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All Journal Damianus Journal of Medicine Jurnal Farmasi Indonesia Science Midwifery Jurnal Bakti Masyarakat Indonesia
Prasetyanto, Eko Adi
Prodi Farmasi, Universitas Katolik Indonesia Atma Jaya
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Dentistry Education Electrical & Electronics Engineering Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Journal : Jurnal Farmasi Indonesia

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Pengembangan Molecular Imprinted Polymer Untuk Pemisahan Vitamin C dalam Sediaan Multivitamin Untung Gunawan; Eko Adi Prasetyanto; Shannen Ivanka Gunardi
Jurnal Farmasi Indonesia Vol 18 No 1 (2021): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v18i1.1155

Abstract

Vitamin C has chromophore group that can be analyzed using UV-Vis spectrophotometry, however if the complex matrix to be analyzed like multivitamins, a selective separation method is required to eliminate matrix interferences. One of the selective separation methods is Molecular Imprinted Polymer (MIP) which which hasn’t been widely used in multivitamin samples. The purpose of this study was to obtain selective MIP for separation of vitamin C in multivitamins.. Research methods included interaction observation of vitamin C with functional monomers using UV spectrophotometry, MIP was synthesized using bulk method for 24 hours at 60 °C. MIP was characterized using spectrophotometry, infrared and scanning electron microscopy MIP selectivity were determined by determination of imprinting factor and its recovery with the liquid-liquid extraction method (LLE) and SPE C18 for separation of vitamin C in multivitamin samples on the market using a validated method. Hypsochromic shift showed interaction between vitamin C and functional monomers, which hydrogen bonds were taking role in MIP synthesis. Imprinting factor more than 1 and recovery value close to 100% indicated MIP selectivity to vitamin C. MIP-1 had the highest selectivity compared to the ECC and SPE C18 methods for separation of vitamin C in multivitamin samples with recovery of 98.17 ± 2.31%, 69.42 ± 3.01%, and 93.26±4.24% respectively. Synthesized MIP-1 was selective for the separation of vitamin C in multivitamins.
Co-Authors Alexander Boentoro Alvin Henrijento Andreas Halim Anugrah Jordan Signori Atthar Luqman Ivansyah Christian Joseph Tanuwidjaja Falena, Pretty Filian Arbiyani Gunawan, Untung Irlianto, Kellie John Louis Christopher Tanaya Juan Almer Dynan Shannen Ivanka Gunardi