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All Journal Majalah Obstetri dan Ginekologi Cermin Dunia Kedokteran The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy
Dyonesia Ary Harjanti
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Health Professions Medicine & Pharmacology Public Health

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Giant Cell Tumor of Tendon Sheath Benedict Djitro, Timotius; Harjanti, Dyonesia Ary; Suryawinata, Kidyarto; Karman, Iwan Irawan
Cermin Dunia Kedokteran Vol 46, No 11 (2019): Kesehatan Anak
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1245.517 KB) | DOI: 10.55175/cdk.v46i11.409

Abstract

Giant cell tumor of tendon sheath (GCTTS) adalah tumor kedua tersering di tangan, tetapi relatif jarang ditemui pada praktek sehari-hari. Tumor yang cenderung timbul pada wanita berusia 30-50 tahun ini tidak memiliki gejala spesifik sehingga sulit dibedakan dari tumor lain. Angka rekurensi tinggi sehingga sering muncul kembali setelah eksisi. Pemeriksaan histopatologi pre-operatif penting untuk diagnosis agar penanganan tepat untuk menekan rekurensi.Giant cell tumor of tendon sheath (GCTTS) is the 2nd most common tumor in the hand but is rarely encountered in everyday practice. The tumor has a tendency to develop in women aged 30-50 years and has no specific symptoms, making GCTTS difficult to be distinguished clinically from other tumors occurring mainly in the hand. High recurrence rate also made these tumors often reappear despite having been excised. Pre-operative histopathologic examination is important in diagnosis so appropriate steps can be taken to suppress the recurrence rate. 
Cytokeratin 7 and Cytokeratin 19 Expressions in Oval Cells and Mature Cholangiocytes as Diagnostic and Prognostic Factors of Cholestasis Dyonesia Ary Harjanti; Ening Krisnuhoni; Santoso Cornain
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 12, NUMBER 1, April 2011
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/121201128-33

Abstract

Background: The activity of liver progenitor cells as bipotent liver stem cells, such as the oval cells, has been observed. The presence of oval cells and mature cholangiocytes forming hepatobiliary ductules may be applied to distinguish extrahepatic and intrahepatic cholestasis of the infants. Method: This cross sectional study was performed on 40 paraffin-embedded sections consisting of 2 groups of 20 cases with extrahepatic and intrahepatic cholestasis of the infants from histophatological examination in Cipto Mangunkusumo hospital Jakarta between January 2000 and September 2011. The liver fibrosis grading was reevaluated by hematoxylin and eosin and also trichrome staining. The specimens were tested by immunohistochemical staining for cytokeratin (CK) 7 and CK 19 expressions in oval cells and mature cholangiocytes. The correlation between CK7/CK19 expressions in oval cells and liver fibrosis were analyzed by Spearman’s correlation test. Results: Expressions of CK7 and CK 19 on oval cells and mature cholangiocytes performed in hepatobiliary ductules, were significantly higher in extrahepatic than intrahepatic cholestasis with p 0.05. CK7 and CK19 expressions in oval cells showed strong correlation with the degree of liver fibrosis with r = 0.793; p 0.05 for CK 7 and r = 0.827; p 0.05 for CK 19. Conclusion: Expressions of CK7 and CK19, in oval cells and mature cholangiocytes, were higher at extrahepatic than intrahepatic cholestasis. Expressions of CK7 and CK19 in oval cells were directly proportional to the degree of liver fibrosis in cholestasis of the infants.   Keywords: cholestasis, oval cell, cholangiocytes, fibrosis, CK7, CK19
Cervical cancer screening before hysterectomy in pelvic organ prolapse patients: Is it essential? A case series Aryasatiani, Ekarini; Surya, Raymond; Harjanti, Dyonesia Ary; Ilona, Florinda; Kartika, Chandra Dewi; Cantika, Catalya Christina; Tenka, Lisda
Majalah Obstetri & Ginekologi Vol. 33 No. 2 (2025): August
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mog.V33I22025.173-179

Abstract

HIGHLIGHTS More advanced cervical precancerous histopathological findings compared with cervical cytology are observed in POP patients undergoing vaginal hysterectomy. Routine use of preoperative biopsy or ultrasound in POP patients undergoing vaginal hysterectomy cannot be recommended.   ABSTRACT Objective: Pelvic organ prolapse (POP) results from weakening of the pelvic floor musculature. The reported prevalence of unexpected premalignant and malignant pathologies following hysterectomy ranges from 0.2 to 0.8%. This study aims to present a case series of patients with POP who underwent vaginal hysterectomy (VH) after preoperative evaluation for abnormal cervical cytology, which subsequently demonstrated more advanced histopathological findings. Case Series: Case 1: A 55-year-old woman, P3A0, was diagnosed with third-degree uterine prolapse and cystocele. Pap smear revealed atypical glandular cells of undetermined significance (AGUS). Histopathological examination after VH demonstrated vaginitis and metaplastic chronic cervicitis with atypia progressing to mild dysplasia of endocervical epithelial cells/low-grade squamous intraepithelial lesion (LSIL). Case 2: A 62-year-old woman, P5A0, was diagnosed with third-degree uterine prolapse. Pap smear revealed atypical squamous cells of undetermined significance (ASCH). Histopathological evaluation after VH demonstrated high-grade squamous intraepithelial lesion (HSIL) up to carcinoma in situ with microinvasive glandular involvement and focal extension. Conclusion: Given that cervical cancer remains the second leading cause of mortality among women in Indonesia, preoperative screening for precancerous gynecological lesions and malignancy is strongly recommended.
Co-Authors Aryasatiani, Ekarini Benedict Djitro, Timotius Cantika, Catalya Christina Ening Krisnuhoni Ilona, Florinda Iwan Irawan Karman, Iwan Irawan Kartika, Chandra Dewi Kidyarto Suryawinata, Kidyarto Raymond Surya Santoso Cornain Santoso Cornain Tenka, Lisda