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Pencil Lead Electrode Termodifikasi Lapisan Tipis Perak Untuk Deteksi Ion Logam Cd2+ Dengan Metode Voltammetri Fadiah; Trisna Kumala Sari
Journal of Research and Education Chemistry Vol. 6 No. 2 (2024): Oktober
Publisher : UIR Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25299/jrec.2024.vol6(2).18661

Cd2+ metal ions are contaminants that threaten the environment and human health. The purpose of the study is to study the electrochemical responses of PLE and Ag/PLE to detect Cd2+ metal ions, as well as to determine the best supporting electrolyte condition for measuring Cd2+ ions. The cyclic voltometric method is used to modify the electrodes by depositing a thin layer of silver. The results of the study show that Ag/PLE is better for detecting Cd2+ ions compared to PLE. The optimum conditions were obtained with a supporting electrolyte of acetate buffer pH 4.

Pengaruh Supporting Electrolyte terhadap Deteksi Ion Logam Pb(II) dan Cu(II) menggunakan PLE Termodifikasi Lapisan Tipis Perak dengan Metode Voltammetri Sisri Wartati; Trisna Kumala Sari
MASALIQ Vol 5 No 4 (2025): MASALIQ: Jurnal Pendidikan dan Sains
Publisher : Lembaga Yasin AlSys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/masaliq.v5i4.6738

This study aims to evaluate the effect of different supporting electrolytes on the detection sensitivity of Pb(II) and Cu(II) ions simultaneously using a Pencil Lead Electrode (PLE) modified with a thin silver layer via electrodeposition. The modification was carried out using a 5 mM AgNO₃ solution in 0.1 M KNO₃ through cyclic voltammetry, producing reduction and oxidation peaks at +0.2256 V and +0.5253 V, respectively, indicating successful silver deposition on the electrode surface. The supporting electrolyte variations included 0.1 M solutions of HNO₃, H₂SO₄, and HClO₄, tested for 1 mM Pb(II) and Cu(II) ion analysis. The voltammogram results showed that 0.1 M HNO₃ yielded the highest current responses 1.3550 mA for Pb(II) and 1.3305 mA for Cu(II) making it the most optimal supporting electrolyte. These differences are attributed to the ionic mobility and diffusion rate of the species toward the electrode surface. The findings demonstrate that the choice of supporting electrolyte significantly influences the performance of electrochemical sensors. This research contributes to the development of efficient, cost-effective, and sensitive PLE-based sensors for simultaneous heavy metal detection.

Pengaruh Supporting Electrolyte untuk Deteksi Ion Logam Cd(II) dan Zn(II) menggunakan PLE Termodifikasi Lapisan Tipis Perak dengan Metode Voltametri Fatimah As Sarah; Trisna Kumala Sari
MASALIQ Vol 5 No 4 (2025): MASALIQ: Jurnal Pendidikan dan Sains
Publisher : Lembaga Yasin AlSys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/masaliq.v5i4.6847

Cd(II) and Zn(II) metal ions are toxic environmental contaminants that pose potential risks to human health, necessitating accurate and efficient detection methods. This study aims to optimize the supporting electrolyte conditions for the simultaneous electrochemical detection of Cd(II) and Zn(II) ions using a Pencil Lead Electrode (PLE) modified with a thin silver layer (Ag/PLE). Cyclic voltammetry was employed to evaluate the effectiveness of electrode modification and the influence of electrolyte variation on the detection sensitivity of both metal ions. Experimental results indicate that 0.1 M acetate buffer is the optimal supporting electrolyte, yielding an anodic potential (Epa) of –0.37 V and a peak current of 1.48 mA, as well as a cathodic potential (Epc) of –0.9140 V for Cd(II). For Zn(II), the Epa was observed at –0.79 V with a current of 0.54 mA and Epc at –0.6790 V. The difference in detection sensitivity between the two metal ions is attributed to variations in analyte diffusion rates at the electrode surface. These findings demonstrate that the Ag/PLE-based electrochemical approach offers a simple, sensitive, and cost-effective method for the simultaneous detection of heavy metal ions, contributing significantly to rapid and practical environmental monitoring systems.

Pengaruh Variasi Pencil Lead Electrode (PLE) terhadap Deteksi Ion Logam Cu²⁺ menggunakan Modifikasi MnO₂ dengan Metode Voltametri Siklik Mutiara Permatasari; Trisna Kumala Sari
MASALIQ Vol 5 No 4 (2025): MASALIQ: Jurnal Pendidikan dan Sains
Publisher : Lembaga Yasin AlSys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/masaliq.v5i4.6859

This study is motivated by the limited research on the use of modified pencil lead electrodes in electrochemical detection, despite their advantages as simple, low-cost, environmentally friendly, and highly sensitive heavy metal sensors. Copper ions (Cu²⁺) are essential elements for biological functions, but in excessive amounts, they become toxic and can damage vital organs such as the liver and kidneys. The aim of this research is to develop an effective electrochemical sensor for detecting Cu²⁺ ions by optimizing the type and modification of pencil lead electrodes. Electrode modification was performed using the drop-casting method with manganese dioxide (MnO₂) on three pencil hardness grades (2B, B, and HB), with voltammogram analysis based on the resulting current and redox potential. The results indicate that the MnO₂/PLE (2B) electrode demonstrated the most optimal performance compared to the other variations. This advantage is attributed to the electrocatalytic properties of MnO₂ and the higher graphite content in 2B pencils, which enhance the electrode’s conductivity and electrochemical response. These findings confirm that MnO₂/PLE (2B) is effective for Cu²⁺ ion detection and holds potential for development as an efficient electrochemical sensor for heavy metal analysis. Keywords: Cu²⁺ Ion; MnO₂; Pencil Electrode; Cyclic Voltammetry; Electrochemical Sensor

Sintesis dan Karakterisasi ZnO/Co dengan Aditif Diethanolamine (DEA) dan Uji Aktivitas Katalitiknya pada Zat Warna Congo Red Mutiara Oktaviani; Hary Sanjaya; Trisna Kumala Sari; Riga Riga
MASALIQ Vol 6 No 2 (2026): MASALIQ: Jurnal Pendidikan dan Sains
Publisher : Lembaga Yasin AlSys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/masaliq.v6i2.9232

Congo red is an azo dye widely used in the textile industry; however, its wastewater poses serious environmental problems because it is toxic to aquatic organisms, potentially carcinogenic, causes turbidity, and is difficult to degrade naturally. This study aimed to synthesize cobalt-doped ZnO nanoparticles with the addition of diethanolamine (DEA) as an additive to reduce the ZnO bandgap energy and to evaluate their photocatalytic activity in degrading Congo red dye. The material was synthesized using a sol–gel method with Co doping concentrations of 5%, 10%, 15%, 20%, and 25%, and DEA additions of 1 mL, 2 mL, and 3 mL, respectively. The optical properties were characterized using UV-DRS spectroscopy in the wavelength range of 185–1100 nm, and the bandgap energy was calculated using the Kubelka–Munk equation. Photocatalytic activity tests on Congo red were carried out under visible light (sunlight) and UV irradiation, with monitoring using UV–Vis spectrophotometry at a maximum wavelength of 498 nm. The results showed that the addition of 20% Co doping reduced the ZnO bandgap energy from 3.20 eV to 1.76 eV, and the combination of 20% Co doping with 2 mL DEA produced an optimum bandgap of 1.68 eV. Photocatalytic tests indicated that ZnO/Co 20% with 2 mL DEA exhibited the highest activity, with Congo red degradation percentages of 98.63% under visible light and 98.57% under UV light within 120 minutes of irradiation. These findings demonstrate that cobalt-doped ZnO nanoparticles with DEA as an additive can enhance the photocatalytic activity of ZnO and have potential application as a photocatalyst-based solution for the treatment of textile dye wastewater.

In Silico Senyawa Bioaktif Tanaman Obat Indonesia sebagai Inhibitor Xanthine Oxidase melalui Pendekatan Molecular Docking dan ADMET Shalsa Fitria Zanti; Trisna Kumala Sari
MASALIQ Vol 6 No 3 (2026): MASALIQ: Jurnal Pendidikan dan Sains
Publisher : Lembaga Yasin AlSys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/masaliq.v6i3.9662

Xanthine oxidase (XO) plays a role in the formation of uric acid and contributes to hyperuricemia, whereas the use of synthetic inhibitors such as allopurinol is known to have side effects, thus requiring alternatives from the bioactive compounds of medicinal plants. This study aims to evaluate the potential of Dillapiole, Piperine, Hydroxychavicol, Panduratin A, and Isolicoflavonol as XO inhibitors through an in silico approach using molecular docking, as well as Lipinski and ADMET analyses. The results showed that most ligands met the drug-likeness criteria, except for Panduratin A, which had one violation of LogP. All ligands showed negative binding affinity, with Isolicoflavonol having the best affinity (−9.5 kcal/mol), followed by Piperine and Panduratin A. ADMET predictions showed that most ligands had good absorption and were not mutagenic, although some ligands had the potential to interact with CYP450 enzymes. Overall, Isolicoflavonol showed the best potential as an XO inhibitor candidate based on binding affinity and ADMET profile. These findings affirm the potential of medicinal plant bioactive compounds as alternative XO inhibitors, although further in vitro and in vivo testing is still needed for further validation.

Studi in silico Molecular Docking Senyawa Bioaktif Tumbuhan Pelawan (Tristaniopsis merguensis Griff) sebagai Kandidat Inhibitor α-Glukosidase untuk Antidiabetes Mesi Anggun Sari; Trisna Kumala Sari
MASALIQ Vol 6 No 4 (2026): MASALIQ: Jurnal Pendidikan dan Sains
Publisher : Lembaga Yasin AlSys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/masaliq.v6i4.11178

Diabetes mellitus is a metabolic disease with a continuously increasing prevalence and may be influenced by dietary patterns, diet, physical activity, and age. One strategy for controlling it is to inhibit the activity of the α-glucosidase enzyme, which plays a role in breaking down carbohydrates into glucose. Pelawan (Tristaniopsis merguensis Griff.) contains bioactive compounds, such as flavonoids, terpenoids, saponins, and phenols, that have the potential to be developed as antidiabetic agents. This study aimed to evaluate the potential of bioactive compounds from pelawan to inhibit the activity of the α-glucosidase enzyme (PDB ID: 1LHU) through an in silico approach. Molecular docking simulations were performed using PyRx and PyMOL software, while protein–ligand interactions were visualized using Discovery Studio 2025. The results showed that kaempferol had the best binding affinity, with a value of −8.1 kcal/mol, followed by resveratrol, with a value of −7.3 kcal/mol. The visualization results showed interactions between the protein and ligands through hydrogen bonds as well as hydrophobic and alkyl interactions. These findings indicate that kaempferol and resveratrol from T. merguensis have the potential to inhibit α-glucosidase activity. This study supports the potential of bioactive compounds from pelawan as natural antidiabetic candidates and provides a basis for further research to validate their biological activity.

In Silico Study of Bioactive Compounds from Moringa oleifera Extract as Anti-Inflammatory Candidates Targeting the Inflammatory Mediator PGD2 Putri Sabilla; Trisna Kumala Sari
Journal of Multidisciplinary Science: MIKAILALSYS Vol 4 No 3 (2026): Journal of Multidisciplinary Science: MIKAILALSYS
Publisher : Darul Yasin Al Sys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/mikailalsys.v4i3.11832

Conventional anti-inflammatory drugs may cause serious adverse effects, creating a need for safer plant-derived therapeutic candidates. Although Moringa oleifera has recognized biological potential, computational evidence regarding the anti-inflammatory activity of its phytoconstituents against prostaglandin D₂ 11-ketoreductase (AKR1C3; PDB ID: 1S2A) remains limited. This in silico study evaluated 12 bioactive compounds from an ethanolic extract of M. oleifera as potential inhibitors of this molecular target. Pharmacokinetic properties and oral bioavailability were predicted using SwissADME according to Lipinski’s rule of five. Molecular docking was subsequently performed using Molecular Operating Environment 2019 to evaluate ligand–receptor binding affinities based on Gibbs free energy (ΔG) and root-mean-square deviation (RMSD). The physicochemical assessment showed that 11 compounds had favorable predicted membrane permeability and systemic absorption, whereas rutin violated Lipinski’s criteria. Docking analysis identified quercetin, apigetrin, chlorogenic acid, ellagic acid, and naringenin as the most promising candidates. These compounds exhibited the lowest ΔG values and stable binding conformations, with RMSD values below 2.0 Å. The findings indicate that these five phytoconstituents have favorable predicted interactions with AKR1C3 and may possess potential anti-inflammatory activity associated with PGD₂ metabolism. Accordingly, they represent promising lead compounds for developing selective plant-derived anti-inflammatory agents. This study provides a computational foundation for future molecular dynamics simulations and clinical validation.

Pengaruh Supporting Electrolyte terhadap Deteksi Ion Logam Cr(VI) Menggunakan PLE Termodifikasi Lapisan Tipis Perak dengan Metode Voltammetri Nella Aulia Putri; Trisna Kumala Sari
MASALIQ Vol 5 No 3 (2025): MASALIQ: Jurnal Pendidikan dan Sains
Publisher : Lembaga Yasin AlSys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/masaliq.v5i3.5508

Chromium (VI) ions are recognized for their toxicity, mutagenicity, and carcinogenic properties, posing significant risks to both human health and the environment. This study aims to optimize the conditions of supporting electrolytes for the electrochemical detection of Cr(VI) ions using a Pencil Lead Electrode (PLE) modified with a thin layer of silver (Ag/PLE). Employing cyclic voltammetry, we investigated the modification of the PLE and analyzed the effects of varying supporting electrolytes on the detection sensitivity of Cr(VI) ions. Our findings indicate that a 0.1 M HNO3 solution serves as the optimal supporting electrolyte, with oxidation and reduction potentials recorded at +1.4287 V and +0.3906 V, respectively. The observed differences in the sensitivity of Cr(VI) detection can be attributed to the varying diffusion rates of the analyte across the electrode surface. This study presents a straightforward, sensitive, and cost-effective electrochemical method for detecting Cr(VI) ions, offering significant implications for environmental monitoring and public health safety. By enhancing detection methodologies, this research contributes to the broader discourse on mitigating the adverse effects of hazardous metal ions in ecological systems.

Pengaruh Variasi Pencil Lead Electrode (PLE) terhadap Deteksi Ion Logam Pb (II) menggunakan Modifikasi MnO2 Metode Voltametri Siklik Rahmi Wahyuni; Trisna Kumala Sari
MASALIQ Vol 5 No 3 (2025): MASALIQ: Jurnal Pendidikan dan Sains
Publisher : Lembaga Yasin AlSys

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58578/masaliq.v5i3.5804

This study is motivated by the limited research on modified pencil lead electrodes in electrochemical detection, despite their significant potential as simple, low-cost, and environmentally friendly heavy metal sensors. The aim of this research is to evaluate the performance of MnO₂/pencil lead electrode (MnO₂/PLE) with variations in pencil hardness—2B, B, and HB—in detecting K₃[Fe(CN)₆] and Pb²⁺ ions using cyclic voltammetry. The electrodes were modified using the drop-casting method, and voltammogram data were analyzed based on current and redox potential values. The results show that MnO₂/PLE (2B) demonstrated the best performance among the variants. This is attributed to the synergy between the electrocatalytic properties of MnO₂ and the high graphite content of the 2B pencil, which enhances conductivity and electrochemical response. MnO₂/PLE (2B) proved effective in detecting Pb²⁺ ions, making it a strong candidate for use as an electrochemical heavy metal sensor. The implications of this study contribute to the literature on modified carbon-based sensors and open opportunities for the development of portable, low-cost sensors for environmental monitoring.

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