Article Per Year (5 Year)
p-Index From 2020 - 2025
1.908
P-Index
This Author published in this journals
All Journal AVERROUS: Jurnal Kedokteran dan Kesehatan Malikussaleh Narra J Cermin Dunia Kedokteran Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Journal of Medical Science; Jurnal Ilmu Medis Rumah Sakit Umum Daerah dr. Zainoel Abidin, Banda Aceh The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Narra X
Hendra Zufry, Hendra
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health

Published : 13 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 13 Documents
Search

 1   2 
LAMA RAWATAN DAN DIRECT COST PASIEN KAKI DIABETIK TERAMPUTASIDI RS DR. ZAINOEL ABIDIN BANDA ACEH : PRE-ELIMINARY STUDY Zufry, Hendra
AVERROUS: Jurnal Kedokteran dan Kesehatan Malikussaleh Averrous, Vol. 4: No. 1 (Mei, 2018)
Publisher : Fakultas Kedokteran Universitas Malikussaleh

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (236.42 KB) | DOI: 10.29103/averrous.v4i1.807

Abstract

Kaki Diabetik adalah salah satu komplikasi Diabetes Mellitus (DM) yang sangat umum terjadi dan dapat menyebabkan infeksi, amputasi bahkan kematian. Amputasi sendiri menghabiskan banyak kerugian sehingga menjadi beban dalam pelayanan kesehatan. TujuanPenelitian ini bertujuan melihat gambaran lama rawatan dan direct cost pasien kaki diabetik teramputasi di RS Dr.Zainoel Abidin Banda Aceh.Metode Penelitian :Penelitian ini merupakan suatu pre-eliminary study yang bersifat deskriptif. Data pasien diambil dari rekam medis pasien. Setiap pasien akan dinilai tipe luka , masa rawatan dan biaya yang dihabiskan selama rawatan.Hasil  : Dari 37 pasien yang menjalani amputasi , didapatkan rerata  rawatan selama 15 hari dengan rerata  biaya yang dihabiskan sebesar 45,5 juta rupiah. Dari keseluruhan, 5 orang (14%) memiliki tipe luka  neuropati, 20 orang (54 %)  tipe vaskulopati dan 12 orang (32%) tipe infeksi. Dari 5 orang pasien dengan luka neuropati, lama  rawatan adalah 11 ± 7,19 hari dan rerata biaya yang dihabiskan sebesar 42,3 juta rupiah . Pada 20 pasien dluka vaskulopati, lama rawatan adalah 14  ± 6,95hari serta rerata biaya yang dikeluarkan adalah 41,1 juta rupiah. Sedangkan 12 pasien luka infeksi, didapatkan rerata lama rawatan adalah 17 ± 8,13 hari dengan rerata  biaya sebesar 54 juta rupiah  Kesimpulan  : Hasil penelitian ini memperlihatkan  bahwa rerata  masa  rawatan dan rerata biaya rawatan pasien ulkus diabetikum yang menjalani amputasi di RS dr.Zainoel Abidin pada tahun 2017  cukup tinggi. Akan tetapi untuk masing ? masing tipe luka, lama masa rawatan dan biaya yang dikeluarkan tidak terlalu jauh berbeda.
Korelasi Derajat Graves’ Ophthalmopathy dengan Durasi Menderita Hipertiroid Fajar, Jonny Karunia; Hidayah, Cut Intan; Zaini, Lia Meuthia; Zufry, Hendra; -, Jamhur
Cermin Dunia Kedokteran Vol 42, No 5 (2015): Kardiologi
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (148.188 KB) | DOI: 10.55175/cdk.v42i5.1006

Abstract

Graves’ ophthalmopathy merupakan penyakit autoimun. Studi ini bertujuan untuk mengetahui distribusi manifestasi klinis Graves’ ophthalmopathy dan mengetahui kaitan lama menderita hipertiroid dengan derajat keparahan Graves’ ophthalmopathy. Penelitian ini merupakan penelitian observasional analitik dengan 34 sampel penderita Graves’ ophthalmopathy. Data dianalisis menggunakan uji Spearman. Hasil penelitian ini menunjukkan bahwa distribusi manifestasi klinis penderita Graves’ ophthalmopathy di poliklinik endokrin RSUZA adalah 23,5% derajat 0; 8,8% derajat 1; 14,7% dengan derajat 2; 14,7% derajat 3; 11,7% derajat 4; 20,5% derajat 5; dan 5,8% derajat 6. Terdapat asosiasi signifikan antara lama menderita hipertiroid dengan derajat Graves’ ophthalmopathy (p=0,000). Kebanyakan penderita Graves’ ophthalmopathy memiliki manifestasi klinis derajat 0 dan lama menderita hipertiroid berbanding lurus dengan tingkat keparahan Graves’ ophthalmopathy.Graves’ ophthalmopathy is an autoimmune disease. The aim of this study is to determine the characteristic of the clinical manifestations of Graves’ ophthalmopathy and the association between duration of hyperthyroidism and the degree of Grave’s ophthalmopathy. It is an analytical observational study in 34 patients with Graves’ ophthalmopathy. Data were analyzed using the Spearman test. It showed that 23.5% of the patients were in stage 0; 8.8% were in stage 1; 14.7% were in stage 2; 14.7% were in stage 3; 11.7% were in stage 4; 20.5% were in stage 5; and 5.8% were in stage 6. There was a significant association between the degree of Graves’ ophthalmopathy and duration of hyperthyroidism. Majority of the patients with Graves’ ophthalmopathy had clinical manifestation of stage 0 and the duration of hyperthyroidism was significantly associated with the severity of Graves’ ophthalmopathy.
Targeting phosphoglycerate dehydrogenase enzyme using ginger compounds to suppress thyroid cancer progression Rahman, Faris I.; Zulfa, Putri O.; Beočanin, Anđelija; Faisal, Ibraheem M.; Louca, Nicolas; Carstoiu, Maria I.; Zufry, Hendra
Narra X Vol. 2 No. 1 (2024): April 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narrax.v2i1.112

Abstract

Recent studies have recognized the potential of inhibiting phosphoglycerate dehydrogenase (PHGDH) enzyme as a therapeutic strategy for treating papillary thyroid cancer. However, research on the efficacy of herbal compounds in inhibiting the PHGDH enzyme that have been reported to possess anticancer activities, including those found in ginger (Zingiber officinale), remains limited. The aim of this study was to examine the potential of ginger compounds in inhibiting PHGDH enzyme and to identify its potential use in the treatment of papillary thyroid cancer. The study employed computational methods to identify ginger-derived compounds that inhibit the PHGDH and impede papillary thyroid cancer progression. Crystallized protein structures were obtained from the Protein Data Bank, and Discovery Studio software was utilized to remove water molecules, double chains, and ligands. The receptor was modified by adding polar hydrogen, and AutodockTools4 software was employed to establish an accurate binding site based on the position of the previous ligand. Molecular docking experiments were conducted with 125 ginger-derived phytochemicals retrieved from the PubChem database. The results revealed nine active compounds found in ginger (galanolactone, myricetin, quercetin, cyanin, kaempferol, chlorogenic acid, delphinidin, alpha-cadinol, and curcumin) with strong binding affinities to PHGDH (minimum score threshold <-7 kcal/mol), indicating their potential for drug development. Galanolactone, myricetin, and quercetin were the top three compounds with the strongest binding affinity (-8.2, -7.9, and -7.9 kcal/mol, respectively), involving multiple bonds in the ligand-protein complex interaction. Notably, myricetin and quercetin formed three hydrogen bonds each, contributing to strong and stable bonds with the pocket region of PHGDH. In conclusion, ginger-derived compounds show promise in inhibiting PHGDH for the treatment of papillary thyroid cancer. However, further research is needed to validate the efficacy of these compounds and their interactions with the PHGDH in the context of thyroid cancer therapy.
Normal intellectual ability and hyperprolactinemia as unique clinical manifestations of congenital hypothyroidism: A case report and review of hypotheses Zulfa, Putri O.; Debbyousha, Maulina; Sucipto, Krishna W.; Ekadamayanti, Agustia S.; Firdausa, Sarah; Zufry, Hendra
Narra J Vol. 3 No. 3 (2023): December 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v3i3.205

Abstract

Congenital hypothyroidism is the deficiency of thyroid hormone in infants and hyperprolactinemia is frequently observed. Previously reported cases typically involve intellectual disability, highlighting this particular unique case report to the first reported patient demonstrating normal intellectual ability despite experiencing growth and gonad dysfunction. This study aims to present a case and review medical hypotheses related to the patient's condition. A 19-year-old female presented with a chief complaint of irregular menstruation for up to 40 days or not occurring at all. The patient experienced the first menstruation at the age of 16 years old. The patient's height was 133 cm, body weight 40 kg, and body mass index 22.61 kg/m2; other family members were normal. Physical examination showed no abnormalities, and laboratory examination showed suppressed serum free T4 (FT4) level (6.41 pmol/L), elevated thyroid stimulating hormone (TSH) level (333.700 µIU/mL), and elevated prolactin hormone level (32.03 ng/mL). Ultrasound of the thyroid gland found hypoplasia of the left and right thyroid glands. The patient was a college student enrolled in a public national university and had never complained about academic performance throughout the patient's education. The patient was diagnosed with congenital hypothyroidism and hyperprolactinemia. The patient was administered up to 100 μg daily of oral levothyroxine, which improved the patient’s menstrual cycles. The patient's delayed diagnosis may be attributed to central congenital hypothyroidism being underdiagnosed. We hypothesized that thyroid-releasing hormone receptor (TRHR) gene mutation might contribute to the underlying cause of hyperprolactinemia and normal intellectual ability of the patient. Further study on the significance of TRHR gene mutations in congenital hypothyroidism is required to improve diagnosis and treatment.
Comparative analysis of accuracy between fine-needle aspiration biopsy and postoperative histopathology for detecting large thyroid nodules: A retrospective observational study Zufry, Hendra; Nazaruddin, Nazaruddin; Zulfa, Putri O.; Sucipto, Krishna W.; Kamarlis, Reno K.; Ekadamayanti, Agustia S.; Beočanin, Anđelija; Firdausa, Sarah
Narra J Vol. 3 No. 2 (2023): August 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v3i2.206

Abstract

To avoid unnecessary surgeries, ultrasound-guided fine-needle aspiration biopsy (FNAB) is an effective and reliable procedure for the preoperative evaluation of thyroid nodules. However, there have been only a limited number of studies exploring the ability of preoperative FNAB to distinguish malignancy compared to postoperative histopathology in thyroid nodules larger than 4 cm. The aim of this study was to investigate the diagnostic accuracy of FNAB compared to postoperative histopathology in distinguishing malignancy in thyroid nodules larger than 4 cm. A single-center retrospective observational study was conducted at Dr. Zainoel Abidin Hospital, Banda Aceh, Indonesia, between January 2014 and December 2018. The sensitivity, specificity, positive predictive value, negative predictive value, and diagnostic accuracy were calculated. A total of 83 patients were included in the study. The results showed that preoperative FNAB may have the ability to distinguish malignancy compared to postoperative histopathology. The sensitivity, specificity, positive predictive value, negative predictive value, and diagnostic accuracy were 42.85%, 98.38%, 90.00%, 83.56%, and 84.33%, respectively. These data suggested that ultrasound-guided preoperative FNAB is a reliable diagnostic tool in the preoperative evaluation of thyroid nodules larger than 4 cm, but it has limited capability in distinguishing malignancies. In conclusion, although FNAB may be useful in reducing unnecessary surgeries, histopathology remains the preferred method for confirming malignancy in thyroid nodules.
Complexity of diagnosis and management of a giant thyroid nodule: A case report and a concise literature Firdausa, Sarah; Zufry, Hendra; Ekadamayanti, Agustia S.; Sucipto, Krishna W.; Burhan, Henry W.; Pratama, Sergio; Benalcazar, Andrés MMB.
Narra J Vol. 3 No. 3 (2023): December 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v3i3.224

Abstract

It is crucial for doctors to decide whether a thyroid nodule is benign or malignant when a patient presents with one, as it will significantly impact how the patient is managed in the future. However, it is not as straightforward to determine between the two; even a physical examination, thyroid function test, ultrasonography, and biopsy have been well performed. It can be more stressful if a patient has an increased risk of malignancy, such as age (below 20- and above 60-year-old), solid nodule, rapid growth, hoarseness, lymphadenopathy, and microcalcifications on the ultrasonography. The aim of this case was to present the management of a giant thyroid nodule with malignancy presentation and a benign biopsy finding. A 41-year-old male complained of a palpable neck mass, hoarseness, and dysphagia. The thyroid function test was normal. Ultrasonography revealed suspicion of malignancy with category 4 of American College of Radiology-Thyroid Imaging Reporting and Data System (ACR-TIRADS). The biopsy revealed follicular neoplasm, and was classified as Bethesda IV. The patient underwent a total thyroidectomy due to the large tumor size and symptoms. Histopathological findings post-surgery revealed a follicular thyroid adenoma. This case highlights a complex diagnosis and management of follicular thyroid neoplasm due to their potential for both benign and malignant. Comprehensive pre- and post-operative care is essential to determine the nature of nodules. Post-operative follow-up care might improve the patient’s outcome and prevent complications.
Severe hypocalcemia as a cause of transient ischemic attack? A debatable case and evidence from literature Zufry, Hendra; Debbyousha, Maulina; Firdausa, Sarah; Ekadamayanti, Agustia S.; Sucipto, Krishna W.; Sari , Julia
Narra J Vol. 3 No. 2 (2023): August 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v3i2.228

Abstract

Hypocalcemia and transient ischemic attack (TIA) are different medical disorders; however, limited evidence suggests a possible link between the two. The underlying pathomechanisms by which hypocalcemia may cause cerebrovascular damage are difficult to comprehend. The aim of the study was to present an individual experiencing TIA that possibly due to severe hypocalcemia that associated with hypoparathyroidism after total thyroidectomy; and to explore the available evidence of its cause-effect relationship through available literature. A 68-year-old man presented to Dr. Zainoel Abidin Hospital, Banda Aceh, Indonesia with complaints of weakness, especially in the right limbs that had worsened in the last week. The patient experienced unconsciousness for an hour before the admission; disorientation and anterograde amnesia over the time of recovering of consciousness. Other complaints included frequent muscle cramps, numbness in both arms and legs, dizziness, swallowing difficulty, nausea, and vomiting. The patient had a history of total thyroidectomy for a large struma diffuse 18 years ago and was prescribed several medications. However, the patient was overwhelmed by forgetfulness which had become more frequent in recent months resulting in medication nonadherence. The vital sign was stable and Chovsteck's sign was positive. The Montreal Cognitive Assessment (MoCA) revealed impairment in the visuospatial/executive component and delayed memory. Laboratory tests revealed severe hypocalcemia, altered thyroid function, hypomagnesemia, elevated D-dimer and fibrinogen, and vitamin D deficiency. TIA and severe hypocalcemia were proposed as the diagnosis. Prompt initiation of appropriate treatment, including calcium supplementation, anticoagulation, and neuroprotective agents, led to significant clinical improvement. Evidence from available literature suggests that there is a possible link between severe hypocalcemia and TIA that occurred in this patient. However, more studies are warrant to establish this cause-effect relationship.
Perioperative Management In Patients With Long-Term Steroid Use Ekadamayanti, Agustia Sukri; Zufry, Hendra; Sucipto, Krishna Wardhana
Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Vol. 2 No. 1 (2020): Journal of Endocrinology, Tropical Medicine, and Infectiouse Disease (JETROMI)
Publisher : TALENTA Publisher, Universitas Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (547.915 KB) | DOI: 10.32734/jetromi.v2i1.2061

Abstract

Abstract. Systemic corticosteroid given with oral or parenteral route is widely use in the treatment of various condition and has potent anti-inflammatory, immunomodulatory, and anti-neoplastic effect. Although steroid has potentially clinical benefit effects, long-term use of this regiment also associated with several serious risks and may deteriorate life quality and highly cost management. Long-term steroid use may altered our body response to stress due to HPA Axis suppression. Surgical procedure will increase stress in our body, which can led into higher demand of cortisol. When surgery performed, a signal from the operation site through afferent nervus will activate hypothalamus to release corticotropin releasing hormone, that will stimulate cortisol hyper secretion. Preoperative management guidelines recommend the use of stress dose or supplementation dose for patient with long-term steroid use, which will be discussed further in this review. Keyword. CORTICOSTEROID, HPA AXIS, SURGERY Abstrak. Kortikosteroid sistemik yang diberikan dengan rute oral atau parenteral banyak digunakan dalam pengobatan berbagai kondisi dan memiliki efek antiinflamasi, imunomodulator, dan anti neoplastik yang kuat. Meskipun steroid berpotensi memiliki efek manfaat klinis, penggunaan jangka panjang resimen ini juga dikaitkan dengan beberapa risiko serius dan dapat menurunkan kualitas hidup dan manajemen biaya tinggi. Penggunaan steroid jangka panjang dapat mengubah respons tubuh kita terhadap stres karena penekanan HPA Axis. Prosedur bedah akan meningkatkan stres di tubuh kita, yang dapat menyebabkan permintaan kortisol yang lebih tinggi. Ketika operasi dilakukan, sinyal dari tempat operasi melalui afferent nervus akan mengaktifkan hipotalamus untuk melepaskan hormon pelepas kortikotropin, yang akan merangsang sekresi hiper kortisol. Pedoman manajemen pra operasi merekomendasikan penggunaan dosis stres atau dosis suplemen untuk pasien dengan penggunaan steroid jangka panjang, yang akan dibahas lebih lanjut dalam ulasan ini. Keyword. CORTICOSTEROID, HPA AXIS, SURGERY
Diagnostic accuracy of preoperative ultrasonography-guided fine-needle aspiration biopsy in distinguishing malignancy in large thyroid nodules: A systematic review, meta-analysis, and meta-regression Zulfa, Putri O.; Iqhrammullah, Muhammad; Zufry, Hendra
Narra J Vol. 5 No. 1 (2025): April 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i1.1120

Abstract

Controversy persists regarding the effectiveness of ultrasonography-guided fine-needle aspiration biopsy (US-FNAB) in distinguishing malignancies in large thyroid nodules. The prevailing belief that larger thyroid nodules inherently pose a higher risk of malignancy has led to a common practice of suggesting thyroidectomy for large thyroid nodules. Herein, the aim of this study was to assess the diagnostic accuracy of preoperative US-FNAB for distinguishing malignancy in large thyroid nodules. A search for published records was carried out on 20 October 2023, utilizing the search feature available on PubMed, Scopus, Embase, and Google Scholar. Patients with large thyroid nodules (3 cm or larger) who underwent preoperative US-FNAB and postoperative histopathological tests were included. Related outcomes, including false positive (FP), false negative (FN), true negative (TN), true positive (TP), specificity, and sensitivity, were extracted from each study. Pooled specificity and sensitivity were estimated, and the summarized receiver operating characteristic (sROC) curve, along with the summarized area under the curve (sAUC), was calculated. Out of 133 articles identified across four databases, 10 studies with a total sample of 2752 patients were included. The overall diagnostic sensitivity was 72% (95%CI: 50–86%; p=0.00) and specificity was 96% (95%CI: 87–90%; p=0.00). The positive predictive value (PPV) and negative predictive value (NPV) were 93% (95%CI: 89–98%) and 75% (95%CI: 72–79%), respectively. sAUC was 93%, suggesting the diagnostic tool is accurate. Meta-regression analysis revealed that factors such as the number of samples, country (high-income vs upper-middle income), demographic characteristics (age and gender), and different thyroid size cut-off values did not significantly impact the sensitivity or specificity of US-FNAB. In conclusion, the present study confirms the reliability of US-FNAB in distinguishing malignancy in large thyroid nodules, emphasizing its role in reducing unnecessary thyroidectomy by identifying high-risk patients and challenging the conventional practice of routine thyroidectomy for large thyroid nodules.
Model Matematika Sebagai Kecerdasan Buatan dalam Memprediksi Lama Rawatan Pasien Diabetes Melitus dengan Hipoglikemia Zufry, Hendra; Sucipto, Krishna Wardhana; ekadamayanti, agustia sukri
Journal of Medical Science Vol 2 No 2 (2021): Journal of Medical Science
Publisher : LITBANG RSUDZA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (352.345 KB) | DOI: 10.55572/jms.v2i2.48

Abstract

Background: Diabetes Mellitus (DM), a burden disease that has contributed to the health burden globally. The most common acute complication is hypoglycemia. Hypoglycemia in hospitalized diabetic patients is associated with increased length of stay (LOS), mortality, and costs. Patients with co-morbidities are often not in accordance with the clinical pathway, so a mathematical model is needed which estimates length of stay and the required resources can be estimated. Aim: To formulate a mathematical model predicting the LOS of hypoglycemic patients treated with various conditions Methode: This study is a retrospective cohort study using secondary data of DM patients who experienced hypoglycemia from January 1, 2011 to December 2020 which obtained from the medical records of Zainoel Abidin Hospital Banda Aceh, Indonesia. Data collected from May to November 2021. The data were analyzed using multivariate analysis with logistic regression test. using R software to obtain a mathematical modeling of length of stay. The variables that affect the length of stay using logistic regression test with p value <0.05. Result: There were 573 hypoglycemic patients, most of the patients who experienced hypoglycemia were male (51.3 %), the average age was 59.6 years. Most of the patients who experienced hypoglycemia were type 2 DM patients (96.4%), Infection was the main comorbid (46.6 %), Mild hypoglycemia was the highest (47.2%) and the average length of stay was 8.06 days. Based on mathematical modeling, it was found that for every additional unit of age, the length of treatment increased by 6.99 7 days. Then a logistic regression test was carried out to see the influential variables. Conclusion: Based on the mathematical modeling obtained, it is known that for each additional unit of age, the length of stay will increase by about 6.9≈7 days. Furthermore, the formulation of this mathematical model is expected to be able to predict the length of stay for various comorbidities, predict the number of consumable materials and as a basis for making artificial intelligence applications that is beneficial to efficiency.
Co-Authors -, Jamhur Azzaki Abubakar, Azzaki Benalcazar, Andrés MMB. Beočanin, Anđelija Burhan, Henry W. Carstoiu, Maria I. Edward, Meutia Nailan Ekadamayanti, Agustia S. Ekadamayanti, Agustia Sukri Faisal, Ibraheem M. Fajar, Jonny Karunia Fauzi Yusuf, Fauzi FIRDAUSA, SARAH Gunawan, Andrie Hidayah, Cut Intan Ho, Khek Yu Iqhrammullah, Muhammad Kamarlis, Reno K. Lia Meuthia Zaini, Lia Meuthia Louca, Nicolas Maghfirah, Desi Maulina Debbyousha N. Nazaruddin Pratama, Sergio Rachmad Suhanda Rahman, Faris I. Sari , Julia Sucipto, Krishna W. Sucipto, Krishna Wardhana Sukri Ekadamayanti, Agustia Wardhana Sucipto, Krishna Zulfa, Putri O.