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All Journal The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Jurnal Kedokteran Meditek Indonesian Journal of Endocrinology Metabolism and Diabetes (InaJEMD)

Marshell Tendean

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Author-ID : 2732728

Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Articles

Liver Disorders in Type 2 Diabetes Mellitus Suzanna Ndraha; Marshell Tendean; Fendra Wician; Henny Tanadi Tan; Helena Yap
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 14, NUMBER 3, December 2013
Publisher : The Indonesian Society for Digestive Endoscopy

Background: Patients with type 2 diabetes mellitus (T2DM) are frequently diagnosed with some abnormal liver features. These liver abnormalities are suggested to be correlated with insulin resistance. The aim of thisstudy was to evaluate liver abnormalities and fasting insulin levels in patients with T2DM.Method: This study was conducted in Koja Hospital from February to July 2013. Study design was analytical study. Data for sex, age, complication, body mass index (BMI), liver function, liver enzyme, and fasting insulinlevel were collected. Univariate and bivariate statistical analyses were done using SPSS 20.Results: Twenty eight patients were included in this study, 71.43% of them were female. The age group of 40-60 years was the highest among the patients (64.28%). Highest complication was neuropathy, BMI of mostpatients were obese. Liver abnormalities were documented in 35.8% patients, liver enzyme increased in 21.4% patients. Non alcoholic fatty liver disease (NAFLD) were noted in 46.6% patients, and one patient was positive for hepatitis B. Mean fasting insulin in T2DM with NAFLD were higher than in T2DM without NAFLD. However, it was not statistically significant (40.08 ± 36.8 μU/mL vs. 54.3 ± 37.1 μU/mL; p = 0.27).Conclusion: Liver abnormalities found in T2DM patients were elevated liver enzyme, decreased albumin and increased of bilirubin. Through ultrasound, NAFLD and liver cirrhosis were found. Fasting insulin levelwas higher in T2DM with NAFLD but it was not statistically significant.Keywords: type 2 diabetes mellitus, non alcoholic steato-hepatitis, fasting insulin

Diabetes Mellitus Due to Liver Cirrhosis in 33-Year-Old Female Henny Tanadi Tan; Suzanna Ndraha; Helena Fabiani; Fendra Wician; Mardi Santoso; Marshell Tendean
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 14, NUMBER 2, August 2013
Publisher : The Indonesian Society for Digestive Endoscopy

Impaired glucose metabolism can occur in patient with chronic liver disease, either it is impaired glucose tolerance or diabetes mellitus (DM). DM due to liver cirrhosis is known as hepatogenous diabetes (HD). HDis different from type 2 DM in clinical signs and management.A 33-year-old female came with chief complaint of fatigue since three days before admission. Patient also complained of nausea, vomiting, and increased abdominal circumference since one year ago. Patient wasdiagnosed with DM two months ago. From physical examination, anemic and ascites without signs of cirrhosis were obtained. Laboratory test showed mild anemia with hemoglobin levels 6.5 g/dL, elevated serum bilirubinand liver enzymes, decreased serum albumin, prolonged prothrombin time and elevated random blood glucose. Serologic test showed chronic hepatitis B with HBV DNA 1.61 x 104 copy/mL. The abdominal ultrasound resultshowed liver cirrhosis with ascites.The patient was diagnosed with hepatogenous diabetes in liver cirrhosis due to chronic hepatitis B infection and anemia of chronic disease. The management of this patient was quite complex especially in administrationof oral antidiabetic agent which could affect the liver function.Keywords: hepatogenous diabetes, liver cirrhosis, diabetes mellitus, chronic hepatitis B infection

Gejala Klinik dan Pemeriksaan Laboratorium pada Pasien Diare di RSUD Koja Agustus-Oktober 2009 Susanna Ndraha; Marshell Tendean; Agnes Clement; Lambu Da Costa; Andri Andri
Jurnal Kedokteran Meditek vol. 16 no. 42 September-Desember 2009
Publisher : Fakultas Kedokteran Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jkdoktmeditek.v16i42.197

Komplikasi Penderita Sirosis Hati Di RSUD KOJA Pada Bulan Juli - November 2017 Suzanna Ndraha; Imelda Imelda; Marshell Tendean; Mardi Santoso
Jurnal Kedokteran Meditek VOL. 24 NO. 67 JULI-SEPTEMBER 2018
Publisher : Fakultas Kedokteran Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jkdoktmeditek.v24i67.1590

Sirosis merupakan tahap akhir dari berbagai penyakit hati kronis. Penyebab tersering adalah infeksi virus hepatitis B, virus hepatitis C dan alkohol. Sirosis hati dengan komplikasinya merupakan masalah kesehatan yang masih sulit diatasi. Hal ini ditandai dengan angka kesakitan dan kematian yang tinggi. Penelitian ini bertujuan untuk mengetahui karakteristik dan komplikasi apa saja yang didapatkan pada pasien sirosis hati yang dirawat di RSUD Koja. Penelitian ini menggunakan rancangan penelitian observasional deskriptif, dengan mengambil pasien rawat inap Penyakit Dalam RSUD Koja selama Juli–November 2017. Didapatkan sebanyak 63 pasien yang terdiri dari 41 orang (65,1%) laki-laki dan 22 orang (34,9%) perempuan, usia 20-40 tahun sebanyak 11 orang (17,5%) , usia 40 -60 tahun 46 orang (73%), dan usia lebih dari 60 tahun 6 orang (9,5%). Keluhan utama terbanyak adalah perut membesar (40%). Stigmata sirosis terbanyak adalah ikterus (51%), dan komplikasi terbanyak adalah asites, pada 55 orang (87,3%). Hal ini memberikan kesan penting sekali melakukan evaluasi pada pasien dengan penyakit hati kronis khususnya hepatitis B mengenai kemungkinan sirosis hati. Kata kunci: Sirosis hati, gender, usia, komplikasi

Transition of Care of Disorders of Sexual Development: A Twist of Two Cases with Ambiguous Genitalia Marshell Tendean; Nanny Natalia. M Soetedjo; Maya Kusumawati; Ervita Ritonga; Hikmat Permana
‎ InaJEMD - Indonesian Journal of Endocrinology Metabolic and Diabetes Vol. 1 No. 1 (2024): InaJEMD Vol. 1, No. 1
Publisher : PP PERKENI

Show Abstract | Download Original | Original Source | Check in Google Scholar

Disorders of sexual development (DSD) is a congenital condition that requires an alteration in the development of chromosomal, gonadal, and anatomical sex is atypical. A report showed most of the patients in the 46XX DSD had congenital adrenal hyperplasia (CAH) at 69.23% followed by unknown under-virilization in the 46XY DSD group at 60.09%. Patient 1 diagnosed as DSD 46XX/non-classic congenital adrenal hyperplasia (NCAH) presented with primary amenorrhea, short stature, over-virilization (Prader 2), and 46XX karyotype. Laboratory examination showed elevated 17-hydroxyprogesterone (17OHP): 166.7 ng/ml (2.83 ng/ml), without salt wasting feature. Patient 2 diagnosed with DSD 46XY/type 2 5α -reductase deficiency (SAD) presented with cryptorchidism, under-masculinization (sinecker stage 3b), and 46XY karyotype. Laboratory examination showed elevated testosterone 613 ng/dL (4.6-38.3 ng/dL), decreased dihydrotestosterone (DHT) 11 ng/dL (>20 ng/dL), and elevated testosterone T/DHT ratio 55.73 (8-16). A deep understanding of pathophysiology, and approach to disease in each stage of life is important and warrants special treatment. Comprehensive multidisciplinary team management (MDT) is warranted in DSD management. Disease prognosis varies among each disorder: early detection, treatment compliance, and continuity of care are important to improve patient outcomes.

Co-Authors Agnes Clement Andri Andri Fendra Wician Hanung Adi Nugroho Helena Fabiani Helena Yap Henny Tanadi Tan Hikmat Permana Imelda Imelda Kusumawati, Maya Lambu Da Costa Mardi Santoso Nanny Natalia. M Soetedjo Ritonga, Ervita Susanna Ndraha Suzanna Ndraha

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