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Arinta Puspita Wati
Departement Of Neurology, Faculty Of Medicine, Universitas Diponegoro Semarang Indonesia
Dentistry Health Professions Medicine & Pharmacology Nursing Public Health

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Asosiasi Varian Genetik Angiotensin Converting Enzyme ( ACE ) Terhadap Karakteristik Faktor Risiko Pada Penderita Stroke Iskemik di Rumah Sakit Umum Pusat Dr. Kariadi Semarang Dodik Tugasworo Pramukarso; Herlina Suryawati; Soetedjo Soetedjo; Jimmy Eko Budi Hartono; Trianggoro Budisulistyo; Arinta Puspita Wati; Aditya Kurnianto; Patria Adri Wibhawa
Medica Hospitalia : Journal of Clinical Medicine Vol. 8 No. 3 (2021): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (347.542 KB) | DOI: 10.36408/mhjcm.v8i3.565

Abstract

BACKGROUND : Stroke is the leading cause of death and disability in the world. The occurrence of ischemic stroke is indicated by genetic factors, environmental factors and the interaction between it. Angiotensin Converting Enzyme (ACE) genetic variant is associated with various characteristics of risk factors for ischemic stroke. OBJECTIVE : Identifying genetic variants of Angiotensin Converting Enzyme (ACE) with the Polymerase Chain Reaction (PCR) method and to find it’s correlation beetwen risk factor in patients with Ischemic Stroke at Dr. Kariadi Semarang METHOD : The subjects of the study were 72 patients with ishcemic stroke who were treated at the polyclinic of the Neurology Department Dr. Kariadi Semarang in January - December 2013. DNA extraction of research subjects was carried out at the Laboratory of the Center of Biomedical Research (CEBIOR), Faculty of Medicine, Diponegoro University from January to March 2020. Amplification using the Polymerase Chain Reaction (PCR) method was carried out using an Eppendorf thermocycler. Data were analyzed with SPSS for Windows Version 25 RESULT : 72 samples analyzed obtained genetic variants of ACE II 39 (54.2%) samples, genetic variants of ACE DI 30 samples (41.7%), and genetic variants of ACE DD 3 (4.2%) samples. Meanwhile, there was no significant relationship ( p>0,05 ) between genetic variants of ACE and the characteristics of risk factors for ischemic stroke, namely age, gender, Body Mass Index, smoking history, triglyceride levels, HDL levels, LDL levels, obesity and hypertension. CONCLUSION : There are three types of ACE genetic variants, including the ACE II genetic variant, the ACE DI genetic variant, and the ACE DD genetic variant. Among the three genetic variants, ACE II genetic variant is the most common variant and there is no significant relationship to the various risk factor characteristics found in ischemic stroke patients at Dr. Kariadi Gneeral Hospital Semarang.
The Effect of High Intensity Interval Training (HIIT) on Reaction Time Study Among Medical Student in Semarang Chikita Dian Rahma Saphira; Sumardi Widodo; Arinta Puspita Wati; Tanjung Ayu Sumekar
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 3 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i3.29283

Abstract

Background: Reaction time is a cognitive-motoric connection that is important in making quick decisions. Due to the lack of time, medical student has low physical activity.  High Intensity Interval Training (HIIT) is a strong and intense exercise interspersed with low intensity exercise that does not require much time. It has been known that can improve cognitive function.Objective: To determine the effect of HIIT on an individual’s reaction time.Methods: Quasi-experimental research with pre-test and post-test groups design. The research subjects were 29 medical students of Diponegoro University, woman, normal IMT, 18-22 ages, has no neurologic deficit. The control group instructed not to do any physical exercises (n=15) and the experimental group was given an intervention of HIIT exercises that consists of warm-up, core, and cool-down movements for 6 weeks (n=14). Reaction time scores before and after were measured using the Attention Network Test (ANT). The significance of the data was analyzed using the paired sample t-test the independent sample t-test.Results: A significant decrease in reaction time scores (p=0,007) in both the experimental and control groups. A significant difference in reaction time scores (p=0.007) between the experimental group before and after the intervention was 592,07±74,82 to 517,21±56,77 milisecond. A significant difference in reaction time scores (p=0.024) between the control group before and after the intervention was 611,73±78,93 to 574,06±47,06 milisecond.Conclusion: HIIT for 6 weeks has been proved to reduce reaction time scores.  Keywords: High Intensity Interval Training, Physical Exercise, Reaction Time, Attention Network Test.
EFFECT OF LEMON AROMATHERAPY ON THE ANXIETY LEVEL OF DENTAL EXTRACTION PATIENTS IN RSND SEMARANG Hayuratri Purwalalita Laksmidevi; Devi Farida Utami; Arinta Puspita Wati; Maria Belladonna Rahmawati
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 5 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i5.30522

Abstract

Background: Dental treatment that is often done is the tooth extraction procedure. The treatment and the use of sharp instruments such as syringes, pliers, bein during extraction can cause anxiety. Anxiety will be responded by several changes in the body such as the increasing of MAP, pulse rate, and respiratory rate. Handling anxiety can be done with aromatherapy, one is lemon aromatherapy.Aim: To determine the effect of lemon aromatherapy on anxiety levels and the correlation of anxiety levels with the results of MAP, pulse rate, and respiratory rate in tooth extraction patients at RSND SemarangMethod: Experimental study with pretest and posttest control group design with sampling simple random to get 40 respondents that indicated as extraction teeth patient. Respondents were divided into 2 groups: 20 control respondents and 20 intervention respondents. Anxiety level was measured by the Modified Dental Anxiety Scale (MDAS) questionnaire. Data that was not distributed normally were the difference in pulse rate and the difference in respiratory rate, while the results of the homogeneity test obtained data that were not homogeneous were the difference between the MDAS questionnaire and the difference in the MAP. The rest of the mentioned data above were all distributed normally and homogeneous. Analysis of differences in anxiety levels between before and after lemon aromatherapy was given using paired t-test, analysis of differences in anxiety levels between the control group and the intervention group using the independent t-test, and to analyzing the correlation of anxiety levels with the results of MAP, pulse rate, and respiratory rate using the Spearman test..Results: There was a significant difference in anxiety scale between before and after lemon aromatherapy was given p = 0,000135 (p <0.05) and between the control group and the intervention group p = 0.000002 (p <0.05). There was a positive correlation between anxiety levels with the results of MAP, pulse rate, and respiratory rate.Conclusion: Anxiety of tooth extraction patients shows a decreased after inhaling lemon aromatherapy. When someone is anxiety, there will be an increase in MAP, pulse rate, and respiratory rate.Keywords: Anxiety, tooth extraction, lemon aromatherapy, MAP, pulse rate, respiratory rate.
The Correlation between Mean Aterial Pressure and Bleeding Volume with The National Institute of Health Stroke Scale (NIHSS) Score for Intracerebral Hemmorhage Patients Shonia Syvafiftyan Rosaline; Hermina Sukmaningtyas; Arinta Puspita Wati; Sukma Imawati
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 3 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i3.29315

Abstract

Introduction: Intracerebral hemorrhage refers to primary, spontaneous, and non-traumatic bleeding that occurs in the brain parenchyma. Intracerebral hemorrhage accounts for approximately 10-20% of all stroke. The most common risk factor for non-traumatic hemorrhagic stroke is hypertension. The increase in Mean Arterial Pressure leads to the incidence of intracerebral hemmorhage. The NIHSS is a systematic assessment tool that quantitatively measures stroke associated with neurologic deficits. Neurological deficits that occur in intracerebral hemorrhage occur because blood enters the brain parenchyma. The incoming blood was measured by the Automatic Volume Method (software volume evaluation), namely the calculation of volume by computer software on the CT Scan tool.Aim: To determine the correlation between Mean Arterial Pressure and bleeding volume with NIHSS score in intracerebral hemorrhage patients.Methods: The research design used in this study was cross sectional. The sample of this study was 40 research subjects using purposive sampling, this study has independent variables, namely Mean Arterial Pressure and bleeding volume, while the dependent variable is the NIHSS score (National Institute of Health Stroke Scale). This study conducted an analysis using Spearman's.Results: : The results of this study indicate that there is no significant relationship between bleeding volume and NIHSS score (p = 0,157, r = 0,228) and there is no significant relationship between MAP and NIHSS score (p = 0,268, r = -0,179)Conclusion: There is no statistically significant relationship between Mean Arterial Pressure and bleeding volume with the NIHSS scoreKeywords: Mean Arterial Pressure, Bleeding Volume, National Institute of Health Stroke Scale, Intracerebral Hemorrhage
THE CORRELATION OF LONG-TERM COMBINATION TREATMENT OF VALPROIC ACID AND TOPIRAMATE ON SERUM VITAMIN D LEVELS AMONG CHILDREN WITH EPILEPSY Hexanto Muhartomo; M.I Widiastuti; Endang Kustiowati; Aris Catur Bintoro; Arinta Puspita Wati; Alifiani Hikmah Putranti; Rony Parlindungan Sinaga
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 11, No 1 (2022): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v11i1.32563

Abstract

Background: Epilepsy is a chronic condition characterized by unprovoked seizure. Vitamin D is necessary in child development process and is strongly influenced by the presence of anti-epileptic drugs.Objective: To determine the correlation of treatment duration and serum vitamin D levels in children with epilepsy who use the combination of valproic acid and topiramateMethods: A cross sectional study among forty pediatric patients with epilepsy with age range of 5-10 years at Dr. Kariadi Hospital Semarang. Examination of serum vitamin D levels is done by ELISA. Statistical analysis using Spearman correlation test and partial correlation test with significance level p = 0.05.Results: The mean of serum vitamin D levels in patient with combination treatment after 24 months was 21.87±1.21ng/ml, in those who still having seizure was 27.94±2.40ng/ml, and among who received delayed therapy was 23.23±2.07ng/ml. Bivariate analysis depicted that there was negative correlation between duration of treatment (rho= -0.850, p<0.001), onset of therapy (rho=0.604, p<0.001) and seizure frequency (rho=0.559, p<0.001) with serum vitamin D levels. Partial correlation analysis showed a significant correlation between duration of treatment and serum vitamin D levels after adjusted by onset of therapy (rho=-0.839, p<0.001) and seizure frequency (rho=-0.856, p<0.001).Conclusion: There is a correlation between the duration of treatment and serum vitamin D levels among children with epilepsy
THE CORRELATION BETWEEN MEAN ATERIAL PRESSURE AND BLEEDING VOLUME WITH THE NATIONAL INSTITUTE OF HEALTH STROKE SCALE (NIHSS) SCORE FOR INTRACEREBRAL HEMORRHAGE PATIENTS Shonia Syvafiftyan Rosaline; Hermina Sukmaningtyas; Arinta Puspita Wati; Sukma Imawati
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 4 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i4.30061

Abstract

ABSTRACT Introduction: Intracerebral hemorrhage refers to primary, spontaneous, and non- traumatic bleeding that occurs in the brain parenchyma. Intracerebral hemorrhage accounts for approximately 10-20% of all stroke. The most common risk factor for non-traumatic hemorrhagic stroke is hypertension. The increase in Mean Arterial Pressure leads to the incidence of intracerebral hemmorhage. The NIHSS is a systematic assessment tool that quantitatively measures stroke associated with neurologic deficits. Neurological deficits that occur in intracerebral hemorrhage occur because blood enters the brain parenchyma. The incoming blood was measured by the Automatic Volume Method (software volume evaluation), namely the calculation of volume by computer software on the CT Scan tool.Aim: To determine the correlation between Mean Arterial Pressure and bleeding volume with NIHSS score in intracerebral hemorrhage patients.Methods: The research design used in this study was cross sectional. The sample of this study was 40 research subjects using purposive sampling, this study has independent variables, namely Mean Arterial Pressure and bleeding volume, while the dependent variable is the NIHSS score (National Institute of Health Stroke Scale). This study conducted an analysis using Spearman's.Results: : The results of this study indicate that there is no significant relationship between bleeding volume and NIHSS score (p = 0,157, r = 0,228) and there is no significant relationship between MAP and NIHSS score (p = 0,268, r = -0,179)Conclusion: There is no statistically significant relationship between Mean Arterial Pressure and bleeding volume with the NIHSS scoreKeywords: Mean Arterial Pressure, Bleeding Volume, National Institute of Health Stroke Scale, Intracerebral Hemorrhage
Relationship Between Frequency Of Tension Type Headache (TTH) In Epilepsy With Cognitive Function Diah Patlika; Herlina Suryawati; M.I. Widiastuti; Endang Kustiowati; Hexanto Muhartomo; Arinta Puspita Wati
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 11, No 2 (2022): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v11i2.32620

Abstract

Background : Epilepsy is a chronic disease that increases the risk of interictal headaches, one of which is tension type headache (TTH). TTH in epilepsy is triggered by recurrent neurogenic inflammation and central sensitization leading to pericranial tenderness. Recurrent neurogenic inflammation can affect cognitive function. The frequency of TTH in epilepsy is thought to be related to cognitive function score.Objective : Analyzing the relationship between the category of TTH frequency, onset of epilepsy, seizure frequency, age and education with cognitive score.Methods : Our study is an analytic observational study with a cross sectional design that took place from April to September 2021. The subjects of the study were epilepsy patients suffering from TTH at Dr. Kariadi Hospital, Semarang who met the inclusion and exclusion criteria. Patients’s data was obtained by filling out a questionnaire form. Assessment of the category of TTH frequency used ICHD-3 beta 2013 criteria. Assessment of cognitive function used the MoCA-Ina score. Data was analyze with Spearman correlation test, the results were significant if the p value <0.05.Results : Forty one epilepsy patients consist of 14 infrequent episodic TTH, 14 frequent episodic TTH and 13 chronic TTH. There was significant relationship between the MoCA-Ina score and the TTH frequency category (r=0,362; p=0,02), and education level (r=0,493; p=0,001). There was a weak relationship between the MoCA-Ina score and the onset of epilepsy or seizure frequency, while there was no relationship with age.Conclusion : There was a moderate relationship between the TTH frequency in epilepsy with cognitive function. Keywords : epilepsy, tension type headache (TTH), Montreal Cognitive Assesment -  Indonesian version (MoCA-Ina)
Correlation between Interleukin 10 Serum Levels and Severity of Peripheral Neuropathy in Multibacillary Leprosy Patients a Research Article Fajar Sekti Reliyana; Hexanto Muhartomo; Endang Kustiowati; Yosep Ferdinand Rahmat Sugiyanto; Retnaningsih Retnaningsih; Arinta Puspita Wati; Rahmi Ardhini; Aditya Kurnianto
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 11, No 2 (2022): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v11i2.32648

Abstract

ABSTRACT  Background of the ResearchLeprosy is a chronic infectious peripheral neuropathy caused by Mycobacterium leprae. Clinical presentations of leprosy neuropathy are obtained when the nerve damage is more than 30% of peripheral nerve fibers. The anti-inflammatory property of interleukin 10 is supposed to protect tissue from the damage caused by proinflammatory cytokines. Instead, it causes extensive nerve damage due to suppression of the cellular immune system, failure of forming granuloma to limit the growth of Mycobacterium leprae. As a result, it multiplies and spreads. Purpose of the ResearchThe purpose of the research is to analyze the correlation between interleukin levels 10 serum and the severity of peripheral neuropathy. Methods of the ResearchThe method used is cross-sectional research on 30 subjects with multibacillary leprosy aged 18-65 at the Neurology Department of Kelet Hospital Jepara from September to October 2021. The questionnaire was used to collect data of the patients. Interleukin level 10 serum evaluation is assessed by examining blood serum. Data analysis used Spearman Correlation Test. The significant result occurs if it is p<0.05. Research resultPatients with multibacillary leprosy are mostly men (73.3%). There is also a strong significant correlation between interleukin 10 levels and the severity of peripheral neuropathy (p<0.001) with rho (0.7) ConclusionThere is a strong and significant correlation between serum interleukin 10 levels and the severity of peripheral neuropathy in multibacillary leprosy Keywords: multibacillary leprosy, interleukin 10, peripheral neuropathy
KNOWLEDGE OF GENERAL DOCTORS OF PRIMARY HEALTH SERVICE FACILITIES IN SEMARANG CITY ABOUT DEMENTIA IN SEMARANG CITY Arinta Puspita Wati; Hexanto Muhartomo; Fatiha Sri Utami Tamad; Retna Putri
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 11, No 4 (2022): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v11i3.33250

Abstract

Background. Dementia is a syndrome due to brain disease, usually chronic or progressive and there is a disturbance of sublime function. Lack of knowledge and awareness of health workers about the occurrence of dementia can worsen dementia due to delays in diagnosis and treatment. Method. This study is a descriptive study with a cross sectional design involving 66 respondents who have agreed to the informed consent and are general practitioners who work in Primary Health Care Facilities. Sampling using consecutive sampling technique, samples that meet the inclusion and exclusion criteria. Data collection was carried out in November 2021. Data analysis used SPSS 22.0 ver. Results. The average knowledge of respondents before the training was described from the pretest score of 5.2. Conclusion. Lack of knowledge about dementia in general practitioners who work in primary health care facilities in the Semarang.
Co-Authors Aditya Kurnianto Aditya Kurnianto Alifiani Hikmah Putranti Aris Catur Bintoro Chikita Dian Rahma Saphira Devi Farida Utami Diah Patlika Dodik Tugasworo Pramukarso Endang Kustiowati Endang Kustiowati Endang Kustiowati Fajar Sekti Reliyana Fatiha Sri Utami Tamad Hayuratri Purwalalita Laksmidevi Herlina Suryawati Herlina Suryawati Hermina Sukmaningtyas Hexanto Muhartomo Jimmy Eko Budi Hartono M.I Widiastuti M.I. Widiastuti Maria Belladonna Rahmawati Patria Adri Wibhawa Rahmi Ardhini Retna Putri Retnaningsih Retnaningsih Rony Parlindungan Sinaga Shonia Syvafiftyan Rosaline Shonia Syvafiftyan Rosaline Soetedjo Soetedjo Sukma Imawati Sumardi Widodo Tanjung Ayu Sumekar Trianggoro Budisulistyo Yosep Ferdinand Rahmat Sugiyanto