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All Journal The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Healthcaring: Jurnal Ilmiah Kesehatan
Helena Fabiani
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Dentistry Medicine & Pharmacology Nursing Public Health

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A Deterioration of Anemia in Hemoglobin E Disease caused by Cholestatic Hepatitis A Helena Fabiani; Suzanna Ndraha; Henny Tanadi Tan; Fendra Wician; Mardi Santoso
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 13, NUMBER 3, Desember 2012
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (314.026 KB) | DOI: 10.24871/1332012185-188

Abstract

ABSTRACTPatients with hemoglobin E disease usually have mild hemolytic anemia and mild splenomegaly. Acute infection including acute inflammatory disease of the liver caused by hepatitis A viral, which attacks patients with previous hemolytic anemia, may result in deterioration of anemia.A 17-year-old female patient was admitted with chief complaint of having jaundiced body and non-specific prodromal symptoms within one week prior to admission. Physical examination revealed jaundiced skin and sclera as well as tenderness in right upper quadrant of the abdomen. Laboratory tests revealed microcytic hypochromic anemia with hemoglobin (Hb) level of 6.3 g/dL, increased reticulocyte count and abnormal morphology of erythrocyteson blood smear. Hemoglobin electrophoresis indicated hemoglobin E disease and serologic tests suggested a positive anti-HAV immunoglobulin M (IgM) with increased level of liver enzymes and functions. Abdominal ultrasound showed hepatosplenomegaly without extra-hepatic cholestasis. The working diagnosis was hepatitis A with intrahepatic cholestasis and hemoglobin E disease. The patient was treated with hepatoprotector and ursodeoxycholic acid. Anemia was not treated specifically. It was assumed that hemolytic anemia was worsened by acute infection of hepatitis A viral. The assumption had been proven to be right since there was improvement of anemia after the acute infection had recovered. Patients with hemoglobin E disease usually have mild anemia; however, in this case, the hemoglobin level decreased significantly due to the acute co-infection. Keywords: hemoglobin E disease, anemia, acute infection, acute hepatitis A infection
Diabetes Mellitus Due to Liver Cirrhosis in 33-Year-Old Female Henny Tanadi Tan; Suzanna Ndraha; Helena Fabiani; Fendra Wician; Mardi Santoso; Marshell Tendean
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 14, NUMBER 2, August 2013
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (294.011 KB) | DOI: 10.24871/1422013117-119

Abstract

Impaired glucose metabolism can occur in patient with chronic liver disease, either it is impaired glucose tolerance or diabetes mellitus (DM). DM due to liver cirrhosis is known as hepatogenous diabetes (HD). HDis different from type 2 DM in clinical signs and management.A 33-year-old female came with chief complaint of fatigue since three days before admission. Patient also complained of nausea, vomiting, and increased abdominal circumference since one year ago. Patient wasdiagnosed with DM two months ago. From physical examination, anemic and ascites without signs of cirrhosis were obtained. Laboratory test showed mild anemia with hemoglobin levels 6.5 g/dL, elevated serum bilirubinand liver enzymes, decreased serum albumin, prolonged prothrombin time and elevated random blood glucose. Serologic test showed chronic hepatitis B with HBV DNA 1.61 x 104 copy/mL. The abdominal ultrasound resultshowed liver cirrhosis with ascites.The patient was diagnosed with hepatogenous diabetes in liver cirrhosis due to chronic hepatitis B infection and anemia of chronic disease. The management of this patient was quite complex especially in administrationof oral antidiabetic agent which could affect the liver function.Keywords: hepatogenous diabetes, liver cirrhosis, diabetes mellitus, chronic hepatitis B infection
The Effect of Perioperative Probiotics or Synbiotics on Postoperative Ileus in Patients Undergoing Abdominal Surgery: An Evidence-based Case Report Fabiani, Helena; Lestari, Wiji
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 25, No 1 (2024): VOLUME 25, NUMBER 1, April, 2024
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/251202476-82

Abstract

Aims: To explore the effects of perioperative probiotics or synbiotics supplementation on postoperative in patients undergoing abdominal surgery.Method: A literature search was conducted on four databases, PubMed, Cochrane, ProQuest, and Scopus, by using MeSH Term. The article selection process was undertaken by screening the titles or abstracts, reviewing the full texts, and determining their compliance with the inclusion and exclusion criteria. Two systematic review/meta-analysis of randomized controlled trial were critically appraised for validity, importance, and applicability.Results: Perioperative probiotics or synbiotics supplementation may contribute to gastrointestinal function recovery, including reducing postoperative ileus in gastrointestinal cancer. Supplementation of probiotics or synbiotics reduced overall postoperative complications in patients undergoing colorectal cancer surgery and did not cause any side effects. However, the administration of probiotics or synbiotics was not associated with the incidence of postoperative ileus.Conclusion: Perioperative probiotics or synbiotics supplementation can be considered in promoting postoperative gastrointestinal function in abdominal surgery. However, their effect on reducing the incidence of postoperative ileus is still inconsistent.
Penatalaksanaan dan Pemberian Nutrisi pada Krisis Tiroid dengan HIV dan Sirosis Hati : Sebuah Laporan Kasus Tan, Henny Tannady; Fabiani, Helena
Healthcaring: Jurnal Ilmiah Kesehatan Vol. 4 No. 2 (2025): Vol : 4 No : 2 : Periode Juli 2025
Publisher : Information Technology and Science (ITScience)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47709/healthcaring.v4i2.5331

Abstract

Abnormalitas fungsi tiroid banyak terjadi pada pasien dengan HIV. Infeksi HIV mempengaruhi fungsi hormon tiroid melalui perubahan metabolisme, penurunan asupan nutrisi dan peningkatan penurunan berat badan. Terapi dengan Anti Retroviral Terapi (ART) dan Immune Reconstitution Inflammatory Syndrome (IRIS) turut mempengaruhi fungsi hormon tiroid. Hipertiroid merupakan abnormalitas hormon tiroid yang paling jarang terjadi pada pasien dengan HIV. Pada laporan kasus ini kami melaporkan mengenai kejadian krisis tiroid pada seorang pria usia 30 tahun dengan komorbid HIV dan sirosis hati. Seorang pria usia 30 tahun datang dengan keluhan berdebar-debar sejak 1 bulan terakhir. Ia memiliki riwayat penyakit HIV dan sirosis hati akibat alkohol. Pada pemeriksaan lebih lanjut terdapat peningkatan hasil TRAb. Penatalaksanaan hipertiroid pada pasien dengan HIV tidak berbeda dengan populasi umum namun pasien ini terdapat penyulit lain yaitu Sirosis Hati. Selain medikamentosa, pemberian nutrisi turut menunjang penatalaksanaan pasien ini. Kata kunci: graves ; hipertiroid ; HIV ; sirosis
Co-Authors Cecep Kusmana Fendra Wician Fendra Wician Henny Tanadi Tan Henny Tannady Tan Mardi Santoso Marshell Tendean Marshell Tendean Suzanna Ndraha Wiji Lestari