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All Journal Jurnal Midpro Lumbung Farmasi : Jurnal Ilmu Kefarmasian
Rully Yuliandhari
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Health Professions Medicine & Pharmacology

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Disinfectan from Sodium Hypochloride And Essential Oil Prevents Covid-19 Irma Susanti; Virgianti Nur Faridah; Rully Yuliandhari
Jurnal MIDPRO Vol 13, No 1 (2021): JURNAL MIDPRO
Publisher : Universitas Islam Lamongan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30736/md.v13i1.264

Abstract

One of the efforts to prevent the transmission of COVID-19 is by disinfection of places/surfaces of inanimate objects such as door handles, tables, chairs, electric switches, banisters, bathrooms and others. The material that can be used to disinfect the surface of inanimate objects is NaOCl. The use of high-effectiveness NaOCl for disinfecting at low cost and easy use. NaOCl product on the market are generally only pure solutions without the addition of other ingredients so that the resulting NaOCl product give a distinctive odor of NaOCl which is sharp and hard to lose, so in this study, the addition of essential oils from fresh ginger and lemongrass which have anti-bacterial effectiveness for scent NaOCl covered. This research is an experimental research conducted at the Laboratory of Pharmaceutical Technology, University of Muhammadiyah Lamongan. The working procedure in this study is to make extracts from fresh ginger and lemongrass with maceration method by making NaOCl disinfectant solution with liquid extract from fresh ginger and lemongrass were then observed every month for 3 months in the study in the form of testing on alcohol levels and organoleptic of observations on color, odor and sediment. The results of this study showed that the disinfectant solution based on NaOCl with the addition of essential oils contained in the liquid extract of fresh ginger and lemongrass made by maceration method can change the scent of the product. The results of this formulation can be used as an alternative to disinfectants on the market. 
Algoritme Naranjo sebagai Metode Identifikasi Dini Efek Samping Obat pada Pasien Tuberkulosis Resisten Obat di RS Muhammadiyah Lamongan Devi Ristian Octavia; Rully Yuliandhari; Dimas Prayogo Pangestu
Lumbung Farmasi: Jurnal Ilmu Kefarmasian Vol 5, No 2 (2024): Juli
Publisher : UNIVERSITAS MUHAMMADIYAH MATARAM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/lf.v5i2.19659

Abstract

Mengelola TB-MDR memerlukan pengobatan jangka panjang dengan campuran beberapa obat lini kedua. Obat-obatan ini terkait dengan beragam efek samping yang dapat menyebabkan ketidakefektifan pengobatan, sehingga memerlukan dilakukannya investigasi untuk memastikan efek samping obat. Penilaian kausalitas memiliki peran penting dalam praktik klinis serta pengembangan obat. Penelitian ini bertujuan mengetahui kausalitas kejadian tidak diinginkan akibat efek samping obat dengan algoritma Naranjo pada pasien TB-MDR. Penelitian ini merupakan penelitian prospektif observasional cross-sectional design. Populasi merupakan seluruh pasien rawat jalan Poliklinik TB-MDR RS Muhammadiyah sejumlah 72 pasien, sampel diambil dengan teknik purposive sampling dan didapatkan sampel penelitian sejumlah 45 pasien. Dilakukan wawancara kepada pasien TB-MDR terkait efek samping yang dirasakan oleh pasien selama pengobatan OAT lini kedua. Kejadian kelainan fungsi hati yang di sebabkan oleh penggunaan obat Bedaquiline (13,33%), Linezolid (11,11%) dan Levofloxacin (15,56%) serta kelainan hematologi (anemia) karena penggunaan obat Linezolid (33,33%) menjadi kasus dengan highly probable menyebabkan kelainan fungsi hati karena efek hepatotoksisitas dari obat tersebut. Penilaian kausalitas dengan Algoritma Naranjo memiliki peran penting dalam praktik klinis serta pengembangan obat. Keputusan untuk menghentikan suatu obat yang efektif, atau obat dikontraindikasikan untuk penggunaan di masa depan, dapat merugikan dan bahkan membahayakan pasien.
Co-Authors Devi Ristian Octavia Dimas Prayogo Pangestu Irma Susanti Virgianti Nur Faridah, Virgianti