.25 to a post-test score of 81.76. Based on the description, it can be concluded that the community service program carried out was successful in increasing the understanding and skills of the community in Cemani Village.
Uji Antiinflamasi Krim Ekstrak Herba Krokot (Portulaca Oleracea L.) Pada Tikus Putih Jantan Wistar Yang Diinduksi Karagenan Ariffanisa, Azzahro; Murtisiwi, Lusia
Jurnal Ners Vol. 9 No. 4 (2025): OKTOBER 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v9i4.49054

Abstract

Krokot (Portulaca oleracea L) mengandung tannin, saponin, vitamin B dan C, serta memiliki sifat antiinflamasi. Penelitian ini memiliki tujuan untuk mengetahui efek antiinflamasi dari krim ekstrak herba krokot pada tikus putih jantan wistar yang diberi induksi karagenan 3%. Ekstrak herba krokot dibuat dalam sediaan krim dengan konsentrasi 0,5%, 1% dan 1,5% serta kontrol negatif yaitu basis krim dan kontrol positif krim hidrokortison 1%. Larutan induksi yang dipakai adalah karagenan 3%. Penelitian ini menggunakan metode inflammation associated oedema. Hasil yang didapatkan menujukkan krim ekstrak herba krokot pada konsentrasi 0,5%, 1%, dan 1,5% memiliki persentase daya inhibisi udem berturut-turut sebesar ,44%, 63%, dan 74,04% pada tikus putih jantan wistar. Semua krim ekstrak herba krokot konsentrasi 0,5%, 1%, dan 1,5% dapat memberikan efek penurunan inflamasi pada punggung tikus.
Sintesis 2,5-bis(4-hidroksibensilidin) siklopentanon dari p-hidroksibenzaldehid dan Siklopentanon dengan Katalis Asam Sulfat Murtisiwi, Lusia; Lusia Murtisiwi
Jurnal Farmasi (Journal of Pharmacy) Vol. 1 No. 1 (2012): Jurnal Farmasi (Journal of Pharmacy), October 2012
Publisher : Jurnal Farmasi (Journal of Pharmacy)

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

2,5-bis(4-hydroxybenzilidene)cyclopentanone is one of curcumin analog compound. The aim of this research is to synthesize 2,5-bis(4-hydroxybenzilidene)cyclopentanone               from              p- hydroxybenzaldehyde and cyclopentanone using sulfuric acid as a catalyst. Persumably, sulfuric acid, a diprotic acid can be used as a catalyst in synthesizing 2,5-bis(4-hydroxybenzilidene)cyclopentanone. The The research could be clasified as the descriptive explorative non-analytic research with the succedd of synthesizing of 2,5-bis(4- hydroxybenzilidene)-cyclopentanone as the parameter. The research was done by reacting 0,06 mol p-hydroxybenzaldehyde and 0,03 mol cyclopentanone in methanol solution with sulfuric acid as a catalyst. The analysis was occupied with two ways, they were qualitative and quantitative. The qualitative analysis was done in a series of test. They were organoleptic test, solubility test, thin layer chromatography (TLC) test, melting point estimation, elucidation of synthesized compound with infra red (IR) spectroscopy, proton nuclear magnetic resonance (1H-NMR) and carbon-13 nuclear magnetic resonance (13C-NMR) spectroscopy. The quantitative analysis was done by estimating the yield of synthesized compound. The research result showed that synthesized compound was a yellowish powder, specified odor, tasteless but it has specified effect on tongue. The melting point of synthesized compound was more than 300˚C. The TLC test showed that synthesized compound has an Rf as much as 0,73 which was different with p-hydroxybenzaldehyde that was 0,84. The IR, 1H-NMR and 13C-NMR spectra showed that the synthesized compound was 2,5-bis(4-hydroxybenzilidene)- cyclopentanone with yield for about 10,64%.  
Pengembangan Formula Gel Ekstrak Teh Hijau (Camellia sinensis L.) sebagai Penyubur Rambut Yety Lindawati, Novena; Murtisiwi, Lusia; C.E. Dhurhania
Jurnal Farmasi (Journal of Pharmacy) Vol. 3 No. 1 (2014): Jurnal Farmasi (Journal of Pharmacy), October 2014
Publisher : Jurnal Farmasi (Journal of Pharmacy)

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Abstract

Hair loss is can be a fashionable matter. Green tea extract which the concentration is about 5% can stimulate hair growing (Sumakdjaja, et.al.,2008). The compound in green tea extract are catecine and their derivate. They are epicatecine (EC), epicatecine galat (ECG), and epigalocatecine (EGCG). In green tea axtract there are also contains galat acid, galocatecine galat (GCG), galocatecine (GC), catecine galat (CG), catecine (C), vitamin B and vitamin C (Agus, 2007) which can make hair root stronger, prefent hair loss, to inhibit free radical, neutralize poisson, and protect head skin from infection. People more interest to use cosmetics and foods with green tea extract. There is no hair growth stimulating gel with green tea extract in the market. This is the reason of this research, is to develope hair growth stimulating gel formula. There are four formula in this research. They are formula I (Carbopol 1%, TEA0 3%, and glycerine 1%), formula II (CMC Na 3% and glycerine 1%), formula III (PEG 400 72%, PEG 4000 8%, and glycerine 1%) and formula IV (carbopol 0,75%, TEA 2%, PEG 400 12%, and glycerine 1%). The concentration of green tea axtract in each formula are 5%. In each formula contains 0,1% nipagin as a preservative, and 0,1% sodium metabisulfit. The quality of each gel formula tested by organoleptic test, homogenity test, pH test, spread test, thickening test, protection test, primary iritation test, aceptability test, and hair growth stimulating activity test.
Perbandingan Kualitas Hidup Pasien yang Menjalani Hemodialisis dengan Terapi Epoetin Alfa dan Epoetin Beta di RS PKU Muhammadiyah Yogyakarta Murtisiwi, Lusia; Murti Andayani , Tri; Yuniarti, Endang
Jurnal Farmasi (Journal of Pharmacy) Vol. 4 No. 1 (2015): Jurnal Farmasi (Journal of Pharmacy), October 2015
Publisher : Jurnal Farmasi (Journal of Pharmacy)

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Abstract

In patients with chronic kidney disease who undergo hemodialysis are anemic. Anemia in chronic kidney disease (CKD) can be treated by administration of epoetin. Quality of life is an important aspect evaluated as outcomes of intervention in hemodialysis patients. This study aims to determine differences in the quality of life for patients undergoing hemodialysis therapy with epoetin alfa and epoetin beta in PKU Muhammadiyah Yogyakarta Hospital. Cross-sectional study on regular hemodialysis patients in PKU Muhammadiyah Yogyakarta Hospital was conducted in November 2014- January 2015. Assessment of the quality of life of patients using questionnaires KDQOL-SF version 1.3. The subjects of this study consisted of two groups, the first group of patients using epoetin alfa for treatment anemia, while the second group is patients taking epoetin beta therapy for the treatment of anemia. Data were analyzed using Levene test, Chi-Square Goodness of Fit, Independent t-test, Mann-Whitney test and ANCOVA. The results showed that in general the overall quality of life for patients undergoing hemodialysis therapy with epoetin alfa and epoetin beta in RS PKU Muhammadiyah Yogyakarta showed different results was not significant (p> 0.05) in the amount of 60.25 ± 12.97, group epoetin alfa and 63.93 ± 15.53 in the epoetin beta group.
Co-Authors Adiningsih, Retnowati Agustin, Riska Sulistyani Andriani, Disa Annisya, Difa Suci Ariffanisa, Azzahro C.E. Dhurhania Endang Yuniarti Ina Damayanti Latipah, Ayu Lindawati, Novena Yeti Lusia Murtisiwi Murti Andayani , Tri Nani, Sisilia Laurentin Evelin Novena Yety Lindawati, Novena Yety Ovikariani Ovikariani, O Putra, Greggy Giovananda Afandty Rahma Noviyanti, Eka Sailirrahma, Nabila Sepgialuni Sulistyoningrum, Endah Syahrullah Murwati, Isna Tyas, Jatining Yety Lindawati, Novena