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All Journal Alchemy : Journal of Chemistry
Hafidatul Hasanah
Jurusan Kimia Fakultas Sains dan Teknologi Universitas Islam Negeri (UIN) Maulana Malik Ibrahim Malang
Chemical Engineering, Chemistry & Bioengineering Chemistry Energy Materials Science & Nanotechnology

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Therapy Effect of Ethanol Extract of Binahong Tuber on Superoxide Dismutase (SOD) of Kidney of Rat Induced by Alloxan Ummah, Silviana Maslakhatul; Hasanah, Hafidatul
ALCHEMY ALCHEMY (Vol. 4, No.2
Publisher : Department of Chemistry, Faculty of Science and Technology UIN Maulana Malik Ibrahim Malan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (306.107 KB) | DOI: 10.18860/al.v4i2.3201

Abstract

Binahong (Anredera cordifolia (Ten.)Steenis) tuber is one of the plant that is not utilized yet for medicine. The aims of this research are to extract Binahong tuber  and determine superoxide dismutase (SOD) activity of kidney of rat (RattusNorvegicus) induced by Aloxsan. Extraction of binahong tuber was conducted by maceration method using 70% ethanol. The ethanol extract was used for therapy of Rat induced by Aloxsan and to determine SOD activity. Measuring of SOD kidney activity was conducted on 6 group of rat are D1 (control), D2 (0,5 % CMC-Na, dose 1 mL/200 g body weight), D3 (aloxsan 32 mg/200g body weight), D4, D5, D6 (aloxan 32 mg/kg body weight with therapy. Doses of extract binahong tuber were 25, 50 and 75 mg/kg body weight, respectively.The results showed that therap y of 70 % ethanol extract of Binahong tuber could increase the SOD activity of rat kidneys. But, after analyzed by ANAVA one way, the therapy did not give a real effect with value of α0,05 (0,1290,05). Duncan test showed that there was significant difference between D3 and D4. So the effective dose was 25 mg/kg body weight. Phytochemical test showed that ethanol extract of binahong tuber contained alkaloid, flavonoid, saponin, tanin and terpenoid. Keywords: Tuber of Anredera cordifolia (Ten.) Steenis, Superoxide Dismutase, Alloxan
PENGARUH LAMA FERMENTASI TERHADAP KADAR ALKOHOL TAPE SINGKONG (Manihot utilissima Pohl). Hasanah, Hafidatul; Jannah, Akyunul; Fasya, Ahmad Ghanaim
ALCHEMY ALCHEMY (Vol.2 No.1
Publisher : Department of Chemistry, Faculty of Science and Technology UIN Maulana Malik Ibrahim Malan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (383.261 KB) | DOI: 10.18860/al.v0i0.2294

Abstract

Tape is one of the products of fermentation. Of the agreement MUI, foods and beverages containing alcohol should not exceed 1%, so the food / drinks that contain high levels of alcohol exceeding 1% are included in the category of haram for consumption. This study aimed to determine the effect of fermentation time on ethanol content of cassava (Monihotutilissima Pohl) tapai. The method that is used to separate the two or more component of volatile and non volatile from tapai is called distillation while to analyze an ethanol level used gas chromatography (GC) method. To examine the data which differentiate the base concentration of alcohol (%) in cassava tapai since fermentationprocess which were analyzed by variants analysis (ANOVA). In the next experiment, if there was different significant result, then continued by the test of BNT which the level for about 1%.The samples of cassava (Monihot utilissima Pohl) tapai fermented for about 24, 48, 72, 96 and 120 hours. Those tapai were mashed and added the aquades. The mixed materials were distillated, then entered into the bottle and considered as gram unit. The considered distillations were being analyzed used gas chromatography (GC) method.The result of the research showed that there is the influence of long fermentation to ethanol level’s of cassava (Manihot utilissima Phol) tapai. The level of cassava ethanol was 0.844%, 2.182%, 4.904%, 6.334% and 11.811%. The long fermentation was for about 120 hours and it was an indeed influence (p 0,01) to the level of cassava’s ethanol among the period of long fermentation.
UJI EFEKTIVITAS ANTIOKSIDAN EKSTRAK ETANOL 70 %, EKSTRAK DAN ISOLAT SENYAWA FLAVONOID DALAM UMBI BINAHONG (Anredera cordifolia (Ten.) Steenis) Rizkia, Putri; Jannah, Akyunul; Hasanah, Hafidatul
ALCHEMY ALCHEMY (Vol.3, No.2
Publisher : Department of Chemistry, Faculty of Science and Technology UIN Maulana Malik Ibrahim Malan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (447.891 KB) | DOI: 10.18860/al.v0i1.2917

Abstract

Tanaman Binahong (Anredera cordifolia (Ten.) Steenis) diketahui memiliki potensi sebagai antioksidan. Salah satunya bagian umbi tanaman binahong. Sebagaimana firman Allah SWT dalam QS. Asy Syu’Araa’; 7, QS. Thaha; 53 dan QS. Luqman; 10 bahwasannya Allah menciptakan tumbuhan baik yang dapat dimanfaatkan oleh manusia. Salah satu pemanfaatan umbi binahong adalah sebagai obat. Penelitian ini bertujuan untuk mengetahui efektivitas antioksidan dalam ekstrak etanol 70 %, ekstrak dan isolat senyawa flavonoid umbi binahong Anredera cordifolia (Ten.) Steenis.Ekstraksi senyawa aktif umbi tanaman binahong dilakukan dengan metode maserasi menggunakan etanol 70 %. Hasil ekstraksi dihidrolisis dengan HCl 2N dan dipartisi untuk mendapatkan ekstrak senyawa flavonoid. Ekstrak etanol 70 % dan ekstrak senyawa flavonoid umbi binahong diuji efektivitas antioksidannya menggunakan metode  DPPH (1,1-difenil-2-pikrilhidrazil) dengan variasi konsentrasi. Identifikasi golongan senyawa aktif dilakukan dengan penambahan reagen dan diamati secara kualitatif. Ekstrak flavonoid dipisahkan dengan metode KLT menggunakan eluen n-butanol-asam asetat-air (4:1:5) selanjutnya isolat diuji antioksidan kembali.Hasil penelitian  menunjukkan bahwa ekstrak flavonoid memiliki efektivitas antioksidan lebih baik daripada ekstrak etanol 70 %. Nilai EC50 ekstrak flavonoid sebesar 178,60 mg/L dan ekstrak etanol 70 % umbi binahong sebesar 298,10 mg/L. Hasil pemisahan KLT Preparatif didapatkan empat isolat, efektivitas antioksidan fraksi aktif senyawa flavonoid tertinggi terdapat pada isolat ketiga sebesar 7,16 %.
Identifikasi Senyawa Flavonoid dan Efek Terapi Ekstrak Etanol 70 % Umbi Binahong (Anredera cordifolia (Ten.) Steenis) Terhadap Kadar Glukosa Darah dan Aktifitas SOD (Superoksida dismutase) Jantung Tikus yang Diinduksi Aloksan Andrieyani, Andrieyani; Hanapi, Ahmad; Fasya, Ahmad Ghanaim; Hasanah, Hafidatul
ALCHEMY ALCHEMY (Vol.4, No.1
Publisher : Department of Chemistry, Faculty of Science and Technology UIN Maulana Malik Ibrahim Malan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (261.773 KB) | DOI: 10.18860/al.v4i1.3146

Abstract

The  aims  of  this  research was to identify the flavonoid content in binahong tuber and determine the effect of 70 % ethanol extract of binahong tuber on blood glucose level and SOD activity in rats (Rattus norvegicus) induced alloxan. The extract was maceration and then used to test the classes of its compound content using phytochemical test, the flavonoid compound contained in the extract was separated by analytic thin layer chromatography (TLC) and antidiabetic effect against rats induced alloxan with dose of alloxan was 32 mg / 200 g BW. The results showed that the 70 % ethanol extract of binahong tuber contains flavonoids, alkaloids, tannins, saponins and terpenoids. Butanol: acetic acid: water (4: 1: 5) was the best eluent for separation of flavonoid compound in extract and binahong tuber extracts treatment with variation of extract dose, 25, 60 and 75 mg/kg BW, reduced the blood glucose levels and increased the SOD (Superoxide dismutase) activity of rat, that are 5,511 ; 5,217 and 4,942 u/mL respectively. Keywords: alloxan, antidiabetic, flavonoids, binahong tubers, SOD
Co-Authors A. Ghanaim Fasya Ahmad Hanapi Akyunul Jannah Andrieyani Andrieyani, Andrieyani Putri Rizkia, Putri Silviana Maslakhatul Ummah, Silviana Maslakhatul