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All Journal Journal of Health (JoH) Jurnal Farmasi Indonesia
Shannen Ivanka Gunardi
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Pengembangan Molecular Imprinted Polymer Untuk Pemisahan Vitamin C dalam Sediaan Multivitamin Untung Gunawan; Eko Adi Prasetyanto; Shannen Ivanka Gunardi
Jurnal Farmasi Indonesia Vol 18 No 1 (2021): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v18i1.1155

Abstract

Vitamin C has chromophore group that can be analyzed using UV-Vis spectrophotometry, however if the complex matrix to be analyzed like multivitamins, a selective separation method is required to eliminate matrix interferences. One of the selective separation methods is Molecular Imprinted Polymer (MIP) which which hasn’t been widely used in multivitamin samples. The purpose of this study was to obtain selective MIP for separation of vitamin C in multivitamins.. Research methods included interaction observation of vitamin C with functional monomers using UV spectrophotometry, MIP was synthesized using bulk method for 24 hours at 60 °C. MIP was characterized using spectrophotometry, infrared and scanning electron microscopy MIP selectivity were determined by determination of imprinting factor and its recovery with the liquid-liquid extraction method (LLE) and SPE C18 for separation of vitamin C in multivitamin samples on the market using a validated method. Hypsochromic shift showed interaction between vitamin C and functional monomers, which hydrogen bonds were taking role in MIP synthesis. Imprinting factor more than 1 and recovery value close to 100% indicated MIP selectivity to vitamin C. MIP-1 had the highest selectivity compared to the ECC and SPE C18 methods for separation of vitamin C in multivitamin samples with recovery of 98.17 ± 2.31%, 69.42 ± 3.01%, and 93.26±4.24% respectively. Synthesized MIP-1 was selective for the separation of vitamin C in multivitamins.
Aktivitas Antibakteri dari Sinularia sp. terhadap Escherichia coli dan Staphylococcus aureus: Meta-analisis dan Telaah Sistematis: Antibacterial Activity of Sinularia sp. Against Escherichia coli and Staphylococcus aureus: Meta-Analysis and Systematic Review Prismawan, Deka; Monika Arvia Chiara; Shannen Ivanka Gunardi; Karmill Trinanda; Robby Sutedjo; Michael, Michael
Journal of Health (JoH) Vol 12 No 1 (2025): Journal of Health (JoH) - January
Publisher : LPPM STIKES Guna Bangsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30590/joh.v12n1.1094

Abstract

The Ocean covers more than 70% of Indonesian archipelago, providing various bioactive compounds with great potential, however, it is relatively underexplored Sinularia sp, a genus of soft corals, exists at the coral reefs of Indo-Pacific ocean. Several recent studies have shown that Sinularia sp. contains various types of secondary metabolites with antiviral, antibacterial, anticancer, and antimalarial properties. In addition, further exploration and discovery of novel antibacterials that are effective against wide spectrum of bacteria is of great interest, especially to combat the emerging antibiotic resistance. The aim of this study is to evaluate the potential of antibacterial activity from Sinularia sp against E. coli and S. aureus which in turn, may provide an alternative antibacterial to overcome the emerging antibiotic resistance. This study was conducted based on the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) statement to measure the effect size of the antibacterial activity from Sinularia sp. against E. coli and S. aureus. Estimated value of the effect size obtained is 2.52 (CI 95% 0.98 to 4.06) and 5.97 (CI 95% 3.18 to 8.77) towards E. coli and S. aureus. When viewed as a whole, published data appears to show a positive antibacterial effect from Sinularia sp.
Co-Authors Deka Prismawan Gunawan, Untung Karmill Trinanda Michael Michael Monika Arvia Chiara Prasetyanto, Eko Adi Robby Sutedjo