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All Journal Medula Bioscientia Medicina : Journal of Biomedicine and Translational Research Bioscientia Medicina : Journal of Biomedicine and Translational Research
Defa Agripratama Ali
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Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Description of Food Comsumption Patterns in Pregnant Women in the Coastal Area of Kendari City Juminten Saimin; Ade Rizky Amalia; Amalia Nur Azizah; Muhammad Faisal; Defa Agripratama Ali
MEDULA JURNAL ILMIAH FAKULLTAS KEDOKTERAN UNIVERSITAS HALU OLEO Vol 6, No 3 (2019): Edisi Suplemen
Publisher : Halu Oleo University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (46.845 KB) | DOI: 10.46496/medula.v6i3.9647

Abstract

ABSTRAKKebutuhan gizi ibu hamil meningkat seiring dengan bertambahnya umur kehamilan. Pemenuhanasupan gizi dan  pola  makanan  yang  tepat berperan  penting  terhadap  kesehatan  ibu dan  janin. Penelitian ini bertujuan untuk mengetahui gambaran pola konsumsi makanan   pada ibu hamil didaerah pesisir Kota Kendari. Metode: Jenis penelitian ini adalah deskriptif observasional dengan metode cross-sectional.  Pengambilan sampel secara consecutive sampling yang dilakukan pada ibu hamil trimester ketiga di daerah pesisir Kota Kendari pada bulan September-Desember 2016. Data diambil menggunakan  food  frequency  questionaire  (FFQ)  pada  50  responden  ibu  hamil.  Hasil: Penelitian ini menunjukkan bahwa makanan yang tersering dikonsumsi adalah nasi (100%) dan ikan segar (94%). Sayuran yang paling sering dikonsumsi adalah bayam (52%). Makanan yang jarang dikonsumsi adalah ikan asin (34%). Sebagian besar responden tidak pernah mengkonsumsi kerang (98%). Sumber karbohidrat yang tersering dikonsumsi adalah nasi (100%) dengan skor 50, sumber protein tersering adalah ikan segar (94%) dengan skor 46,5 dan sayuran tersering adalah bayam (52%) dengan skor 31,8.Simpulan: Ibu hamil di daerah pesisir Kota  Kendari mempunyai pola  konsumsi makanan yang banyak dari sumber karbohidrat dan protein, serta sayuran. Perlu senantiasa dilakukan penyuluhanpemenuhan gizi seimbang dan variasi makanan dari bahan makanan lokal. Kata kunci: daerah pesisir, food frequency questionnaire, ibu hamil, pola konsumsi
Rhodomyrtus tomentosa Leaf Extract Cream Suppresses MMP-1 Expression and Epidermal Thickening in UVB-Irradiated Swiss Webster Mice Defa Agripratama Ali; Zen Hafy; Veny Larasati; Nora Ramkita
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 10 No. 6 (2026): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v10i6.1609

Abstract

Background: Ultraviolet B (UVB) radiation induces matrix metalloproteinase-1 (MMP-1) expression and epidermal hyperplasia, contributing to photoaging. Rhodomyrtus tomentosa (karamunting) is rich in polyphenolic compounds with documented antioxidant properties, but its in vivo photoprotective effects remain unexplored. Methods: We investigated the effects of R. tomentosa leaf extract cream at varying concentrations (0%, 12.5%, 25%, 50%) on UVB-irradiated Swiss Webster mice (n=4 per group). UVB exposure was standardized at approximately 150 mJ/cm² per session over seven consecutive days. Vitamin E cream served as a positive control. Immunohistochemical staining quantified MMP-1 expression as a percentage of positive cells, while hematoxylin-eosin histology measured epidermal thickness. Results: Kruskal-Wallis testing revealed significant differences in both MMP-1 expression (H=10.43, p=0.015) and epidermal thickness (H=10.88, p=0.012). The 25% extract concentration optimally suppressed MMP-1 expression (mean 45.94% of positive cells) compared to the untreated UVB control (89.53%). A biphasic dose-response pattern emerged, with hormetic effects observed at 50% concentration (76.45%), suggesting polyphenol pro-oxidant activity at excessive concentrations. Epidermal thickness normalized with 25% treatment (71.8 μm) versus UVB control (93.4 μm). Immunohistochemical intensity decreased progressively with treatment intensification through 25%, supporting suppression of MMP-1-mediated collagen degradation. Conclusion: R. tomentosa leaf extract cream at 25% concentration effectively suppresses MMP-1 expression and normalizes UVB-induced epidermal thickening in mice. The hormetic response at higher concentrations highlights the importance of dose optimization in phytotherapeutic development. This work establishes the first in vivo evidence for karamunting leaf extract as a photoprotective agent and supports further clinical translation.
Rhodomyrtus tomentosa Leaf Extract Cream Suppresses MMP-1 Expression and Epidermal Thickening in UVB-Irradiated Swiss Webster Mice Defa Agripratama Ali; Zen Hafy; Veny Larasati; Nora Ramkita
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 10 No. 6 (2026): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v10i6.1609

Abstract

Background: Ultraviolet B (UVB) radiation induces matrix metalloproteinase-1 (MMP-1) expression and epidermal hyperplasia, contributing to photoaging. Rhodomyrtus tomentosa (karamunting) is rich in polyphenolic compounds with documented antioxidant properties, but its in vivo photoprotective effects remain unexplored. Methods: We investigated the effects of R. tomentosa leaf extract cream at varying concentrations (0%, 12.5%, 25%, 50%) on UVB-irradiated Swiss Webster mice (n=4 per group). UVB exposure was standardized at approximately 150 mJ/cm² per session over seven consecutive days. Vitamin E cream served as a positive control. Immunohistochemical staining quantified MMP-1 expression as a percentage of positive cells, while hematoxylin-eosin histology measured epidermal thickness. Results: Kruskal-Wallis testing revealed significant differences in both MMP-1 expression (H=10.43, p=0.015) and epidermal thickness (H=10.88, p=0.012). The 25% extract concentration optimally suppressed MMP-1 expression (mean 45.94% of positive cells) compared to the untreated UVB control (89.53%). A biphasic dose-response pattern emerged, with hormetic effects observed at 50% concentration (76.45%), suggesting polyphenol pro-oxidant activity at excessive concentrations. Epidermal thickness normalized with 25% treatment (71.8 μm) versus UVB control (93.4 μm). Immunohistochemical intensity decreased progressively with treatment intensification through 25%, supporting suppression of MMP-1-mediated collagen degradation. Conclusion: R. tomentosa leaf extract cream at 25% concentration effectively suppresses MMP-1 expression and normalizes UVB-induced epidermal thickening in mice. The hormetic response at higher concentrations highlights the importance of dose optimization in phytotherapeutic development. This work establishes the first in vivo evidence for karamunting leaf extract as a photoprotective agent and supports further clinical translation.
Co-Authors Ade Rizky Amalia Amalia Nur Azizah Juminten Saimin Larasati, Veny Muhammad Faisal Nora Ramkita Zen Hafy