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HUBUNGAN ANEMIA DAN TRANSFUSI DARAH TERHADAP RESPONS KEMORADIASI PADA KARSINOMA SERVIKS UTERI STADIUM IIB - IIIB Saiful Hadi; Mirza Iskandar
Medica Hospitalia : Journal of Clinical Medicine Vol. 1 No. 1 (2012): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (238.837 KB) | DOI: 10.36408/mhjcm.v1i1.37

Abstract

Pendahuluan. Karsinoma serviks uteri (KSU) merupakan keganasan kedua terbanyak pada wanita di seluruh dunia. Radiasi dan kemoterapi yang diberikan secara bersama- sama akan memberikan efek supradiktif dalam membunuh sel kanker, tetapi dapat mengakibatkan berbagai efek antara lain anemia, leukopenia dan trombositopenia. Tujuan penelitian adalah untuk mengetahui efek toksisitas hematologi terhadap respon terapi kemoradiasi lengkap pada karsinoma serviks uteri stadium IIB - IIIB. Metode : Penelitian kohort prospektif dilakukan di bangsal Obstetri Ginekologi RSUP Dr. Kariadi pada bulan Agustus 2010-Januari 2011. Kriteria inklusi adalah pasien KSU stadium IIB - IIIB yang mendapatkan terapi kemoradiasi. Pemeriksaan laboratorium dilakukan setiap 5 kali radiasi sebelum brakhiterapi. Respons terapi dievaluasi selama 3 bulan setelah kemoradiasi. Hasil : Selama 6 bulan didapatkan 60 pasien, 74,19% dengan gambaran histologi sel skuamosa dan 75,81% stadium III B.. Toksisitas hematologi yaitu anemia terjadi pada 45,97% orang, leukopenia 32,27% dan trombositopenia 13,70%. Transfusi darah diberikan pada 52 (86,67%) orang, 44 orang (73,33%) satu macam dan 8 orang (26,67%) mendapatkan 2 macam transfusi darah. Respon komplit / remisi terjadi pada 26 orang (43,3%). Anemia tidak berhubungan dengan respon komplit, baik anemia sebelum kemoradiasi (OR 2,38 ; 95% CI 0,71-8,15; p=0,116) maupun anemia selama kemoradiasi (OR 2,63 ; 95% CI 0,63-11,66; p=0,136). Kesimpulan : Transfusi darah mampu mengatasi toksisitas hematologi selama terapi kemoradiasi. Anemia tidak berhubungan dengan respon komplit kemoradiasi. Kata kunci : Karsinoma serviks uteri, toksisitas hematologi, transfusi darah
ANALISIS BIAYA PEREMAJAAN PERKEBUNAN KELAPA SAWIT PLASMA POLA PIR-BUN DI KECAMATAN KOTO GASIB KABUPATEN SIAK Romadani Siregar; Saiful Hadi; Sakti Hutabarat
Jurnal Online Mahasiswa (JOM) Bidang Pertanian Vol 8 (2021): Edisi 2 Juli s/d Desember 2021
Publisher : Jurnal Online Mahasiswa (JOM) Bidang Pertanian

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Abstract

This study aims to calculate the cost of replanting oil palm plants. This research was conducted in KeranjiGuguh Village and TasikSeminai Village, Koto GasibSubdistrict, Siak Regency, Riau Province, the selection of this location was based on the consideration that in these two villages the majority of the population cultivated oil palm plantations with an average plant age of 39 years. Respondents in this study were oil palm planters in KeranjiGuguh Village and TasikSeminai Village, the sampling technique used the Simple Random Sampling method, the number of samples taken was 10 farmers and 7 experts from each village. The analysis used in this research is descriptive analysis. The results of the study explain that the total cost of P0-P3 is Rp. 52,960,661/ha. While the size of the loan provided by Bank Mandiri is Rp. 87,700,000. If the land for replanting is 2 ha for each farmer, then the total cost required is Rp. 105,921,322 and the planters still have to find a lack of funds of Rp. 18,221,322. The use of the highest cost is in the activity of planting oil palm seeds, which is Rp. 7,318,500/ha and the lowest cost is for land preparation activities, which is Rp. 88,331/haKeywords: Rejuvenation, Palm Oil, Rejuvenation Cost