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All Journal Jurnal Kedokteran Syiah Kuala Narra J KESANS : International Journal of Health and Science
Reza Maulana
Fakultas Kedokteran Universitas Syiah Kuala
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Physics Public Health

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PERAN INTERLEUKIN-10 PADA INFEKSI MALARIA Nur Wahyuniati; Reza Maulana
Jurnal Kedokteran Syiah Kuala Vol 15, No 2 (2015): Volume 15 Nomor 2 Agustus 2015
Publisher : Universitas Syiah Kuala

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Abstract

Abstrak. Malaria merupakan suatu penyakit infeksi yang memiliki patogenesis sangat kompleks. Teori imunologis merupakan salah satu teori utama yang berupaya menjelaskan secara lebih rinci dan komprehensif terkait patogenesis infeksi malaria. Interleukin-10, yang merupakan sitokin anti-inflamasi,memainkan peranan yang penting dalam regulasi respon imun pada host. Interleukin-10 menghambat pelepasan mediator-mediator pro-inflamasi dari monosit/makrofag, dan hal ini akan menghambat sekresi TNF-α, IL-1β, IL-6, IL-8, G-CSF, dan GM-CSF. Interleukin-10 juga menghambat proliferasi dan juga sintesis sitokin sel T CD4+, termasuk produksi IL-2 dan IFN-γ oleh Th1 dan IL-4 dan IL-5 oleh Th2. Timbulnya komplikasi malaria berat ditentukan oleh keseimbangan antara kadar sitokin proinflamasi dan anti-inflamasi, yaitu berupa rasio IL-10 rendah. Rasio IL-10:TNF-α yang kurang dari 1 beresiko mengalami malaria serebral dan anemia berat, sebaliknya rasio lebih dari 1 sering ditemukan pada pasien hiperparasitemia.Abstract. Malaria is an infectious disease which has a very complex pathogenesis. Immunological theory is one of the main theories that attempt to explain a more detail and comprehensive pathogenesis of malaria infection. Interleukin-10, which an anti-inflammatory cytokines, play an important role in the regulation of immune response in the host. Interleukin-10 inhibits the release of mediators of pro-inflammatory monocyte/macrophages, and it will inhibit the secretion of TNF-α, IL-1β, IL-6, IL-8, G-CSF and GM-CSF. Interleukin-10 also inhibits the proliferation and synthesis of CD4+ T cell cytokines, including IL-2 and IFN-γ by Th1 and IL-4 and IL-5 by Th2. The incidence of complications of severe malaria is determined by the balance between the levels of pro-inflammatory and anti-inflammatory cytokines, in the form of a low ratio of IL-10. The ratio of IL-10: TNF-α less than 1 is believed to have a risk of cerebral malaria and severe anemia, whereas the ratio more than 1 is often related to hyper parasitemia condition.
TIBIAL STRESS FRACTURE Reza Maulana
Jurnal Kedokteran Syiah Kuala Vol 15, No 1 (2015): Volume 15 Nomor 1 April 2015
Publisher : Universitas Syiah Kuala

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Abstract

Stres fraktur merupakan cedera yang sering terjadi pada kegiatan yang banyak melibatkan aktifitas fisik seperti pada atlet dan militer. Cedera ini sering terjadi pada ekstremitas bawah dan paling sering terjadi pada tulang tibia dibandingkan lainnya. Stres fraktur disebabkan oleh aktifitas berulang dimana aktifitas osteoblastik tertinggal dari aktifitas osteoklastik, sehingga tulang mengalami mikrofraktur selama aktifitas dan akhirnya mikrofraktur terkonsolidasi menjadi stres fraktur. Stres fraktur dapat dicegah dengan pemanasan sebelum kegiatan dan menaikkan frekuensi dan intensitas kegiatan sedikit demi sedikit. Terapi obat-obatan berupa antiinflamasi dan antinyeri, istirahat sampai bebas rasa sakit.
PERAN GEN TWIST PADA KROMOSOM 7P21 TERHADAP KEJADIAN SINDROM SAETHRE-CHOTZEN Reza Maulana
Jurnal Kedokteran Syiah Kuala Vol 15, No 2 (2015): Volume 15 Nomor 2 Agustus 2015
Publisher : Universitas Syiah Kuala

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Abstrak. Sindrom Saethre-Chotzen merupakan salah satu tipe dari acrocephalosindaktili. Sindrom ini dapat menyebabkan terjadinya craniosinostosis berupa penutupan/penyatuan dini sutura-sutura cranial sehingga dapat menimbulkan malformasi saat kelahiran. Sindrom ini disebabkan mutasi gen TWIST pada kromosom 7p21 yang merupakan regulator transisi epithelial-mesenkim dan migrasi selular pada tahap awal perkembangan fetus. Gen TWIST akan menginisiasi perkembangan mesoderm yang berlanjut pada perkembangan tulang, jantung, otot, dan berbagai sel lainnya. Pemeriksaan klinis harus dilakukan untuk menegakkan diagnosis, tidak hanya pemeriksaan tulang kepala, namun juga bagian lain yang terkait dengan sindrom ini.Abstract. Saethre-Chotzen syndromeis one of Acrocephalussyndactyly type. This syndromecause a craniosynostosisin the form ofearly closure/unification of the cranialsutures that can causemalformations at birth. This syndrome is causedby a mutation of TWIST geneon chromosome7p21which is aregulatorof epithelial-mesenchymal transitionandcellularmigrationin the early stagesof fetaldevelopment. TWIST genewill initiatethe development ofmesodermwhichcontinues onthe development of bones, heart, muscles, anda variety ofother cells.Clinical examination should beperformed toestablish the diagnosis, notonly the examination ofthe skull, butalsoother parts associated with this syndrome.   
The Relationship of Myofascial Trigger Points (MTrPs) Pain to Headache: Type, Location, and Intensity of Headache Novita Nurul K; Dessy Rakhmawati E.; Reza Maulana; Nasrul Musadir; Sofia Sofia
Jurnal KESANS : Kesehatan dan Sains Vol 1 No 6 (2022): KESANS : International Journal of Health and Science
Publisher : Rifa'Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54543/kesans.v1i6.66

Abstract

Headaches are one of the most common nervous system disorders with a major impact on public health. They can be caused by various etiologies, and some of them are symptoms of serious pathology. The location and intensity of the headache are related to the etiology of the headache. In some cases, headaches can be accompanied by pain due to myofascial trigger points (MTrPs), which are small hyper-irritating spots located centrally within bands that have been injured or overworked. The purpose of this study was to determine the relationship between Myofascial Trigger Points (MTrPs) Pain and the Type, Location, and Intensity of Headaches. This type of research is analytic observational with a cross-sectional design. Data were collected in October and December of 2014, and a sample of 50 people was drawn using a consecutive sampling technique.Data were gathered through neurologists' history-taking and physical examinations, as well as interviews using a numerical pain scale (NPS), and then analyzed using Fisher and Mann Whitney.The results showed that MTrPs were positive for M. sternocleidomastoid in 38 people, M. trapezius in 36 people, M. temporalis in 31 people, M. masseter superficialis in 20 people, M. suboccipital in 18 people, M. levator scapulae in 34 people, and M. obliquus superior in 20 people. The highest number of active MTrPs was 4 in 15 people, and referred pain from MTrPs was present in only 5 people. It can be concluded that there is no relationship between Myofascial Trigger Points (MTrPs) pain and the type of headache, but there is a relationship between Myofascial Trigger Points (MTrPs) pain and the location and intensity of the headache.
Attitude towards Zika among frontline physicians in a dengue-endemic country: A preliminary cross-sectional study in Indonesia Amanda Yufika; Samsul Anwar; Reza Maulana; Nur Wahyuniati; Rizki R. Ramadana; Ikram Ikram; Mudatsir Mudatsir; Prattama S. Utomo; Haypheng Te; Seyi Samson Enitan; Salin Sirinam; Ruth Müller; Abdul Malik Setiawan
Narra J Vol. 1 No. 1 (2021): April 2021
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narraj.v1i1.32

Abstract

In dengue-endemic countries such as Indonesia, Zika may be misdiagnosed as dengue, leading to underestimates of Zika disease and less foreknowledge of pregnancy-related complications such as microcephaly. Objective: To assess the attitudes of frontline physicians in a dengue-endemic country toward testing for Zika infection among patients with dengue-like illnesses. Methods: A cross-sectional online survey was conducted among general practitioners (GPs) in Indonesia. The survey assessed their attitude and also collected sociodemographic data, characteristics of their medical education, professional background, and workplace, and exposure to Zika cases. A two-step logistic regression analysis was used to assess possible variables associated with these attitudes. Results: A total of 370 GPs were included in the final analysis of which 70.8% had good attitude. Unadjusted analyses suggested that GPs who were 30 years old or older and those who had medical experience five years or longer had lower odds of having a positive attitude compared to those who aged younger than 30 years and those who had medical experience less than five years, OR: 0.58; 95%CI: 0.37, 0.91 and OR: 0.55; 95%CI: 0.35, 0.86, respectively. No explanatory variable was associated with attitude in the fully adjusted model. Conclusion: Our findings point to younger GPs with a shorter medical experience being more likely to consider testing for Zika infection among their patients presenting with dengue-like illnesses. Strategic initiatives may be needed to enhance older or longer-experienced physicians' capacity in diagnosing Zika infection.
Co-Authors Abdul Malik Setiawan Amanda Yufika Dessy Rakhmawati E. Haypheng Te Ikram Ikram Mudatsir Mudatsir Nasrul Musadir Novita Nurul K Nur Wahyuniati Prattama S. Utomo Rizki R. Ramadana Ruth Müller Salin Sirinam Samsul Anwar Seyi Samson Enitan Sofia Sofia Viskasari P. Kalanjati