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All Journal Jurnal Gizi dan Pangan Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Jurnal Kesehatan Masyarakat Althea Medical Journal Biomedika Jurnal Media Gizi Indonesia (MGI) GIZI INDONESIA Jurnal Gizi dan Dietetik Indonesia (Indonesian Journal of Nutrition and Dietetics) Jurnal SOLMA Indonesian Journal of Medicine Journal of Maternal and Child Health MAGNA MEDICA: Berkala Ilmiah Kedokteran dan Kesehatan World Nutrition Journal Jurnal Aisyah : Jurnal Ilmu Kesehatan Indonesian Journal of Global Health research Nusantara Science and Technology Proceedings Journal of Multidisciplinary Applied Natural Science Nutriology: Jurnal Pangan, Gizi, Kesehatan Proceedings of the International Conference on Nursing and Health Sciences Journal of Health and Nutrition Research Smart Society Empowerment Journal Proceeding of International Conference Health, Science And Technology (ICOHETECH) Media Penelitian dan Pengembangan Kesehatan Indonesian Journal of Pharmacology and Therapy APMa Jurnal Pengabdian Masyarakat

Ratih Puspita Febrinasari

Universitas Sebelas Maret

Author-ID : 265413

Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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The Affecting Factors of Compliance Diabetes Mellitus Type 2 Treatment in Pandemic Era Febrinasari, Ratih Puspita; Solikah, Tri Agusti; Nasirochmi, Dyonisa; Dilma’aarij, Dilma’aarij
KEMAS: Jurnal Kesehatan Masyarakat Vol 17, No 4 (2022)
Publisher : Department of Public Health, Faculty of Sport Science, Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/kemas.v17i4.29885

Diabetes mellitus (DM) is one of the non-communicable diseases that cause serious health problems. This chronic disease requires lifelong treatment to prevent complications and death. In the pandemic era, DM became comorbid that contributed to the death rate in Covid-19 cases, so that patients with type 2 DM become important to comply with the treatment underway. Aim: This study aimed to evaluate the treatment compliance in patients with DM type 2 at the Purwodiningratan primary health care, Surakarta. Method: This study was conducted in 2020 used an analytical method with crosssectional design. Populations were all of the patients who experience DM type 2, sampling techniques used total sampling with 108 respondents. Univariate, bivariate analysis, and logistic regression were used in this study. Compliance levels measured used the MMAS-8 questionnaire. Result: The results of this study were obtained from several independent variables that related to compliance with DM type 2 treatment. The descriptive analysis result of patient compliance showed that 70.4% of patients were obedient. The significant variable was the side effects on DM drugs with (OR = -0.44; 95% CI = -0.74 - 0.15; p = 0.003). Conclusion: Most of the patients were adherent to the treatment and the most influencing factor was the side effect of the drug.

Increasing Serum Transaminase and The Relation with The Serum Concentration of Isoniazid and Rifampicin of Tuberculosis Patients which Given Antituberculosis Fixed Dose Combination in Yogyakarta Ratih Puspita Febrinasari; Erna Kristin; Iwan Dwiprahasto
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 47, No 4 (2015)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

ABSTRACT Tuberculosis is still a major health problem in Indonesia. Isoniazid and rifampicin are major antituberculosis drugs. These two drugs have been known to cause hepatotoxicity which is characterized by an increase of serum transaminase concentration. Previous study proved the increase of hepatotoxicity due to isoniazid and rifampicin but did not explain about the correlation with the drugs concentration. The aim of this study is to know the relation between increasing serum transaminase and the serum concentration of isoniazid and rifampicin of tuberculosis patients which given antituberculosis fixed dose combination in Yogyakarta. We carried out a cross sectional study involving 31 TB patients who received antituberculosis fixed dose combination containing isoniazid and rifampicin. Serum transaminase was measured with an automatic chemical analyzer. Isoniazid and rifampicin concentration was measured by using HPLC. We used t- test, Mann Whitney, Fisher and Spearman to analyze the data. There is no correlation between mean isoniazid concentration with high (7,07±6,24mg/ml) and normal ALT (2,42±0,26mg/ml) (p>0,05). There is no correlation between mean isoniazid concentration with high (5,03+4,14 mg/ml) and normal AST (p>0,05). There is no correlation between mean rifampicin concentration with high (10,67+3,76 mg/ml) and normal ALT (3,66+0,30 mg/ml) (p>0,05). There is no correlation between mean rifampicin concentration with high (8,52+3,06 mg/ml) and normal AST (3,64+0,32 mg/ml) (p>0,05). Mean of rifampicin concentration in this study are low (4, 12+0,46 mg/ml). So the conclusion that there are no correlation between isoniazid serum concentration with an increase of serum transaminase and no correlation between rifampicin serum concentration with an increase of serum transaminase.

BURNOUT DAN KUALITAS HIDUP CIVITAS AKADEMIKA PADA MASA PANDEMI COVID-19: STUDI DI UNIVERSITAS SEBELAS MARET Yusuf Ari Mashuri; Widana Primaningtyas; Heni Hastuti; Lukman Aryoseto; Novelia Qothrunnada; Ratih Puspita Febrinasari; Vitri Widyaningsih; Ari Natalia Probandari
Biomedika Vol 14, No 1 (2022): Biomedika Februari 2022
Publisher : Universitas Muhamadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/biomedika.v14i1.13280

ABSTRAKBurnout sering dikaitkan dengan penurunan prestasi kerja maupun belajar, bahkan mempengaruhi kehidupan keseharian individu. Sejak bulan Maret 2020 Indonesia terkena efek pandemi coronavirus disease 2019 (COVID-19), tak terkecuali pada seluruh civitas akademika Universitas Sebelas Maret (UNS). Penelitian ini bertujuan untuk mengetahui hubungan burnout dengan kualitas hidup pada civitas akademika UNS pada masa pandemi COVID-19. Penelitian ini merupakan penelitian observasional dengan pendekatan potong lintang. Survei online tentang burnout dan kualitas hidup dilakukan pada bulan Agustus – September 2020. Burnout diukur dengan skala Maslach Burnout Inventory (MBI) yang berisi 22 item pertanyaaan dan telah diadaptasi sesuai dengan konteks Indonesia. Instrumen EQ5D, berisikan 5 item pertanyaaan, yang telah diadaptasi digunakan untuk mengukur kualitas hidup responden. Terdapat hasil korelasi yang signifikan antara skor burnout dengan kualitas hidup pada dosen dan mahasiswa (r= -0,2843 dengan nilai p= 0,011dan r= -0,4045 dengan nilai p= 0,001). Sedangkan untuk tenaga kependidikan didapatkan hasil yang tidak signifikan dengan r= -0,3323 dan p= 0,0903. Usaha komprehensif untuk mengurangi burnout pada civitas akademika diperlukan sebagai upaya peningkatan kualitas hidup.Kata Kunci: Burnout, Komunitas Akademik, COVID-19, Quality of life ABSTRACTBurnout is often associated with decrease of work and study performance and could affect the daily living. Since March 2020, Indonesia has been affected by the 2019 coronavirus disease (COVID-19) pandemic, including the Universitas Sebelas Maret (UNS) academic community. This study aimed to determine the relationship between burnout and quality of life in UNS academic community during the COVID-19 pandemic. This was an observational study with a cross sectional approach. An online survey on burnout and quality of life was conducted in August - September 2020. Burnout was measured by the Maslach Burnout Inventory (MBI) scale which contains 22 question items and has been adapted according to the Indonesian context. The EQ5D instrument, which contains 5 question items, has been adapted to measure the quality of life of the respondent. There were significant correlations between the burnout score and the quality of life for the lecturers and students (r = -0.2843 with p-value = 0.011 and r = -0.4045 with p-value 0.001). Meanwhile, there was no significant result in educational staff group (r = -0.3323 with p-value = 0.0903). There were significant correlations between burnout score and quality of life for lecturers and students, but there was no significant correlation between burnout score and quality of life for education personnel. Comprehensive action to prevent burnout in academic community is needed to improve quality of life. Keywords: Burnout, Academic Community, COVID-19, Quality of life

Efforts to Improve Public Understanding of COVID-19 Prevention through Kader Empowerment Rizka Ayu Setyani; Ahmad Ahid Mudayana; Colti Sistiarani; Nita Dwi Astikasari; Sri Mulyani; Ratih Puspita Febrinasari; Sumardiyono
Jurnal SOLMA Vol. 11 No. 1 (2022)
Publisher : Universitas Muhammadiyah Prof. DR. Hamka (UHAMKA Press)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/solma.v11i1.8416

Background: Kasus COVID-19 di Indonesia masih terus ada dan mengalami pasang surut, salah satunya di Kabupaten Klaten. Keterbatasan petugas kesehatan dan rendahnya kesadaran masyarakat dalam menerapkan protokol kesehatan menjadi salah satu penyebab masih adanya kasus COVID-19 di Kabupaten Klaten. Kegiatan ini bertujuan untuk meningkatkan peran kader kesehatan dalam membantu meningkatkan kesadaran masyarakat menerapkan protokol kesehatan. Kegiatan ini dilakukan bekerjasama dengan Puskesmas Trucuk 1 dan Puskesmas Trucuk 2. Peserta kegiatan berjumlah 60 orang perwakilan seluruh Desa di Kecamatan Trucuk. Metode: Metode yang digunakan Focus Group Discussion, workshop serta pelatihan yang dilakukan pada bulan November-Desember 2021. Hasil kegiatan yaitu ada peningkatan pemahaman peserta setelah dilakukan kegiatan workshop dan pelatihan. Hasil: Pelatihan dengan praktik simulasi menambah wawasan peserta dalam melakukan edukasi kepada masyarakat. Kesimpulan: Peran kader kesehatan dapat menjadi solusi dalam menyadarkan masyarakat.

Antioxidant Activity of Ethanol Extract of Secang Wood (Caesalpinia sappan L.), Gotu Kola (Centella asiatica L.), and Their Combinations with DPPH Assay Binti Maulina Putri; Sugiarto; Brian Wasita; Ratih Puspita Febrinasari
Proceeding of International Conference on Science, Health, And Technology 2021: Proceeding of the 2nd International Conference Health, Science And Technology (ICOHETECH)
Publisher : LPPM Universitas Duta Bangsa Surakarta

Antioxidants are the properties of active compounds that can prevent the formation or binding of free radicals and other molecules and inhibit oxidation reactions. Secang wood (Caesalpinia sappan L.) and Gotu kola (Centella asiatica L.) are plants that contain lots of phytochemical compounds used as traditional drinks such as steeping drinks to date. Combining several natural ingredients is believed to provide more benefits and a more effective dosage if used properly. This study aims to determine the antioxidant activity of the ethanol extract of secang wood and gotu kola and their combinations (1:1, 2:1, 1:2) based on the IC50 value with various concentrations and replication 3 times for each sample from the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay. Ascorbic acid was also used as a positive control for this assay. Secang wood and gotu kola were extracted using maceration method with 96% ethanol as solvent. The results showed that the IC50 antioxidant activity of 34.173 ppm of secang wood ethanol extract was more active (very strong) compared to 160.236 ppm of gotu kola extract (weak). The best combination of ethanol extract mixture of secang wood and gotu kola which resulted in the strongest activity among the three combinations was a 1:1 ratio of 59.431 ppm (strong).

The Effectiveness of Red Guava Juice (Psidium guajava L.) and Crystal Guava Juice (Psidium guajava L. “Crystal”) on Physical Fitness of Female Adolescents with Anemia: EFEKTIFITAS JUS JAMBU BIJI MERAH (Psidium guajava L.) DAN JUS JAMBU KRISTAL (Psidium guajava L.“Chrystal”) TERHADAP KEBUGARAN JASMANI REMAJA PUTRI ANEMIA Devi Ratna Mayasari; Yulia Sari; Ratih Puspita Febrinasari
Media Gizi Indonesia Vol. 18 No. 2 (2023): MEDIA GIZI INDONESIA (NATIONAL NUTRITION JOURNAL)
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mgi.v18i2.123-131

Anemia often occurs in female adolescents cause by iron deficiency. Adolescents are diagnosed anemia if the hemoglobin level is <12 g/dl. Someone who has anemia is prone to have low physical fitness. Consumption of foods that are high in iron and vitamin C such as guava juice can help improve physical fitness. The aim of this study was to analyze the effect of red guava juice and crystal guava juice consumption on physical fitness in female adolescents with anemia. The design of this study was a quasi-experimental with pre and post-test control group design with 36 subjects divided into 3 groups, namely control (iron tablets), P1 (iron tablets + red guava juice), P2 (iron tablets + crystal guava juice). Red guava juice and crystal guava juice given 200 ml per day for 30 days. The physical fitness test uses the Harvard Step Test method with a Physical Efficiency Index assessment. Physical fitness before and after control group had a difference of 1.84±15.86, the difference in P1 group was 17.20±20.35, and the difference in P2 group was of 19.69±15.58. Based on the results of statistical tests, it was found that there were differences in the three groups before and after the intervention p=0.031 (p<0.05). Giving red guava juice and crystal guava juice can be an alternative to improve physical fitness in female adolescents with anemia, but crystal guava juice is the most effective in increasing physical fitness in female adolescents with anemia.

A Scoping Review: Catechin-Rich Gambir as A Potential Functional for the Obesity Management Meintansari Manik; Setyo Sri Rahardjo; Ratih Puspita Febrinasari
Proceedings of the International Conference on Nursing and Health Sciences Vol 4 No 1 (2023): January-June 2023
Publisher : Global Health Science Group

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/picnhs.v4i1.1815

Obesity is a complex and severe problem whose prevalence has increased significantly in the last few decades, posing a significant risk to human health. Various weight loss strategies are currently used, and different weight loss supplements are widely available. However, the effectiveness of some of these food supplements is still unknown. Thus, alternative therapy with a pharmaconutrition macronutrient approach is needed. A scoping review is necessary to scope the current article, summarize the scientific data, and guide future investigation into the potential use of catechin-rich gambir for obesity management. Results: Four databases were searched systematically. The scoping review covered articles published after 2013. A total of 251 articles were collected, and five studies (2 experimental studies) met the inclusion criteria. The synthesis results show that catechin-rich gambir has the potential a function in obesity management therapy. This mechanism, through the anti-obesity effect of catechins, is related to the uptake and synthesis of adipose tissue in obese individuals. Conclusions: Available evidence recommends that the catechin content in gambir has the potential for pharmaconutrition therapy for obesity management.

Effectiveness of Pumpkin Extract (Cucurbita moschata) Lowering Blood Glucose and Malondialdehyde Levels in Diabetic Model Rats Ma'rifatul Khoiriyah Ayda; Muthmainah Muthmainah; Ratih Puspita Febrinasari
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 7, No 4: December 2022
Publisher : Universitas Aisyah Pringsewu

Hyperglycemia in uncontrolled diabetes mellitus (DM) can cause oxidative stress, among others, characterized by high levels of malondialdehyde (MDA). This situation continues to cause various complications. Pumpkin (Cucurbita moschata) is known to contain various antioxidants that can reduce blood glucose levels and oxidative stress levels in DM. This study aims to prove the effectiveness of pumpkin in the form of an extract to reduce fasting blood glucose (FBG)and MDA levels in DM rats. The study used 36 male Wistar rats which were divided into 6 groups, namely:KN:normal group;K(-):DM group;K(+):DM group was given glibenclamide 0.45 mg/kgBW/day;P1,P2,P3:DM group which was given the extract with a successive dose of 0.66mg/kgBW/day,1.32mg/200gBW/day,and 2.64mg/200gBW/day.The extract was administered for 21 consecutive days. The DM model was made by induction of streptozotocin (STZ) and nicotinamide (NA). FBG and MDA levels were measured serially 5 times and analyzed statistically. The results showed that the higher the dose of the extract and the longer the administration of the extract, the more effective the extract's ability to reduce blood FBG and MDA levels. Compared to glibenclamide, pumpkin extract was no less effective in reducing blood FBG and MDA levels. It was concluded that pumpkin extract was effective in lowering blood glucose and MDA levels in DM rats. Abstrak: Hiperglikemia pada diabetes melitus (DM) yang tidak terkontrol dapat menyebabkan stres oksidatif antara lain ditandai dengan tingginya kadar malondialdehid (MDA). Keadaan ini terus menimbulkan berbagai komplikasi. Labu kuning (Cucurbita moschata) diketahui mengandung berbagai antioksidan yang dapat menurunkan kadar glukosa darah dan tingkat stres oksidatif pada DM. Penelitian ini bertujuan untuk membuktikan efektivitas labu kuning dalam bentuk ekstrak untuk menurunkan kadar glukosa darah puasa (GDP) dan MDA pada tikus DM. Penelitian menggunakan 36 ekor tikus Wistar jantan yang dibagi menjadi 6 kelompok, yaitu: KN: kelompok normal; K(-): grup DM; K(+): Kelompok DM diberikan glibenklamid 0,45 mg/kgBB/hari; P1, P2, P3 : Kelompok DM yang diberi ekstrak dengan dosis berturut-turut 0.66mg/kgBB/hari, 1.32mg/200gBB/hari dan 2.64mg/200gBB/hari. Ekstrak diberikan selama 21 hari berturut-turut. Model DM dibuat dengan induksi streptozotocin (STZ) dan nicotinamide (NA). Tingkat GDP dan MDA diukur secara serial sebanyak 5 kali dan dianalisis secara statistik. Hasil penelitian menunjukkan bahwa semakin tinggi dosis ekstrak dan semakin lama pemberian ekstrak, semakin efektif kemampuan ekstrak dalam menurunkan kadar GDP dan MDA darah. Dibandingkan dengan glibenclamide, ekstrak labu tidak kalah efektif dalam menurunkan kadar GDP dan MDA darah. Disimpulkan bahwa ekstrak labu kuning efektif menurunkan kadar glukosa darah dan MDA pada tikus DM.

The relationship of vitamin A, C, and E intake with premature aging of facial skin in female market traders Chintya Wulandarie; Sumardiyono Sumardiyono; Ratih Puspita Febrinasari
World Nutrition Journal Vol. 7 No. 01 (2023): Volume 07 Issue 1, August 2023
Publisher : Indonesian Nutrition Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25220/10.25220/WNJ.V07.i1.0007

Background: Women's market traders are jobs that are often exposed to free radicals, including air pollution, cigarette smoke, sun exposure and have a high workload that causes stress. Antioxidants can protect the skin from free radicals and can inhibit the process of premature aging of facial skin which are found in vegetables and fruits such as vitamins A, C, E. Objective: To determine the relationship between intake of vitamins A, C, and E with premature aging of market traders in the form of wrinkles around the face. Methods: Observational research with cross sectional method. The sampling technique is multi-stage cluster sampling. This research was conducted at Beringharjo Market with a total sample of 172 respondents with inclusion criteria namely female traders, aged 26â€“45 years, workers in the market area. The exclusion criteria are tourists/market visitors, women who are pregnant and breastfeeding. The research variables for intake of vitamins A, C, and E used the SQ-FFQ (Semi-Quantitative Food Frequency Questionnaire) questionnaire with the interview method. In measuring the number of wrinkles on facial skin using photoaging through facial shooting using a Sony A7R3 camera with a 24-70 lens that is analyzed by a dermatologist (skin expert). Data analysis technique using multiple logistic regression analysis. This analysis uses SPSS software version 22.0. Results: In the multiple logistic regression test, p = 0.037 (p <0.05) means that there is a relationship between vitamin A intake and premature aging of facial skin. On vitamin C intake, p = 0.436 (p> 0.05), meaning that there is no relationship between vitamin C intake and premature aging of facial skin. And on vitamin E intake, p = 0.171 (p> 0.05) there is no relationship between vitamin E intake and premature aging of facial skin. Conclusion: Intake of vitamin A has a significant relationship with the occurrence of premature aging of the face, but vitamins C and E do not have a significant relationship with the occurrence of premature aging of the facial skin

EFEKTIVITAS KUERSETIN DARI EKSTRAK APEL LOKAL TERHADAP BERAT BADAN DAN GLUKOSA DARAH PUASA TIKUS MODEL DIABETES Nila Authoria Authoria; Lilik Wijayanti Wijayanti; Ratih Puspita Febrinasari
GIZI INDONESIA Vol 46 No 2 (2023): September 2023
Publisher : PERSATUAN AHLI GIZI INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36457/gizindo.v46i2.847

Diabetes mellitus is a metabolic disease characterized by an increase in blood glucose levels due to insulin resistance by pancreatic β cells. Local apple plants can be used as a therapy for diabetes mellitus due to their content of quercetin which can control the increase in blood glucose levels. This study aims to determine the effectiveness of local apple extract of Romebeauty and Manalagi types to changes in body weight and fasting blood glucose levels in type 2 diabetes mellitus rats. This experimental study used pre and post-tests with a control group design involving 25 Wistar rats with diabetes mellitus model by injection STZ-NA. They were divided into 5 groups: negative control (KN), positive control with glibenclamide 0.09 mg/kg BW (KP), and the treatment group with local apple extract of Romebeauty and Manalagi at a dose of 90 mg/kg BW with 32,5 mg/g quercetin (P1), 180 mg/kg BW with 65 mg/g quercetin (P2), and 270 mg/kg BW with 97,5 mg/g quercetin (P3). The rats were weighed 4 times and fasting blood glucose levels were measured before and after the intervention. The results showed that there was a significant difference in body weight in all treatment groups after 14 days of intervention (p=0.003). Besides, there were significant differences in fasting blood glucose levels before and after the intervention in the KP (p=0.043), P1 (p=0.001), and P3 (p=0.005). Thus, it can be concluded that local apple extract affects changes in blood glucose levels and body weight of the diabetes mellitus rat model.ABSTRAK Diabetes melitus adalah penyakit metabolik ditandai dengan peningkatan kadar glukosa darah akibat resistensi insulin oleh sel β pankreas. Tumbuhan apel lokal sebagai tanaman komoditi holtikultura mampu dijadikan sebagai terapi untuk diabetes melitus karena mempunyai kandungan kuersetin yang mampu mengontrol kenaikan kadar glukosa darah. Tujuan penelitian ini untuk mempelajari efektivitas pemberian ekstrak apel lokal jenis romebeauty dan manalagi terhadap perubahan berat badan dan kadar glukosa darah puasa tikus model diabetes melitus tipe 2. Penelitian ini adalah eksperimental pre and post test with control group design menggunakan 25 tikus wistar model diabetes mellitus dengan injeksi STZ-NA dibagi menjadi 5 kelompok yaitu kontrol negative (KN), kontrol positif dengan glibenklamide 0,09 mg/kgBB (KP), dan kelompok perlakuan diberikan ekstrak apel lokal jenis romebeauty dan manalagi dosis 90 mg/ kgBB mengandung 32,5 mg/g kuersetin (P1), 180 mg/ kgBB mengandung 65 mg/g kuersetin (P2) dan 270 mg/ kgBB mengandung 97,5 mg/g kuersetin (P3). Selama penelitian berlangsung, tikus dilakukan penimbangan sebanyak 4 kali serta dilakukan pengukuran kadar glukosa darah puasa sebelum dan sesudah intervensi . Hasil menunjukkan bahwa terjadi perbedaan berat badan tikus yang signifikan pada semua kelompok perlakuan setelah 14 hari diberikan intervensi (p=0,003). Terdapat perbedaan signifikan kadar glukosa darah puasa sebelum dan sesudah intervensi pada kelompok KP (p=0,043), P1 p=(0,001), dan P3 (p=0,005). Kesimpulan penelitian ini adalah terdapat pengaruh pemberian ekstrak apel lokal terhadap perubahan kadar glukosa darah dan berat badan tikus model diabetes melitus.Keywords: ekstrak apel lokal, kadar glukosa darah, berat badan, diabetes melitus

Co-Authors . Suyatmi . Suyatmi . Widardo ., Hudiyono ., Muthmainah ., Suyatmi A.A. Ketut Agung Cahyawan W Adi Magna Patriadi Nuhriawangsa AGYA GHILMAN FAZA Ahmad Ahid Mudayana Ahmad Ahid Mudayana Akhmad Azmiardi Alfi Yasmina Ali, Agni Shalha Amer Abdulwahab Al-aghbari, Nuha Amira, Nadya Kemala Anggraeni, Selvia Anis Nurhidayati Anshari, Shafira Yasmine Argyo Demartoto, Argyo Ari Natalia Probandari Ari Probandari Arsita Eka Prasetyawati Arsita Eka Prasetyawati Asaduddin, Aiman Hilmi Asih Anggraini Asih Anggraini Astrida Fesky Febrianty Astrika Yunita, Fresthy Bachnas, Muhammad Adrianes Berlian Permata Sakti Bhisma Murti Binti Maulina Binti Maulina Putri Brian Wasita Brian Wasita Brian Wasita Bustami, Mursyid Chintya Wulandarie Colti Sistiarani Colti Sistiarani Dara, Rizki Wulan Dedi Febriandaru Devi Ratna Mayasari DIAN LESTARI Didik Gunawan Tamtomo Dilma’aarij, Dilma’aarij Dyonisa Nasirochmi Pakha Endang Listyaningsih Suparyanti Erna Kristin Ernawati, Dwi Arini Eti Poncorini Pamungkasari Fairuz Zamani FAZA, AGYA GHILMAN Hamka, Dwi Wulandari Aaas Hanif Mustikasari Harioputro, Dhani Redhono Hariyanti, Lusiana Pradana Hartono Hartono Haruni, Diah Sekar Heni Hastuti Hudiyono . Hutami Sri Ummiyati Ida Nurwati Ignatius Gonggo Prihatmono Imanisa, Octavia Intan Indarta, Ardhia Fefrine Irma Prasetyowati iwan Dwiprahasto Kenneth Tan Khoiriyah, A'maliatul Kisrini . Komang Windayani Kristiani, Shinta Laksmi Wardhani, Tri Martya Ningrum Leli Saptawati Lilik Wijayanti Lilik Wijayanti Lilik Wijayanti Wijayanti Lisyawati, Shanti Lukman Aryoseto Ma'rifatul Khoiriyah Ayda Maryati, Warsi Mashuri, Yusuf Ari Meintansari Manik MIFTAKHUL JANNAH Mochammad Fairuz Zahran Muchsin Doewes Mustara, Mustara Mustiqa Febriniata MUTHMAINAH . Muthmainah Muthmainah Nadya Kemala Amira Nafi'ah, Radifatun Naila Shofwati Putri Nanang Wiyono Nila Authoria Authoria Nita Dwi Astikasari Novelia Qothrunnada Novika, Revi Gama Hatta Nur Hafidha Hikmayani Nur Hafidha Hikmayani Nur Hasanah, Laras Eka Nur Hidayah Nurholis Majid Oktaviani oktaviani Paramasari Dirgahayu Paramasari Dirgahayu Poncorini Pamungkasari, Eti Prabowo, Nurhasan Agung Primaningtyas, Widana Putri, Desy Puspa Putri, Naila Shofwati Rahardjo, Setyo Sri Rio Nanda Pratama Rio Nanda Pratama Riris Arizka Wahyu Kumala Riris Arizka Wahyu Kumala, Riris Arizka Wahyu Rizaldy Pinzon RR. Ella Evrita Hestiandari Sakti, Berlian Permata Saptawati, Leli Satwika, Ariq Ratya Selvia Anggraeni Setyani, Rizka Ayu Setyani, Rizka Ayu Setyo Sri Rahardjo Setyo Sri Rahardjo Shinta Retno Wulandari Shinta Shinta Siswahyudianto Siti Fatimah R Solikah, Tri Agusti Sopianti, Densi Selpia Sri Darnoto Sri Mulyani Sri Mulyani Sugiarto Sumandjar, Tatar Sumardiyono Sumardiyono Sumardiyono Sumardiyono Suparyanti, Endang Listyaningsih Suparyanti, Endang Listyaningsih Susanto, Agnes Suyatmi . Syamsiar, Syamsiar Tri Agusti Sholikah Ummiyati, Hutami Sri Veronika Ika Budiastuti Vitri Widyaningsih Vitri Widyaningsih Wahyu Anjas Sari Wasita, Brian Widardo . Windayani, Komang Wiyono, Nanang Wulandari, Shinta Retno Yanuarini, Triatmi Andri Yulia Lanti Retno Dewi Yulia Sari

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