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ASAP ROKOK KONVENSIONAL DAN ELEKTRONIK MEMBERIKAN GAMBARAN KERUSAKAN STRUKTUR ALVEOLUS YANG SAMA Jenny Lauvita; Tena Djuartina; Dyonesia Ary; Iskandar Rahardjo Budianto; Robi Irawan
Bahasa Indonesia Vol 21 No 1 (2022): Damianus Journal of Medicine
Publisher : Atma Jaya Catholic University of Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25170/djm.v21i1.2093

Introduction: Cigarettes have become the cause of health problems and even death, especially in developing countries like Indonesia. Cigarettes contain various free radical components for the body, thereby increasing inflammation in various organs and tissues, especially the lungs. This will trigger proteolysis so that the alveoli lose elasticity. Electronic cigarettes are then introduced as an alternative to reduce smoking. However, there has been not enough research conducted on their safety and long-term effects of e-cigarettes, so researcher aim to compare the impact of conventional and electronic cigarettes on alveolar damage. Methods: This research was conducted experimentally, using 30 male Sprague Dawley rats aged 10-12 weeks and weighing 150-250 grams as sample. These rats were necropsed after being exposed to cigarettes smoke and e-cigarettes vapor for 2 weeks and 4 weeks to make lung tissue preparations with HE staining. These preparations were observed under a microscope to measure the degree of alveolar damage based on the edema, alveolar septal destruction, and inflammatory cell infiltration. Finally, the data was analyzed using Kruskal-Wallis followed by one-Mann-Whitney statistical tests with STATA. Results: Rats exposed to conventional cigarette smoke and e-cigarette vapor in the second week already showed significant alveolar damage compared to the control group. (p<0.05). However, there was no significant difference between exposure for 2 weeks and 4 weeks. (p>0.05) Between rats given conventional cigarette smoke and electronic cigarette vapor, there was no significant difference in degree of alveolar damage at week 2 and week 4. (p>0.05) Discussion: As a result, both conventional cigarette smoke and e-cigarette vapor have the same effect on alveolar damage. This is because both conventional cigarette smoke and e-cigarette vapor contain nicotine which will trigger the release of fibronectin so that it can trigger fibrosis in the lung parenchyma. In addition, the carbon monoxide contained in both can inhibit fibroblast proliferation and damage the elastin in the alveolar wall, so that the alveoli lose its elasticity and tend to expand. Keywords: Lung inflammation, cigarettes effect on lungs, e-cigarettes, tobacco cigarette, lung damage

John Cunningham Virus T-Antigen Expression on Mild and Severe Dysplasia Adenomatous Polyp, Low and High Grade Adenocarcinoma of The Colon Dyonesia Ary Harjanti; Cyprianus Murtono; Kidyarto Suryawinata; Angelina Halim; Michelle Felicia Wiryokusuma; Timotius Benedict Djitro
Molecular and Cellular Biomedical Sciences Vol 3, No 1 (2019)
Publisher : Cell and BioPharmaceutical Institute

Background: John Cunningham Virus (JCV) was involved in pre-malignant lessions and carcinogenesis of the colon. The purpose of this study was to detect and analyze JCV T-Ag expression in mild and severe dysplasia adenomatous polyp as well as low and high grade adenocarcinoma of the colon.Materials and Methods: This study used analytic descriptive, cross sectional approach. The samples’ paraffin blocks were taken from colon adenomatous polyp cases (all grades of dysplasia) and cases of colon adenocarcinoma (all degrees) at Anatomical Pathology Laboratory, School of Medicine, Atma Jaya Catholic University of Indonesia from 2010-2014 (5 years period). Samples were reviewed from HE slides to determine histopathologic diagnosis, grades of dysplasia and grading. We performed immunohistochemistry staining with monoclonal antibody anti–SV 40-T-Ag to detect JCV T-Ag expression.Results: We found 7 cases of colon adenomatous polyp, of which 4 (57%) were mild dysplasia and 3 (43%) were severe dysplasia. Positive expression of JCV T-Ag was detected in 1 (14%) mild dysplasia case. Data analysis using Fischer’s Exact Test was p>0.05. We also found 16 cases of colon adenocarcinoma. 14 cases (87.5%) of low grade variant and 2 cases (12.5%) of high grade variant. Positive expression of JCV T-Ag was detected in 2 (12.5%) low grade cases. Data analysis using Fischer’s Exact Test was p>0.05.Conclusion: There was no difference of JCV T-Ag expression in colon adenomatous polyp (mild-severe dysplasia) and colon adenocarcinoma (low-high grade) cases at Anatomical Pathology Laboratory School of Medicine, Atma Jaya Catholic University of Indonesia 2010-2014.Keywords: colon adenomatous polyp, adenocarcinoma, JCV T-Ag

Giant Cell Tumor of Tendon Sheath Timotius Benedict Djitro; Dyonesia Ary Harjanti; Kidyarto Suryawinata; Iwan Irawan Karman
Cermin Dunia Kedokteran Vol 46, No 11 (2019): Kesehatan Anak
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v46i11.409

Giant cell tumor of tendon sheath (GCTTS) adalah tumor kedua tersering di tangan, tetapi relatif jarang ditemui pada praktek sehari-hari. Tumor yang cenderung timbul pada wanita berusia 30-50 tahun ini tidak memiliki gejala spesifik sehingga sulit dibedakan dari tumor lain. Angka rekurensi tinggi sehingga sering muncul kembali setelah eksisi. Pemeriksaan histopatologi pre-operatif penting untuk diagnosis agar penanganan tepat untuk menekan rekurensi.Giant cell tumor of tendon sheath (GCTTS) is the 2nd most common tumor in the hand but is rarely encountered in everyday practice. The tumor has a tendency to develop in women aged 30-50 years and has no specific symptoms, making GCTTS difficult to be distinguished clinically from other tumors occurring mainly in the hand. High recurrence rate also made these tumors often reappear despite having been excised. Pre-operative histopathologic examination is important in diagnosis so appropriate steps can be taken to suppress the recurrence rate.

Jejunal MALT (Mucosa Associated Lymphoid Tissue) Lymphoma: A Case Report Alexandria Stephanie Suparman; Daniel Ardian Soeselo; Dyonesia Arie Harjanti
Indonesian Journal of Cancer Vol 12, No 4 (2018): October-December
Publisher : National Cancer Center - Dharmais Cancer Hospital

Background: MALT (Mucosa Associated Lymphoid Tissue) Lymphoma is an uncommon condition. It is an involvement of extranodal site in hematologic malignancy, Non-Hodgkin Lymphoma.Case Presentation: Pondok Indah, Puri Indah Hospital Jakarta treated a 38-year-old female with acute abdomen due to jejunal MALT Lymphoma perforation, one meter from treitz ligament. Emergency laparotomy was performed, the patient had a resection and end to end anastomose. She was hospitalized in intensive care unit for 4 days after the surgery and died because of prolonged septic shock.Conclusions: MALT lymphoma is an uncommon condition which is often encountered in emergency conditions due to acute abdominal pain caused by intra-abdominal perforation of the hollow viscus. Late diagnosis and treatment may cause severe outcome such as perforation and hypovolemic shock. This case report is expected to provide insight and to increase the awareness of the incidence of jejunal MALT lymphoma in Indonesia.

Cytokeratin 7 and Cytokeratin 19 Expressions in Oval Cells and Mature Cholangiocytes as Diagnostic and Prognostic Factors of Cholestasis Dyonesia Ary Harjanti; Ening Krisnuhoni; Santoso Cornain
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 12, NUMBER 1, April 2011
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/121201128-33

Background: The activity of liver progenitor cells as bipotent liver stem cells, such as the oval cells, has been observed. The presence of oval cells and mature cholangiocytes forming hepatobiliary ductules may be applied to distinguish extrahepatic and intrahepatic cholestasis of the infants. Method: This cross sectional study was performed on 40 paraffin-embedded sections consisting of 2 groups of 20 cases with extrahepatic and intrahepatic cholestasis of the infants from histophatological examination in Cipto Mangunkusumo hospital Jakarta between January 2000 and September 2011. The liver fibrosis grading was reevaluated by hematoxylin and eosin and also trichrome staining. The specimens were tested by immunohistochemical staining for cytokeratin (CK) 7 and CK 19 expressions in oval cells and mature cholangiocytes. The correlation between CK7/CK19 expressions in oval cells and liver fibrosis were analyzed by Spearman’s correlation test. Results: Expressions of CK7 and CK 19 on oval cells and mature cholangiocytes performed in hepatobiliary ductules, were significantly higher in extrahepatic than intrahepatic cholestasis with p 0.05. CK7 and CK19 expressions in oval cells showed strong correlation with the degree of liver fibrosis with r = 0.793; p 0.05 for CK 7 and r = 0.827; p 0.05 for CK 19. Conclusion: Expressions of CK7 and CK19, in oval cells and mature cholangiocytes, were higher at extrahepatic than intrahepatic cholestasis. Expressions of CK7 and CK19 in oval cells were directly proportional to the degree of liver fibrosis in cholestasis of the infants. Keywords: cholestasis, oval cell, cholangiocytes, fibrosis, CK7, CK19

Giant Cell Tumor of Tendon Sheath Timotius Benedict Djitro; Dyonesia Ary Harjanti; Kidyarto Suryawinata; Iwan Irawan Karman
Cermin Dunia Kedokteran Vol. 46 No. 11 (2019): Pediatri
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v46i11.406

Giant cell tumor of tendon sheath (GCTTS) adalah tumor kedua tersering di tangan, tetapi relatif jarang ditemui pada praktek sehari-hari. Tumor yang lebih sering terjadi pada wanita berusia 30-50 tahun ini tidak memiliki gejala spesifik sehingga sulit dibedakan dari tumor lain yang ditemukan pada tangan. Angka rekurensi tinggi sehingga sering muncul kembali setelah eksisi. Pemeriksaan histopatologi pre-operatif penting untuk diagnosis agar penanganan tepat untuk menekan rekurensi. Giant cell tumor of tendon sheath (GCTTS) is the 2nd most common tumor in the hand but is rarely encountered in everyday practice. The tumor has a tendency to develop in women aged 30-50 years and has no specific symptoms, making GCTTS difficult to be distinguished clinically from other tumors occurring mainly in the hand. High recurrence rate also made these tumors often reappear despite having been excised. Pre-operative histopathology examination is important in diagnosis so appropriate steps can be taken to suppress the recurrence rate.

Giant Cell Tumor of Tendon Sheath Timotius Benedict Djitro; Dyonesia Ary Harjanti; Kidyarto Suryawinata; Iwan Irawan Karman
Cermin Dunia Kedokteran Vol 46 No 11 (2019): Pediatri
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v46i11.406

Giant cell tumor of tendon sheath (GCTTS) adalah tumor kedua tersering di tangan, tetapi relatif jarang ditemui pada praktek sehari-hari. Tumor yang lebih sering terjadi pada wanita berusia 30-50 tahun ini tidak memiliki gejala spesifik sehingga sulit dibedakan dari tumor lain yang ditemukan pada tangan. Angka rekurensi tinggi sehingga sering muncul kembali setelah eksisi. Pemeriksaan histopatologi pre-operatif penting untuk diagnosis agar penanganan tepat untuk menekan rekurensi. Giant cell tumor of tendon sheath (GCTTS) is the 2nd most common tumor in the hand but is rarely encountered in everyday practice. The tumor has a tendency to develop in women aged 30-50 years and has no specific symptoms, making GCTTS difficult to be distinguished clinically from other tumors occurring mainly in the hand. High recurrence rate also made these tumors often reappear despite having been excised. Pre-operative histopathology examination is important in diagnosis so appropriate steps can be taken to suppress the recurrence rate.

Kualitas Pembelajaran Daring di Fakultas Kedokteran dan Ilmu Kesehatan Universitas Katolik Indonesia Atma Jaya Leandro Chandra; Dyonesia Ary Harjanti; Natalia Puspadewi
Bahasa Indonesia Vol 25 No 1 (2026): Damianus Journal of Medicine
Publisher : Atma Jaya Catholic University of Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25170/djm.v25i1.4926

Pendahuluan: Pandemi COVID-19 memicu era daring baru pada institusi pendidikan kedokteran di seluruh dunia akibat pembatasan sosial, namun penerapannya mendadak dan tanpa persiapan yang baik. Penelitian ini bertujuan untuk mengetahui kualitas pembelajaran daring di Fakultas Kedokteran dan Ilmu Kesehatan Universitas Katolik Atma Jaya (FKIK UAJ) selama masa pandemi COVID-19. Kualitas pembelajaran daring terutama dinilai dari aspek dosen yaitu kemampuan membuat kelas interaktif, memotivasi mahasiswa, dan menerapkan rencana pembelajaran, karena masalah utama dalam penerapan pembelajaran daring selama masa pandemi adalah komunikasi dan motivasi belajar mahasiswa. Metode: Penelitian dilakukan secara retrospektif dari bulan Maret 2020 sampai November 2021 menggunakan data evaluasi akademis dan demografi dosen FKIK UAJ. Pengambilan sampel dilakukan dengan metode purposif. Dari pengambilan sampel didapatkan 60-108 responden. Data diolah dengan uji korelasi ranking Spearman dan analisis regresi linear. Hasil: Penerapan strategi pembelajaran interaktif, upaya motivasi siswa, dan perencanaan pembelajaran terstruktur didapatkan meningkat secara bertahap di setiap semester. Didapatkan hubungan yang signifikan antara pengalaman mengajar dengan kualitas mengajar pada semester genap tahun 2020/2021. Simpulan: Kualitas pembelajaran daring di FKIK UAJ telah berkembang selama masa pandemi COVID-19. Kualitas ini dapat dipengaruhi lama pengalaman mengajar dosen. Semakin sedikit lama pengalaman mengajar, semakin besar kualitas pembelajaran daring yang diberikan. Pelaksanaan pembelajaran daring dapat menjadi salah satu model rekomendasi setelah masa pandemi dan lebih baik dilakukan oleh dosen yang lebih muda.

LAYANAN KESEHATAN BERGERAK UNTUK PEMERIKSAAN PENYAKIT DAN EDUKASI GAYA HIDUP SEHAT DI FLORES TIMUR DAN ENDE Ian Pranandi; Linawati Hananta; Handayani Maria Dara Novi; Dyonesia Ary Harjanti; Felicia Kurniawan; Carmen Claude Margo; Brigitte Leonie Rosadi
Mitramas: Jurnal Pengabdian dan Pemberdayaan Masyarakat Vol. 4 No. 02 (2026): Mitramas, Jurnal Pengabdian dan Pemberdayaan Masyarakat
Publisher : Universitas Katolik Indonesia Atma Jaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25170/mitramas.v4i02.7388

Keterbatasan akses terhadap pelayanan kesehatan di daerah terpencil seperti Kabupaten Flores Timur dan Kabupaten Ende di Nusa Tenggara Timur menjadi tantangan besar dalam pemenuhan hak dasar masyarakat atas kesehatan. Sebagai respons terhadap hal tersebut, Fakultas Kedokteran dan Ilmu Kesehatan Universitas Katolik Indonesia Atma Jaya bekerja sama dengan Yayasan Ignatius Joseph Kasimo menyelenggarakan kegiatan pengabdian kepada masyarakat dalam bentuk pelayanan kesehatan bergerak selama perayaan Semana Santa 2025. Kegiatan ini tidak hanya bertujuan memberikan layanan pengobatan umum dan edukasi kesehatan secara langsung kepada masyarakat, tetapi juga mendokumentasikan pola penyakit yang sering ditemukan serta melakukan refleksi terhadap sistem pelayanan yang dijalankan. Metode pelaksanaan mencakup kunjungan langsung ke desa-desa terpencil, observasi pelayanan, pencatatan data klinis, dan koordinasi dengan tenaga kesehatan setempat. Hasil kegiatan menunjukkan antusiasme masyarakat yang tinggi serta efektivitas pelayanan berbasis tim medis kecil namun adaptif. Kegiatan ini menegaskan pentingnya kolaborasi multi-sektor dan pendekatan desentralisasi dalam menjangkau komunitas yang terisolasi secara geografis. Artikel ini menjadi kontribusi akademik untuk pengembangan model pelayanan kesehatan komunitas yang kontekstual dan berkelanjutan.

LAYANAN KESEHATAN BERGERAK UNTUK PEMERIKSAAN PENYAKIT DAN EDUKASI GAYA HIDUP SEHAT DI FLORES TIMUR DAN ENDE Ian Pranandi; Linawati Hananta; Handayani Maria Dara Novi; Dyonesia Ary Harjanti; Felicia Kurniawan; Carmen Claude Margo; Brigitte Leonie Rosadi
Mitramas: Jurnal Pengabdian dan Pemberdayaan Masyarakat Vol. 4 No. 02 (2026): Mitramas, Jurnal Pengabdian dan Pemberdayaan Masyarakat
Publisher : Universitas Katolik Indonesia Atma Jaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25170/mitramas.v4i02.7388

Keterbatasan akses terhadap pelayanan kesehatan di daerah terpencil seperti Kabupaten Flores Timur dan Kabupaten Ende di Nusa Tenggara Timur menjadi tantangan besar dalam pemenuhan hak dasar masyarakat atas kesehatan. Sebagai respons terhadap hal tersebut, Fakultas Kedokteran dan Ilmu Kesehatan Universitas Katolik Indonesia Atma Jaya bekerja sama dengan Yayasan Ignatius Joseph Kasimo menyelenggarakan kegiatan pengabdian kepada masyarakat dalam bentuk pelayanan kesehatan bergerak selama perayaan Semana Santa 2025. Kegiatan ini tidak hanya bertujuan memberikan layanan pengobatan umum dan edukasi kesehatan secara langsung kepada masyarakat, tetapi juga mendokumentasikan pola penyakit yang sering ditemukan serta melakukan refleksi terhadap sistem pelayanan yang dijalankan. Metode pelaksanaan mencakup kunjungan langsung ke desa-desa terpencil, observasi pelayanan, pencatatan data klinis, dan koordinasi dengan tenaga kesehatan setempat. Hasil kegiatan menunjukkan antusiasme masyarakat yang tinggi serta efektivitas pelayanan berbasis tim medis kecil namun adaptif. Kegiatan ini menegaskan pentingnya kolaborasi multi-sektor dan pendekatan desentralisasi dalam menjangkau komunitas yang terisolasi secara geografis. Artikel ini menjadi kontribusi akademik untuk pengembangan model pelayanan kesehatan komunitas yang kontekstual dan berkelanjutan.

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