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All Journal Mutiara Medika: Jurnal Kedokteran dan Kesehatan Biomedika JKKI : Jurnal Kedokteran dan Kesehatan Indonesia
Rosmelia Rosmelia
Departemen Dermatologi Dan Venereologi, Fakultas Kedokteran, Universitas Islam Indonesia
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health

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Social Demography Study of Gonorrhea and Syphilis at RSUD dr. Soedono Madiun Rahajeng Musy; Vita Widyasari; Rosmelia Rosmelia
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 19, No 2 (2019): July
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mm.190227

Abstract

An understanding of the socio-demographic characteristics is the first step to conduct preventive and promotive measures to reduce the number of sexually transmitted infections. This study described the socio-demographic cha-racteristics of gonorrhea and syphilis in dr. Soedono Hospital Madiun. A descripttive study with a quantitative approach used secondary data from outpatient medical records. This research was conducted in dr. Soedono Hospital Madiun, East Java. The samples used in this study were 61 patients who had been diagnosed with gonorrhea and syphilis in the period from July 2013 - June 2016. The data consisted of 50 (82%) medical records with the diagnosis of gonorrhea and 11 (18%) medical records with a diagnosis of syphilis. Characteristics of patients/respondents are the highest age group of 21-30 years, 22 female patients (36.1%), 55 male patients (90.2%), unmarried status 33 people (54.1%), work as private employees 37 people (60.7%), pay without insurance 48 people (78.7%), and live around Madiun 52 (86.0%). The socio-demographic factors were dominant in patients with gonorrhea and syphilis in dr. Soedono Hospital period of 2013-2016 was 21-30 years old, male, unmarried, living as private sector employees, pay without insurance, and Madiun origin.
The cytotoxic effect of pinostrobin fingerroot (boesenbergia pandurata)on the culture of hela cells Rosmelia Rosmelia; Betty Ekawati Suryaningsih; Hady Anshory; Yohanes Widodo Wirohadidjojo
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 7, No 4, (2016)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol7.Iss4.art4

Abstract

Background : Cancer is one of the leading causes of death worldwide, therefore struggles to find more effective treatment and prevention is needed. Several studies has been performed using natural ingredients, one of which is Temu Kunci (B. pandurata). Temu Kunci extract contains flavonoid pinostrobin that has been showed as having cytotoxicity effects. Cytotoxicity tests of pinostrobin have been performed on several tumor cell lines, but its cytotoxicity effect on HeLa cell line has never been reported. Objective : To assess cytotoxicity effect of pinostrobin temu kunci on HeLa cell culture Methods : This study used simple experimental design. Pinostrobin were isolated from temu kunci and proved by TLC densitometry compared to standard pinostrobin. HeLa cell culture were treated with pinostrobin with concentrations 5, 25, 50, 75, 100, and 250 ug/mL. Cytotoxicity test were performed by MTT assay. Data were analyzed using one-way ANOVA. Results : There was significant difference (p=0.000) of means of cell viability percentage, respectively: 92.58 ± 9.84 (5μg/mL), 91.78 ± 4.4 (25μg/mL), 80.09 ± 4.51 (50μg/mL), 76.89 ± 7.75 (75μg/mL), 67.85 ± 11.31 (100μg/mL), dan 48.82 ± 16.61 (250μg/mL). The IC50 was 250μg/mL. Conclusion : Pinostrobin showed no active cytotoxicity effect on HeLa cell culture.
The prevalence of dermatological infection in outpatient dermatology clinic of RSUD Wonosari in January-September 2016 Trijanto Agoeng Noegroho; Rosmelia .; Lamya Muthia Nabila
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 8, No 2, (2017)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol8.Iss2.art4

Abstract

Background: The Skin is a complex organ that protects humans from their surrounding environment, like an infectious pathogenic agent, sunlight exposure, temperature, or other exposures. Skin infections can be divided into bacterial, viral, or fungal infections where infestations of bugs or worms are included. In Indonesia, the exact number of skin infection incidents has not been established. And until now, there are no research reports about the case pattern of skin infections in the area of Kabupaten Gunung Kidul in 2016. Objective: This research aimed to describe the overview of skin infection cases in Outpatient Dermatology Clinic of RSUD Wonosari, Gunung Kidul fromJanuary 2016 until September 2016. Methods: This research was conducted retrospectively based on medical records of all cases of skin infections in Outpatient Dermatology Clinic of RSUD Wonosari during the period of January 2016 - September 2016. Results: All new cases of skin infections in outpatient dermatology clinic of RSUD Wonosari within the period of January 2016 - September 2016 amounted to 303 cases. The cases consisted of 127 cases of fungal infection (42%) with a variety of cases of dermatophytosis, PVC, and candidiasis; 55 cases of bacterial infections (18%) with a variety of cases of impetigo, folliculitis, leprosy, ektima, erysipelas, furuncles, and abscesses; 40 cases of viral infections (13%) with variaty of cases of HFMD cases, Moluscum contagiosum, zooster, warts, varicella; and 81 cases of parasitic infections (27%) with a variety of cases of scabies, creeping eruption, and pediculosis capitis. Conclusion: Skin diseases caused by infections was still a dominant skin disease in the outpatient Dermatology clinic of RSUD Wonosari, with the number of cases 18.35% of all cases of skin and venereal diseases. The most common cause is infection by fungi (7.69%), followed by parasitic infections, scabies (4.91%), bacterial infections (3.33%), and viral infections (2.42%).
UJI EFEK KOMEDOGENIK PRODUK KOSMETIK BB CREAM PADA TELINGA KELINCI Melly Rahmawati; Betty Ekawati Suryaningsih; Rosmelia Rosmelia
Biomedika Vol 14, No 2 (2022): Biomedika Agustus 2022
Publisher : Universitas Muhamadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/biomedika.v14i2.17309

Abstract

ABSTRAK BB cream merupakan istilah dari blemish balm, blemish base, beblesh balm dan beauty balm di pasar barat yang dirancang menjadi alas bedak, pelembab dan tabir surya sekaligus. Penggunaan BB cream diduga berhubungan bermakna dengan keparahan klinis akne vulgaris, karena penggunaan kosmetik ini dapat meningkatkan sebum akibat unsur komedogenik yang terkandung di dalamnya, seperti: lanolin, petrolatum, butyl stearate, lauryl alcohol dan oleic acid. Kandungan parfum seperti linalool, limonene, caffeine, geraniol, dan citral yang terkandung dalam BB cream juga dapat  menyebabkan reaksi alergi dan iritasi sehingga meningkatkan risiko untuk terjadinya akne vulgaris. Penelitian ini bertujuan untuk mengetahui potensi efek komedogenik dan iritasi akibat pemberian produk kosmetik BB cream pada telinga kelinci. Penelitian ini menggunakan desain true experimental laboratory dengan metode randomized post test only controlled group design. Penelitian ini menggunakan hewan coba kelinci New Zealand white jantan. Dilakukan aplikasi topikal 3 produk BB cream pada telinga kanan selama lima minggu sedangkan telinga kiri berfungsi sebagai kontrol negatif. Efek komedogenik dan iritasi dinilai berdasarkan skoring. Hasil uji statistik dengan menggunakan uji Fisher exact didapatkan nilai p= 1,00 (p0,05), oleh  karena itu disimpulkan bahwa tidak terdapat hubungan bermakna antara aplikasi topikal BB cream dengan pembentukan komedo dan perubahan iritasi pada kulit telinga kelinci. Kata Kunci: BB Cream, Akne Vulgaris, Komedogenik, Skoring Komedogenik, Skoring Iritasi  ABSTRACT BB cream is a marketing term that stands for blemish balm, blemish base, beblesh balm and beauty balm. BB cream is designed to be foundation, moisturizer and sunscreen all at once. The use of BB cream is associated with the clinical severity of acne vulgaris, because the use of BB cream cosmetics can increase sebum production due to the comedogenic ingredients contained in it, such as lanolin, petrolatum, butyl stearate, lauryl alcohol and oleic acid. The perfume content such as linalool, limonene, caffeine, geraniol, and citral contained in BB cream could causes allergic reactions and irritation, thereby increasing the risk for acne vulgaris to occur. This study aimed to determine the comedogenicity dan irritation potency of BB cream cosmetic products applications on rabbit ears. This study used a true experimental laboratory design with a randomized post test only controlled group design method. This study used male New Zealand white rabbits as experimental animals. Topical application of 3 BB cream products was carried out on the right ear for five weeks, while the left ear function as a negative control. Statistical tests using Fisher's exact test obtained a value of p=1.00 (p0.05). It is concluded that there was no significant relationship between the topical application of BB cream with the formation of comedones and changes in irritation of the rabbit ear skin.Keywords: BB Cream, Acne Vulgaris, Comedogenicity, Comedogenicity Scoring, Irritation Scoring
Co-Authors Hady Anshory Lamya Muthia Nabila Melly Rahmawati Rahajeng Musy Suryaningsih, Betty Ekawati Trijanto Agoeng Noegroho Widyasari, Vita Yohanes Widodo Wirohadidjojo