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Balgis .
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Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology

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Hubungan antara Fatty Liver dengan Hipertensi Sistemik di RSUD Dr. Moewardi Surakarta Yeny Ristaning Belawati; Widiastuti .; Balgis .
Nexus Kedokteran Klinik Vol 1, No 2 (2012): Nexus Kedokteran Klinik
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

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Background: Fatty liver is the accumulation of fat in the liver ranging from simple steatosis to nonalcoholic steatohepatitis (NASH) and cirrhosis. Patients fatty liver is often associated with metabolic disorders. It can be seen from the results of laboratory tests of blood, such as elevated levels of Alanin Amino Transferase (ALT), Gamma Glutamyl Transferase (GGT), alkaline phosphatase, ferritin, and another impaired liver function test. Hypertension is one of the conditions of metabolic disorders, and by an unknown mechanism there was an allegation of relationship between fatty liver and systemic hypertension Methods: This study was an analytical observational research with cross-sectional approach. The research was taken place in Radiology Installation of RSUD Dr. Moewardi Surakarta. The samples were consisted of 20 fatty liver patients and 20 non-fatty liver patients. Dependent variable of this research was fatty liver, and independent was systemic hypertension. The data was collected by viewing the result of USG abdomen-hepar examination and measuring patients blood pressure by researcher. The data of research was analyzed using Chi Square test and Odds Ratio. Results: There was a significant relationship between fatty liver and hypertension systemic in RSUD Dr. Moewardi Surakarta (p < 0,05); fatty liver patients had risk of hypertension systemic 7 times higher than the non-fatty liver patients (OR = 7) Conclusions: There was a significant relationship between fatty liver and hypertension systemic in RSUD Dr. Moewardi Surakarta, fatty liver patients have a risk of systemic hypertension 7 times greater than non-fatty liver patients Keywords: Fatty Liver, Hypertension Systemic, USG Abdomen
Perbedaan VO2 Max antara Penarik Becak dengan Supir Taksi di Kota Surakarta Shelly Lavenia Sambodo; Balgis .; Novan Adi Setyawan
Nexus Biomedika Vol 3, No 2 (2014): Nexus Biomedika
Publisher : Nexus Biomedika

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Background: VO2 Max (maximal oxygen uptake) is a capability of oxygen with maximal capacity that used to the body to perform maximal exercise. The factor that most influence of VO2 Max is a physical activity. Cardiorespiratory endurance can be enhanced objectively by doing exercises or sports regularly, structurally, and continuously performed. Pedicab driver does his job by pedaling a pedicab every day, whereas the taxi driver does his job by driving a taxi every day. The aims of this study are to determine the differences of VO2 Max scores between pedicab drivers and taxi drivers in Surakarta. Methods: This study was an observational analytic with cross-sectional approach. The selection of the samples from the population has been conducted with purposive sampling. This study was conducted in the base of Kosti Solo in Mojosongo and in Surakarta. Two groups of samples, 30 taxi drivers and 30 pedicab drivers with the inclusion criteria (man, age 40 - 50 years; BMI ranged from 18.5 kg/m2 25.0 kg/m2; diastolic blood pressure < 100 mmHg; willing to be responders and filling and approved informed-consent; pursue work at least 5 years) conducted a study using Multistage Fitness Test (MFT), which the test is to run back and forth 20 yards. This value can be converted into the equivalent VO2 Max score using prediction table of the VO2 Max. The data were analyzed using non paired t-test (? = 0.05). Results: The results showed the mean scores predicted of the VO2 Max in pedicab driver was 25.79, while the taxi driver was 20.87. The data were analyzed by using non paired t-test that showed significantly differences between the two study groups, p = 0.000 (p < 0.05). Conclusion: There are significant differences of VO2 Max between the pedicab drivers and taxi drivers in Surakarta. Keywords: VO2 Max, pedicab drivers, taxi drivers, cardiorespiratory endurance, MFT
The Acupuncture Effect of Zusanli point (ST36) to Decrease the Number of Leukocytes in Mice (Mus musculus) Model of Sepsis Due to Exposure of Cecal Inoculum Esty Jayanti; Balgis .; Sri Wulandari
Nexus Biomedika Vol 4, No 2 (2015): Nexus Biomedika
Publisher : Nexus Biomedika

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Background:The incidence of sepsis in the Dr. Moewardi Hospital at the end 2007 showed a mortality rate of 50.2 % (115 deaths from 229 patient with sepsis). Associated with the sepsis treatment therapy, the use of low-dose corticosteroids in the early stages of sepsis is still debated. WHO suggests that acupuncture can stimulate corticosteroid. The aim of this study was to know the acupuncture effect of Zusanli point ( ST36 ) to decrease the number of leukocytes in mice (Mus musculus) model of sepsis caused by the exposure of cecal inoculum. Methods:This study was an experimental laboratory research with posttest only control group designs. The samples were 28 male mice, divided by simple random sampling into a control group (KK), Sepsis Group 1 (KS1), Sepsis Group 2 (KS2), and Sepsis Group 3 (KS3). Sepsis groups were made by giving cecal inoculum exposure at a dose of 0.1 mg/mouse/day injected intraperitoneally for 7 days. During the 10 days after exposure, no treatment was given to KS1, while KS2 was treated with corticosteroid therapy, and KS3 was given acupuncture therapy. The low dose corticosteroid used was Methyl prednisolone at a dose of 0.05 mg/mice that was injected intraperitoneally 2 times daily. The acupuncture was given at the Zusanli point (ST36) with a duration of 15 minutes. Blood samples were taken at day 24th. The leukocyte count data were analyzed with One Way ANOVA test (p<0.05) and the Bonferroni post hoc test (p>0.005). Results:Sepsis group were successfully made by exposure of cecal inoculum with significance level (p) of 0.000 (p>0.005). Acupuncture of zusanli point (ST36) could reduce leucocyte count in mice (Mus musculus) model of sepsis caused by exposure to cecal inokulum as same as corticosteroid group with significance level (p) 0.000 (p>0.005). Conclusion:Acupuncture of Zusanli point (ST36) can reduce leukocyte count in mice (Mus musculus) model of sepsis caused by exposure to cecal inoculum. Keywords: Acupuncture, Zusanli point (ST36), leukocyte count, Sepsis.
Screening Indonesian Medical Plants Phytochemistry Using Molecular Docking as Hepcidin Antagonis in Iron Deficiency Anemia Dien Adiparadana; Yuliana Heri Suselo; Balgis .
Nexus Kedokteran Translasional Vol 4, No 2 (2015): Nexus Kedokteran Translasional
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

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Background: Iron deficiency anemia is found in clinical practice and community. There is mutasion in a genetic within iron deficency anemia which regulate iron homeostatis.Mutation in the TMPRSS6 resulting in iron refractory iron deficiency anemia The TMPRSS6 genetic encoding matriptase-2 enzymes which regulate hepcidin. The hepcidin is a principal regulator of iron homeostatis. Indonesia have more than 2.000 medical plants which have many roles and function. Some plants have phytochemisty that potentially in hepcidin antagonis. The phytochemistry is screen using molecular docking method Methods: The research design was a biocomputasion. It had been done at Medical Faculty of Sebelas Maret University on August-Oktober, 2014. The data was collected by using purposive sampling method. All data is docked using Autodock Vina in PyRx software. Docked sample is compared with binding energy of furstulhiamine drug. The data was compared its binding energy and their zone interaction with fursulthamine Results: The result were 10 samples has higher its binding energy than fursulthiamine. The binding energy of fursulthiamine was -6,7 kcal/mol. The highest binding energy was -8,5 kcal/mol and the lowest was -8 kcal/mol. All 10 sample interacted with cys 326. The cys 326 was the residue which can inhibit hepcidin interaction with ferroportin Conclusions: The Molecular Docking can be used to intial screening many phytochemisty. The result was 10 phytochemistry Indonesian medical plants which may inhibit hepcidin interaction. Further research is needed to prove the effect of phytochemistry. Keywords: Hepcidin, molecular docking, phytochemistry
Co-Authors Dien Adiparadana Esty Jayanti Novan Adi Setyawan Shelly Lavenia Sambodo SRI WULANDARI Widiastuti . Yeny Ristaning Belawati Yuliana Heri Suselo