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All Journal Jurnal Kedokteran Syiah Kuala Majalah Kedokteran Bandung Cermin Dunia Kedokteran IJRETINA - International Journal of Retina Ophthalmologica Indonesiana
Lia Meuthia Zaini, Lia Meuthia
Fakultas Kedokteran, Universitas Syiah Kuala
Health Professions Medicine & Pharmacology Public Health

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Korelasi Derajat Graves’ Ophthalmopathy dengan Durasi Menderita Hipertiroid Fajar, Jonny Karunia; Hidayah, Cut Intan; Zaini, Lia Meuthia; Zufry, Hendra; -, Jamhur
Cermin Dunia Kedokteran Vol 42, No 5 (2015): Kardiologi
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (148.188 KB) | DOI: 10.55175/cdk.v42i5.1006

Abstract

Graves’ ophthalmopathy merupakan penyakit autoimun. Studi ini bertujuan untuk mengetahui distribusi manifestasi klinis Graves’ ophthalmopathy dan mengetahui kaitan lama menderita hipertiroid dengan derajat keparahan Graves’ ophthalmopathy. Penelitian ini merupakan penelitian observasional analitik dengan 34 sampel penderita Graves’ ophthalmopathy. Data dianalisis menggunakan uji Spearman. Hasil penelitian ini menunjukkan bahwa distribusi manifestasi klinis penderita Graves’ ophthalmopathy di poliklinik endokrin RSUZA adalah 23,5% derajat 0; 8,8% derajat 1; 14,7% dengan derajat 2; 14,7% derajat 3; 11,7% derajat 4; 20,5% derajat 5; dan 5,8% derajat 6. Terdapat asosiasi signifikan antara lama menderita hipertiroid dengan derajat Graves’ ophthalmopathy (p=0,000). Kebanyakan penderita Graves’ ophthalmopathy memiliki manifestasi klinis derajat 0 dan lama menderita hipertiroid berbanding lurus dengan tingkat keparahan Graves’ ophthalmopathy.Graves’ ophthalmopathy is an autoimmune disease. The aim of this study is to determine the characteristic of the clinical manifestations of Graves’ ophthalmopathy and the association between duration of hyperthyroidism and the degree of Grave’s ophthalmopathy. It is an analytical observational study in 34 patients with Graves’ ophthalmopathy. Data were analyzed using the Spearman test. It showed that 23.5% of the patients were in stage 0; 8.8% were in stage 1; 14.7% were in stage 2; 14.7% were in stage 3; 11.7% were in stage 4; 20.5% were in stage 5; and 5.8% were in stage 6. There was a significant association between the degree of Graves’ ophthalmopathy and duration of hyperthyroidism. Majority of the patients with Graves’ ophthalmopathy had clinical manifestation of stage 0 and the duration of hyperthyroidism was significantly associated with the severity of Graves’ ophthalmopathy.
Corticosteroid induced glaucoma Lia Meuthia Zaini
Jurnal Kedokteran Syiah Kuala Vol 9, No 3 (2009): Volume 9 Nomor 3 Desember 2009
Publisher : Universitas Syiah Kuala

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Abstract

 ABSTR4.K.  Corticosteroid induced glaucoma adalah glaukorna yang  disebabkan   oleh pemakaian terapi kortikosteroid   jangka  panjang  baik secara   oral, intravena,   topikal,  periokular, ataupun  intravitreal. Penyakit ini terjadi oleh karena meningkatnnya tahanan aliran keluar humor akuos yang disebabkan oleh perubahan   mikrostruktur   anyaman   trabekulum,    akumulasi   matriks   ekstraselular    pada   anyaman trabekulum,   atau terhambatnya aktivitas  fagositosis   sel endotel.   Selain  itu juga  dapat berkaitan dengan mutasi gen  myocilin  (MYOC) dan optineurin (OPTN).  Manifestasi klinisnya mirip seperti Glaukoma Primer Sudut Terbuka, sedangkan pada anak-anak   seperti Glaukoma Kongenital.  Diagnosis  ditegakkan dengan  adanya  riwayat  penggunaan kortikosteroid jangka  panjang,  ditemukannya   peningkatan   TIO, ekskavasio  papil  saraf  optik,   dan   defek  lapang   pandang  pada  pemerilcsaan oftalmologis.   Prinsip penataiaksanaan  adalah dengan menghentikan pemakaian kortikosteroid dan  pemberian obat-obat anti glaukoma.   Selain itu pada beberapa kasus perlu ctilakukan  terapi pembedahan.  (JKS2009; J:165·170) Kata  kunci:  Corticosteroid,  Glukoma, myocin, optineurinABSTRACT.  Corticosteroid Induced Glaucoma is Glaucoma disease  associated with  long term treatment of oral, intravenous, topical,  periocular,  or intravitreal  corticosteroid.   This  disease caused by obstruction of aqueous outflow facility resulted from alterations in  trabecular meshwork morphology,  extra cellular matrix accumulation, and inhibition  of phagocytosis  activity of endothelial cells.  There is also association of this disease with mutation of Glaucoma gene, Myocilin (MYOC) and Optineurin (OPTN).  Clinical manifestations  are  similar  with  Primary Open  Angle  Glaucoma,  whereas  in  children  similar   with Congenital Glaucoma.  History of long term used of corticosteroid is important to make the diagnosis, besides   highly elevated of intraocular pressure, optic nerve excavation,  and visual field defect.  This glaucoma is best treated by withdrawal  of the steroid preparation, and antiglaucoma   medication.   In some cases, surgical treatment is also needed.  (JKS 2009; J:165-170) Keyword:  Corticosteroid,  Glukoma, myocin, optineurin
Hubungan derajat sesak napas dengan depresi dan kualitas hidup pada pasien Penyakit Paru Obstruktif Kronik (PPOK) di RSUDZA Banda Aceh Novita Andayani; Lia Meuthia Zaini; Telavani Umri
Jurnal Kedokteran Syiah Kuala Vol 19, No 3 (2019): Volume 19 Nomor 3 Desember 2019
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jks.v19i3.18114

Abstract

Abstrak: Penyakit Paru Obstruktif Kronik (PPOK) adalah penyakit paru yang ditandai adanya hambatan aliran udara di saluran napas yang bersifat progresif akibat inflamasi kronik yang disebabkan oleh merokok ataupun terpapar partikel gas beracun. Adanya keterbatasan aliran udara ini menyebabkan pasien PPOK mengalami sesak napas. Hal ini membuat pasien PPOK cenderung pasif dan menghindari aktivitas agar tidak sesak napas. Apabila hal ini terus berlanjut pasien PPOK cenderung mengalami depresi karena kehidupannya yang serba ketergantungan terhadap obat dan orang lain. Secara keseluruhan hal ini akan menurunkan kualitas hidup pasien PPOK. Penelitian ini bertujuan untuk mengetahui hubungan derajat sesak napas dan depresi terhadap kualitas hidup pasien PPOK di Poliklinik Paru RSUDZA Banda Aceh. Penelitian ini merupakan analitik observasional dengan desain crosssectional. Teknik sampling yang digunakan ialah accidental sampling dengan jumlah responden 65 orang. Hasil analisis komparatif dengan uji Spearman menunjukkan hubungan yang signifikan antara derajat sesak napas dengan kualitas hidup (p = 0,000) dan terdapat hubungan yang signifikan antara depresi dengan kualitas hidup (p = 0,002) pada pasien PPOK di Poliklinik Paru RSUDZA Banda Aceh.Kata kunci: derajat sesak napas, depresi, kualitas hidup.Abstract: Chronic Obstructive Pulmonary Disease (COPD) is a pulmonary disease that marked by airflow limitation in respiratory tract progressively because of chronic inflammation by cigarette or toxic gases. This airflow limitation may cause COPD patient got dyspnea. This could make people with COPD tend to be passive and avoid doing activities. If this happen continuously people with COPD tend to depression because of his/her dependence on drugs or someone else. Overall that would decrease the quality of life people with COPD. This study aims to search the association between degree of dyspnea and depression in people living with COPD in RSUDZA. This study is analytical observation with crossectional design. The sampling method is a accidental sampling with 65 sample. The result using statistical Spearman test show that there is a significant relationship between degree of dyspnea with depression (p = 0.000) and also significant relationship between degree of dyspnea with depression (p = 0.000) in people with COPD in RSUDZA.Keywords: dyspnea, depression, quality of life.
Eales disease’ : etiopatogenesis dan tatalaksana Lia Meuthia Zaini
Jurnal Kedokteran Syiah Kuala Vol 19, No 3 (2019): Volume 19 Nomor 3 Desember 2019
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jks.v19i3.18120

Abstract

Abstrak. Eales disease merupakan kelainan vaskulopati obliteratif idiopatik primer, yang ditandai dengan adanya inflamasi pembuluh darah, oklusi, dan neovaskularisai pada retina, terutama mengenai pembuluh vena retina perifer. Kelainan ini pertama kali dideskripsikan oleh Henry Eales pada tahun 1882. Eales disease ditemukan di negara Inggris, Amerika, dan Kanada pada pertengahan abad ke-19 dan awal abad ke-20. Namun saat ini lebih sering ditemukan di negara India, dengan insidensi 1 dari 200-250 pasien dengan kelainan mata. Pada awal penyakit, beberapa pasien tidak menunjukkan gejala, namun yang lainnya menunjukkan gejala berupa adanya bintik-bintik yang melayang (floaters), serta pandangan kabur atau berkabut yang mungkin diakibatkan dari perdarahan vitreous.Terapi dengan kortikosteroid saat ini masih menjadi terapi utama dalam menangani vaskulitis yang terjadi pada retina. Beberapa tindakan lain yang juga dapat dilakukan adalah pemberian anti-VEGF, laser fotokoagulasi, penggunaan obat anti-tuberculosa, serta bedah vitreo-retina untuk mengatasi perdarahan vitreous yang terjadi. Kata kunci : Eales’disease, vaskulitis retina, tuberculosisAbstract. Eales disease is a primary idiopathic occlusive vasculopathy, characterized by venous inflammation (vasculitis), occlusion, and retinal neovascularization that usually involves the peripheral retina. This disease was first describe by Henry Eales in 1882. Eales disease was initially reported in United Kingdom, U.S.A, and Canada in the mid 19th century and the beginning of the 20th century. Now seen more commonly in the Indian, with the incidence was 1 in 200-250 ophthalmic patients. In the initial stages, some patients are often asymptomatic, but some may develop symptoms such as floaters and blurring vision due to vitreous hemorrhage. Corticosteroids remain the mainstay therapy to treat vasculitis in the retina. Others management are anti VEGF, laser photocoagulation, anti tuberculosis drugs, and vitreo-retinal surgery to manage unresolved vitreous hemorrhage. Key words: Eales’disease, retinal  vaskulitis, tuberculosis
Leber’s Hereditary Optic Neuropathy Lia Meuthia Zaini
Jurnal Kedokteran Syiah Kuala Vol 14, No 3 (2014): Volume 14 Nomor 3 Desember 2014
Publisher : Universitas Syiah Kuala

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Abstract

Abstrak. Leber’s Hereditary Optic Neuropathy (LHON) adalah kelainan genetika mitokondria yang ditandai dengan adanya penurunan tajam penglihatan bilateral tanpa nyeri. Kelainan ini pertama kali ditemukan oleh Theodor Leber (1871), dimana sebagian besar kasus menyerang laki-laki usia 10-30 tahun. LHON berhubungan dengan mutasi DNA mitokondria, terutama pada nukleotida 11778. Beberapa kasus dapat pula disebabkan oleh mutasi pada nukleotida 3460 atau 14484. Manifestasi klinis yang dapat dijumpai adalah kehilangan tajam penglihatan mendadak (2/20), progresif tanpa nyeri. Selain itu juga dapat ditemukan menurunnya refleks cahaya pada pupil, defek lapang pandangan, dan gangguan penglihatan warna merah hijau. Gambaran fundus dapat terlihat hiperemi dan elevasi diskus optik, penebalan peripapil retina (pseudoedema), telangiektasia peripapil, dan arteriol retina berkelok. Diagnosis ditegakkan berdasarkan manifestasi klinis dan pemeriksaan penunjang yang kompleks. Antioksidan, vitamin B12 dan asam folat telah digunakan, namun tidak menunjukkan hasil yang baik.Berbagai strategi pengobatan seperti terapi gen dan obat-obatan lain masih dalam tahap penelitian.Abstract. Leber’s Hereditary Optic Neuropathy (LHON) is mitochondrial genetic disease characterized by a bilateral painless loss of vision, which firstly described by Theodore Leber in 1871. This disease typically affects males age 10-30 years. LHON is related to mitochondria DNA mutations, most frequently at the nucleotides 11778, less commonly at the nucleotides 3460 and 14484. The syndrome presents with acute severe painless loss of vision (2/20, decrease pupillary reflex, visual field defect, and red green color vision defect. The classic fundus appearance includes hyperemia and elevation of the optic disc, thickening of the peripapillary retina (pseudoedema), peripapillary telangiectasia, and tortuosity of the retinal arterioles. Diagnosis made by clinical manifestations and complex investigations. Antioxidants, vitamin B12, and folic acid have been used, but no definite benefit has been shown. Various promising strategies of therapy for LHON, such as gene therapy and pharmacologic agents, are presently being investigated.
Correlation Between Diabetic Retinopathy, Depression Level and Quality of Life in Eye Clinic Zainoel Abidin Hospital Lia Meuthia Zaini; Devia Alfiza Sari; Vera Dewi Mulia; Annisa Meivira Budiman
Majalah Kedokteran Bandung Vol 54, No 2 (2022)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v54n2.2609

Abstract

Diabetic retinopathy (DR) is one of the eye disorders caused by complications of diabetes mellitus (DM). Indonesia has a high prevalence of DR (43.1%) compared to other Asia-Pacific countries. Damage and blockage of blood vessels in the retina causes impaired vision, which may lead to a total vision loss. DR requires special treatment, coupled with regular treatment, that is expensive and may result in depression and poor quality of life. This study aimed to determine the association between the degree of diabetic retinopathy with the level of depression and quality of life in people with DR in the eye clinic of Zainoel Abidin General Hospital Banda Aceh. This cross-sectional study was conducted from April 2018 to January 2019. Data were obtained through funduscopy reading, Hamilton Depression Rating Scale (HDRS) questionnaire, and Short-Form Health Survey (SF-36). The subjects of this study were all diabetic retinopathy patients who were sampled using the accidental sampling method. Based on the Spearman correlation analysis, there was a correlation between degree of DR and depression level (p value of 0.004) and quality of life (p value of 0,037). In conclusion, there is a moderate correlation between the degree of DR with depression level and quality of life among DM patients.
Korelasi Derajat Graves’ Ophthalmopathy dengan Durasi Menderita Hipertiroid Jonny Karunia Fajar; Cut Intan Hidayah; Lia Meuthia Zaini; Hendra Zufry; Jamhur -
Cermin Dunia Kedokteran Vol 42, No 5 (2015): Kardiologi
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v42i5.1006

Abstract

Graves’ ophthalmopathy merupakan penyakit autoimun. Studi ini bertujuan untuk mengetahui distribusi manifestasi klinis Graves’ ophthalmopathy dan mengetahui kaitan lama menderita hipertiroid dengan derajat keparahan Graves’ ophthalmopathy. Penelitian ini merupakan penelitian observasional analitik dengan 34 sampel penderita Graves’ ophthalmopathy. Data dianalisis menggunakan uji Spearman. Hasil penelitian ini menunjukkan bahwa distribusi manifestasi klinis penderita Graves’ ophthalmopathy di poliklinik endokrin RSUZA adalah 23,5% derajat 0; 8,8% derajat 1; 14,7% dengan derajat 2; 14,7% derajat 3; 11,7% derajat 4; 20,5% derajat 5; dan 5,8% derajat 6. Terdapat asosiasi signifikan antara lama menderita hipertiroid dengan derajat Graves’ ophthalmopathy (p=0,000). Kebanyakan penderita Graves’ ophthalmopathy memiliki manifestasi klinis derajat 0 dan lama menderita hipertiroid berbanding lurus dengan tingkat keparahan Graves’ ophthalmopathy.Graves’ ophthalmopathy is an autoimmune disease. The aim of this study is to determine the characteristic of the clinical manifestations of Graves’ ophthalmopathy and the association between duration of hyperthyroidism and the degree of Grave’s ophthalmopathy. It is an analytical observational study in 34 patients with Graves’ ophthalmopathy. Data were analyzed using the Spearman test. It showed that 23.5% of the patients were in stage 0; 8.8% were in stage 1; 14.7% were in stage 2; 14.7% were in stage 3; 11.7% were in stage 4; 20.5% were in stage 5; and 5.8% were in stage 6. There was a significant association between the degree of Graves’ ophthalmopathy and duration of hyperthyroidism. Majority of the patients with Graves’ ophthalmopathy had clinical manifestation of stage 0 and the duration of hyperthyroidism was significantly associated with the severity of Graves’ ophthalmopathy.
Surgical Treatment of Bilateral Bullous Exudative Retinal Detachment Following Systemic Corticosteroid Therapy: A Case Report from Aceh Lia Meuthia Zaini
Majalah Oftalmologi Indonesia Vol 48 No 1 (2022): Ophthalmologica Indonesiana
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/journal.v48i1.100068

Abstract

Introduction: Exudative retinal detachment refers to elevation of the neural retina caused by subretinal fluid accumulation in the absence of a retinal break or significant preretinal traction. Management of exudative retinal detachment should include management of the underlying disease. When the fluid is not resolved, surgical intervention is planned after failure of conventional treatment.  We demonstrated the successful surgical management of exudative bullous retinal detachment using the internal drainage technique. Case Presentation: A 45 years old man presented with complaint of blurred vision since 5 months before admission. Worsening occurred mainly after administration of high dose methylprednisolone infusion therapy. Visual acuity of the right eye was hand motion, and left eye was 1 meter finger counting. Fundus examination revealed exudative bullous retinal detachment in both eyes. Discussion: Surgery can be considered as a treatment of choice for exudative retinal detachment if medical management is unsuccessful. A complete examination to determine the cause of the disease is needed before carrying out surgery. External and internal drainage techniques have been reported to be successful in managing subretinal fluid in chronic exudative retinal detachment. We chose vitrectomy with internal drainage because large amount of dense subretinal fluid can make transscleral drainage very difficult. Conclusions: Surgical management (vitrectomy with internal drainage) can provide good results in chronic exudative retinal detachment, but should not be used as first-line therapy.
HYPERTENSIVE OPTIC NEUROPATHY AS A PRESENTATION OF SYSTEMIC LUPUS ERYTHEMATOSUS Zaini, Lia Meuthia; Mulya, Putri Nabillah
International Journal of Retina Vol 8 No 2 (2025): International Journal of Retina (IJRetina) - INAVRS
Publisher : Indonesian Vitreoretinal Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35479/ijretina.2025.vol008.iss002.323

Abstract

Introduction: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease affecting multiple organ systems, including the eyes. Hypertensive optic neuropathy is a rare but serious manifestation of SLE that may precede SLE diagnosis. This case highlights the early ocular involvement in a young patient with undiagnosed SLE. Case Report: A 21-year-old female presented to our ophthalmology clinic with blurry vision in both eyes, along with elevated blood pressure at 165/126 mmHg. Ophthalmic examination revealed visual acuity of 20/200 on both eyes, bilateral optic disc swelling, macular edema, flame-shaped hemorrhages, and cotton-wool spots. These findings are consistent with hypertensive optic neuropathy. The antihypertensive drugs were initiated and planned for intravitreal bevacizumab administration. The patient was referred to internal medicine. Laboratory tests and clinical findings indicated secondary hypertension, anemia, leukopenia, and thrombocytopenia. Immuno-serological testing confirmed a diagnosis of SLE. The patient was initiated on systemic immunosuppressive therapy. Eight weeks after the first visit, she showed significant improvement, with the resolution of macular edema and optic disc swelling. The patient’s visual acuity improved to 20/50 in the right eye (RE) and 20/20 in the left eye (LE). Discussion: Hypertension in SLE is multifactorial, involving endothelial dysfunction, kidney injury, immune activation, and autoantibodies. Hypertensive retinopathy progresses through three phases: vasoconstrictive, sclerotic, and exudative, characterized by arterial narrowing, structural vascular changes, and blood-retina barrier disruption, leading to macular edema and ischemia. Diagnosis is based on fundoscopic examination and Optical Coherence Tomography (OCT), while management focuses on blood pressure control, anti-VEGF therapy, and close monitoring to prevent further complications. Conclusion: Early detection and multidisciplinary management are crucial in preventing irreversible visual loss and systemic complications. Regular ophthalmic follow-up and blood pressure monitoring are essential in SLE management.
ENDOPHTHALMITIS IN ACEH: ANALYSIS OF MICROBIAL SPECTRUM AND ANTIBIOTIC RESISTANCE Samira, Cut Putri; Nilawati, Enny; Zaini, Lia Meuthia; Islami, Dian; Mulya, Putri Nabillah
International Journal of Retina Vol 9 No 1 (2026): International Journal of Retina (IJRetina) - INAVRS
Publisher : Indonesian Vitreoretinal Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35479/ijretina.2026.vol009.iss001.344

Abstract

Introduction: Endophthalmitis is a rare but vision-threatening intraocular infection that requires prompt and appropriate antimicrobial therapy. The microbial spectrum and antibiotic resistance patterns vary by region, yet data from Aceh, Indonesia, are limited. This study aimed to analyze the microbial profile and antibiotic susceptibility patterns of endophthalmitis cases treated at a tertiary healthcare center in Aceh. Methods: A retrospective descriptive study was conducted using medical records of patients diagnosed with endophthalmitis at dr. Zainoel Abidin General Hospital, Banda Aceh, from January 2021 to December 2024. Data collected included demographics, predisposing factors, etiological classification, microbiological culture results, and antibiotic susceptibility profiles. Microbiological identification and susceptibility testing were performed using standard culture methods and the VITEK2 Compact system. Result: A total of 111 eyes with unilateral endophthalmitis were included. Exogenous endophthalmitis predominated (95.5%), with post–cataract surgery (36.0%), traumatic (29.7%), and keratitis-related (27.1%) cases being most common. The mean patient age was 52.7 ± 18.5 years, with male predominance (63%). Bacterial isolates were identified in 26 eyes (23.5%), with Gram-negative organisms accounting for 65.4%. Pseudomonas aeruginosa was the most frequently isolated pathogen (58.8%). Gentamicin showed the highest overall susceptibility (75.0%), while vancomycin demonstrated complete sensitivity against Gram-positive isolates. Conclusion: Endophthalmitis in Aceh is predominantly exogenous and commonly caused by Gram-negative bacteria, particularly Pseudomonas aeruginosa. Gentamicin demonstrated the highest in vitro activity, while vancomycin and ceftazidime remain key components of empirical intravitreal therapy to ensure broad antimicrobial coverage. These findings provide important local microbiological data to support evidence-based management of endophthalmitis.
Co-Authors -, Jamhur Annisa Meivira Budiman Budiman, Annisa Meivira Cut Intan Hidayah Devia Alfiza Sari Fajar, Jonny Karunia Hendra Zufry Hendra Zufry, Hendra Hidayah, Cut Intan Islami, Dian Jamhur - Marlinda, Sri Mulya, Putri Nabillah Nilawati, Enny Novita Andayani Samira, Cut Putri Telavani Umri Vera Dewi Mulia