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All Journal Jurnal Kedokteran Jurnal Imejing Diagnostik Journal of Medicine and Health Medicinus : Jurnal Kedokteran Medica Hospitalia IJECA (International Journal of Education and Curriculum Application) JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Deka in Medicine
Hendra Budiawan, Hendra
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Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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Generalized Lymphadenopathy due to Chronic Lymphocytic Leukemia (CLL) : 18F-FDG PET Imaging Hidayat, Basuki; Hutomo, Febby; Yudistiro, Ryan; Mulyanto, Ivana D.; Budiawan, Hendra; Masjhur, Johan S.
Journal of Medicine and Health Vol 1, No 3 (2016)
Publisher : Maranatha Christian University

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Lymphadenopaty is a common clinical finding with a broad differential diagnosis, withCarcinoma of Unknown Primary (CUP) as one of it’s most common causes. Flourine-18 fluoro-2 deoxy glucose (18F- FDG) positron emission tomography (PET) is a Nuclear Medicinescintigraphy procedure commonly used to localize suspected a primary lesion by depicting ametabolic status. However, in the expertise of 18F FDG PET study, clinical finding andepidemiologic data must be considered to get a better conclusion. We describe 18F-FDG PETstudy in the presence of generalized lymphadenopathy due to chronic lymphocytic leukemia(CLL), a rare disease which is initially suspected of having CUP.Keywords: 18F-FDG PET, lymphadenopathy, lymphoma, leukemia
PEPTIDE RECEPTOR RADIONUCLIDE THERAPY Hidayatullah, Rian; Budiawan, Hendra; Darmawan, Budi; Affandi, Erwin
Jurnal Kedokteran Vol 10 No 1 (2021): volume 10 nomor 1 2021
Publisher : Faculty of Medicine Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jku.v10i1.480

Abstract

Peptide receptor radionuclide therapy (PRRT) is an effective and usually well-tolerated treatment for unresectable or metastatic neuroendocrine tumors expressing somatostatin receptors. Somatostatin analog which is labeled by ?- or ?-emitting radionuclide binds specifically to SSTRs abnormally expressed in NETs. The two radiopharmaceuticals most commonly used for PRRT are 90Y-DOTATOC and 177Lu-DOTATATE which have been demonstrated to provide an effective tumor response and symptom relief with positive impact on survival. Chronic side effects on the kidneys and bone marrow are generally mild. The radiopharmaceuticals is internalized into the cell for the irradiation. Furthermore, the long half-life of the analog maintains a persistent therapeutic effect. Different approaches are now under evaluation to improve PRRT efficacy, it may be expected that the use of PRRT will increase in the coming years.
Somatostatin Hidayatullah, Rian; Budiawan, Hendra; Darmawan, Budi; Affandi, Erwin
Jurnal Kedokteran Vol 10 No 2 (2021): Jurnal Kedokteran Juni 2021
Publisher : Faculty of Medicine Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jku.v10i2.482

Abstract

Somatostatin, also known as growth hormone-inhibiting factor (GIF) or somatotropin release-inhibiting factor (SRIF), is a peptide hormone that regulates the endocrine system and affects neurotransmission and cell proliferation. Somatostatin can be regarded as secretory pan-inhibitory,because it can inhibit secretion of almost all endocrine and exocrine glands. Somatostatin has 2 active forms (somatostatin-14 and 28), but the short half-life of the hormone was one of the reasons why the native hormone was not feasible for routine clinical practice. Somatostatin analog was synthesized for the first time in 1980-1982 and proved to be more resistant to degradation and more potent than native hormone. There are five somatostatin receptors (SSTR1-5). The genes encoding human SSTR1-5 are located in chromosome 14q13, 17q24, 22q13.1, 20p11.2 and 16p13.3. SSTR expression pattern and complex signaling make somatostatin be such an extraordinary neurotransmitter and hormone. The potent inhibitory action of SSTR on cellular processes such as secretion, proliferation, and apoptosis is the reason for somatostatin to be the target for therapy development. Radiopharmaceuticals used for therapy consist of three parts: somatostatin analog, chelator, and radionuclide (alpha or beta-emitting). Combinations of different peptides, chelators, and radionuclides have been tested in vitro and/or in vivo for their use in peptide receptor radionuclide therapy (PRRT). These compounds are able to irradiate tumors and their metastases via the internalization through a specific receptor subtype which is generally overexpressed on the cell membrane.
The Appropriate Acquisition Time Interval Following Injection of 99mTc-Sestam ibi with Water Protocol in Single Photon Emission Computed Tomography Myocardial Perfusion Imaging: First Experience in Indonesia Prasetyo, Nora Anggun; Soeriadi, Erwin Affandi; Budiawan, Hendra; Kartamihardja, Achmad Hussein Sundawa
Medicinus Vol 12, No 1 (2022): October
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v10i2.7016

Abstract

Introduction: According to EANM/ESC guideline, image acquisitions in stress test should be begun at 30-60 minutes after tracer administration. Our center is a referral hospital for nuclear medicine imaging with many patients but limited number of gamma camera. The shorter time between injection of radiopharmaceutical and imaging acquisition will add to the number of examinations that can be performed. The aim of this study was to evaluate the appropriate acquisition time interval with water protocol in 99mTc-Sestamibi SPECT myocardial perfusion imaging.Methods: Patients who were referred to undergo stress MPI between October 2020 to December 2020 were included in this study. Cardiac stress procedure was performed using treadmill with modified Bruce Protocol. Subjects drank a total of 330 mL water following 99mTc-Sestamibi injection. Image acquisitions were performed 10 and 30 minutes afterwards. Quantitative assessment was done by calculating target background ratio (TBR). Statistical analysis was performed using student t-test with Microsoft Excel version 2019. P-value < 0.05 was considered to be statistically significant.Result: Thirty out of 35 subjects were included in this study. Sixteen of them are male and 14 are female with a mean age of 48.7 years old (28 – 80). Mean target background uptake ratio (TBR) in 10- and 30-minutes images were 0.67 (0.44 – 1.11) and 0.76 (0.43 – 1.18) respectively (p-value = 0.15).Conclusion: There was no significant difference of target to background ratio between 10- and 30-minutes acquisition time interval following injection of 99mTc- Sestamibi with water protocol in myocardial perfusion imaging.
Thyroid Storm Post-Radioactive Iodine Therapy Hardina, Septi; Budiawan, Hendra
Medica Hospitalia : Journal of Clinical Medicine Vol. 10 No. 1 (2023): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v10i1.785

Abstract

Background Thyroid storm is an endocrine disorder emergency which has a high morbidity and mortality rates. The incidence of thyroid storm is seen in less than 10% of all hospitalized thyrotoxicosis patients. However, it has a high mortality rate, which accounts to 20-30% of the cases. It is important to diagnose early to facilitate appropriate immediate management, which can improve prognosis and clinical outcome in patients. Thyroid storm usually begins with precipitating factor. Thyroid storm precipitated by radioactive iodine therapy is rare. Case Report We report a rare case in a 28 year old female patient. Patient came with complaints of palpitations, nausea without vomiting, fever, >3x diarrhea, and shortness of breath after radioactive iodine therapy. The clinical presentation of thyroid storm is polymorphic that becomes a diagnostic problem as it can delay treatment and increase the risk of mortality. It is important to suspect a thyroid storm based on the patient's clinical presentation, because the diagnosis of thyroid storm is based more on the patient's clinical presentation. The existence of the Burch-Wartofsky scoring system facilitates the diagnosis of a thyroid storm. The total Burch-Wartofsky score in this patient based on the clinical presentation is 45, which is highly suggestive of thyroid storm. Conclusion Thyroid storm precipitated by radioactive iodine therapy is rare. The incidence of thyroid storm after administration of radioactive iodine therapy is 0.34 percent. Precipitating factors other than the administration of radioactive iodine therapy such as infection and discontinuation of antithyroid drug therapy can trigger a thyroid storm.
Analisis Perbedaan Citra SPECT Non-AC dan CTAC pada Pemeriksaan Scintigrafi Perfusi Miokard Nuryadin, Ridwan; Nurbaiti, Nurbaiti; Apriantoro, Nursama Heru; Budiawan, Hendra
Jurnal Imejing Diagnostik (JImeD) Vol 11, No 1 (2025): JANUARY 2025
Publisher : Poltekkes Kemenkes Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jimed.v1i1.11971

Abstract

Background: Myocardial Perfusion Scan displays SPECT images, which is a non invasive imaging method for a quantitative view of myocardial ischemia which can’t be done with CT myocardial perfusion. The principle of myocardial perfusion scan is that the myocardial absorption of radiopharmaceuticals is proportional to coronary heart blood flow to the myocardium. The main problem with SPECT myocardial perfusion scan imaging is photon attenuation caused by soft tissue around the heart which causes inaccurate information and attenuation artifacts. One method to reduce attenuation artifacts is hybrid CT Scan imaging with SPECT tools. CT Scan images are used to correct attenuation in SPECT images. The purpose of this research is to analyze the differences between non-AC and CTAC SPECT images which will have an impact on myocardium perfusion values on myocardial perfusion scans.Methods: This research is a quantitative analysis with a direct observation approach. The research was undertaken at Nuclear Medicine and Molecular Theranostics Installation of Dr. Hasan Sadikin General Hospital in Bandung, starting November 2023 using a SPECT CT GE NM/CT 860 gamma camera. A total of 28 patients were examined for myocardial perfusion scans. Data processing is conducted by comparing the perfusion values of myocardium on non-AC and CTAC SPECT images for 28 samples by conducting hypothesis testing using paired test sample T-Test.Result: Based on the research results, non-AC, and CTAC SPECT image data showed a normal distribution using the Shapiro-Wilk test, allowing the analysis of differences using the Paired-Samples T-test. In general, the analysis results indicate a significant difference between non-AC and CTAC SPECT images, as the sig value is less than 0.05 in the RCA and LCx vascular segments, as well as in the septal, inferior, lateral, and apical wall segments. However, no significant differences were found in the LAD vascular segment and the anterior wall segment, as the sig value is greater than 0.05.Conclusions: There are differences between non-AC and CTAC SPECT images in the RCA and LCx blood vessel segments, as well as in the septal, inferior, lateral, and apical wall segments. However, no differences are observed in the LAD blood vessel segment and the anterior wall segment.
The role of parathyroid and bone scintigraphy in detecting multiple parathyroid adenomas with fibrous dysplasia: A case report Khairunnisa, Alifina; Budiawan, Hendra; Affandi, Erwin; Kartamihardja, Achmad
Deka in Medicine Vol. 2 No. 1 (2025): April 2025
Publisher : PT. DEKA RESEARCH INSTITUTE

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69863/dim.2025.e576

Abstract

BACKGROUND: Primary hyperparathyroidism is the leading cause of hypercalcemia, usually caused by a parathyroid adenoma and potentially leading to metabolic bone disorders. Fibrous dysplasia is a rare skeletal disorder that can coexist with hyperparathyroidism, although it is rarely found without McCune-Albright syndrome. CASE: A 31-year-old woman with a history of hemodialysis presented with progressive swelling of the upper and lower jaw over the past two years, accompanied by bone pain and fatigue. Laboratory tests revealed elevated parathyroid hormone levels, serum creatinine, and hypocalcemia. Magnetic resonance imaging (MRI) of the neck identified an isointense lesion in the left thyroid gland but failed to localize the parathyroid adenoma. 99mTc-Sestamibi parathyroid scintigraphy showed multiple adenomas in the lower poles of both thyroid lobes. 99mTc-MDP bone scintigraphy demonstrated a metabolic superscan pattern, leading to a diagnosis of primary hyperparathyroidism with polyostotic fibrous dysplasia. The patient underwent minimally invasive parathyroidectomy, which was histopathologically confirmed as bilateral inferior parathyroid adenomas. Postoperatively, the patient experienced significant symptom improvement, including reduced bone pain and improved quality of life. CONCLUSION: The coexistence of primary hyperparathyroidism and fibrous dysplasia without McCune-Albright syndrome is rare but important to recognize. Parathyroid and bone scintigraphy play a crucial role in diagnosis, assessing bone involvement, and planning appropriate therapy. A multimodal imaging approach enables early detection and more effective surgical strategies, improving clinical outcomes for patients.
The Appropriate Acquisition Time Interval Following Injection of 99mTc-Sestam ibi with Water Protocol in Single Photon Emission Computed Tomography Myocardial Perfusion Imaging: First Experience in Indonesia Prasetyo, Nora Anggun; Soeriadi, Erwin Affandi; Budiawan, Hendra; Kartamihardja, Achmad Hussein Sundawa
Medicinus Vol. 12 No. 1 (2022): October
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v10i2.7016

Abstract

Introduction: According to EANM/ESC guideline, image acquisitions in stress test should be begun at 30-60 minutes after tracer administration. Our center is a referral hospital for nuclear medicine imaging with many patients but limited number of gamma camera. The shorter time between injection of radiopharmaceutical and imaging acquisition will add to the number of examinations that can be performed. The aim of this study was to evaluate the appropriate acquisition time interval with water protocol in 99mTc-Sestamibi SPECT myocardial perfusion imaging.Methods: Patients who were referred to undergo stress MPI between October 2020 to December 2020 were included in this study. Cardiac stress procedure was performed using treadmill with modified Bruce Protocol. Subjects drank a total of 330 mL water following 99mTc-Sestamibi injection. Image acquisitions were performed 10 and 30 minutes afterwards. Quantitative assessment was done by calculating target background ratio (TBR). Statistical analysis was performed using student t-test with Microsoft Excel version 2019. P-value < 0.05 was considered to be statistically significant.Result: Thirty out of 35 subjects were included in this study. Sixteen of them are male and 14 are female with a mean age of 48.7 years old (28 - 80). Mean target background uptake ratio (TBR) in 10- and 30-minutes images were 0.67 (0.44 - 1.11) and 0.76 (0.43 - 1.18) respectively (p-value = 0.15).Conclusion: There was no significant difference of target to background ratio between 10- and 30-minutes acquisition time interval following injection of 99mTc- Sestamibi with water protocol in myocardial perfusion imaging.
Analisis Perbedaan Citra SPECT Non-AC dan CTAC pada Pemeriksaan Scintigrafi Perfusi Miokard Nuryadin, Ridwan; Nurbaiti, Nurbaiti; Apriantoro, Nursama Heru; Budiawan, Hendra
Jurnal Imejing Diagnostik (JImeD) Vol. 11 No. 1 (2025): JANUARY 2025
Publisher : Poltekkes Kemenkes Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jimed.v1i1.11971

Abstract

Background: Myocardial Perfusion Scan displays SPECT images, which is a non invasive imaging method for a quantitative view of myocardial ischemia which can’t be done with CT myocardial perfusion. The principle of myocardial perfusion scan is that the myocardial absorption of radiopharmaceuticals is proportional to coronary heart blood flow to the myocardium. The main problem with SPECT myocardial perfusion scan imaging is photon attenuation caused by soft tissue around the heart which causes inaccurate information and attenuation artifacts. One method to reduce attenuation artifacts is hybrid CT Scan imaging with SPECT tools. CT Scan images are used to correct attenuation in SPECT images. The purpose of this research is to analyze the differences between non-AC and CTAC SPECT images which will have an impact on myocardium perfusion values on myocardial perfusion scans.Methods: This research is a quantitative analysis with a direct observation approach. The research was undertaken at Nuclear Medicine and Molecular Theranostics Installation of Dr. Hasan Sadikin General Hospital in Bandung, starting November 2023 using a SPECT CT GE NM/CT 860 gamma camera. A total of 28 patients were examined for myocardial perfusion scans. Data processing is conducted by comparing the perfusion values of myocardium on non-AC and CTAC SPECT images for 28 samples by conducting hypothesis testing using paired test sample T-Test.Result: Based on the research results, non-AC, and CTAC SPECT image data showed a normal distribution using the Shapiro-Wilk test, allowing the analysis of differences using the Paired-Samples T-test. In general, the analysis results indicate a significant difference between non-AC and CTAC SPECT images, as the sig value is less than 0.05 in the RCA and LCx vascular segments, as well as in the septal, inferior, lateral, and apical wall segments. However, no significant differences were found in the LAD vascular segment and the anterior wall segment, as the sig value is greater than 0.05.Conclusions: There are differences between non-AC and CTAC SPECT images in the RCA and LCx blood vessel segments, as well as in the septal, inferior, lateral, and apical wall segments. However, no differences are observed in the LAD blood vessel segment and the anterior wall segment.
Developing Local-based English Module with Scavenger Hunts to Foster Pancasila Learners Profile Haiyudi, Haiyudi; Tohir, Muhammad; Agil, Sofwan Arif; Safira, Tiara Putri; Budiawan, Hendra; Andini, Andini; Art-in, Sitthipon
IJECA (International Journal of Education and Curriculum Application) Vol 6, No 3 (2023): December
Publisher : Universitas Muhammadiyah Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/ijeca.v6i3.19436

Abstract

Since this research was conducted, Junior high school, 1 Kepulauan Pongok has just started implementing the Kurikulum Merdeka (Independent Curriculum). Therefore, this research aims developing an English Module with local content to strengthen Pancasila Learners’ Profile. This belongs to Research and Development using 4D (defining, designing, developing, disseminating) approach. The sample was an English teacher and 31 students of class IX at Junior high school, 1 Kepulauan Pongok. The data were gained through interview and observation as the need analysis process. Distributing questionnaire is another data collecting technique to be then quantitatively analyzed using comparative analysis to the prescribed criteria. Based on the results of the validity questionnaire conducted by two expert validators, an average percentage of 86.40% was obtained as very valid. The practicality results from the students’ side show a percentage of 92.50% and 87.50% from the teachers which indicates very practical category. It can be concluded that the local cultural values of Bangka Belitung integrated to the English module with Scavenger Hunts are suitable, practical, and useful for students and teachers. Researchers further recommend the use of this module for teaching English, especially for the type of descriptive text that is appropriate to learning outcomes.
Co-Authors Agil, Sofwan Arif Alyani, Hilmi Andini, Andini Art-In, Sitthipon Basuki Hidayat Budi Darmawan Erwin Affandi Febby Hutomo, Febby Haiyudi, Haiyudi Hardina, Septi Ivana D. Mulyanto, Ivana D. Johan S. Masjhur, Johan S. Kartamihardja, Achmad Kartamihardja, Achmad Hussein Sundawa Khairunnisa, Alifina Nurbaiti Nurbaiti NURSAMA HERU APRIANTORO Nuryadin, Ridwan Prasetyo, Nora Anggun Rian Hidayatullah Ryan Yudistiro, Ryan Safira, Tiara Putri Soeriadi, Erwin Affandi Tohir, Muhammad Trias Nugrahadi, Trias