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PEPTIDE RECEPTOR RADIONUCLIDE THERAPY Hidayatullah, Rian; Budiawan, Hendra; Darmawan, Budi; Affandi, Erwin
Jurnal Kedokteran Vol 10 No 1 (2021): volume 10 nomor 1 2021
Publisher : Faculty of Medicine Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jku.v10i1.480

Abstract

Peptide receptor radionuclide therapy (PRRT) is an effective and usually well-tolerated treatment for unresectable or metastatic neuroendocrine tumors expressing somatostatin receptors. Somatostatin analog which is labeled by ?- or ?-emitting radionuclide binds specifically to SSTRs abnormally expressed in NETs. The two radiopharmaceuticals most commonly used for PRRT are 90Y-DOTATOC and 177Lu-DOTATATE which have been demonstrated to provide an effective tumor response and symptom relief with positive impact on survival. Chronic side effects on the kidneys and bone marrow are generally mild. The radiopharmaceuticals is internalized into the cell for the irradiation. Furthermore, the long half-life of the analog maintains a persistent therapeutic effect. Different approaches are now under evaluation to improve PRRT efficacy, it may be expected that the use of PRRT will increase in the coming years.
Somatostatin Hidayatullah, Rian; Budiawan, Hendra; Darmawan, Budi; Affandi, Erwin
Jurnal Kedokteran Vol 10 No 2 (2021): Jurnal Kedokteran Juni 2021
Publisher : Faculty of Medicine Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jku.v10i2.482

Abstract

Somatostatin, also known as growth hormone-inhibiting factor (GIF) or somatotropin release-inhibiting factor (SRIF), is a peptide hormone that regulates the endocrine system and affects neurotransmission and cell proliferation. Somatostatin can be regarded as secretory pan-inhibitory,because it can inhibit secretion of almost all endocrine and exocrine glands. Somatostatin has 2 active forms (somatostatin-14 and 28), but the short half-life of the hormone was one of the reasons why the native hormone was not feasible for routine clinical practice. Somatostatin analog was synthesized for the first time in 1980-1982 and proved to be more resistant to degradation and more potent than native hormone. There are five somatostatin receptors (SSTR1-5). The genes encoding human SSTR1-5 are located in chromosome 14q13, 17q24, 22q13.1, 20p11.2 and 16p13.3. SSTR expression pattern and complex signaling make somatostatin be such an extraordinary neurotransmitter and hormone. The potent inhibitory action of SSTR on cellular processes such as secretion, proliferation, and apoptosis is the reason for somatostatin to be the target for therapy development. Radiopharmaceuticals used for therapy consist of three parts: somatostatin analog, chelator, and radionuclide (alpha or beta-emitting). Combinations of different peptides, chelators, and radionuclides have been tested in vitro and/or in vivo for their use in peptide receptor radionuclide therapy (PRRT). These compounds are able to irradiate tumors and their metastases via the internalization through a specific receptor subtype which is generally overexpressed on the cell membrane.
Tinjauan Kelengkapan dan Keakuratan Pengisian Resume Medis Pasien Rawat Inap pada Ruangan Paru di BLUD RSU Ratu Zalecha Martapura Tahun 2012 Irmawan Irmawan; Apit Widiarta; Rian Hidayatullah; STIKES Husada Borneo
Jurnal Kesehatan Indonesia Vol 4 No 1 (2013): November
Publisher : HB PRESS

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Abstract

Completeness and accuracy of resume filing medical inpatients in the lung’s room in BLUD RSU Ratu Zalecha Martapura there is still a form of medical resume incomplete and inaccurate contents so greatly influence the information needs of patients and in a report prepared by the hospital. The purpose of this study was to determine the completeness of medical resume charging patients hospitalized on the pulmonary room, knowing the accuracy of resume charging medical inpatients at room Knowing factor ng and factors that affect the completeness and accuracy of resume charging medical inpatients at room lungs. This type of survey research is descriptive method with quantitative approach, data collection and conduct interviews conducted by review of inpatient medical records room filled lung. The samples were 123 medical inpatients resume on lung room. The results indicate medical resume charging the completeness of data on the identification of 80,21%, 13,23% critical reports, authentication and recording 66,66% are either 100% do not use coretandan type-x. The accuracy of medical resume charging the identification data of 77,50%, 11,85% critical report, authenticated 65,05%, and a good record 100% accurate. Human resources (HR) at Hospital BLUD RSU Ratu Zalecha Martapura mainly assembling already plays an important part of the completeness of medical records but the constraints of the charging current is D3 because they are not medical records so it is difficult to understand how the actual provisions of the comprehensiveness and accuracy of medical resume. Doctors have a special room facilities are available, after providing direct care to patients physicians complete medical records of patients in the room. Assembling parts already using Standard Operating Procedure (SOP) in 2010 but has not been going well.
Pengaruh Model Latihan Variasi Terhadap Kemampuan Menyudul Bola Bagi Anak di SSB Bima Putra Lampung Timur Rian Hidayatullah; Rahmat Hermawan; Lungit Wicaksono
JUPE (Jurnal Penjaskesrek) Vol 7, No 3 (2019): JUPE
Publisher : JUPE (Jurnal Penjaskesrek)

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Abstract

The problem of this research is the children average ability of heading a ball in the SBB Bima Putra, East Lampung which is relatively not reaching the maximum level. The aim of this study was to find out the effect of children's ability of heading a ball by providing a treatment that is a variation exercise model. The subject of this study was 30 children of SBB Bima Putra, East Lampung. The result showed that the variation exercise model has a significant influence toward children’s heading a ball ability in SBB Bima Putra, East lampung (tvalue = 9.701 ttable = 2.045). It indicates that variation exercise model gives an influence to improve children’s ability of heading a ball in football.Masalah dalam penelitian ini adalah kemampuan rata-rata menyundul bola (heading) pada SSB Bima Putra Lampung Timur relatif belum mencapai tingkat maksimal. Penelitian ini bertujuan untuk mengetahui pengaruh dengan memberikan suatu perlakuan yaitu model latihan variasi. Penelitian yang digunakan adalah eksperimen dengan sampel sebanyak 30 orang. Hasil penelitian menunjukkan model latihan variasi terdapat pengaruh yang signifikan dalam kemampuan menyundul bola pada anak di SSB Bima Putra Lampung Timur (t hitung = 9.701   t tabel =  2.045). Hal ini menunjukkan bahwa model latihan variasi  memberikan pengaruh lebih baik untuk meningkatkan kemampuan menyundul bola dalam sepakbola.Kata kunci : menyundul bola, model latihan variasi, pengaruh
ANALISIS KINERJA DINAS SOSIAL DAN PEMAKAMAN KOTAPEKANBARU (STUDI KASUS : PEMBINAAN ANAK JALANAN) Rian Hidayatullah; Hery Suryadi
Jurnal Online Mahasiswa (JOM) Bidang Ilmu Sosial dan Ilmu Politik Vol 1, No 2: WISUDA OKTOBER 2014
Publisher : Fakultas Ilmu Sosial dan Ilmu Politik Universitas Riau

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Abstract

Pekanbaru is the capital of Riau province who also have serious concerns about the derelict in this regard are street children. Figures existence of street children in the city of Pekanbaru is high enough to be one of the social problems in the community. Pekanbaru city government was not without effort to eradicate street children in the city of Pekanbaru. One way to conduct training to street children, it is the primary goal of the research conducted by the author. In this paper the authors study using qualitative analysis methods. While the data analysis technique used is descriptive analysis of spoken words and observable behavior of the people studied.Based on the results of research conducted and followed by analyzing the data obtained from the question and answer directly to the informant, resulting in that the views of the five substances of government functions: (1) Provision of Services, as a concept has been well formulated but they lack the facilities that support, because only 1 has a facility to conduct training. (2) setting, Pekanbaru City does not have specific regional regulation of street children, street children is only one study in Pekanbaru City Regulation No. 12 Year 2008 on the Social Order. (3) Coordination of the review has been going pretty well, it is seen from the joint raid Social Service and Pekanbaru City Cemetery with other institutions that together took to the streets. (4) Representatives, Parliament representatives of the people, has synergy with the Department of Social and Pekanbaru City Cemetery, special support from relevant Council special budget for development of street children. (5) Development, Social Services and Funeral Pekanbaru, only have one container that LBK, the last condition is far from manicured, and until the end of this research in the LBK has been no activity on social issues. Judging from the five substances, some shortcomings do Social Service and Funeral Pekanbaru City street children in foster such development activities, the construction of additional homes built, as well as the need for understanding and support of all components of both the public and the government to resolve at least reduce the problem of street children.Keywords: Performance of Social Service, Government Functions, Street Child Development.
Memanfaatkan Teknologi untuk Mengabdi Kepada Masyarakat di Era Modernisasi Purnamasari, Ismi; Rizky Ikhsan; Rudiat, Lukman; Darmawan, Alwan Kusuma; Hudaya, Hamdan; Satria Gentara; Hidayatullah, Rian; Juniar Malika Mulya; Oktaviani, Dela; Nurkholisah, Nurkholisah; Nugraha, Arif; Ruhimat, Jajat; Fatimah, Raden Dini Destiani Siti
Jurnal PkM MIFTEK Vol 2 No 2 (2021): Jurnal PkM MIFTEK
Publisher : Institut Teknologi Garut

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33364/miftek/v.2-2.1125

Abstract

COVID-19 merupakan salah satu virus yang saat ini sedang menjadi perbincangan di dunia, khususnya di Indonesia. Maka dari itu, masyarakat perlu lebih ekstra lagi dalam beberapa bidang seperti pendidikan, ketenagakerjaan dll. Banyak hal yang perlu dijadikan sebuah acuan dalam pembelajaran yang saat ini merupakan sebuah permasalahan dan keluhan dikalangan pelajardan pengajar. Masalah pemberlakuan tatap muka yang terbatas dan belajar secara jarak jauh (sistem daring) di Desa Parakan, Kecamatan Pasirwangi, Kabupaten Garut menjadi sebuah kendala besar dalam keberlangsungan pembelajaran,baik itu terkait jaringan ataupun fasilitas yang kurang memadai. Sehingga dibutuhkanlah kiat-kiat dalam menyusun strategi dan sistem pembelajaran. Selain dalam bidang pendidikan, bidang ketenagaakerjaan pun menjadi masalah yang dialami oleh masyarakat desa Parakan. Dimulai dari terbatasnya aktivitas masyarakat untuk bekerja, sampai kegagalan-kegagalan yang dirasakan oleh masyaraka saat ini. Kegagalan tersebut didasarkan pada hal yang dirasakan masyarakat dari kurangnya aktivitas dan faktor lingkungan. Faktor lingkungan yang menyebabkan kegagalan tersebut salahsatunya dari kurang baiknya distribusi air karena mayoritas pekerjaan di desa Parakan yaitu dalam bidang pertanian. Oleh sebab itu, dari masalah-masalah yang terjadi membuat kami terdorong untuk mengadakan kegiatan webinar yang diadakan dalam program Kuliah Kerja Nyata (KKN) Institut Teknologi Garut (ITG) dengan menyampaikan beberapa strategi pembelajaran di masa pandemic, ketenagakerjaan, beserta pengelolaan lingkungan untuk memperbaiki distribusi air. Webinar tersebut terbukti dapat meningkatkan pemahaman masyarakat dengan persentase 27%. Pada seluruh topic yang diberikan dari pemahaman sebelumnya.
Detection of Small Lesion Insulinoma with 68Ga-DOTATATE PET/CT scan: A Case Report Irma Wahyuni; Tri Juli Edi Tarigan; Hendra Budiawan; Alvita Dewi; Rian Hidayatullah; Hasan Maulahela
‎ InaJEMD - Indonesian Journal of Endocrinology Metabolic and Diabetes Vol. 2 No. 1 (2025): InaJEMD Vol. 2, No. 1
Publisher : PP PERKENI

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Abstract

Endogenous hyperinsulinism is a rare condition characterized by inappropriate insulin secretion, with insulinoma accounting for approximately 55% of cases. A 36-year-old woman presented with recurrent hypoglycemic episodes for 4.5 years, particularly in the morning, relieved by glucose intake. Laboratory findings during a supervised fasting test revealed a blood glucose of 44 mg/dL, elevated insulin (15 μIU/mL), C-peptide (2.27 ng/mL), proinsulin (53.1 pmol/L), and suppressed beta-hydroxybutyrate (0.1 mmol/L), indicating endogenous hyperinsulinemia. Initial imaging modalities including CT, MRI, and EUS failed to localize the lesion. The patient discontinued investigation but resumed a year later with nuclear imaging studies. A 99mTc-HYNIC-TOC scan was inconclusive, but subsequent ^68Ga-DOTATATE PET/CT at Hasan Sadikin Hospital revealed a somatostatin receptor-expressing nodule at the pancreatic head, consistent with insulinoma. Given the lesion's location and imaging findings, treatment options were discussed, including Whipple’s procedure versus radiofrequency ablation. Insulinomas are typically small, with 80% under 2 cm and 40% under 1 cm, often making localization challenging. While CT and MRI have detection rates of 70% and 86% respectively, the combination of CT and EUS may reach 100% sensitivity. In cases where conventional imaging is inconclusive, ^68Ga-DOTATATE PET/CT provides a valuable alternative, capable of detecting neuroendocrine tumors as small as 6 mm. This case highlights the critical role of nuclear medicine in localizing elusive insulinomas and guiding definitive treatment.