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Serum calcium ions, ratio of calcium/ creatinine urine and bone mass density in perimenopausal and postmenopausal women Harjo Mulyono, Riswan Hadi Kusuma Windarwati
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 46, No 02 (2014)
Publisher : Universitas Gadjah Mada

Early diagnosis of osteoporosis is important to take early prevention and treatment. Dual energyX-ray absorbtiometry (DEXA) scan is gold standard diagnosis of osteoporosis. However, it ishigh technology and high cost. Biochemical marker using calcium could be developed for diagnosisof osteoporosis. The study was conducted to evaluate the correlation between serum calciumions level as well as urine calcium and urine creatinine (UCa/UCr) ratio and Bone Mineral Density(BMD) in perimenopausal and postmenopausal women. This was an observational study withcross-sectional design involving women aged 45-75 years who fulfilled the inclusion and exclusioncriteria. Bone Mineral Density was measured using DEXA method. Serum and urine calcium ionswere measured using ISE method, while serum and urine creatinine were determined using Jaffemethod. Ratio of UCa/UCr were then calculated. The correlation between serum calcium ions aswell as the ratio UCa/UCr and BMD of subjects were then analyzed. A total 63 subjects wereinvolved in this study consists of 21 normal subjects, 22 subjects with osteopenia and 20subjects with osteoporosis. Negative correlation between BMD and age (r=-0.591; p=0.001)and positive correlation between BMD and body mass index (BMI) (r=0.432; p=0.001) wereobserved. No correlation between serum calcium ions and BMD (r= -0.145; p=0.258), howevernegative correlation between UCa/UCr ratio and BMD (r=-0.310; p=0.013) were reported.Furthermore, no correlation was found between serum calcium ions and lumbar BMD (r=0.036;p=0.778), while negative correlation was found between UCa/UCr ratio and lumbar BMD (r= -0.414; p=0.001). In conclusion, there is no correlation between serum calcium ions levels andBMD, however there is a weak negative correlation between UCa/UCr ratio and BMD

Serum calcium ions, ratio of calcium/ creatinine urine and bone mass density in perimenopausal and postmenopausal women Riswan Hadi Kusuma; . Windarwati; Harjo Mulyono
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 46, No 02 (2014)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Early diagnosis of osteoporosis is important to take early prevention and treatment. Dual energyX-ray absorbtiometry (DEXA) scan is gold standard diagnosis of osteoporosis. However, it ishigh technology and high cost. Biochemical marker using calcium could be developed for diagnosisof osteoporosis. The study was conducted to evaluate the correlation between serum calciumions level as well as urine calcium and urine creatinine (UCa/UCr) ratio and Bone Mineral Density(BMD) in perimenopausal and postmenopausal women. This was an observational study withcross-sectional design involving women aged 45-75 years who fulfilled the inclusion and exclusioncriteria. Bone Mineral Density was measured using DEXA method. Serum and urine calcium ionswere measured using ISE method, while serum and urine creatinine were determined using Jaffemethod. Ratio of UCa/UCr were then calculated. The correlation between serum calcium ions aswell as the ratio UCa/UCr and BMD of subjects were then analyzed. A total 63 subjects wereinvolved in this study consists of 21 normal subjects, 22 subjects with osteopenia and 20subjects with osteoporosis. Negative correlation between BMD and age (r=-0.591; p=0.001)and positive correlation between BMD and body mass index (BMI) (r=0.432; p=0.001) wereobserved. No correlation between serum calcium ions and BMD (r= -0.145; p=0.258), howevernegative correlation between UCa/UCr ratio and BMD (r=-0.310; p=0.013) were reported.Furthermore, no correlation was found between serum calcium ions and lumbar BMD (r=0.036;p=0.778), while negative correlation was found between UCa/UCr ratio and lumbar BMD (r= -0.414; p=0.001). In conclusion, there is no correlation between serum calcium ions levels andBMD, however there is a weak negative correlation between UCa/UCr ratio and BMD

KADAR CTX PEREMPUAN OSTEOPOROSIS LEBIH TINGGI DARIPADA PEREMPUAN NORMAL DAN OSTEOPENIA Ira Puspitawati; Windarwati Windarwati; Usi Sukorini; Erlina Erlina; Pratiwi Herowati; Arlan Prabowo; Riswan Hadi Kusuma
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 19, No 3 (2013)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v19i3.413

Regarding to the ageing population in most countries, degenerative and metabolism diseases included osteoporosis are becoming increasingly and need special attention in all country especially in the developing country such as Indonesia. Current WHO recommendation of using a gold standard for establishing osteoporosis is by Dual X-Ray Absorptiometry (DEXA), but it is expensive and not yet widely available. There are some alternatives of biochemical markers that can reflect the bone turn over. One of them is Cterminal cross-linking telopeptide of type I collagen (CTX) or betacrosslabs, a marker of bone resorbtion. There are still limited studies on correlation of CTX and osteoporosis in peri menopausal and post menopausal women. The aim of this study is to know whether there are any differences of CTX level among peri menopausal and post menopausal women with different bone density. This research was a cross sectional study and aimed to know whether there is any correlation between CTX level and Bone Mineral Density Score measured with DEXA. The study was conducted in June-August 2010. The included subjects were women with age more than 45 years old, without apparent history of neoplasm, impaired renal function, bone metabolic diseases, and not currently pregnant. CTX level were measured using immunochemiluminescent. Their data were analysed using One Way ANOVA. This study showed that there are differences of CTX levels among women with osteoporosis, osteopenia, and normal (0.633±0.25 ng/mL vs 0.514±0.21 ng/mL vs 0.406±0.21 ng/mL p=0.02). Osteoporosis women have higher CTX level compared to Osteopenia and Normal women.

Correlation of Glycated Albumin Levels and the Glycated Albumin/HbA1c Ratio with Diabetic Retinopathy Kusuma, Riswan Hadi; Windarwati, Windarwati; Mulyono, Budi
Academic Hospital Journal Vol 8, No 1 (2026)
Publisher : Rumah Sakit Akademik Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ahj.v8i1.114306

Background: Diabetic retinopathy is one of the microvascular complications of Diabetic Mellitus (DM). Diagnosis of diabetic retinopathy based on clinical manifestations of retinal vascular disorders, assessed using the Early Treatment Diabetic Retinopathy Study (ETDRS) severity scale. Fluctuations in blood glucose levels are thought to play a role in the progression of DM complications, and glycated albumin appears to reflect greater fluctuations in blood glucose levels. The aim of this study was to determine the difference and correlation between glycated albumin levels and glycated albumin/HbA1c ratio (GA/HbA1c ratio) with the degree of severity of diabetic retinopathy.Methods: The research design was cross-sectional. The subjects of the study were DM patients who were examined for glycated albumin, HbA1c, and GA/HbA1c ratio calculation, and for clinical examination of retinal vascular disorders using the ETDRS severity scale.Result : The median glycated albumin level in the non-diabetic retinopathy group was lower than the diabetic retinopathy group (18.8 vs 24.3; p=0.018), while the median GA/HbA1c ratio appeared to be lower than the diabetic retinopathy group but did not differ significantly (2.4 vs 3.4; p=0.238). The level of glycated albumin and the GA/HbA1c ratio did not appear to be linear with the severity of diabetic retinopathy. There was a significant weak positive correlation between glycated albumin levels and diabetic retinopathy (r=0.304; p=0.006), while the correlation between the GA/HbA1c ratio and diabetic retinopathy was not significant (r=0.218; p>0.176).Conclusion : There is a significant difference in glycated albumin levels between non-diabetic non-retinopathy and diabetic retinopathy. There is a significant positive correlation between glycated albumin levels and diabetic retinopathy. It needs further study with a larger sample and a balanced distribution of non-diabetic retinopathy and diabetic retinopathy groups to be used independently.

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