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Yuliana Heri Suselo
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Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology

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Journal : Nexus Biomedika

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Roxburghine B and OxoxylopinePotential as Hepcidin Antagonist Insilico for Inflammatory Anemia Safirah . Yotriana; Yuliana Heri Suselo; Muthmainah . .
Nexus Biomedika Vol 6, No 2 (2017): Nexus Biomedika
Publisher : Nexus Biomedika

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Introduction: Anemia affects half a billion women in the world and become a problem, especially in pregnant women. One of the cause of anemia is inflammatory disease which also has a high prevalence in Indonesia. Therapies currently used to treat anemia are based on the underlying disease. Anticalin is a protein that works as hepcidin antagonist. Anticalin has completed the clinical phase II, but it has not been distributed to public market yet. Therefore, a new, easily accessible and more effective drug is required. Indonesian herbs have been widely used as medicinal plants in the community and are potential to be developed as drugs. The purpose of this study is to identify Indonesian phytochemicals that can act as hepcidin antagonist. Methods: The research was a bioinformatics study with molecular docking method. Three-dimensional structure of human hepcidin as a target protein and Anticalinas a standar therapy were downloaded from the website of the Protein Data Bank (PDB). The active compounds were obtained from HerbalDB and the three-dimensional structure was from PubChem National Center for Biotechnology Information (NCBI). This study was performing using AutoDock Vina 1.1.2 to analyze the binding affinity. Molecular modification was performed with Autodock Tools 1.5.6. Visualization was done with Chimera 1.10 and PyMol 1.3. Results: The docking scores between hepcidin and Anticalin was -4.6 kcal/mol at Cys13,Cys14, Arg16, and Ser17. The compound Roxburghine B and Oxoxylopine could interact with the ligand binding domain and had the docking scores lower than Anticalin. Conclusions: Roxburghine B and Oxoxylopine are potential to become hepcidin antagonists insilico for inflammatory anemia. Keywords: anemia inflamasi, phytochemical, molecular docking, hepcidin, Anticalin
The Difference of Forced Vital Capacity Ratio (%FVC) between Junior High School Students Living in High Altitude and Low Altitude Fery Ardi Kurniawan; Yuliana Heri Suselo; Amandha Boy Timor Randita
Nexus Biomedika Vol 4, No 3 (2015): Nexus Biomedika
Publisher : Nexus Biomedika

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Background: Environment will affect the condition and bodys ability to adapt. The difference of characteristics and environmental conditions between high altitude and low altitude causes the adaptation of body, in order to work normally. This adaptation causes change in many organ systems including the respiratory system. Forced Vital Capacity Ratio (%FVC) is the ratio between Forced Vital Capacity (FVC) and predicted value of vital capacity. FVC is influenced by lungs ability to compliance and recoil. The limitations on these ability will reduce the ability to inspire the air so it will be difficult to get oxygen. This research aimed to analyze the difference of %FVC between junior high school students living in high altitude and low altitude. Methods:This research was a cross-sectional observational analytic. The subjects were 30 male students of SMP Amal Mulya Tawangmangu Karanganyar (altitude 966 meters) and 30 male students of SMP Negeri 2 Kretek Bantul (altitude 15 meters). The subjects were selected by using non random purposive sampling and met the inclusion and exclusion criteria. Data of %FVC were measured by Minato AutoSpiro AS.300 Spirometry. The data were analyzed using Independent t-test with significance level ? = 95%. Results: Mean of %FVC of junior high school students in high altitude was 77.67 8.806 whereas mean of that in low altitude was 76.38 8.493 with p = 0.564. Conclusions: There is no significant difference of %FVC between junior high school students living in high altitude and low altitude. Keywords: Forced Vital Capacity Ratio (%FVC), high altitude, low altitude, spirometry
Oxonantenine Derives from Annona reticulata is a Potential Candidate of DPP-4 Inhibitor for Diabetes Therapy PRATHITA NITYASEWAKA; DONO INDARTO; YULIANA HERI SUSELO
Nexus Biomedika Vol 5, No 2 (2016): Nexus Biomedika
Publisher : Nexus Biomedika

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Introduction: DPP-4 inhibitor is a new diabetic drug for patients with type 2 diabetes who do not achieve normal blood glucose levels using standard drugs such as metformin, sulfonylurea, meglitinide, thiazolidinedione, and ?-glucosidase inhibitor. Pharmacologically, DPP-4 inhibitor increases GLP-1 and GIP blood levels, leading to increase of insulin secretion. So far, Indonesian herbal plants have been used as an alternative therapy for diabetes but their active compounds have been unknown. The aim of this study was to identify phytochemicals derived from Indonesian herbal plants with DPP-4 inhibitor activity. Methods: This study was a bioinformatic study with a molecular docking method. Three-dimensional structure of DPP-4 was downloaded from Protein Data Bank with access code PDB 3F8S. Sitagliptin, a DPP-4 inhibitor, was used as a standard ligand and was obtained from ZINC database with access code ZINC22007143. HerbalDB and Pubchem databases were used to search three-dimensional structures of Indonesian phytochemicals. Before running molecular docking, all phytochemicals were selected using Lipinskis rule of five criteria. Molecular docking of these phytochemicals with DPP-4 was performed three times using Autodock Vina 1.1.2. Results of molecular docking were visualized using PyMol 1.7 and Chimera 1.9. Result: 422 Indonesian phytochemicals were docked with DPP-4. A lower binding affinity was observed in oxonantenine, compared with sitagliptin (-8.3 vs -8.5 kcal/mol respectively). In addition, oxonantenine has as same as binding sites with sitagliptin (Glu 205 and Glu 206). Oxonantenine interacts with DPP-4 at Tyr 547 as third residue, while third residue interaction of sitagliptin and DPP-4 was at Tyr 662. Oxonantenine was found in Annona reticulata. Conclusions: Oxonantenine which is an Indonesian phytochemicals may computationally become a candidate of DPP-4 inhibitor. In vitro study is needed to verify whether or not oxonantenine can inhibit DPP-4. Keywords: DPP-4, type 2 diabetes, molecular docking, oxonantenine.
Co-Authors Amandha Boy Timor Randita Ayusari, Amelya Augusthina Balgis . Dien Adiparadana DONO INDARTO Fery Ardi Kurniawan Mila Ulfia Muhammad Rizki Kamil Muthmainah . . PRATHITA NITYASEWAKA R. Aj Sri Wulandari Safirah . Yotriana