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All Journal The Journal of Pure and Applied Chemistry Research
Eny Rahma Wati
Department of Chemistry, Faculty of Mathematics and Science, Brawijaya University
Chemical Engineering, Chemistry & Bioengineering Chemistry Materials Science & Nanotechnology Medicine & Pharmacology

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Potential of Anthocyanin From Purple Sweet Potato (Ipomoea batatas) To Increase BDNF Level and VEGF Expression in The Cerebellum of Ischemic Stroke Rats Eny Rahma Wati; Sasangka Prasetyawan; Chanif Mahdi; Arie Srihardyastutie; Made Oka Adnyana; Aulanni’am Aulanni’am
The Journal of Pure and Applied Chemistry Research Vol 7, No 1 (2018): Edition January-April 2018
Publisher : Chemistry Department, The University of Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1011.607 KB) | DOI: 10.21776/ub.jpacr.2018.007.01.363

Abstract

This research studies the effect of anthocyanin from purple sweet potato in the cerebellum of stroke ischemic rats by MCAO (Middle Cerebral Artery Occlusion) technique. This technique was carried out by ligating the blood flow in ECA and CCA region for 3 hours, followed by reperfusion. The MCAO technique proved as a technique for preparing ischemic stroke rats. This technique induces releasing of BDNF and VEGF in the cerebellum of ischemic stroke rats. The level of BDNF measured by ELISA technique and VEGF expression used immunohistochemistry technique. The results showed that anthocyanin from purple sweet potato increased the level of both BDNF and VEGF expression in the cerebellum in ischemic stroke rats. It is suggested that anthocyanin could be used as a therapeutic agent for ischemic stroke.
Co-Authors Arie Srihardyastutie Aulanni’am Aulanni’am Chanif Mahdi Made Oka Adnyana Sasangka Prasetyawan