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All Journal Jurnal Kesehatan Andalas Jurnal Ilmiah Universitas Batanghari Jambi Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia)
Defrin Defrin
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Kajian Pustaka: Kadar Brain Derived Neurotrophic Factor Mempengaruhi Berat Badan Lahir pada Bayi Yessi Ardiani; Defrin Defrin; Husna Yetti
Jurnal Ilmiah Universitas Batanghari Jambi Vol 19, No 1 (2019): Februari
Publisher : Universitas Batanghari Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (501.882 KB) | DOI: 10.33087/jiubj.v19i1.576

Abstract

Brain Derived Neurotrhophic Factor (BDNF) is one of the proteins needed for the growth of neurons. During its development period BDNF plays a role in nerve growth, differentiation, repair, and survival of nerve cells. In addition, researchers from certain groups found that BDNF also had an important role during the implantation period, placental development and development of fetal growth. BDNF is known to have an important role in regulating angiogenesis needed for placental development. Because of this role, BDNF deficiency will cause disruption in placental growth which will eventually cause fetal growth disorders or Intrauterine growth restriction (IUGR). In recent years studies have shown that neurotrophins play an important role in the regulation of placental development and fetal growth. BDNF has been found to be expressed in large amounts in blastocysts which indicate the potential role of BDNF in implantation and development of the placenta. BDNF is also produced in the muscle tissue of one of them in the uterus precisely in the endometrium and myometrium. The discovery of the role of BDNF, is expected to be used as an indicator to assess the occurrence of growth disorders in the fetus as well as additional information about the etiology and pathophysiology of IUGR. Keywords: BDNF; IUGR; Neurotrophin
Hubungan Perdarahan Postpartum dengan Paritas di RSUP Dr. M. Djamil Periode 1 Januari 2010 - 31 Desember 2012 Nola Eriza; Defrin Defrin; Yuniar Lestari
Jurnal Kesehatan Andalas Vol 4, No 3 (2015)
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v4i3.360

Abstract

Abstrak Penyebab utama kematian ibu di Indonesia adalah perdarahan (28%), eklampsia (24%) dan infeksi (11%). Perdarahan postpartum merupakan penyebab tersering dari keseluruhan kematian akibat perdarahan obstetrik. Paritas merupakan salah satu faktor risiko untuk terjadinya perdarahan postpartum.  Tujuan penelitian ini adalah menentukan hubungan perdarahan postpartum dengan paritas di RSUP Dr. M. Djamil Padang. Penelitian ini merupakan studi analitik menggunakan desain cross sectional study dengan cara mengambil data rekam medis pasien perdarahan postpartum di RSUP Dr. M. Djamil Padang periode 1 Januari 2010 sampai 31 Desember 2012, dengan jumlah 72 orang. Analisis statistik yang digunakan adalah uji chi-square dengan derajat kemaknaan 0,05. Hasil penelitian menunjukkan bahwa perdarahan postpartum terbanyak adalah perdarahan postpartum primer (69,4%), paritas terbanyak adalah paritas > 3 (37,5%).  Pada uji statistik chi-square diperoleh p = 0,49 (p>0,05) yang berarti secara statistik tidak terdapat perbedaan yang bermakna antara perdarahan postpartum primer dan sekunder dengan paritas. Walaupun tidak bermakna secara statistik, perdarahan postpartum meningkat seiring dengan peningkatan paritas. Saran kepada ibu hamil dengan paritas tinggi untuk secara rutin memeriksakan kehamilannya kepada petugas kesehatan agar kesehatan ibu dapat dikontrol dalam upaya mencegah perdarahan postpartum.Kata kunci: perdarahan postpartum, paritas, kematian ibu Abstract The main causes of maternal mortality in Indonesia are hemorrhage (28%), eclampsia (24%) and infection (11%). Postpartum hemorrhage is a common cause of all deaths due to obstetric hemorrhage. Parity is one of the risk factors for the occurrence of postpartum hemorrhage. The objective of this study was to determine the relationship between postpartum hemorrhage and parity at RSUP Dr. M. Djamil Padang.This research was analytic study using cross sectional study design by taking 72 medical record of postpartum hemorrhage at RSUP Dr. M. Djamil Padangwithin the period 1 January 2010 until 31 December 2012. The statistical analysis used was chi-square test with a significance level of 0,05. The result showed that most of postpartum hemorrhage in this research is primary postpartum hemorrhage (69,4%), the most parity is parity > 3 (37,5%). Chi-square statistical test obtained p = 0,49 (p > 0,05) which means there is no significant statistically between primary and secondary postpartum hemorrhage with parity. Although it’s not significant statistically, postpartum hemorrhage was increase along with the increased of parity. It is suggested to pregnant women with risk factors of high parity to regularly check her pregnancy to health providers so that maternal health can be controlled in order to prevent primary postpartum hemorrhage.Keywords: postpartum hemorrahage, parity, maternal mortality
Hubungan Stres dengan Kejadian Dismenore Primer pada Mahasiswi Pendidikan Dokter Fakultas Kedokteran Universitas Andalas Diana Sari; Adnil Edwin Nurdin; Defrin Defrin
Jurnal Kesehatan Andalas Vol 4, No 2 (2015)
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v4i2.301

Abstract

AbstrakDismenore primer merupakan nyeri menstruasi yang dijumpai tanpa kelainan yang nyata pada alat-alat genital. Lebih dari 50% wanita mengalami dismenore primer dan 15% diantaranya mengalami nyeri yang hebat.Tujuan penelitian ini adalah untuk menentukan hubungan tingkat stres dengan derajat dismenore primer. Penelitian dilakukan pada mahasiswi pendidikan dokter Fakultas Kedokteran Universitas Andalas angkatan 2009 dan 2010. Desain penelitian ini menggunakan cross sectional study dengan jumlah subjek 165 orang. Pengumpulan data dari responden dilakukan dengan wawancara terpimpin (pengisian kuesioner). Analisa statistik yang digunakan adalah uji chi-square dan uji koefisien korelasi sederhana. Uji chi-square menunjukan ada hubungan yang bermakna antara stres dengan kejadian dismenore primer dan uji statistik koefisien korelasi sederhana menunjukkan ada hubungan yang bermakna dengan korelasi agak lemah antara tingkat stres dengan derajat dismenore primer.Kata kunci: stres, dismenore primer, mahasiswi fakultas kedokteran AbstractPrimary dysmenorrhoea is menstrual pain founded without real abnormalities in genital organs. More than 50% woman experiance it and 15% had severe pain. The objective of this study was to determine relationship between stress and primary dysmenorrhoea. Research was executed to education medical female students medical faculty of Andalas University class of 2009 and 2010. This research use cross sectional study design with 165 subjects. Data was collected by guided interview. Statistic analysis use chi-square test and simple correlation test. Chi-square test show there is significant relationship between stress and primary dysmenorrhoea and simple coefficient test show there is weak correlation between stress levels and degree of primary dysmenorrhoea.Keywords: stress, primary dysmenorrhoea, female student of medical faculty
Prevalensi Kanker Serviks Berdasarkan Paritas di RSUP. Dr. M. Djamil Padang Periode Januari 2011- Desember 2012 Septia Haryani; Defrin Defrin; Yenita Yenita
Jurnal Kesehatan Andalas Vol 5, No 3 (2016)
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v5i3.592

Abstract

AbstrakKanker serviks menempati urutan pertama penyebab kematian akibat kanker pada wanita usia reproduktif di negara berkembang. Jumlah paritas di Sumatera Barat masih cukup tinggi, paritas merupakan salah satu faktor risiko terjadinya kanker serviks yang berhubungan dengan hormon dan trauma saat persalinan. Tujuan penelitian ini adalah mengetahui prevalensi kanker serviks berdasarkan jumlah paritas di RSUP. DR. M. Djamil Padang. Penelitian ini merupakan penelitian deskriptif observasional. Data sekunder diambil dari rekam medik pasien kanker serviks di RSUP.Dr. M. Djamil Padang periode Januari 2011- Desember 2012. Penelitian ini dilakukan dari Oktober 2013 - Juni 2014. Pada penelitian ini didapatkan 63 kasus kanker serviks. Distribusi kanker serviks berdasarkan umur terbanyak pada kelompok umur >50 tahun sebanyak 27 kasus (42,9%), berdasarkan jenis pembayaran pasien kanker serviks banyak memakai jamkesmas sebanyak 21 kasus (38,1%), jenis histopatologi terbanyak ditemukan pada jenis karsinoma sel skuamosa sebanyak 46 kasus (73%) dan jumlah paritas yang terbanyak pada kelompok paritas 3-5 kali sebanyak 40 kasus (63,5%). Umur dan paritas tidak ada hubungannya dengan jenis kanker serviks.Paritas bukan merupakan faktor risiko terjadinya kanker serviks.Kata kunci: kanker serviks, paritas, histopatologi AbstractThe cervical cancer is the  first rank cause of cancer death in women of reproductive age in developing countries. The number of parity in West Sumatera is still high, parity is one of the risk factors for cervical cancer relating to hormone and birth trauma. The objective of this study was to identify the prevalence of cervical cancer based on parity in  Dr. M. Djamil Hospital Padang. This research was descriptive observational study. Secondary data was taken from medical record of cervical cancer patients in Dr. M.Djamil Hospital Padang from January 2011 until  December 2012. The study was held from October 2013 until June 2014.The research found 63 cases of cervival cancer. Distribution cervical cancer by the age of majority in the age group >50 years old were 27 cases (42,9%), based on kind of payment is mostly used jamkesmas were 21 cases (38,1%), based on histopathology of majority on squamous cell carcinoma is 46 cases (73%) and based on the highest number of parity is the parity group 3-5 were 40 cases (63,5%). People’s age and parity are not related to the type of cervical cancer. Parity is not a risk factor of having cervical cancer.Keywords: cervical cancer, parity, histopathology
The Accuracy of Modified Risk Malignancy Index (RMI) in Predicting Malignancy of Epithelial Type Ovarian Cancer: Akurasi Modifikasi Risk of Malignancy Index dalam Memprediksi Keganasan Tumor Ovarium Tipe Epitel Esfi Triana; Defrin Defrin; Joserizal Serudji; Adriswan Adriswan
Indonesian Journal of Obstetrics and Gynecology Volume 7 No. 3 July 2019
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (70.75 KB) | DOI: 10.32771/inajog.v7i3.900

Abstract

Abstract Objective:To investigate the accuracy of modified Risk of Malignancy Index (RMI) in predicting malignancy of epithelial type ovarian tumour. Method: This research was comparative research using cross-sectional study design, which compared RMI modification and RMI method in predicting malignancy of epithelial type ovarian tumour. The sampling technique was consecutive sampling. This research was conducted on October 2017 until samples were fulfilled in Obstetrics and Gynecology Division of RSUP Dr. M. Djamil and Laboratory of RSUP Dr. M Djamil in Padang. Chi-square test was used to compare specificity, sensitivity, positive predictive value (PPV), negative predictive value (NPV), positive likelihood ratio (PLR), negative likelihood ratio (NLR, and accuracy of RMI modification and RMI with 95% CI (p≤0,05). Results: A total of 61 subjects were recruited in this study. Sensitivity, specificity, PPV, NPV, PLR, NLR, and accuracy RMI modification scoring was 90.5%, 82.5%, 73.1%, 94.3%, 5.1, 0.1, dan 85.2%. Sensitivity, specificity, PPV, NPV, PLR, NLR, and accuracy RMI scoring was 66.7%, 70%, 53.8%, 80%, 2.2, 0.4, and 70% Conclusions:Modified RMI scoring method was more accurate in predicting the malignancy of ovarian type epithelial tumours than RMI. Keywords: CA125, malignancy, ovarian tumor,pelvic mass, RMI, Abstrak Tujuan: Mengetahui akurasi Risk of Malignancy Index (RMI) dalam prediksi keganasan tumor ovarium tipe epitel. Metode: Penelitian ini merupakan penelitian komparatif dengan desain penelitian potong lintang yang membandingkan metode RMI modifikasi dan RMI dalam prediksi keganasan tumor ovarium tipe epitel. Jumlah sampel sebanyak 61 orang. Teknik pengambilan sampel berurutan. Penelitian di mulai pada bulan Oktober 2017 hingga jumlah sampel terpenuhi di Departemen Obstetri dan Ginekologi RSUP Dr. M Djamil dan Laboratorium RSUP Dr. M Djamil Padang. Untuk membandingkan spesifisitas, sensitivitas, nilai duga positif (NDP), nilai duga negatif (NDN), rasio kemungkinan positif (RKP), rasio kemungkinan negatif (RKN), dan akurasi RMI modifikasi dan RMI digunakan uji chi-square dengan 99% CI (p≤0,01). Hasil: Sensitivitas, spesifisitas, NDP, NDN, RKP, RKN, dan akurasi skoring RMI modifikasi adalah 90,5%, 82,5%, 73,1%, 94,3%, 5,1, 0,1, dan 85,2%. Sensitivitas, spesifisitas, NDP, NDN, RKP, RKN, dan akurasi skoring RMI adalah 66,7%, 70%, 53,8%, 80%, 2,2, 0,4, dan 70%. Kesimpulan: Metode skoring RMI modifikasi lebih akurat dalam memprediksi keganasan tumor ovarium tipe epitel dibandingkan RMI. Kata kunci: CA125, keganasan, massapelvik, RMI, tumor ovarium
Co-Authors Adnil Edwin Nurdin Adriswan Adriswan Diana Sari Esfi Triana Husna Yetti Nola Eriza Septia Haryani Yenita . Yessi Ardiani Yuniar Lestari