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All Journal The Indonesian Biomedical Journal JSFK (Jurnal Sains Farmasi & Klinis)
Verda Farida
Farmasi UAD
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Investigating the Impact of Surfactant and Cosolvent on the Polyphenolic Content in Arumanis Mango Leaf Extract (Mangifera indica L.) Fatimah, Siti Fatmawati; Farida, Verda; Nuari, Yudha Rizky; Viviandhari, Daniek; Pertiwi, Deasy Vanda
JSFK (Jurnal Sains Farmasi & Klinis) Vol 11 No 1 (2024): J Sains Farm Klin 11(1), April 2024
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.11.1.39-47.2024

Abstract

The leaf of Mangifera indica L. contains flavonoids and mangiferin which showed positive effects on wound healing of diabetic ulcer. The used of suitable surfactant and co-solvent is required to ensure the high solubility of the active pharmaceutical ingredient (API), thereby optimizing the efficacy. This study aims to determine the ideal surfactant and cosolvent for a thermosensitive hydrogel formula of Mangifera indica leaf ethanol extract. The leaf was fextracted by maceration using 70% ethanol then determined for moisture content.  The extract was prepared for solubility tests of flavonoid and mangiferin on surfactants (Kolliphor® EL, Tween® 20, Tween® 80, Miranol® C2M) and co-solvents (Glycerin, PEG 400, and transcutol). Methods for total flavonoids content were Spectrophotometry UV-Vis and mangiferin with RP-HPLC method. The moisture content in the extract is 8.590 ± 0.754%. The surfactant demonstrating the highest capability in flavonoid dissolution is Tween 20 (1863.750 ± 0.838 µgQE/g extract), followed by Tween 80, Kolliphor EL, and Miranol C2M. In the context of co-solvents, PEG 400 (1309.583 ± 0.292 µgQE/g extract) show superior flavonoid dissolution capability, with glycerin and Transcutol following in descending order. Tween 20 and Tween 80 exhibite comparable efficacy in mangiferin dissolution, followed by Miranol C2M and Kolliphor EL. Among co-solvents, Transcutol demonstrate the highest aptitude for mangiferin dissolution, succeeded by PEG 400 and glycerin. This study indicates Tween 20 is a preferable surfactant and PEG 400 was considered as co-solvent to be further used in a thermosensitive gel formula for diabetic ulcer. 
Ultraviolet B (UVB) Radiation Induces Skin Alterations, Emperipolesis and Decreases the Erythroid-to-myeloid Ratio in Rats Farida, Verda; Dewananda, Dion Adiriesta; Sahid, Muhammad Novrizal Abdi; Salasia, Siti Isrina Oktavia
The Indonesian Biomedical Journal Vol 16, No 6 (2024)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v16i6.3227

Abstract

BACKGROUND: Ultraviolet B (UVB) radiation is commonly known to be related to skin inflammation. The inflammation process is orchestrated by many cell types, including immune cells. Changes in bone marrow cellularity can also be an indicator of inflammation. Megakaryocytes, myeloid immune cells progenitor and erythroid progenitor cells, are at high risk of changes upon UVB irradiation. However, there are still limited study observing the change of bone marrow cell population after UVB irradiation. Therefore, this study was conducted to investigate the alteration of the skins, emperipolesis, and the change in erythroid and myeloid cell population in bone marrow after UVB irradiation.METHODS: Ten Wistar rats were divided equally into control and UVB-irradiated group. The skin superficial condition before and after UVB irradiation was observed with a skin analyzer camera. On the 9th day, skin tissues were processed for the observation of general skin structure with hematoxylin-eosin (HE) staining, mast cells infiltration with toluidine blue staining, and collagen fibers with Mallory staining. Bone marrow and peripheral blood samples were collected and proceeded for Giemsa-staining to observe the cell population.RESULTS: Erythema appeared on the skin as marked by orange-red spots. There were hyperkeratosis and pigment accumulations in the skin of UVB-irradiated group. The depletion of collagen-density and hemorrhage were clearly observed in the skin of UVB-irradiated group. There were higher mast cell numbers in the UVB-irradiated skin compared to non-treated skin. The erythroid-to-myeloid ratio in the bone marrow was decreased to around 1.6:11.2 from the normal ratio of 1:4. In addition, emperipolesis was observed in the bone marrow induces by UVB-irradiation.CONCLUSION: These results indicate that UVB-irradiation alters the skin structure, erythroid-to-myeloid ratio, and induced emperipolesis.KEYWORDS: emperipolesis, erythroid, myeloid, skin, UVB radiation
Co-Authors Dewananda, Dion Adiriesta Nuari, Yudha Rizky Pertiwi, Deasy Vanda Sahid, Muhammad Novrizal Abdi Siti Fatmawati Fatimah, Siti Fatmawati Siti Isrina Oktavia Salasia Viviandhari, Daniek