Claim Missing Document
Check
Articles

Found 5 Documents
Search

Nilai Prognostik FLT3 Pada Pasien Leukemia Mieloid Akut Hendra Asputra
Jurnal Ilmu Kedokteran Vol 15, No 1 (2021): Jurnal Ilmu Kedokteran
Publisher : Fakultas Kedokteran Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26891/JIK.v15i1.2021.1-7

Abstract

Acute myeloid leukemia (AML) is a disease characterized by neoplastic transformation and abnormality of progenitor cells differentiation from myeloid cells. In AML there is a heterogeneous abnormality in hematopoietic progenitor cells, this abnormality has been identified and affects the balance between proliferation, survival and differentiation of body cells. Mutation of FMS-like tyrosin kinase 3 (FLT3) gene causes overexpression which is one of the most often found mechanism that has been identified could trigger genetic changes that can disturb intracellular signaling tissue in pathogenesis of leukemia. Besides being used as a diagnostic tool, FLT3 overexpression can also be used to assess the prognosis of AML.
Correlation between Proteinuria and Glomerular Filtration Rate in Type 2 Diabetes Mellitus Dani Rosdiana; Mukhyarjon Mukhyarjon; Hendra Asputra; Nisa Faradisa Hernita; Olivia Makmur; Prayogo Prayogo; Hetty Hirfawaty
Majalah Kedokteran Bandung Vol 52, No 2 (2020)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2469.618 KB) | DOI: 10.15395/mkb.v52n2.1811

Abstract

Indonesia faces a double burden of communicable and non-communicable diseases, including metabolic and degenerative problems. Delay in the detection of diabetic nephropathy (DN) as one of the chronic microvascular complications is often seen, leading to the need for hemodialysis due to the end-stage renal disease (ESRD). An assessment of diabetes mellitus (DM) control target achievement, based on the guideline from the Indonesian Society of Endocrinology (Perkumpulan Endokrinologi Indonesia, PERKENI), and nephropathy early detection was performed in 54 Type-2 DM patients from 5 private hospitals in Pekanbaru Riau, Indonesia, from November 2018 to September 2019. Results showed poor achievement of DM control with 61.1% had abnormal body mass index, 57.5% had HbA1c>7%, and 77.7% had LDL serum >100 mg/dL. Nevertheless, most patients achieved good blood pressure control (74%). A high percentage of nephropathy-proteinuria was seen (40.7%) with 40.9% of them revealed renal insufficiency classified as chronic kidney disease (CKD) stage 3 and 4. There was a significant correlation between proteinuria and declined GFR (p=0.016), onset of DM (p=0.02), and diastolic blood pressure (p=0.03). No correlation was found between HbA1c and declined GFR, which may be due to the cross-sectional nature of the study. It will be interesting to perform a prospective study on proteinuria modification as a predictor of nephropathy early detection in DM patients since kidney biopsy and urine albumin creatinine ratio assessment are not available in primary health care services in remote areas. Korelasi antara Proteinuria dan Laju Filtrasi Glomerulus pada Diabetes Melitus Tipe 2Indonesia menghadapi beban ganda penyakit menular dan tidak menular, termasuk masalah metabolisme dan degeneratif. Keterlambatan dalam deteksi nefropati diabetik sebagai salah satu komplikasi mikrovaskular kronis sering terlihat, mengarah pada kebutuhan untuk hemodialisis karena penyakit ginjal stadium akhir (ESRD). Dari 54 pasien diabetes melitus (DM) tipe-2 tanpa keluhan edema, sesak, dan lemas dari 5 rumah sakit swasta di Pekanbaru, Riau, Indonesia, dari November 2018 hingga September 2019, dilakukan penilaian kontrol DM sesuai panduan Perkumpulan Endokrinologi Indonesia (PERKENI). Didapatkan hasil bahwa pencapaian kontrol DM masih buruk dengan 61,1% memiliki indeks massa tubuh abnormal 57,5% memiliki HbA1c >7%, dan 77,7% memiliki serum LDL >100 mg/dL. Namun demikian, sebagian besar pasien mencapai kontrol tekanan darah yang baik (74%). Pasien terdeteksi proteinuria >25 mg/dL mencapai 40,7% dengan 40,9% diantaranya mengalami gangguan filtrasi ginjal yang didefinisikan sebagai GFR <60 diklasifikasikan penyakit ginjal kronis tahap 3 dan 4. Walaupun secara statistik tidak ditemukan hubungan bermakna antara kontrol glikemik dengan insufisiensi renal, namun ditemukan hubungan yang bermakna antara nefropati dengan penurunan laju filtrasi glomerulus (GFR) (p=0.016), awitan DM (p=0,02), dan tekanan darah diastolik (p=0,03). Tidak ada hubungan bermakna antara HbA1c dan penurunan GFR yang mungkin disebabkan observasi sesaat. Akan menarik untuk melakukan studi prospektif pada modifikasi proteinuria sebagai prediktor deteksi dini nefropati pada pasien DM karena biopsi ginjal dan penilaian rasio albumin kreatinin urin tidak tersedia di layanan perawatan kesehatan primer di daerah terpencil.
SEMINAR AWAM BAHAYA SINDROMA METABOLIK DAN CARA PENCEGAHANNYA DI KOTA SIAK SRI INDERAPURA, KABUPATEN SIAK, RIAU Fajri Marindra Siregar; Hendra Asputra; Mukhyarjon; Imelda Tresia Pardede
Panrita Abdi - Jurnal Pengabdian pada Masyarakat Vol. 5 No. 1 (2021): Jurnal Panrita Abdi - Januari 2021
Publisher : LP2M Universitas Hasanuddin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/pa.v5i1.7847

Abstract

Abstract This community service was carried out at Siak Sri Inderapura, Siak Regency, Riau Province.  The activity was done in the form of a lay seminar on metabolic syndrome hazards and how to prevent it which targeting the general public. This activity aims to educate the public about metabolic syndrome, its danger to health, and how to prevent it so that people are expected to be able to recognize the signs as early as possible. The service activity begins with filling out the pretest questionnaire, delivery of talks by a health expert and discussion between participants and speaker, then at the end of the event the participants return to fill in the posttest questionnaire. The results of this community service showed a significant increase in knowledge from participants of lay seminars "The dangers of metabolic syndrome and how to prevent it" in Siak Sri Inderapura, Siak Regency, Riau.     Abstrak. Pengabdian masyarakat ini dilaksanakan di Kota Sri Inderapura, Kabupaten Siak, Provinsi Riau. Kegiatan ini berupa seminar awam dengan topik bahaya sindroma metabolik dan cara pencegahannya dengan sasaran masyarakat umum. Kegiatan ini bertujuan untuk mengedukasi masyarakat mengenai gejala sindroma metabolik, bahayanya terhadap kesehatan, dan cara pencegahannya sehingga diharapkan masyarakat dapat mengenali tanda-tandanya sedini mungkin. Kegiatan pengabdian diawali dengan pengisian kuisioner pretest, penyampaian materi oleh pakar kesehatan dan dilanjutkan proses tanya jawab antara peserta dan narasumber, selanjutnya pada akhir acara para peserta kembali diminta untuk mengisi kuisioner posttest. Hasil pengabdian masyarakat menunjukkan terdapat peningkatan pengetahuan yang signifikan dari peserta seminar awam  “Bahaya sindroma metabolik dan cara pencegahannya” di Kota Siak Sri Inderapura, Kabupaten Siak, Riau.  
Penapisan Tekanan Darah Tinggi Pada Masyarakat Kota Bangkinang Sebagai Upaya Pencegahan Penyakit Ginjal Kronis: Screening for High Blood Pressure in Bangkinang City Community As an Effort to Prevent Chronic Kidney Disease Fajri Marindra Siregar; Hendra Asputra; Nanda Fito Mela
Jurnal Pengabdian Kesehatan Komunitas Vol. 2 No. 1 (2022): Jurnal Pengabdian Kesehatan Komunitas
Publisher : STIKes Hang Tuah Pekanbaru

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25311/jpkk.Vol2.Iss1.1215

Abstract

Penyakit ginjal kronis (PGK) merupakan masalah kesehatan dunia yang insidensi dan prevalensinya semakin meningkat dengan keluaran yang buruk dan biaya perawatan yang tinggi. Salah satu faktor risiko penyebab PGK adalah tekanan darah tinggi. Kegiatan pengabdian masyarakat ini bertujuan untuk melakukan penapisan tekanan darah tinggi pada masyarakat sebagai upaya pencegahan PGK. Penapisan dilakukan dengan melakukan pemeriksaan tekanan darah dan edukasi pada peserta yang terdeteksi memiliki tekanan darah tinggi. Kegiatan pengabdian ini dilaksanakan di Kota Bangkinang, Kabupaten Kampar, Provinsi Riau. Dari 100 orang masyarakat yang mengikuti kegiatan didapatkan sebanyak 19% memiliki tekanan darah normal, 33% prehipertensi, 23% hipertensi derajat 1 dan 25% hipertensi derajat 2. Tingginya angka kejadian tekanan darah tinggi yang ditemukan pada kegiatan penapisan ini menggambarkan urgensinya usaha kesehatan berbasis masyarakat sebagai upaya tindak lanjut pencegahan penyakit ginjal kronis dan penyakit lainnya yang lebih serius.  Abstract Chronic kidney disease (CKD) is a global health problem that incidence and prevalence increase with poor outcomes and high treatment costs. One of the risk factors for CKD is high blood pressure. This community service activity aims to screen the community for high blood pressure to prevent CKD. Screening is done by checking blood pressure and educating participants who are detected to have high blood pressure. This service activity is located in Bangkinang City, Kampar Regency, Riau Province. Of the 100 people who participated in the program, 19% had normal blood pressure, 33% had prehypertension, 23% had hypertension grade 1, and 25% had hypertension grade 2. The high incidence of high blood pressure in this screening activity illustrates the urgency of community-based health programs as a follow-up effort to prevent chronic kidney disease and other more severe diseases.
Putative and pretreatment drug resistance mutations in reverse transcriptase gene among untreated chronic hepatitis B patients at Arifin Achmad Regional District Hospital, Riau, Indonesia Arfianti Arfianti; Fauzia Andrini Djojosugito; Maisaroh Maisaroh; Hendra Asputra; Dita Kartika Sari; Tubagus Odih Rhomdani Wahid
Acta Biochimica Indonesiana Vol. 5 No. 1 (2022): Acta Biochimica Indonesiana
Publisher : Indonesian Society for Biochemistry and Molecular Biology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32889/actabioina.68

Abstract

Background: Mutations within the hepatitis B virus (HBV) reverse transcriptase (RT) gene have been associated with drug resistance against nucleos(t)ide analogs (NAs). Objective: This study aimed to identify mutations in the RT gene among patients with chronic hepatitis B (CHB) before receiving antiviral therapy and its relationship with the HBV genotypes. Methods: A total of 26 HBV DNA was extracted from the blood plasma of CHB patients. HBV RT gene was amplified and sequenced using the Sanger dideoxy sequencing method. The HBV genotype was determined through phylogenetic analysis using the Maximum Likelihood method. Results: The study subjects comprised 14 CHB patients without complications and 12 CHB patients with cirrhosis/hepatoma. CHB patients with cirrhosis/hepatoma were older than those without complications. The HBV genotypes comprised 15 (57.7%) genotype C and 11 (42.3%) genotype B. All treatment-naïve CHB patients did not demonstrate any classical NA resistance mutations within the RT gene. However, several putative and pretreatment resistance mutations, including F221Y, N238H, and V224I, were high frequency in more than 40% of study subjects. In addition, F221Y and N238H/Q mutations were frequently observed in genotype B, while V224 I was only found in patients infected with genotype C (p=0.000). Conclusions: There was no evidence of classical RT gene mutations associated with NA resistance in treatment-naïve patients with CHB. However, several putative and pretreatment mutations were identified as genotype-specific mutations and may contribute to antiviral resistance against NAs.