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All Journal JURNAL ILMIAH MAKSITEK JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Ibnu Sina: Jurnal Kedokteran dan Kesehatan - Fakultas Kedokteran Universitas Islam Sumatera Utara
Prita Murani Nugraheti
Departemen Patologi Klinik, Fakultas Kedokteran, Universitas Islam Indonesia
Agriculture, Biological Sciences & Forestry Humanities Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Engineering Health Professions Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Public Health Social Sciences

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PERBEDAAN PERUBAHAN KADAR KOLESTEROL TOTAL DAN TRIGLISERID ANTARA PEMAKAIAN MONOTERAPI INSULIN DENGAN TERAPI KOMBINASI INSULIN DAN METFORMIN PADA PASIEN DIABETES MELITUS TIPE II Prita Murani Nugraheti; Erlina Marfianti; Linda Rosita
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 10, No 1, (2019)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol10.Iss1.art3

Abstract

Backround: Diabetes mellitus (DM) is a degenerative disease predicted by WHO to increase in Indonesia from 8.4 million in 2000 to around 21.3 million in 2030. Diabetes mellitus is closely related to dyslipidemia which can increase the risk of coronary artery disease (CAD). Current DM treatment is using oral hypoglycemic drugs, insulin, or a combination of both. Many previous studies have not examined the effect of these therapies on lipid profiles, specifically total cholesterol and triglyceride levels.Objective: To determine the differences in changes in total cholesterol and triglyceride levels between the use of insulin monotherapy and combination therapy of insulin and metformin in patients with type II diabetes mellitus in Sleman Yogyakarta Hospital from January 2010 toJune 2012.Methods: This study was an observational analytic study using a retrospective cohort study method with samples (n = 64). Samples were taken by non-probability consecutive sampling, carried out in DM patients inpatient or outpatient at Sleman Yogyakarta Hospital for the period of January 2010 - June 2012. The samples were divided into two groups, insulin monotherapy group and insulin and metformin combination therapy group. The data taken was the total cholesterol and the first triglyceride level, then the second total cholesterol and triglyceride data were made after four months of getting therapy.Result: Analysis of statistical data using the Mann Whitney test for changes in total cholesterol levels in the two treatment groups showed p = 0.166, whereas for changes in triglyceride levels in the two treatment groups it was found that p = 0.840.Conclusion: There were no significant differences in changes in total cholesterol and triglyceride levels between the two treatment groups.
EVALUASI PENETAPAN NILAI KRITIS PARAMETER HEMATOLOGI DI INSTALASI LABORATORIUM KLINIK RSUD WATES PRITA MURANI NUGRAHETI; TEGUH TRIYONO
JURNAL ILMIAH MAKSITEK Vol 8 No 2 (2023): JURNAL ILMIAH MAKSITEK
Publisher : LP2MTBM MAKARIOZ

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Abstract

Timely and accurate reporting critical value of laboratory examination helps support decision making, improves patient safety, and promotes successful therapy. A very extensive or very exclusive list of critical values has the potential to cause problems. This study is aimed to evaluate the determination of critical values, especially hematological parameters, in the Clinical Laboratory Installation of RSUD Wates. This study is a descriptive study of laboratory examination data for hematological parameters at RSUD Wates on January-June 2021. The proportion of critical values is calculated according to the cut off determined by the Clinical Laboratory of RSUD Wates. The cut off of critical values for the Laboratory of RSUP Dr. Sardjito was used as a comparison. The difference in proportion between the two groups was analyzed using the Chi Square test with p<0.05 is statistically significant. The most examination data was leukocyte count (7903 or 25.1%) and the examination with the most critical values is hematocrit (363 or 4.59%). There is a statistically difference in the number of critical values on the parameters of hematocrit, platelet count, leukocyte count and APTT, between the use of the cut off critical value of the clinical laboratory of RSUD Wates compared to the laboratory of RSUP Dr. Sardjito (p<0.01). The different two cut offs has the potential to increase the workload of laboratory staff and more time in reporting critical values. The cut off of critical values at the Clinical Laboratory of RSUD Wates should be reviewed, revised and updated regularly.
PROFIL HEMATOLOGI PADA INFEKSI VIRUS DENGUE DI RS PKU MUHAMMADIYAH WONOSARI YOGYAKARTA: HEMATOLOGICAL PROFILE OF DENGUE VIRUS INFECTION AT RS PKU MUHAMMADIYAH WONOSARI YOGYAKARTA Prita Murani Nugraheti; Nabila Nabila; Utami Mulyaningrum
Ibnu Sina: Jurnal Kedokteran dan Kesehatan - Fakultas Kedokteran Universitas Islam Sumatera Utara Vol. 25 No. 1 (2026): Januari 2026
Publisher : Faculty of Medicine Universitas Islam Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30743/ibnusina.v25i1.1038

Abstract

Demam berdarah merupakan penyakit demam akut yang disebabkan virus dengue (DENV), yaitu penyakit Flavivirus yang ditularkan nyamuk. Menurut Survei Kesehatan Indonesia tahun 2023, prevalensi Demam Berdarah Dengue (DBD) di Indonesia sebanyak 0,64% dengan prevalensi terbanyak terdapat di Provinsi Papua Tengah (3,90%). Di Kabupaten Gunung Kidul angka kesakitan DBD mencapai 245 per 100.000 penduduk di tahun 2024. Variasi dalam parameter hematologi dan biokimia seperti jumlah trombosit, kadar hematokrit, jumlah leukosit, dan jumlah limfosit dikaitkan dengan infeksi dengue. Tujuan penelitian ini adalah untuk mengetahui gambaran profil parameter pemeriksaan hematologi pada infeksi virus Dengue. Penelitian merupakan penelitian observasional dengan desain cross sectional yang diambil dari data sekunder pasien suspek Dengue yang dilakukan pemeriksaan Serologi Dengue, diambil secara keseluruhan dari data pemeriksaan laboratorium RS PKU Muhammadiyah Wonosari Januari-Desember 2024 sesuai kriteria inklusi dan eksklusi. Dari data pemeriksaan laboratorium hematologi RS PKU Muhammadiyah didapatkan sebanyak 61 pasien dengan infeksi virus dengue yang terdiri dari 26 pasien laki-laki (42,6 %) dan 35 pasien perempuan (57,4%), dengan median umur 11 tahun. Profil hematologi pada infeksi virus Dengue cenderung didapatkan leukopenia dan trombositopenia. Terdapat perbedaan signifikan secara statistik beberapa nilai parameter hematologi antara subjek perempuan dan laki-laki juga antara subjek anak dan dewasa. Angka trombosit lebih rendah pada subjek laki-laki, sedangkan nilai limfosit, angka trombosit, lebih rendah pada subjek dewasa. Profil ini dapat sebagai panduan dalam membantu mendiagnosis, memantau klinis dan tingkat keparahan pada pasien dengan infeksi virus Dengue.
Co-Authors Erlina Marfianti, Erlina Linda Rosita Nabila Nabila Teguh Triyono Utami Mulyaningrum