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Rachmat Kosman
Fakultas Farmasi Universitas Muslim Indonesia, Makassar
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology

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ISOLASI DAN IDENTIFIKASI FUNGI ENDOFIT BATANG SESURU (Euphorbia antiquorum L.) SEBAGAI PENGHASIL ANTIBAKTERI DENGAN METODE KLT-BIOAUTOGRAFI Asnita Asnita; Herwin Herwin; Rachmat Kosman; Ayyub Harly Nurung
As-Syifaa Jurnal Farmasi Vol 12, No 2 (2020): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jifa.v12i2.718

Abstract

The  research  aimed  to  obtain antibacterial  activity  of  isolate  fermentate  of  endophytic  fungi  of  antique spurge stem (Euphorbia antiquorum L.) on Staphylococcus aureus and Escherichia coli by TLC-Bioautography. The methods used in this research were isolation, purification and isolate screening. The  screening results of endophytic  fungi isolate  of  antique  spurge  stem  showed  the  largest  inhibitory  zone  in preventing  both  bacteria  growth  using  code  IFBS-03  and  IFBS-06.  The chromatogram profile  of antibacterial activity isolate fermentate  of the codes IFBS-03  and  IFBS-06  showed  active  spots  using  TLC-Bioautographic method showed that code IFBS-03 isolate obtained Rf 0.87 and 0.27 values, indicating active spots on  Staphylococcus aureus  and  Escherichia coli. The result of code IFBS-06 isolate obtained Rf 0.83 value active spots against Staphylococcus aureus and  values  Rf  0.83  and  0.27  value on  Escherichia  coli.  Based on isolation and identification some chemical components obtained that dietyl ether ekstract of thin layer cromatography obtained chemicals components flavanoid at Rf 0.83 and 0.27 value with reagent Antimo (III) chloride.
EFEK HEPATOPROTEKTOR DARI EKSTRAK ETANOL DAUN JOHAR (Cassia siamea LAMK.) PADA TIKUS (Rattus norvegicus) Safriani Rahman; Rachmat Kosman; Andi Cassia Siamea
As-Syifaa Jurnal Farmasi Vol 9, No 2 (2017): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (153.34 KB) | DOI: 10.33096/jifa.v9i2.276

Abstract

Johar leaf has been empirically used as malaria and hepatitis medicine. This research aims to determine hepatoprotective effect of ethanol extract of Johar leaves (Cassia siamea Lamk.) of rats liver. This  research used 15 tested rats divided into 5 groups, group I was given Na.CMC 1% (negative control), group II ethanolic extract of Johar leaves of 50 mg/kgBB, group III ethanolic extract of Johar leaves of 250 mg/kgBB, group IV ethanolic extract of Johar leaves of 500 mg/kgBB, and group V as a comparison given suspension curliv® of 42,86 mg/kgBB. Giving suspension curliv® was orally done once a day for 7 days. On the 8th day, the experimental rats were given paracetamol suspension dosage of 2,5 g/kgBB. Measurements of SGPT content was done before therapy (normal), after therapy, and after administration of paracetamol. The results showed that the ethanolic extract of Johar leaves with the dose of 50; 250; 500 mg/kgBB have a hepatoprotective effect and dose is 500 mg/kgBB which was not statistically significantly different from curliv®.
KOMBINASI EKSTRAK ETANOL DAUN KEMANGI (Ocimum bacilicum L.) DAN DAUN SALAM (Syzygium polyanthum (Wight) Walp) SEBAGAI ANTIINFLAMASI PADA TIKUS (Rattus norvegicus) JANTAN YANG DIINDUKSI KARAGEN sukmawati sukmawati; Rachmat Kosman; Nurwasi Saharuddin
As-Syifaa Jurnal Farmasi Vol 10, No 1 (2018): AS-SYIFAA Jurnal Farmasi
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (476.497 KB) | DOI: 10.33096/jifa.v10i1.314

Abstract

Inflammation is a normal protective response to tissue injury caused by physical trauma that could damage characterized by symptoms such as pain (dolor), heat (kalor), redness (rubor), swelling (tumor) and functional changes (fungsiolaesa). This research aimed to determine the anti-inflammatory effects of the ethanol extract combination of kemangi folium (Ocimum bacilicum L.) and salam folium (Syzygium polyanthum (Wight) Walp) in male rats (Rattus norvegicus) induced carrageen. This research used 15 rats divided into 5 groups: group I Na CMC (Naïve), group II Sodium Diclofenac (negative), group III was administered the ethanol extract of kemangi folium  and salam folium with dose 125:125 mg/kgBW, group IV with dose of 125:75 mg/kgBW and group V with dose 250:75 mg/kgBW. The entire of administration was done orally. The measurement of male rat foot was performed every 30 minutes to 150 minutes. The data were statistically analyzed using One Way ANOVA followed by Post Hoc LSD test. The results showed that the ethanol extract of Kemangi folium with dose of 250 mg/kgBW and the ethanol extract of Salam folium with dose of 75 mg/kgBW had the effect of decreasing the edema volume of the rat foot effectively the same as anti-inflammatory drugs NSAID where the results of statistical analysis were obtained significance (p>0.05).
UJI EFEK EPITELISASI EKSTRAK BATANG WOLE WOE ASAL KABUPATEN HALMAHERA TENGAH TERHADAP PENYEMBUHAN LUKA BAKAR PADA TIKUS Safriani Rahman; Rachmat Kosman; Sitti Amirah
As-Syifaa Jurnal Farmasi Vol 14, No 1 (2022): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56711/jifa.v14i1.792

Abstract

Wole woe is a native plant of Indonesia which is widely used by the people of Central Halmahera as a medicinal plant. Empirically this plant is widely used for wound treatment. This study aims to determine the effect of epithelialization of wole woe stem extract and determine the effective concentration and duration of wound healing in rats after administration of wole woe stem extract. This research was conducted experimentally in a laboratory using 25 rats which were divided into 5 groups consisting of 1 control group, 1 comparison group, and 3 treatment groups of wole woe stem extract. Wound induction was carried out using a 100 0C hot plate measuring 2x2 cm and affixed to the surface of the rat's back skin for 2 seconds. After a burn is formed, the extract is applied 2 times a day for 21 days. Observations on wound healing were carried out macroscopically and measuring the surface area of the wound. The results showed that the administration of wole woe bark extract influenced healing second-degree burns in rats. The results of statistical analysis showed that there was no difference between the comparison group and the extract test group (p>0.05). Based on the percent reduction in wound, the most effective concentration in wound healing was 5% (99.75%). Wound healing time in rats was 21 days.
Co-Authors Andi Cassia Siamea Asnita Asnita Herwin Herwin Nurung, Ayyub Harly Nurwasi Saharuddin Safriani Rahman Sitti Amirah