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All Journal EKSAKTA: Journal of Sciences and Data Analysis Walisongo Journal of Chemistry PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Ilmu Kefarmasian Indonesia Stannum : Jurnal Sains dan Terapan Kimia
Santi Nur Handayani
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Earth & Planetary Sciences Health Professions Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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ANTI-INFLAMMATION ACTIVITY OF AGERATUM CONYZOIDES LEAF ETHANOL EXTRACT ON RATTUS NORVEGICUS Saputri, Maylani Permata; Utami, Riani; Fadila, Jasmine; Handayani, Santi Nur
Walisongo Journal of Chemistry Vol 3, No 1 (2020): Walisongo Journal of Chemistry
Publisher : Department of Chemistry Faculty of Science and Technology Walisongo

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (856.735 KB) | DOI: 10.21580/wjc.v3i1.6136

Abstract

Bandotan  (Ageratum conyzoides L) merupakan tanaman yang mengandung senyawa metabolit sekunder berupa flavonoid dan alkaloid yang diduga mempunyai efek anti-inflamasi.  Tujuan penelitian adalah mengetahui aktivitas anti-inflamasi ekstrak etanol daun A. conyzoides pada tikus yang diinduksi karagenan. Tahapan penelitian adalah maserasi daun A. conyzoides dalam pelarut etanol, uji fitokimia, dan uji aktivitas anti-inflamasi. Uji aktivitas anti-inflamasi dilakukan terhadap 25 tikus putih (Rattus norvegicus L.) jantan yang terbagi menjadi lima kelompok perlakuan yaitu kontrol (-) larutan CMC 0,5%, kontrol (+) natrium diklofenak, dan pemberian ekstrak dengan dosis 30, 200 dan 448 mg/kgBB. Parameter yang diamati yaitu volume kaki tikus setelah diinduksi 0,1 mL karagenan 1% selama 300 menit diukur dengan pletismometer. Hasil uji anti-inflamasi menunjukkan bahwa ekstrak etanol daun A. conyzoides dengan dosis 30, 200 dan 448 mg/kgBB memiliki aktivitas anti-inflamasi dengan persen daya anti-inflamasi masing-masing sebesar 10,43; 21,67; dan 30,34 %. Dosis 448 mg/kgBB menunjukkan tidak ada perbedaan signifikan dengan kontrol (+) pada uji ANOVA. Hasil penelitian menunjukkan ekstrak etanol daun A. conyzoides memiliki aktivitas anti-inflamasi.
Screening of Secondary Metabolites Compounds in Stem Bark of Frangipangi (Plumeria alba) and Toxicity Test on Shrimp Larvae (Brine Shrimp Lethality Test) Santi Nur Handayani; Moch. Chasani
EKSAKTA: Journal of Sciences and Data Analysis VOLUME 12, ISSUE 1, February 2011
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam

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Abstract

Frangipani  is  a  plant  belonging  to  the  family  Apocynacea  and  potential  for development as anti-cancer drug material. Content of secondary metabolites, anti-cancer compounds from frangipani (Plumeria alba) steam bark, especially it has not been made. This  research aims  to  identify compounds  secondary metabolites  from  frangipani  steam bark extract potential for development as anti-cancer drug material. Steps undertaken in this study include:  Extraction of secondary metabolites with frangipani  stem  bark  maceration  method  of  storey  with  n-hexane,  chloroform,  ethyl acetate, and ethanol. Each tested extracts obtained using prawn shrimp toxicity A. salina Leach  and  continued  with  the  testing  of  secondary  metabolites  using  color  reagents. fraction  extract  has  potential  as  an  anti-cancer  drugs  is  purified  using  gravity  column chromatography  technique  with  elusi  gradient  technique  using  a  solvent  mixture  n-hexane:ethyl acetate hen conducted toxicity tests followed by identification using GC-MS  Extraction  results obtained by  the  four extracts namely: n-hexane extract  (E1)  is positive flavonoid groups, chloroform extract (E2), ethyl acetate extract (E3) and ethanol extract (E4)  is positive for secondary metabolite groups flavonoid and alkaloid. Toxicity test results obtained LC50 values respectively participated: 973. 7 ppm (E1), 451.35 ppm (E2), 112.557 ppm(E3), and 637.50 ppm(E4).   Keywords: Plumeria alba, secondary metabolite, toxicity test, and A. salina Leach 
Isolasi Senyawa Polifenol Black garlic Dan Uji Toksisitasnya Terhadap Larva Udang (Artemia salina Leach) Santi Nur Handayani; Lidya Cahyo Bawono; Diana Pramesti Ayu; Hesti Nurrizqi Pratiwi
JURNAL ILMU KEFARMASIAN INDONESIA Vol 16 No 2 (2018): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (347.801 KB) | DOI: 10.35814/jifi.v16i2.561

Abstract

Cancer is one of diseases caused by cell division that is uncontrollable. Cervical cancer is a cancer that suffered by many women. Alternative medicine of cancer disease is use black garlic. Black garlic is the result of processing the garlic with high temperature and humidity without addition of other substances. In that process occur Maillard reaction that cause changes in the color, smell, and taste of the original on the garlic. Such reaction also lead to an increase some bioactive compounds such as S-allyl cysteine ​​(SAC), amino acids, flavonoids, and polyphenols. To determine the toxic properties of black garlic extract, it is necessary to do isolation of polyphenolic compounds and toxicity test against Artemia salina Leach. When calculated by SPSS application, the obtained LC50 values of black garlic extract on the aging prosess time variations of 30 days and 40 days showed concentration of 682.433 and 572.403 ppm.
Isolasi dan Identifikasi Senyawa Bioaktif Batang Combrang (Nicolaia speciosa Horan) Sri Sutji Susilowati; Santi Nur Handayani
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 05 No. 03 Desember 2007
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

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Abstract

Indonesia terkenal sebagai negara yang memiliki banyak tanaman obat seperti famalia Zingiberaceae. Nicolaia speciosa Horan yang dikenal dengan nama combrang merupakan salah satu tanaman kelompok famalia Zingiberaceae. Combrang berpotensi digunakan sebagai obat tradisional karena combrang mengandung senyawa metabolit sekunder. Tujuan dari penelitian ini adalah mengisolasi komponan bioaktif pada kulit batang combrang dan melakukan identifikasi dengan Gas Chromatography-Mass Spectrometry. Isolasi senyawa bioktif pada kulit batang combrang dilakukan dengan maserasi menggunakan n-heksan sebagai solven dilanjutkan dengan kloroform dan etil asetat. Sekrining senyawa bioaktif pada kulit batang combrang menggunakan reagen warna menunjukkan adanya golongan senyawa nitrogen, flavonoid dan saponin. Golongan senyawa yang terekstraksi dengan kloroform adalah alkaloid, flavonoid dan fenolik sedangkan yang terekstraksi dengan etil asetat adalah fenolik, flavonoid dan saponin. Ekstrak kloroform selanjutnya diidentifikasi dengan Gas Chromatography-Mass Spectrometry. Hasilnya menunjukkan bahwa ekstrak kloroform mengandung 32 puncak dengan waktu retensi yang berbeda. Lima puncak dengan % area tertinggi diidentifikasi dan hasilnya adalah dodecanol, desil asetat, 9-dekanal, tredesil vinil eter dan 14-(2 metil butil) bisiklo (10,3,0) pentadeka-13-o1.
The Toxicity Test on Larvae of Shrimp (Artemia salina L.) of Lindur Fruit Peel Extract (Bruguiera gymnorrhiza) and Identification of Its Bioactive Compounds Ana Mardliyah; Undri Rastuti; Santi Nur Handayani
Stannum : Jurnal Sains dan Terapan Kimia Vol 3 No 2 (2021): Oktober 2021
Publisher : Department of Chemistry - Universitas Bangka Belitung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33019/jstk.v3i2.2548

Abstract

Indonesia is the most mangrove-rich country, both in terms of area quantity and number of species. Mangrove plants have potential as a source of medicinal compounds. Bruguiera gymnorrhiza is a type of mangrove plant which is a source of medicinal plants from the Rhizoporaceae family. Ethanol extract of the stem bark of B. gymnorhiza has been known to have cytotoxic activity with an IC50 of 508.19 µg/mL against myeloma cancer cells (Rahmah, 2021). The aim of this study was to determine the toxicity of lindur fruit peel extract (B. gymnorrhiza) on Artemia salina Leach shrimp larvae. Lindur fruit peel extraction was carried out by maceration method using methanol solvent which was then fractionated with n-hexane and ethyl acetate as solvent. All extract fractions obtained were then tested for toxicity against shrimp larvae Artemia salina Leach by BSLT (Brine Shrimp Lethality Test) method. Extract fractions with the highest toxicity were identified for their bioactive compounds using UV-Visible and FT-IR spectrophotometers. The results of the toxicity test showed that the lindur fruit peel extract was toxic to A. salina L. and the most toxic fraction was the n-hexane fraction with an LC50 value of 34.109 ppm. The results of the analysis using UV-Visible and FT-IR spectrophotometers the active compound in the hexane fraction of lindur fruit extract (B. gymnorrhiza) contains terpenoid which has double bond conjugated that showed by the existence of an electronic transition of π →π* that was conjugated and there are clusters of -OH, C=O, C=C, aromatic, C-H and C-O groups.
Co-Authors Ana Mardliyah Diana Pramesti Ayu Fadila, Jasmine Hesti Nurrizqi Pratiwi Lidya Cahyo Bawono Moch. Chasani Saputri, Maylani Permata Sri Sutji Susilowati Undri Rastuti Utami, Riani