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All Journal Jurnal Kedokteran Syiah Kuala Jurnal Ilmiah Mahasiswa Kedokteran Biomedis Narra J
Nur Wahyuniati
Bagian Parasitologi Fakultas Kedokteran Universitas Syiah Kuala
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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PERAN INTERLEUKIN-10 PADA INFEKSI MALARIA Nur Wahyuniati; Reza Maulana
Jurnal Kedokteran Syiah Kuala Vol 15, No 2 (2015): Volume 15 Nomor 2 Agustus 2015
Publisher : Universitas Syiah Kuala

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Abstract

Abstrak. Malaria merupakan suatu penyakit infeksi yang memiliki patogenesis sangat kompleks. Teori imunologis merupakan salah satu teori utama yang berupaya menjelaskan secara lebih rinci dan komprehensif terkait patogenesis infeksi malaria. Interleukin-10, yang merupakan sitokin anti-inflamasi,memainkan peranan yang penting dalam regulasi respon imun pada host. Interleukin-10 menghambat pelepasan mediator-mediator pro-inflamasi dari monosit/makrofag, dan hal ini akan menghambat sekresi TNF-α, IL-1β, IL-6, IL-8, G-CSF, dan GM-CSF. Interleukin-10 juga menghambat proliferasi dan juga sintesis sitokin sel T CD4+, termasuk produksi IL-2 dan IFN-γ oleh Th1 dan IL-4 dan IL-5 oleh Th2. Timbulnya komplikasi malaria berat ditentukan oleh keseimbangan antara kadar sitokin proinflamasi dan anti-inflamasi, yaitu berupa rasio IL-10 rendah. Rasio IL-10:TNF-α yang kurang dari 1 beresiko mengalami malaria serebral dan anemia berat, sebaliknya rasio lebih dari 1 sering ditemukan pada pasien hiperparasitemia.Abstract. Malaria is an infectious disease which has a very complex pathogenesis. Immunological theory is one of the main theories that attempt to explain a more detail and comprehensive pathogenesis of malaria infection. Interleukin-10, which an anti-inflammatory cytokines, play an important role in the regulation of immune response in the host. Interleukin-10 inhibits the release of mediators of pro-inflammatory monocyte/macrophages, and it will inhibit the secretion of TNF-α, IL-1β, IL-6, IL-8, G-CSF and GM-CSF. Interleukin-10 also inhibits the proliferation and synthesis of CD4+ T cell cytokines, including IL-2 and IFN-γ by Th1 and IL-4 and IL-5 by Th2. The incidence of complications of severe malaria is determined by the balance between the levels of pro-inflammatory and anti-inflammatory cytokines, in the form of a low ratio of IL-10. The ratio of IL-10: TNF-α less than 1 is believed to have a risk of cerebral malaria and severe anemia, whereas the ratio more than 1 is often related to hyper parasitemia condition.
PERAN INTERFERON GAMMA PADA INFEKSI Mycobacterium tuberculosis Nur Wahyuniati
Jurnal Kedokteran Syiah Kuala Vol 17, No 2 (2017): Volume 17 Nomor 2 Agustus 2017
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jks.v17i2.8992

Abstract

Abstrak.Penyakit tuberkulosis masih tetap merupakan masalah kesehatan yang utama di dunia. Penyakit ini menyebabkan angka kesakitan yang tinggi pada jutaan penduduk dunia setiap tahunnya. Mycobacterium tuberculosis (M.Tb) memiliki kemampuan aktifitas replikasi dan metabolisme yang tinggi dan memiliki kemampuan untuk bertahan hidup di dalam fagosit profesional. Respon imun seluler sangat berperan penting untuk proses eliminasi M. Tb. Sel TH1 yang teraktivasi akan mengeluarkan interferon gamma yang akan mengaktivasi makrofag. Interferon gamma memiliki peran yang sangat penting dalam imunitas protektif terhadap infeksi M.Tb.(JKS 2017; 2: 131-137)Kata kunci: Tuberkulosis, Mycobacterium tuberculosis, respon T­H1,Interferon gammaAbstract. Tuberculosis remains a major health problem in the world. This disease causes a high morbidity rate in millions of the world's population each year. Mycobacterium tuberculosis (M.Tb) has high replication and metabolism activity and has the ability to survive in professional phagocytes. Cellular immune responses play an important role in the elimination process of M. Tb. The activated TH1 cell will secrete interferon gamma that leads to activation of macrophages. Interferon gamma has a very important role in protective immunity against infection M.Tb.(JKS 2017; 2: 131-137)Keywords: Tuberculosis, Mycobacterium tuberculosis, TH­1 response, Interferon gamma
Hubungan Tajam Penglihatan dengan Kualitas Hidup Pasien Sebelum dan Sesudah Operasi Katarak Senilis di RSUDZA Banda Aceh Tria Mairizka; Saiful Basri; Nur Wahyuniati
Jurnal Ilmiah Mahasiswa Kedokteran Biomedis Vol 2, No 3 (2017): Volume 2 Nomor 3 Agustus 2017
Publisher : Jurnal Ilmiah Mahasiswa Kedokteran Biomedis

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ABSTRAKKatarak senilis merupakan kekeruhan yang terjadi pada lensa mata. Katarak senilis dapat menyebabkan gangguan pada tajam penglihatan dan dapat mempengaruhi kualitas hidup pasien. Penurunan tajam penglihatan dapat diperbaiki dengan operasi katarak. Penelitian ini bertujuan untuk mengetahui hubungan tajam penglihatan dengan kualitas hidup sebelum dan sesudah operasi katarak senilis di RSUDZA Banda Aceh. Jenis penelitian ini adalah penelitian quasi eksperimental dengan rancangan time series design. Pengambilan sampel dengan metode purposive sampling dan didapatkan 39 sampel yang diambil pada bulan September sampai November 2016. Data kemudian dianalisis menggunakan uji Spearman. Hasil menunjukkan terdapat hubungan antara tajam penglihatan dengan kualitas hidup sebelum operasi katarak senilis (p value 0,003) dan terdapat hubungan tajam penglihatan dengan kualitas hidup sesudah operasi katarak senilis (p value 0,003). Dapat disimpulkan bahwa terdapat hubungan tajam penglihatan dengan kualitas hidup sebelum dan sesudah operasi katarak senilis di RSUDZA Banda Aceh. Kata Kunci: Katarak senilis, Tajam penglihatan, Kualitas hidup ABSTRACTSenile cataract is opacity that occurs in the eye lens. Senile cataract can cause problem on visual acuity and affects the quality life of the patient. Degradation of visual acuity can be corrected with cataract surgery. This research objectives is to determine the relationship between visual acuity with patient’s quality of life before and after cataract surgery at dr. Zainoel Abidin hospital Banda Aceh. Type of this research is quasi-experimental with time series design. Sampling was done by purposive sampling technique and 39 samples been taken in September until November 2016. Data analyzed by using Spearman test. The result showed that there was a significant correlation between visual acuity with quality of life before cataract surgery (0,003) and there was a significant correlation between visual acuity after cataract surgery (0,003). It can be concluded that there is correlation between visual acuity and quality of life before and after cataract surgery at dr. Zainoel Abidin hospital Banda Aceh. Keyword: Senile Cataract, Visual acuity, Quality of life. 
Attitude towards Zika among frontline physicians in a dengue-endemic country: A preliminary cross-sectional study in Indonesia Amanda Yufika; Samsul Anwar; Reza Maulana; Nur Wahyuniati; Rizki R. Ramadana; Ikram Ikram; Mudatsir Mudatsir; Prattama S. Utomo; Haypheng Te; Seyi Samson Enitan; Salin Sirinam; Ruth Müller; Abdul Malik Setiawan
Narra J Vol. 1 No. 1 (2021): April 2021
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narraj.v1i1.32

Abstract

In dengue-endemic countries such as Indonesia, Zika may be misdiagnosed as dengue, leading to underestimates of Zika disease and less foreknowledge of pregnancy-related complications such as microcephaly. Objective: To assess the attitudes of frontline physicians in a dengue-endemic country toward testing for Zika infection among patients with dengue-like illnesses. Methods: A cross-sectional online survey was conducted among general practitioners (GPs) in Indonesia. The survey assessed their attitude and also collected sociodemographic data, characteristics of their medical education, professional background, and workplace, and exposure to Zika cases. A two-step logistic regression analysis was used to assess possible variables associated with these attitudes. Results: A total of 370 GPs were included in the final analysis of which 70.8% had good attitude. Unadjusted analyses suggested that GPs who were 30 years old or older and those who had medical experience five years or longer had lower odds of having a positive attitude compared to those who aged younger than 30 years and those who had medical experience less than five years, OR: 0.58; 95%CI: 0.37, 0.91 and OR: 0.55; 95%CI: 0.35, 0.86, respectively. No explanatory variable was associated with attitude in the fully adjusted model. Conclusion: Our findings point to younger GPs with a shorter medical experience being more likely to consider testing for Zika infection among their patients presenting with dengue-like illnesses. Strategic initiatives may be needed to enhance older or longer-experienced physicians' capacity in diagnosing Zika infection.
Co-Authors Abdul Malik Setiawan Amanda Yufika Haypheng Te Ikram Ikram Mudatsir Mudatsir Prattama S. Utomo Reza Maulana Rizki R. Ramadana Ruth Müller Saiful Basri Salin Sirinam Samsul Anwar Seyi Samson Enitan Tria Mairizka