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All Journal Majalah Kedokteran Bandung Damianus Journal of Medicine BIOLINK (Jurnal Biologi Lingkungan, Industri, Kesehatan) Journal Health & Science : Gorontalo Journal Health and Science Community Jurnal Maternitas Kebidanan Jurnal Aisyah : Jurnal Ilmu Kesehatan Budapest International Research in Exact Sciences (BirEx Journal) Jurnal Penelitian Farmasi dan Herbal Jurnal Kesehatan Tambusai
Linda Chiuman
Universitas Prima Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Dentistry Health Professions Medicine & Pharmacology Nursing Physics Public Health Transportation Veterinary

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EFFECTIVENESS TEST OF BLACK CUMIN SEEDS (NIGELLA SATIVA) EXTRACT ON THE GROWTH OF KLEBSIELLA PNEUMONIAE AND PSEUDOMONAS AERUGINOSA BACTERIA Nadya Nazimuddin Putri; Linda Chiuman; Chrismis Novalinda Ginting; Ermi Girsang
BIOLINK (Jurnal Biologi Lingkungan Industri Kesehatan) Vol 7, No 2 (2021): February 2021
Publisher : Universitas Medan Area

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31289/biolink.v7i2.3702

Abstract

Black cumin seeds are known to have beneficial contents as antibacterial. This study aimed to determine the effectiveness of black cumin seed extract (Nigella sativa) on the growth of Klebsiella pneumoniae and Pseudomonas aeruginosa. The method used was the disc diffusion method. The ethanol extract of black cumin seeds gain by maceration method and was made into various concentration (5, 7.5, 10, 12.5, and 15)%. For positive control, ciprofloxacin disc were used and negative control used distilled water. The research model used was in vitro experimental research. The results showed that ethanol extract of black cumin seeds have antibacterial activity against Klebsiella pneumoniae with inhibition zone diameters (4.5, 6.7, 10.1, 11, 12.8) mm, Pseudomonas aeruginosa with inhibition zone diameters (7.5, 12, 12.6, 13.4, 15.6) mm, positive controls respectively (24.3 and 20.7) mm and negative controls (0). It can be concluded that black cumin seed extract has an inhibiting effect on the growth of Klebsiella pneumoniae and Pseudomonas aeruginosa.
EFFECTIVENESS TEST OF ANTI-BACTERIAL LIME JUICE (Citrus aurantifolia) ON SALMONELLA SP BACTERIA IN SALMON FISH (Oncorhynchus nerka) Qori Fadillah; Linda Chiuman; Chrismis Novalinda Ginting; Ermi Girsang
BIOLINK (Jurnal Biologi Lingkungan Industri Kesehatan) Vol 7, No 1 (2020): August 2020
Publisher : Universitas Medan Area

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (444.003 KB) | DOI: 10.31289/biolink.v7i1.3322

Abstract

Salmonella Sp is a gram-negative pathogens that are often found in marine foods,one of  process of serving  salmon is channeling lime juice, where lime juice is acidic and has phytochemical properties that have anti-bacterial properties. This study aims to explore anti-bacterial effect lime juice on Salmonella thypii bacteria in Salmon. This research is an experimental study using  disc diffusion method. Lime samples that were used were purchased from one of the modern markets in Medan which were made in several series of concentrations using distilled water as a solvent, while the salmon samples used in this study were purchased from one of the Japanese dining restaurants located in Medan City. Meanwhile, isolation of Salmonella thypii bacteria from salmon samples was carried out using nutrient broth and SSA media. The results of this study indicate that differences in concentration indicate the differences in the diameter of the inhibitory zone (P value = 0.000). With the diameter of the widest inhibition zone formed by a concentration of 100% is 15.40 ± 0.44 mm and the smallest diameter is formed by a concentration of 5% which is 7.23 ± 0.55 mm. Thus, it can be concluded that the lime juice has anti-bacterial activity against Salmonella thypii bacteria from salmon.
LITERATUR REVIEW : EFEKTIVITAS PLATELET-RICH PLASMA TERHADAP PERBAIKAN ORGAN GINJAL Linda Chiuman; Chrismis Novalinda Ginting
Jurnal Maternitas Kebidanan Vol. 6 No. 2 (2021): Jurnal Maternitas Kebidanan
Publisher : Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jumkep.v6i2.2052

Abstract

Kidney Failure is a health condition that worsen the quality of life. In Acute Kidney Injury and Chronic Kidney Disease there is a damage not only in function but also in the structure of kidney. Platelet Rich Plasma is known to has a lot of benefits as a medical treatment. Platelet Rich Plasma is a plasma that rich in platelets which has the function of regenerating and repairing tissue structures, especially damaged kidneys. This study aimsTo determine the effectiveness of Platelet-Rich Plasma on the improvement of  damaged kidneys. This paper uses a literature study or literature review by searching through Google Scholar or Pubmed using the keywords “Platelet-Rich Plasma”, “Acute Kidney Injury”, “Chronic Kidney Disease” for the last 5 years studies published between 2016 to 2021. Based on the literature search, there were 5 research articles related to the effectiveness of Platelet Rich Plasma on the improvement of damaged kidney, where all studies were tested on experimental animals. Based on the results of the literature study, it can be concluded that there is a relationship between the effectiveness of Platelet-Rich Plasma on the improvement of damaged kidneys in experimental animals.
IGF-1 levels in Patients with Type 2 Diabetes Mellitus Thipani Angela; Chrismis Novalinda Ginting; Linda Chiuman; Sahna Ferdinand Ginting
Majalah Kedokteran Bandung Vol 53, No 2 (2021)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v53n2.2278

Abstract

Type 2 Diabetes Mellitus (Type 2 DM) is a metabolic disorder group with mechanisms that include hyperglycemia, insulin resistance and hyperinsulinemia. Type 2 DM has a close association with IGF-1, where the active form of the IGF-1 becomes elevated by reason of the fact that hyperinsulinemia inhibits the production of IGF-binding proteins (IGFBP) 1/IGFBP 2. The active form of IGF-1 has the ability to promote cell proliferation and inhibit apoptosis, hence becomes one of the risk factors for cancer cell growth. This was an analytical study conducted in August at the Harapan Bunda Clinic, Medan, Indonesia to determine the difference between the IGF-1 level and blood glucose level in type 2 DM patients in different age groups. Twenty subjects with Type 2 DM participated in this study and were divided based on their age into 35-50 years old or Group 1 and 51-65 year old group or Group 2. The IGF-1 levels in both groups were compared and analyzed using the T-test dependent method. Results showed that the IGF-1 and blood glucose levels were higher in Group 1 (35-50 years old) when compared to Group 2 and the difference was significant. The change in the IGF-1 level in diabetic patients cannot be determined only by the blood sugar level.
IDENTIFICATIONTEST OF ANDALIMAN METHANOL EXTRACT STEROID COMPOUNDS (ZANTHOXYLUM ACANTHOPODIUM DC) BY THIN LAYER CHROMATOGRAPHY Natasya Sabaria Aritonang; Sherlyn Sherlyn; Linda Chiuman; Rudy Rudy
Journal Health & Science : Gorontalo Journal Health and Science Community Vol 6, No 2 (2022): JULI: JOURNAL HEALTH AND SCIENCE : GORONTALO JOURNAL HEALTH AND SCIENCE COMMUNIT
Publisher : Gorontalo State University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35971/gojhes.v5i3.13626

Abstract

Andaliman is one of the many spice plants native to North Sumatra and is known to have many benefits as a pain reliever, anti-inflammatory, cough medicine, rheumatism, and back pain. In this study, a series of test was done to  identify for steroid compounds from the fraction of methanol andaliman extract (Zanthoxylum acanthopodium DC) by using thin layer chromatography. This study was designed to determine the presence of terpenoid/steroid compounds in the andaliman (Zanthoxylum acanthopodium DC) extract . Extraction was carried out using by maceration method  using methanol as solvent, followed by phytochemical test and confirmation test using TLC (Thin Layer Chromatography) namely GF254 plate as stationary phase, mixture of n-hexane:ethyl acetate with ratio of 7:3 as mobile phase,the appearance of the stains were carried out on UV with wavelenghts of 254 nm and 366 nm and by spraying Liebermann Burchard reagent as a spot viewer. The results of the phytochemical screening analysis on the Andaliman extract showed that the methanol andaliman extract contained steroid compounds and the TLC analysis showed a blue color, which was the result of a fraction indicating the presence of steroids and a pink color indicating the presence of terpenoids. The smallest terpenoid Rf stain was 0 cm and the highest Rf was 0.92 cm, while the smallest steroid Rf stain was 0 cm and the highest Rf was 0.71cm. Therefore, the Rf value for terpenoids, which is the result of the fraction of ethyl acetate and the Rf value of steroids, which is the result of the fraction of n-hexane and ethyl acetate, has met the requirements for a good Rf value between 0.2 to 0.8.Keywords: Andaliman; Steroids; Fractionation; Thin layer chromatography.                                                                   AbstrakAndaliman merupakan salah satu dari sekian banyak tanaman rempah asli Sumatera Utara dan diketahui memiliki banyak khasiat sebagai pereda nyeri, antiinflamasi, obat batuk, rematik, dan sakit punggung. Pada penelitian ini dilakukan uji identifikasi steroid fraksi metanol andaliman (Zanthoxylum acanthopodium DC) secara kromatografi lapis tipis. Penelitian ini dirancang untuk mengetahui adanya senyawa terpenoid/steroid dalam fraksi ekstrak metanol andaliman (Zanthoxylum acanthopodium DC). Proses ekstraksi dilakukan dengan metode maserasi menggunakan metanol sebagai pelarut, dilanjutkan dengan uji fitokimia dan uji konfirmasi menggunakan KLT (Kromatografi Lapis Tipis) yaitu plat GF254 sebagai fase diam, campuran n-heksan:etil asetat dengan perbandingan 7:3 sebagai fase gerak, penampakan noda dilakukan pada UV dengan panjang gelombang 254 nm dan 366 nm serta dengan penyemprotan pereaksi Lieberman Buchard sebagai penampak bercak. Hasil analisa skrinning fitokimia pada ekstrak andaliman menunjukkan bahwa ekstrak metanol andaliman mengandung senyawa steroid dan pada hasil analisa KLT menunjukkan warna biru yaitu hasil fraksi yang menampakkan adanya steroid dan warna merah muda yang menampakkan adanya terpenoid. Noda Rf  terpenoid terkecil adalah 0 cm dan Rf tertinggi 0,92 cm, sedangkan noda Rf steroid terkecil 0 cm dan Rf terbesar 0,71cm. Oleh karena itu, nilai Rf untuk terpenoid yaitu hasil fraksi dari etil asetat dan nilai Rf steroid yaitu hasil fraksi dari n-heksana dan etil asetat telah memenuhi syarat nilai Rf yang baik adalah di antara 0,2 sampai 0,8.Kata kunci: Andaliman; Steroid; Fraksinasi; Kromatografi Lapis Tipis.                                                                   
Analysis of Anti-Bacterial Activity of Ethanol Extract Fragrant Pandan Leaves (Pandanus amaryllifolius Roxb) Against the Growth of Disease Cause Pathogen Bacteria Using the Agar Diffusion Method Cut Eliza Hidayani; Chrismis Novalinda Ginting; Linda Chiuman
Budapest International Research in Exact Sciences (BirEx) Journal Vol 3, No 3 (2021): Budapest International Research in Exact Sciences, July
Publisher : Budapest International Research and Critics University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33258/birex.v3i3.2349

Abstract

Fragrant pandan (Pandanus amaryllifolius Roxb.) is a plant commonly used as fragrance and food coloring. Fragrant pandan contains many substances or bioactive compounds that have medicinal properties so they are also used as traditional medicine. One of the properties of fragrant pandan is as an antimicrobial (antibacterial and antifungal) which is thought to come from the content of alkaloids, flavonoids, phenolics, as well as steroids and terpenoids. This study aims to determine the inhibitory power of fragrant pandan extract (EPW) against the growth of pathogenic bacteria. The test method used is the agar diffusion method by looking at the temperature comparison. Time and Ph.
PENGARUH EKSTRAK KULIT BUAH MANGGIS (Garcinia Mangostana Linn) TERHADAP PERISTALTIK ILEUM TERPISAH MARMOT JANTAN SEBAGAI ANTI DIARE Zaim Anshari; Chrismis Novalinda Ginting; Linda Chiuman; Yuliani Mardiati Lubis
Jurnal Penelitian Farmasi & Herbal Vol 2 No 1 (2019): Jurnal Penelitian Farmasi & Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v2i1.73

Abstract

Objective: to determine the effect of mangosteen peel extract (Garcinia mangostana Linn) on ileal peristalsis separate male guinea pigs as diarrhea. Results: t-independent test, the difference: Contraction of ileum Acethlcholin with Atropine + Acethylcholin is 6.333 compared to Acethylcholin with extract + Acethylcholin is 8,500 with ANOVA test P value meaning the difference between the two contractions of the ileum is significant. The t-independent test results are the difference: Contraction of ileum Histamine with Diphenhidramine + Histamine is 8.333 compared to Histamine with extract + Histamine is 10.833 with ANOVA test P value meaning the difference between the two contractions of the ileum is significant. The results of the t-independent test are the difference: Contraction of the Barrium ileum with Papaverine + Barrium is 2,500 compared to the contraction of Barrium ileum with extract + Barrium is 2,500 with ANOVA test P value meaning that there is no difference between the two contractions of the ileum. From the three experimental groups, it was concluded that the extract worked similar to Papaverine. Cecilia's study, fruit skin extract can be used as diarrhea in Diare Effect of Mangosteen Ethanol Extract of Oleum ricini-induced Webster Swiss Mice.
HUBUNGAN TINGKAT PENGETAHUAN OSTEOPOROSIS DENGAN TINDAKAN PENCEGAHAN OSTEOPOROSIS PADA MAHASISWA FK UNPRI ANGKATAN 2019 Adrian Khu; Aditya Syahputra; Meisya Melissa; Linda Chiuman
Jurnal Maternitas Kebidanan Vol. 7 No. 2 (2022): Jurnal Maternitas Kebidanan
Publisher : Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jumkep.v7i2.3057

Abstract

Osteoporosis doesn't only affect elderly people, but it can also appear in younger people. Therefore, we must have well prepare prevention at a young age to prevent osteoporosis at an older age. This study intends to see the correlation between the education level and with prevention measure of osteoporosis. It uses an analytical observational research design with a cross-sectional study approach. The respondent sample was 76 respondents which were calculated through the Slovin formula. This research was conducted by using a questionnaire. The result of the studies was analyzed using spearman correlation with Cronbach Alpha 0,05. Most of the resulting studies, contain 81,6% of people who have a good education level. 84,2% of respondents have a prevention measure mild. Spearman value (p=0,770), where p is larger than alpha (p>0,05). Therefore, it can be concluded there's no relation between the education level of osteoporosis and with prevention measure of osteoporosis. Furthermore, the correlation coefficient value (r = -0.034), which indicates the correlation strength is very low and has a negative correlation direction that can be concluded if the level of knowledge is good then the precautions will be bad and vice versa as well.
Prediksi Toksisitas In Silico Senyawa Bioaktif Daun Kemangi (Ocimum sanctum L.) Ester Wangsasaputra; Satria Prihandini; Chrismis Novalinda Ginting; Linda Chiuman
Bahasa Indonesia Vol 22 No 2 (2023): Damianus Journal of Medicine
Publisher : Atma Jaya Catholic University of Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25170/djm.v22i2.4634

Abstract

Pendahuluan: Ocimum sanctum L. (daun kemangi) banyak ditemukan dan sering digunakan sebagai bahan makanan di Indonesia. Senyawa flavonoid merupakan kelompok senyawa kimia yang banyak terkandung dalam Ocimum sanctum L. Senyawa ini dikenal dengan aktivitas biologisnya yang beragam, antara lain antibakteri, antimikroba, antiinflamasi, antimalaria, dan antikanker. Pada penelitian ini, kami bertujuan untuk menyelidiki penyerapan, distribusi, metabolisme, ekskresi, dan toksisitas (the absorption, distribution, metabolism, excretion, and toxicity/ADMET) senyawa flavonoid dalam Ocimum sanctum L. Metode: Dalam mencapai tujuan penelitian, prediksi properti ADMET senyawa flavonoid pada Ocimum sanctum L. dilakukan menggunakan tiga web server yang terdiri dari SwissADME, pkCSM, dan ProTox-II. Parameter yang diamati dibagi menjadi parameter ADMET. Hasil: Hasil penelitian menunjukkan bahwa senyawa flavonoid dalam Ocimum sanctum L. memiliki median lethal dose (LD50) yang berkisar antara 2000 mg/kg hingga 5600 mg/kg, dengan klasifikasi kelas toksisitas IV, V, dan VI. Selain itu, senyawa flavonoid ini menunjukkan imunotoksisitas, sitotoksisitas, dan dampak pada Mitochondrial Membrane Potential (MMP). Simpulan: Penelitian kami menunjukkan bahwa senyawa metabolik yang berasal dari Ocimum sanctum L. dianggap aman.
DETEKSI BAKTERI SALMONELLA TYPHI PADA SAMBAL TERASI DI RUMAH MAKAN PADANG DI JALAN AYAHANDA MEDAN Muhammad Aji Sandi Putra; Qori Fadillah; Linda Chiuman
Jurnal Kesehatan Tambusai Vol. 4 No. 4 (2023): DESEMBER 2023
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v4i4.19122

Abstract

Bakteri dalam makanan dan minuman dapat diakibatkan oleh penjual yang tidak memperhatikan kebersihan dan keamanannya, pertumbuhan mikroorganisme dalam makanan memegang peranan penting dalam pembentukkan senyawa yang memproduksi bau tidak enak dan menyebabkan makanan tidak layak untuk dimakan. Sambal terasi adalah jenis sambal yang paling sering dijumpai di warung makan atau bahkan restoran. Rasa pedas dan aroma khas dari sambal terasi ini bisa meningkatkan selera makan, sehingga membuat sambal ini jadi favorit orang Indonesia. Namun dalam proses pengolahannya besar kemungkinan terdapat bakteri didalamnya seperti halnya bakteri Salmonella Typhi. Makanan yang terkontaminasi bakteri Salmonella Typhi dapat menyebabkan beberapa penyakit seperti demam tifoid. Tujuan penelitian ini adalah untuk mengetahui apakah terdapat Bakteri Salmonella Typhi Pada Sambal Terasi di Rumah Makan Padang di Jalan Ayahanda Medan. Jenis penelitian ini adalah observasi laboratorik yang bersifat deskriptif populasi dalam penelitian ini yaitu 7 rumah makan Padang yang ada di Jalan Ayahanda Medan. Dalam penelitian ini sampel sambal terasi diambil secara aseptis kemudian sampel dimasukkan ke dalam wadah steril. Selanjutnya sampel dibawa ke Laboratorium Universitas Prima Indonesia untuk kemudian dilakukan penelitian untuk mendeteksi bakteri Salmonella Typhi yang terdapat di sambal terasi. Hasil penelitian menunjukkan bahwa hasil uji laboratorium terhadap tujuh sampel sambal Terasi yang diperjualbelikan dirumah makan padang dijalan ayahanda Medan tidak ditemukan sampel yang terkontaminasi oleh bakteri Salmonella Typhi.
Co-Authors Aditya Syahputra Adrian Adrian Chrismis Novalinda Ginting Cut Eliza Hidayani Ermi Girsang Ester Wangsasaputra Fadillah, Qori Meisya Melissa Muhammad Aji Sandi Putra Nadya Nazimuddin Putri Natasya Sabaria Aritonang Natasya Sabaria Aritonang Rudy Rudy Rudy Rudy Sahna Ferdinand Ginting Satria Prihandini Sherlyn Sherlyn Sherlyn Sherlyn Suhartomi Suhartomi Thipani Angela Yuliani Mardiati Lubis Zaim Anshari