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Sahna Ferdinand Ginting
Universitas Prima Indonesia
Dentistry Health Professions Medicine & Pharmacology Nursing Public Health

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NARATIVE REVIEW: POTENSI INULIN UMBI DAHLIA SEBAGAI ANTI DIABETES Sunarti Sunarti; Chrismis Novalinda Ginting; Sahna Ferdinand Ginting
Jurnal Keperawatan Priority Vol. 5 No. 1 (2022)
Publisher : Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jukep.v5i1.2134

Abstract

Inulin is a type of polysaccharide that is commonly found in nature derived from the dahlia tuber plant, and other plants such as chicory, Jerusalem artichoke, Yaco´n potato and asparagus. Inulin is widely used in industry and pharmaceuticals. In the industrial world, inulin is used as a source of natural sweetener, enhances the taste of food, ferments, and is a low-fiber food source. While in the pharmaceutical world, inulin can be used in several studies, one of which is as an anti-diabetic. This study aims to determine the potential of dahlia tuber inulin as an anti-diabetic. The type of research is a narrative review. Search data using three databases, namely Elsevier (SCOPUS), Pubmed and Google Scholar with a limitation of the last 10 years of articles with the keyword "inulin for diabetes", with the PRISMA method. The results showed that inulin works on glucose absorption in the intestine, lowers blood sugar levels, lowers hemoglobin A1c, increases circulating GLP-1, reduces hyperglycemia, reduces insulin resistance (IR) and hyperlipidemia, reduces oxidative stress, increases insulin and leptin levels, facilitates glucose transport of GLUT4 by activating the PI3K/Akt pathway, is anti-inflammatory, and is involved in the expression of several anti-hyperglycemic genes. The conclusion is that dahlia tuber inulin has an anti-diabetic effect.
IGF-1 levels in Patients with Type 2 Diabetes Mellitus Thipani Angela; Chrismis Novalinda Ginting; Linda Chiuman; Sahna Ferdinand Ginting
Majalah Kedokteran Bandung Vol 53, No 2 (2021)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v53n2.2278

Abstract

Type 2 Diabetes Mellitus (Type 2 DM) is a metabolic disorder group with mechanisms that include hyperglycemia, insulin resistance and hyperinsulinemia. Type 2 DM has a close association with IGF-1, where the active form of the IGF-1 becomes elevated by reason of the fact that hyperinsulinemia inhibits the production of IGF-binding proteins (IGFBP) 1/IGFBP 2. The active form of IGF-1 has the ability to promote cell proliferation and inhibit apoptosis, hence becomes one of the risk factors for cancer cell growth. This was an analytical study conducted in August at the Harapan Bunda Clinic, Medan, Indonesia to determine the difference between the IGF-1 level and blood glucose level in type 2 DM patients in different age groups. Twenty subjects with Type 2 DM participated in this study and were divided based on their age into 35-50 years old or Group 1 and 51-65 year old group or Group 2. The IGF-1 levels in both groups were compared and analyzed using the T-test dependent method. Results showed that the IGF-1 and blood glucose levels were higher in Group 1 (35-50 years old) when compared to Group 2 and the difference was significant. The change in the IGF-1 level in diabetic patients cannot be determined only by the blood sugar level.
Co-Authors Chrismis Novalinda Ginting Linda Chiuman Sunarti Thipani Angela