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Murtisiwi, Lusia
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Standarisasi Ekstrak Sarang Semut untuk Pemenuhan Mutu Ekstrak Menuju Obat Herbal Terstandar Antikanker Lindawati, Novena Yeti; Murtisiwi, Lusia
Jurnal Farmasi Indonesia Vol 8, No 2 (2016)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (459.701 KB) | DOI: 10.35617/jfi.v8i2.522

Abstract

Dry extract of sarang semut (Myrmecodia pendens Merr & Perry) water/n-butanol fraction is native plant from Papua is proven to be active against cancer cells. This research aims to improve the quality of extracts of sarang semut become the raw material that meets the standards of medicinal plant extracts in the fulfillment of the quality of the extracts into anticancer Standardized Herbal Medicine / Obat Herbal Terstandar (OHT). Extraction with ultrasonic methods (1:10 with methanol) and fractionation with water:butanol (1:1) as much as 1:20. Standardization and data analysis based on parameters of the Medicinal Plant Extracts (Kepmenkes RI No: 55/Menkes/SK/I/2000) and BPOM RI Regulation No. 12, Year 2014 about quality requirements of traditional medicine. Dry extract of sarang semut (water/n-butanol fraction) met the standards of raw material preparation for OHT with organoleptics shaped dried extracts, dark brown color, aromatic smell, and has a sour-bitter taste. Moisture content was 9,259 ± 0.001 (� 10%). Total Plate Count was 5 x 103 colonies/g (< 104 colonies/g). Yeast and Mold Count was 0,5 x 101 colonies/g (< 103 colonies/g). Pathogenic bacteria test shows that MPN Coliform value was 0 colonies/g and negatively to the presence of Escherichia coli, Salmonella sp, Staphylococcus aureus, Pseudomonas aeruginosa, and Shiggella sp. The extract was not detected the presence of aflatoxin total (aflatoxin B1, B2, G1 and G2). The content of heavy metal Cd was 0,0052 ± 0.0005 ppm (� 0.3 ppm) and heavy metals Pb was 0,9429 ± 0,0087 ppm (� 10 ppm).
UJI TOKSISITAS AKUT KAPSUL BAWANG PUTIH LANANG (Allium sativum Linn) Murtisiwi, Lusia; Lindawati, Novena Yety
Jurnal Ilmiah Manuntung Vol 2 No 2 (2016): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung akademi farmasi samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1697.086 KB) | DOI: 10.51352/jim.v2i2.65

Abstract

Garlic (Allium sativum Linn) is evidently active against Mycobacterium tuberculosis. Garlic contains allicin that is able to inhibit the bacteria causing tuberculosis. This dried extract garlic is also qualified as content of capsules of traditional medicine, score of Total Plate Count is1.5 (required not over 10); figures of mold and yeast extract of garlic is 4.102 (required not over 104); does not contain microbial pathogens (uncontaminated with coliform bacteria, Escherichia coli, Salmonella sp, and Staphylococcus aureus); and aflatoxin is not detected (required not more than 30 CPM); the average of moisture content is 2% (required notmore than 10%). Capsule of dried extract garlic (Allium sativum Linn) meets pharmaceutical requirements for traditional medicine capsule dosage form, with9 minutes as disintegrating time (required not more than 15 minutes) and meets the uniformity of weight as required for capsule. Results of the research indicates that dried extract of garlic indose above 48.750 mg/ kg body weightto get LD50in garlic, belongs to ‘relatively harmless’. Dried extract garlic in 4 doses variations do not affect the liver functions of mice, so significant clinical toxicity symptoms that happen on entire animals test have not gained yet
UJI AKTIVITAS ANTIOKSIDAN EKSTRAK ETANOL 70% BUNGA TELANG (CLITORIA TERNATEA L) DARI DAERAH SLEMAN DENGAN METODE DPPH Andriani, Disa; Murtisiwi, Lusia
Pharmacon: Jurnal Farmasi Indonesia Vol 17, No 1 (2020)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v17i1.9321

Abstract

Telang flower (Clitoria ternatea L.) contains phenolic compounds which can act as antioxidants by donating hydrogen so as to stabilize the lack of electrons in free radicals. This study aims to determine the antioxidant potential of telang flower ethanol extract by looking at the IC50 value. Telang flowers were extracted by maceration method using 70% ethanol solvent. The potential for antioxidants was determined by the DPPH (1,1-diphenyl-2-picrylhydrazyl) method with a comparison of vitamin C which had been shown to have the potential of free radicals which were very potent. The results showed the IC50 value of telang flower ethanol extract was 41.36 ± 1.191 ?g / mL, based on that value the telang flower extract from the Sleman area was in the very potent category so that it could be developed as a source of antioxidants from natural ingredients.
Hubungan Karakteristik Pasien dengan Tingkat Kepatuhan Penggunaan Obat Antihipertensi pada Pasien Hipertensi di Puskesmas Gajahan Surakarta Annisya, Difa Suci; Ovikariani, O; Murtisiwi, Lusia
Indonesian Journal on Medical Science Vol 11 No 2 (2024): IJMS 2024
Publisher : Unit Penelitian dan Pengabdian Masyarakat Politeknik Kesehatan Bhakti Mulial

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70050/ijms.v11i2.495

Abstract

Hypertension is a chronic disease with an increase in arterial blood pressure that cannot be cured so it requires long-term medical therapy, so that long-term medical therapy will affect the fulfillment of many medications. Previous research results showed that less than 50% of patients were non-compliant in taking medication. The results of previous research show that there are factors characteristic of respondents such as age, gender, education level, employment status, comorbidities, and medical therapy. The aim of the research was to determine the characteristics of respondents, the level of respondent compliance and analyze the relationship between characteristics and the level of respondent compliance at the Gajahan Surakarta Community Health Center. This research is a Cross Sectional Study and uses the MARS-5 questionnaire. The number of respondents was 176 selected using purposive sampling. The validity test obtained valid and reliable results, namely the coefficient value for each statement was >0.463 and the Cronbach's Alpha value was 0.704>0.70. The characteristics of respondents were based on age, the highest was 40-60 years, gender was female, educational level, the highest was low education, unemployed employment status, comorbidities with comorbidities and a lot of medical therapy, namely ? 2 drug therapy. The results of the satisfaction level of respondents obtained a high level of satisfaction (51.1%) and low satisfaction (48.9%). The research results show that there is a relationship between the age of the respondent and the level of compliance with a p-value of 0.022 <0.05.
Hubungan Tingkat Pengetahuan dengan Kepatuhan Penggunaan Obat Anti Tuberkulosis Pada Pasien Penderita Tuberkulosis Di Rumah Sakit Umum Pusat Surakarta Tyas, Jatining; Murtisiwi, Lusia; Adiningsih, Retnowati
JURNAL KESEHATAN KARTIKA Vol. 17 No. 2 (2022): Jurnal Kesehatan Kartika
Publisher : Faculty of Health Science and Technology, University of Jenderal Achmad Yani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/jkkes.v17i2.240

Abstract

Tingkat kepatuhan pasien tuberkulosis paru dalam meminum obat anti tuberkulosis masih rendah. Berdasarkan penelitian di BKPM Pati tingkat kepatuhan pasien TB paru sebesar 26% (Dhewi, 2011) di Puskesmas Umbulsari sebesar 44,2% (Fauziyah, 2016). Salah satu faktor yang menjadi penyebab ketidakpatuhan adalah keterbatasan pengetahuan mengenai penyakit TB. Penelitian ini bertujuan untuk mengetahui hubungan tingkat pengetahuan dengan kepatuhan penggunaan OAT pada pasien penderita TB. Penelitian ini menggunakan rancangan studi cross sectional. Penentuan sampel menggunakan teknik purposive sampling. Besar sampel yang digunakan minimal 105 responden. Instrumen penelitian ini menggunakan kuesioner pengetahuan yang telah diuji validitas dan reliabilitas oleh Febriyanti (2020) dan kuesioner Medication Adherence Report Scale (MARS) yang telah diuji validitas dan reliabilitas oleh Zuhra (2019). Hasil penelitian menunjukkan pasien dengan pengetahuan baik sebesar 50,9% pengetahuan cukup sebesar 42,5% dan pengetahuan kurang sebesar 6,6%. Pasien dengan kepatuhan tinggi sebesar 87,7% dan kepatuhan rendah sebesar 12,3%. Uji analisis hubungan pengetahuan dengan kepatuhan penggunaan obat yang dilakukan dengan chi square menunjukkan adanya hubungan antara pengetahuan dengan kepatuhan didapatkan nilai P value = 0,004 (P<0,05). Hasil ini menunjukkan bahwa terdapat hubungan yang bermakna antara pengetahuan dengan kepatuhan penggunaan obat anti tuberkulosis.
Evaluasi Kepatuhan Penggunaan Obat Antidiabetik Oral Pada Pasien Rawat Jalan Diabetes Melitus Tipe 2 Di Rumah Sakit Universitas Sebelas Maret: EVALUATION OF ADHERENCE TO THE USE OF ORAL ANTIDIABETIC DRUGS IN OUTPATIENTS WITH TYPE 2 DIABETES MELLITUS AT THE UNS HOSPITAL Latipah, Ayu; Murtisiwi, Lusia; Adiningsih, Retnowati
JURNAL KESEHATAN KARTIKA Vol. 17 No. 2 (2022): Jurnal Kesehatan Kartika
Publisher : Faculty of Health Science and Technology, University of Jenderal Achmad Yani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/jkkes.v17i2.242

Abstract

Diabetes mellitus is a chronic disease that can cause complications, both microangiopathy and macroangiopathy if not treated properly. The success of diabetes mellitus therapy is influenced by patient compliance in drug use. The purpose of this study was to determine adherence to the use of oral antidiabetic drugs in outpatients with type 2 diabetes mellitus at Sebelas Maret University Hospital. This research is a non-experimental descriptive research. Sampling was done by purposive sampling in accordance with the inclusion criteria and exclusion criteria that have been determined. Compliance data retrieval using the Medication Adherence Report Scale questionnaire in Indonesian which has been tested for validity and reliability by Alfian (2017) which is distributed to patients. Data collection techniques were direct interviews with patients and filling out a questionnaire for patient data and the MARS-5 medication adherence questionnaire. Data analysis was carried out descriptively by describing the patient's characteristics. Analysis of the level of compliance in this study using a total scoring questionnaire MARS-5. This research has obtained a research permit with an ethical feasibility letter No: 788/VI/HREC/2022. Data collection was carried out in June-July 2022. The results showed that from 205 respondents, the level of adherence to the use of oral antidiabetic drugs included a low adherence rate of 50.2% and a high adherence rate of 49.8%.
Hubungan Tingkat Pengetahuan dengan Kepatuhan Minum Obat Pasien Tuberkulosis di RSUD Banten Murtisiwi, Lusia
Jurnal Novem Medika Farmasi Vol. 3 No. 3 (2024): volume 3 Issue 3 2024
Publisher : Program Studi Farmasi, Universitas Islam Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59638/junomefar.v3i3.1283

Abstract

Tuberkulosis (TB) merupakan penyakit infeksi menular kronis yang disebabkan oleh infeksi Mycobacterium Tuberculosis. Salah satu faktor yang sangat mempengaruhi keberhasilan terapi tuberkulosis adalah kepatuhan pasien dalam meminum obat. Meski demikian dari beberapa penelitian masih ada pasien yang tidak patuh dalam meminum obat anti-tuberkulosis. Ketika pasien tidak patuh dalam meminum obat dapat menyebabkan kegagalan terapi yang dapat mengakibatkan terjadinya Multi Drug Resistant Tuberculosis (MDR-TB). Pengetahuan pasien tentang penyakit tuberkulosis menjadi salah satu faktor yang dapat mempengaruhi kepatuhan pasien dalam mengkonsusmsi obat sesuai aturan. Penelitian ini bertujuan untuk mengetahui hubungan tingkat pengetahuan dengan tingkat kepatuhan pada pasien TB. Penelitian merupakan penelitian analitik korelatif dengan desain cross sectional. Populasi pada penelitian ini adalah seluruh pasien tuberkulosis di RSUD Banten dan sample yang digunakan adalah pasien tuberkulosis yang memenuhi kriteria inklusi dan ekslusi dengan teknik purposive sampling sebanyak 41 pasien. Analisis data dilakukan dengan menggunakan uji korelasi Spearman-rank. Menunjukkan bahwa 24 pasien (58,5%) mempunyai tingkat pengetahuan tinggi, 17 pasien (41,5%) mempunyai tingkat pengetahuan sedang dan tidak ada pasien dengan pengetahuan rendah. Sebanyak 30 pasien (73,8%) memiliki kepatuhan tinggi, 11 pasien (26,8%) memiliki kepatuhan sedang dan tidak ada pasien memiliki kepatuhan rendah.
Edukasi pencegahan diabetes melitus dan pemanfaatan daun stevia sebagai alternatif pengganti gula pada penderita diabetes melitus Utami, Nastiti; Sari, Vitria Maya; Fitriasari, Murtia; Saputri, Anri Anggra; Ariani, Entita; Zhanjaya, Zhanjaya; Murtisiwi, Lusia
SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Vol 8, No 4 (2024): December
Publisher : Universitas Muhammadiyah Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/jpmb.v8i4.26954

Abstract

Abstrak Desa Dukuh terletak di Kecamatan Delanggu, Kabupaten Klaten, Jawa Tengah. Desa Dukuh memiliki puskesmas pembantu yang memiliki arsip data mengenai warga atau masyarakat yang terkena penyakit diabetes yaitu berkisar 35 orang. Diabetes melitus merupakan suatu penyakit metabolik yang disebabkan oleh terganggunya hormon insulin sehingga ditandai dengan kadar gula darah meningkat.  Salah satu tanaman yang dapat digunakan menjadi pemanis pengganti gula pada makanan atau minuman adalah daun stevia.  Daun stevia juga memiliki banyak manfaat bagi kesehatan yaitu dapat mengontrol kadar gula darah, aman bagi penderita diabetes, dapat menghambat pertumbuhan bakteri di mulut sehingga dapat mencegah kerusakan gigi. Adanya kegiatan pengabdian masyarakat di Desa Dukuh ini bertujuan untuk memberikan informasi kepada masyarakat mengenai penyakit diabetes. Selain itu, dapat memberikan edukasi kepada masyarakat serta mahasiswa dalam pemanfaatan tanaman herbal yang dapat dijadikan suatu produk sebagai salah satu alternatif pengganti gula bagi penderita diabetes. Mitra sasaran pada kegiatan pengabdian ini adalah penderita diabetes melitus dan masyarakat di wilayah Desa Dukuh, Delanggu, Klaten sejumlah 15 orang. Penyuluhan dilakukan dengan metode ceramah, diskusi, dan workshop pembuatan produk. Materi penyuluhan terdiri dari beberapa sub materi yang terdiri dari gambaran umum penyakit diabetes, terapi farmakologi pada penyakit diabetes melitus, dan pembuatan pemanis pengganti gula. Sebelum dan setelah diberikan materi dilakukan test (pretest dan posttest) untuk mengetahui adanya tingkat kenaikan pengetahuan dari peserta terkait materi yang telah disampaikan. Program pengabdian kepada masyarakat berjalan dengan baik dan juga menunjukkan adanya peningkatan pengetahuan masyarakat yang dilihat berdasarkan nilai rata - rata pretest dan posttest. Nilai rata-rata pre-test masyarakat sebesar 82,7, terjadi peningkatan nilai dengan nilai rata-rata post-test sebesar 91,33. Kata kunci: diabetes melitus; gula; stevia; stevia rebaudiana Abstract Dukuh Village located in Delanggu District, Klaten Regency, Central Java Province. In Dukuh Village there was a sub-health center that has archived data on residents or communities affected by diabetes, which around 35 people. Diabetes mellitus is a metabolic disease caused by disruption of the insulin hormone, which characterized by increased blood sugar levels. One of the herbal plants that could be used as a sweetener to replace sugar in food or drinks is stevia leaves. Leaf of stevia also has many health benefits, namely it could control blood sugar levels, safe for diabetics, could inhibit the growth of bacteria in the mouth so that it could prevent tooth decay. The existence of community service activities in Dukuh Village aims to provide knowledge and insight to the community about diabetes. In addition, it could provide education to the community and students in the use of herbal plants that could be used as a product as an alternative sugar substitute for diabetics. The target partners in this community service activity were diabetics and the community in the Dukuh Village area, Delanggu, Klaten, a total of 15 people. Counseling was carried out using lecture methods, question and answer discussions, and product demonstrations.  The counseling material consists of several sub-materials consisting of a general description of the disease, pharmacological therapy for diabetes mellitus, and made sweetner replace sugar. Before and after the material was given, a test (pretest and posttest) was conducted to determine the level of increase in knowledge from participants related to the material that had been delivered. The community service program went well and also showed an increase in community knowledge as seen from the average pretest and posttest values. The average pre-test score of the community was 82.7, there was an increase in the score with an average post-test score of 91.33. Keywords: diabetes mellitus; sugar; stevia; stevia rebaudiana
EDUKASI MENGATASI PERMASALAHAN STUNTING DAN PENGOLAHAN BAHAN PANGAN LOKAL MENJADI MAKANAN YANG TINGGI PROTEIN DAN ZAT BESI BAGI MASYARAKAT DI KELURAHAN CEMANI SUKOHARJO Ovikariani; Murtisiwi, Lusia; Putra, Greggy Giovananda Afandty; Agustin, Riska Sulistyani; Nani, Sisilia Laurentin Evelin; Sailirrahma, Nabila Sepgialuni
Awal Bros Journal of Community Development Vol 6 No 1 (2025): Awal Bros Journal of Community Development
Publisher : LPPM Universitas Awal Bros

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54973/abjcd.v6i1.636

Abstract

Stunting is a health problem that has an impact on inhibiting physical, mental, and health growth of children. Data obtained from the Central Statistics Agency of Sukoharjo District in 2023, the prevalence of stunting in the Sukoharjo area reached 24.3%. The Cemani area is included in one of the sub-districts in the Sukoharjo area. When viewed from the description of the problem, it is necessary to handle it through a community service program that aims to improve community understanding and skills in processing local fish into healthy food as an effort to prevent stunting. Community service activities were carried out at the Nusa Idah Posyandu Center, Cemani, which consisted of several stages such as planning, implementation, pre-test, socialization, product demonstration, Q&A and post-test. The results of the community service activities were that the activities ran smoothly with 37 participants attending. The question and answer session showed that participants were interested in the demonstration of the use of local food ingredients as a solution to prevent stunting. In addition, the community service carried out was able to increase community understanding as evidenced by the average pre-test score of 71.25 to a post-test score of 81.76. Based on the description, it can be concluded that the community service program carried out was successful in increasing the understanding and skills of the community in Cemani Village.
Uji Antiinflamasi Krim Ekstrak Herba Krokot (Portulaca Oleracea L.) Pada Tikus Putih Jantan Wistar Yang Diinduksi Karagenan Ariffanisa, Azzahro; Murtisiwi, Lusia
Jurnal Ners Vol. 9 No. 4 (2025): OKTOBER 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v9i4.49054

Abstract

Krokot (Portulaca oleracea L) mengandung tannin, saponin, vitamin B dan C, serta memiliki sifat antiinflamasi. Penelitian ini memiliki tujuan untuk mengetahui efek antiinflamasi dari krim ekstrak herba krokot pada tikus putih jantan wistar yang diberi induksi karagenan 3%. Ekstrak herba krokot dibuat dalam sediaan krim dengan konsentrasi 0,5%, 1% dan 1,5% serta kontrol negatif yaitu basis krim dan kontrol positif krim hidrokortison 1%. Larutan induksi yang dipakai adalah karagenan 3%. Penelitian ini menggunakan metode inflammation associated oedema. Hasil yang didapatkan menujukkan krim ekstrak herba krokot pada konsentrasi 0,5%, 1%, dan 1,5% memiliki persentase daya inhibisi udem berturut-turut sebesar ,44%, 63%, dan 74,04% pada tikus putih jantan wistar. Semua krim ekstrak herba krokot konsentrasi 0,5%, 1%, dan 1,5% dapat memberikan efek penurunan inflamasi pada punggung tikus.
Co-Authors Adiningsih, Retnowati Agustin, Riska Sulistyani Andriani, Disa Annisya, Difa Suci Ariani, Entita Ariffanisa, Azzahro C.E. Dhurhania Endang Yuniarti Fitriasari, Murtia Ina Damayanti Latipah, Ayu Lindawati, Novena Yeti Lusia Murtisiwi Murti Andayani , Tri Nani, Sisilia Laurentin Evelin Novena Yety Lindawati, Novena Yety Ovikariani Ovikariani, O Putra, Greggy Giovananda Afandty Rahma Noviyanti, Eka Sailirrahma, Nabila Sepgialuni Saputri, Anri Anggra Sari, Vitria Maya Sulistyoningrum, Endah Syahrullah Murwati, Isna Tyas, Jatining Utami, Nastiti Yety Lindawati, Novena Zhanjaya, Zhanjaya