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All Journal Nusantara Medical Science Journal Canrea Journal: Food Technology, Nutritions, and Culinary Journal The International Journal of Medical Science and Health Research
Andi Alief Utama Armyn
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Agriculture, Biological Sciences & Forestry Dentistry Health Professions Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Study in vitro and in silico on effectiveness noni fruit extract (Morinda Citrifolia) to reducing hypertension La Ode Abdul Haris Hijriansyah; Hermilasari Hermilasari; Hardyanty Subair; Irianto Irianto; Andi Alief Utama Armyn; Supartina Hakim
jurnal1 VOLUME 3 ISSUE 2, DECEMBER 2020
Publisher : Hasanuddin University Food Science and Technology Study Program

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/canrea.v3i2.329

Abstract

Hypertension is one of the major causes of stroke. Stroke can be prevented by controlling hypertension. Noni fruit proved to have antihypertensive effect. Noni Fruit contains scopoletin and xeronin compounds that play a role in antihypertensives. This study aims to determine the effectiveness of noni fruit extract to controlling hypertension. The research method used is pre-test and post-test matched control group. The 6 Wistar rats were divided into 3 groups consisting of 1 treatment group and 2 control groups. Group P1 was induced by using ketamine 0.05 ml + epinephrine 0.2 ml + 6 ml noni fruit extract, group K (-) induced by ketamine 0.05 ml + epinephrine 0.2 ml without extract, and group K (+) induced by using ketamine 0.05 ml + epinephrine 0.2 ml + captopril 2.5 mg. The results showed that epinephrine can be used as a hypertensive inducer. Noni fruit extract as much as 6ml can provide antihypertensive effects. In Vitro, test result showed that noni fruit extract can reduce blood pressure by an average decrease in blood pressure of 58,5 mmHg While captopril 25,5 mmHg. in addition to the in vitro test, the results of the in-silico test showed that the noni fruit extract can significantly reduce blood pressure compared to anti-hypertensive drugs (captopril). the value of scopoletin in noni fruit is -7.6. and captopril only -5.7.
Studi In Vitro dan In Silico EfektivitasEkstrak Mentimun (Cucumis sativus) dalam Menurunkan Hipertensi Irianto Irianto; Andi Alief Utama Armyn; La Ode Abdul Haris Hijriansyah; Hermilasari Hermilasari; Hardyanty Subair
Nusantara Medical Science Journal Volume 5 No. 2 Juli - Desember 2020
Publisher : Faculty of Medicine, Hasanuddin University.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/nmsj.v5i2.8181

Abstract

Introduction: Hypertension is one of the major causes of stroke. Stroke can be prevented by controlling hypertension. Cucumber proved to have antihypertensive effect. cucumber contains ficetin compounds that play a role in antihypertensives. This study aims to determine the effectiveness of cucumber extract to controlling hypertension. Methods: The research method used is pre-test and post-test matched control group. The 6 wistar rats were divided into 3 groups consisting of 1 treatment groups and 2 control groups. Group P1 was induced by using ketamine 0.05 ml + epinephrine 0.2 ml + 6 ml cucumber extract, group K (-) induced by ketamine 0.05 ml + epinephrine 0.2 ml without extract, and group K (+) induced by using ketamine 0.05 ml + epinephrine 0.2 ml + captopril 2.5 mg Results The results showed that epinephrine can be used as a hypertensive inducer. cucumber extract as much as 6ml can provide antihypertensive effects. In Vitro test result showed that cucumber extract can reduce blood preassure by an average decrease in blood preassure of 102 mmHg While captopril 25,5 mmHg. Conclusions: in addition to the in vitro test, the results of the in silico test showed that the cucumber extract can significantly reduce blood pressure compared to anti-hypertensive drugs (captopril). the value of fisetin in cucumber is -9.3. and captopril only -5.7.Keywords: Hypertension, cucumber extract, In Silico, In Vitro
Cardiac Rhabdomyoma in 9 Months Infant: From Echocardiography Perspective Jordy Liong; Andi Alief Utama Armyn; Rheza Rivaldi Salam; Jauhar Mario; Herwin Irawan
The International Journal of Medical Science and Health Research Vol. 9 No. 2 (2025): The International Journal of Medical Science and Health Research
Publisher : International Medical Journal Corp. Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70070/cpth0d34

Abstract

Background: The most prevalent benign cardiac tumor in neonates, cardiac rhabdomyoma, is frequently associated with tuberous sclerosis complex (TSC). Based on their dimensions and positioning, these tumors may result in obstructive cardiac lesions, arrhythmias, or hemodynamic instability. Echocardiography is the primary diagnostic instrument for detecting and monitoring cardiac rhabdomyomas, as well as for differentiating them from other intracardiac malignancies. Case Report : This case report describes a 9-month-old newborn diagnosed with cardiac rhabdomyoma, focusing on the echocardiographic findings, clinical presentation, and therapy strategy. Echocardiographic imaging identified many hyperechoic masses within the ventricles; further echocardiographic evaluations demonstrated spontaneous regression, thereby corroborating the diagnosis. Conclusion : The absence of genetic evidence between MRI and TSC hinders a definitive connection. This case underscores the importance of non-invasive imaging in guiding the diagnosis and treatment of pediatric cardiac cancers. 
Co-Authors Hakim, Supartina Hardyanty Subair Hardyanty Subair Hermilasari Hermilasari Hermilasari Hermilasari Herwin Irawan Irianto Irianto Jauhar Mario Jordy Liong La Ode Abdul Haris Hijriansyah La Ode Abdul Haris Hijriansyah Rheza Rivaldi Salam